Florasulam (BioDeep_00000003979)

 

Secondary id: BioDeep_00000408794

human metabolite blood metabolite


代谢物信息卡片


N-(2,6-Difluorophenyl)-5-methoxy-8-fluoro-(1,2,4)-triazolo-(1,5C)-pyrimidine-2-sulfonamide

化学式: C12H8F3N5O3S (359.0299934000001)
中文名称: 双氟磺草胺
谱图信息: 最多检出来源 Homo sapiens(blood) 7.14%

分子结构信息

SMILES: COC1=NC=C(C2=NC(=NN21)S(=O)(=O)NC3=C(C=CC=C3F)F)F
InChI: InChI=1S/C12H8F3N5O3S/c1-23-12-16-5-8(15)10-17-11(18-20(10)12)24(21,22)19-9-6(13)3-2-4-7(9)14/h2-5,19H,1H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7356; ORIGINAL_PRECURSOR_SCAN_NO 7353
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7334; ORIGINAL_PRECURSOR_SCAN_NO 7332
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3508; ORIGINAL_PRECURSOR_SCAN_NO 3504
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7314; ORIGINAL_PRECURSOR_SCAN_NO 7312
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7299; ORIGINAL_PRECURSOR_SCAN_NO 7295
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3579; ORIGINAL_PRECURSOR_SCAN_NO 3576
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3499; ORIGINAL_PRECURSOR_SCAN_NO 3497
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7330; ORIGINAL_PRECURSOR_SCAN_NO 7326
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7351; ORIGINAL_PRECURSOR_SCAN_NO 7349
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3513; ORIGINAL_PRECURSOR_SCAN_NO 3511
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3508; ORIGINAL_PRECURSOR_SCAN_NO 3505
CONFIDENCE standard compound; INTERNAL_ID 386; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3510; ORIGINAL_PRECURSOR_SCAN_NO 3508
INTERNAL_ID 386; CONFIDENCE standard compound; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7351; ORIGINAL_PRECURSOR_SCAN_NO 7349

同义名列表

5 个代谢物同义名

N-(2,6-Difluorophenyl)-5-methoxy-8-fluoro-(1,2,4)-triazolo-(1,5C)-pyrimidine-2-sulfonamide; N-(2,6-Difluorophenyl)-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulphonamide; N-(2,6-difluorophenyl)-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide; Florasulam; Florasulam



