2-Methyl-3-oxopropanoic acid (BioDeep_00000004417)

 

Secondary id: BioDeep_00001869055

human metabolite Endogenous


代谢物信息卡片


Methylmalonic acid semialdehyde

化学式: C4H6O3 (102.0316926)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.38%

分子结构信息

SMILES: CC(C=O)C(=O)O
InChI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)

描述信息

2-Methyl-3-oxopropanoic acid is an intermediate in the metabolism of Propanoate. It is a substrate for 3-hydroxyisobutyrate dehydrogenase (mitochondrial), Alanine--glyoxylate aminotransferase 2 (mitochondrial) and Methylmalonate-semialdehyde dehydrogenase (mitochondrial). [HMDB]
2-Methyl-3-oxopropanoic acid is an intermediate in the metabolism of Propanoate. It is a substrate for 3-hydroxyisobutyrate dehydrogenase (mitochondrial), Alanine--glyoxylate aminotransferase 2 (mitochondrial) and Methylmalonate-semialdehyde dehydrogenase (mitochondrial).

同义名列表

9 个代谢物同义名

Methylmalonic acid semialdehyde; 3-oxo-2-Methylpropanoic acid; 2-methyl-3-oxopropanoic acid; Methylmalonate semialdehyde; Methylmalonate-semialdehyde; CH3-Malonate-semialdehyde; 2-Methyl-3-oxo-propanoate; 3-oxo-2-Methylpropanoate; 2-Methyl-3-oxopropanoate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

12 个相关的代谢反应过程信息。

Reactome(9)

BioCyc(3)

  • 2,4-dinitrotoluene degradation: 2,4-dinitrotoluene + NADH + O2 ⟶ 4-methyl-5-nitrocatechol + NAD+ + nitrite
  • valine degradation: 2-oxoisovalerate + an [apo BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine ⟶ CO2 + an [apo BCAA dehydrogenase E2 protein] N6-S-[2-methylpropanoyl]dihydrolipoyl-L-lysine
  • valine degradation III: H2O + NAD+ + coenzyme A + methylmalonate semialdehyde ⟶ H+ + NADH + hydrogen carbonate + propanoyl-CoA