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Firouzeh Sharifi Kalyani, Sirwan Babaei, Yasin Zafarsohrabpour, Iraj Nosratti, Karla Gage, Amir Sadeghpour. Investigating the impacts of airborne dust on herbicide performance on Amaranthus retroflexus. Scientific reports. 2024 02; 14(1):3785. doi: 10.1038/s41598-024-54134-5. [PMID: 38360846]
  • Haiyan Yu, Xiaotong Guo, Licun Peng, Xiangju Li, Jingchao Chen, Hailan Cui. Target gene mutations endowed cross-resistance to acetolactate synthase-inhibiting herbicides in wild Brassica juncea. Pesticide biochemistry and physiology. 2023 Dec; 197(?):105683. doi: 10.1016/j.pestbp.2023.105683. [PMID: 38072540]
  • Xiaole Wang, Jingwen Zhang, Yu Liu, Chengbo Lu, Kaixuan Hou, Yunchen Huang, Albert Juhasz, Lusheng Zhu, Zhongkun Du, Bing Li. Effect of florasulam on oxidative damage and apoptosis in larvae and adult zebrafish (Danio rerio). Journal of hazardous materials. 2023 03; 446(?):130682. doi: 10.1016/j.jhazmat.2022.130682. [PMID: 36580788]
  • Qin Jiao, Yuelin Mu, Jiahui Deng, Xiangfeng Yao, Xiaoyan Zhao, Xiang Liu, Xiangdong Li, Xingyin Jiang, Fengwen Zhang. Direct toxicity of the herbicide florasulam against Chlorella vulgaris: An integrated physiological and metabolomic analysis. Ecotoxicology and environmental safety. 2022 Nov; 246(?):114135. doi: 10.1016/j.ecoenv.2022.114135. [PMID: 36201917]
  • Hengzhi Wang, Penglei Sun, Wenlei Guo, Xiuxia Dong, Weitang Liu, Jinxin Wang. Florasulam resistance status of flixweed (Descurainia sophia L.) and alternative herbicides for its chemical control in the North China plain. Pesticide biochemistry and physiology. 2021 Feb; 172(?):104748. doi: 10.1016/j.pestbp.2020.104748. [PMID: 33518041]
  • Jian Li, Xingxiang Gao, Mei Li, Feng Fang. Resistance evolution and mechanisms to ALS-inhibiting herbicides in Capsella bursa-pastoris populations from China. Pesticide biochemistry and physiology. 2019 Sep; 159(?):17-21. doi: 10.1016/j.pestbp.2019.05.010. [PMID: 31400779]
  • Qian Wang, Lu'an Ge, Ning Zhao, Lele Zhang, Ludan You, Dandan Wang, Weitang Liu, Jinxin Wang. A Trp-574-Leu mutation in the acetolactate synthase (ALS) gene of Lithospermum arvense L. confers broad-spectrum resistance to ALS inhibitors. Pesticide biochemistry and physiology. 2019 Jul; 158(?):12-17. doi: 10.1016/j.pestbp.2019.04.001. [PMID: 31378346]
  • Nannan Pang, Yu Cui, Jiye Hu. Weather dependent dynamics of the herbicides florasulam, carfentrazone-ethyl, fluroxypyr-meptyl and fluroxypyr in wheat fields through field studies and computational simulation. Chemosphere. 2016 Dec; 165(?):320-328. doi: 10.1016/j.chemosphere.2016.09.026. [PMID: 27664521]
  • Mengmeng Zhong, Tielong Wang, Jiye Hu. Dissipation kinetics and residues of triazolopyrimidine herbicides flumetsulam and florasulam in corn ecosystem. Environmental monitoring and assessment. 2015 Jun; 187(6):390. doi: 10.1007/s10661-015-4593-4. [PMID: 26026845]
  • Bizhang Dong, Wei Qian, Jiye Hu. Dissipation kinetics and residues of florasulam and tribenuron-methyl in wheat ecosystem. Chemosphere. 2015 Feb; 120(?):486-91. doi: 10.1016/j.chemosphere.2014.09.016. [PMID: 25268470]
  • Weitang Liu, Guohui Yuan, Long Du, Wenlei Guo, Lingxu Li, Yaling Bi, Jinxin Wang. A novel Pro197Glu substitution in acetolactate synthase (ALS) confers broad-spectrum resistance across ALS inhibitors. Pesticide biochemistry and physiology. 2015 Jan; 117(?):31-8. doi: 10.1016/j.pestbp.2014.10.005. [PMID: 25619909]
  • Zhuonan Li, Wenbi Guan, Huijie Hong, Yong Ye, Yongqiang Ma. Determination and study on residue and dissipation of florasulam in wheat and soil under field conditions. Bulletin of environmental contamination and toxicology. 2013 Mar; 90(3):280-4. doi: 10.1007/s00128-012-0916-0. [PMID: 23238823]
  • Christophe Délye, Fanny Pernin, Laura Scarabel. Evolution and diversity of the mechanisms endowing resistance to herbicides inhibiting acetolactate-synthase (ALS) in corn poppy (Papaver rhoeas L.). Plant science : an international journal of experimental plant biology. 2011 Feb; 180(2):333-42. doi: 10.1016/j.plantsci.2010.10.007. [PMID: 21421378]
  • Dehuan Ran, Xia Wu, Jinhua Zheng, Jinghe Yang, Haiping Zhou, Meifeng Zhang, Yongjun Tang. Study on the interaction between florasulam and bovine serum albumin. Journal of fluorescence. 2007 Nov; 17(6):721-6. doi: 10.1007/s10895-007-0226-9. [PMID: 17703351]
  • Gerrit J deBoer, Scott Thornburgh, Robert J Ehr. Uptake, translocation and metabolism of the herbicide florasulam in wheat and broadleaf weeds. Pest management science. 2006 Apr; 62(4):316-24. doi: 10.1002/ps.1163. [PMID: 16506146]
  • G Rijckaert, D Lepiece. Study of the selectivity of PRIMSTAR (fluroxypyr + florasulam) in two key grass species (FESRU & LOLPE) grown for seed production. Communications in agricultural and applied biological sciences. 2003; 68(4 Pt A):381-90. doi: . [PMID: 15149133]
  • E A Paterson, Z L Shenton, A E Straszewski. Establishment of the baseline sensitivity and monitoring response of Papaver rhoeas populations to florasulam. Pest management science. 2002 Sep; 58(9):964-6. doi: 10.1002/ps.562. [PMID: 12233189]
  • G Rijckaert, D Lepiece. Selectivity of florasulam in 4 grass species during the seed harvest year. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen). 2001; 66(2b):747-52. doi: . [PMID: 12425099]
  • D Lepiece, J F Salembier, A Thompson. Primus (florasulam 50 G/L), a new triazolopyrimidine sulfonanilide herbicide to control broad-leaved weeds in maize when applied in early postemergence (1 to 6 leaf stage of maize). Preliminary results. Mededelingen (Rijksuniversiteit te Gent. Fakulteit van de Landbouwkundige en Toegepaste Biologische Wetenschappen). 2001; 66(2b):681-704. doi: . [PMID: 12425093]