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mariana Seija, Cecilia Baccino, Nicolás Nin, Carolina Sánchez-Rodríguez, Rosario Granados, Antonio Ferruelo, Leticia Martínez-Caro, Jesús Ruíz-Cabello, Marta de Paula, Oscar Noboa, Andrés Esteban, José Angel Lorente. Role of peroxynitrite in sepsis-induced acute kidney injury in an experimental model of sepsis in rats. Shock (Augusta, Ga.). 2012 Oct; 38(4):403-10. doi: 10.1097/shk.0b013e31826660f2. [PMID: 22777123]
  • Amol R Suryawanshi, Shagufta A Khan, Chetanchandra S Joshi, Vrinda V Khole. Epididymosome-mediated acquisition of MMSDH, an androgen-dependent and developmentally regulated epididymal sperm protein. Journal of andrology. 2012 Sep; 33(5):963-74. doi: 10.2164/jandrol.111.014753. [PMID: 22207704]
  • Jörn Oliver Sass, Melanie Walter, Julian P H Shield, Andrea M Atherton, Uttam Garg, David Scott, C Geoffrey Woods, Laurie D Smith. 3-Hydroxyisobutyrate aciduria and mutations in the ALDH6A1 gene coding for methylmalonate semialdehyde dehydrogenase. Journal of inherited metabolic disease. 2012 May; 35(3):437-42. doi: 10.1007/s10545-011-9381-x. [PMID: 21863277]
  • Myung Hee Nam, Sun Mi Huh, Kyung Mi Kim, Woong June Park, Jong Bok Seo, Kun Cho, Dool Yi Kim, Beom Gi Kim, In Sun Yoon. Comparative proteomic analysis of early salt stress-responsive proteins in roots of SnRK2 transgenic rice. Proteome science. 2012 Mar; 10(?):25. doi: 10.1186/1477-5956-10-25. [PMID: 22462395]
  • Yucheng Zhang, Linyong Mao, Hua Wang, Chad Brocker, Xiangjing Yin, Vasilis Vasiliou, Zhangjun Fei, Xiping Wang. Genome-wide identification and analysis of grape aldehyde dehydrogenase (ALDH) gene superfamily. PloS one. 2012; 7(2):e32153. doi: 10.1371/journal.pone.0032153. [PMID: 22355416]
  • George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes. A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS genetics. 2011 Sep; 7(9):e1002270. doi: 10.1371/journal.pgen.1002270. [PMID: 21931564]
  • Andrej Kochevenko, Alisdair R Fernie. The genetic architecture of branched-chain amino acid accumulation in tomato fruits. Journal of experimental botany. 2011 Jul; 62(11):3895-906. doi: 10.1093/jxb/err091. [PMID: 21436187]
  • Yan Lu, Linda J Savage, Matthew D Larson, Curtis G Wilkerson, Robert L Last. Chloroplast 2010: a database for large-scale phenotypic screening of Arabidopsis mutants. Plant physiology. 2011 Apr; 155(4):1589-600. doi: 10.1104/pp.110.170118. [PMID: 21224340]
  • Linkun Wu, Haibin Wang, Zhixing Zhang, Rui Lin, Zhongyi Zhang, Wenxiong Lin. Comparative metaproteomic analysis on consecutively Rehmannia glutinosa-monocultured rhizosphere soil. PloS one. 2011; 6(5):e20611. doi: 10.1371/journal.pone.0020611. [PMID: 21655235]
  • Hongxiang Guo, Yunchao Kan, Weiqun Liu. Differential expression of miRNAs in response to topping in flue-cured tobacco (Nicotiana tabacum) roots. PloS one. 2011; 6(12):e28565. doi: 10.1371/journal.pone.0028565. [PMID: 22194852]
  • Maria Filippa Addis, Roberto Cappuccinelli, Vittorio Tedde, Daniela Pagnozzi, Iolanda Viale, Mauro Meloni, Fulvio Salati, Tonina Roggio, Sergio Uzzau. Influence of Moraxella sp. colonization on the kidney proteome of farmed gilthead sea breams (Sparus aurata, L.). Proteome science. 2010 Oct; 8(?):50. doi: 10.1186/1477-5956-8-50. [PMID: 20939867]
  • Natalie Lefort, Brian Glancy, Benjamin Bowen, Wayne T Willis, Zachary Bailowitz, Elena A De Filippis, Colleen Brophy, Christian Meyer, Kurt Højlund, Zhengping Yi, Lawrence J Mandarino. Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle. Diabetes. 2010 Oct; 59(10):2444-52. doi: 10.2337/db10-0174. [PMID: 20682693]
  • Patrizia Vaccino, Heinz-Albert Becker, Andrea Brandolini, Francesco Salamini, Benjamin Kilian. A catalogue of Triticum monococcum genes encoding toxic and immunogenic peptides for celiac disease patients. Molecular genetics and genomics : MGG. 2009 Mar; 281(3):289-300. doi: 10.1007/s00438-008-0412-8. [PMID: 19104838]
  • Wangzhen Guo, Caiping Cai, Changbiao Wang, Liang Zhao, Lei Wang, Tianzhen Zhang. A preliminary analysis of genome structure and composition in Gossypium hirsutum. BMC genomics. 2008 Jul; 9(?):314. doi: 10.1186/1471-2164-9-314. [PMID: 18590573]
  • Jeffrey P Simpson, Rosa Di Leo, Preetinder K Dhanoa, Wendy L Allan, Amina Makhmoudova, Shawn M Clark, Gordon J Hoover, Robert T Mullen, Barry J Shelp. Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification. Journal of experimental botany. 2008; 59(9):2545-54. doi: 10.1093/jxb/ern123. [PMID: 18495639]
  • Naoki Tanaka, Hideyuki Takahashi, Hidemi Kitano, Makoto Matsuoka, Shoichiro Akao, Hirofumi Uchimiya, Setsuko Komatsu. Proteome approach to characterize the methylmalonate-semialdehyde dehydrogenase that is regulated by gibberellin. Journal of proteome research. 2005 Sep; 4(5):1575-82. doi: 10.1021/pr050114f. [PMID: 16212409]
  • Hans-Hubert Kirch, Dorothea Bartels, Yanling Wei, Patrick S Schnable, Andrew J Wood. The ALDH gene superfamily of Arabidopsis. Trends in plant science. 2004 Aug; 9(8):371-7. doi: 10.1016/j.tplants.2004.06.004. [PMID: 15358267]
  • Keiko Oguchi, Naoki Tanaka, Setsuko Komatsu, Shoichiro Akao. Methylmalonate-semialdehyde dehydrogenase is induced in auxin-stimulated and zinc-stimulated root formation in rice. Plant cell reports. 2004 Jun; 22(11):848-58. doi: 10.1007/s00299-004-0778-y. [PMID: 15045523]