Bilobalide A (BioDeep_00000003598)
Main id: BioDeep_00000229962
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
(1R,4R,7R,8S,9R,11R)-9-Tert-butyl-7,9-dihydroxy-3,5,12-trioxatetracyclo[6.6.0.01,11.04,8]tetradecane-2,6,13-trione
化学式: C15H18O8 (326.1002)
中文名称: 白果内酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C1(CC2C3(C14C(C(=O)OC4OC3=O)O)CC(=O)O2)O
InChI: InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3
描述信息
Bilobalide A is found in fats and oils. Bilobalide A is a constituent of leaves of Ginkgo biloba (ginkgo).
Constituent of leaves of Ginkgo biloba (ginkgo). Bilobalide A is found in ginkgo nuts and fats and oils.
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC50 value of 2.3 μM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons[1][2].
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC50 value of 2.3 μM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons[1][2].
同义名列表
9 个代谢物同义名
(1R,4R,7R,8S,9R,11R)-9-Tert-butyl-7,9-dihydroxy-3,5,12-trioxatetracyclo[6.6.0.01,11.04,8]tetradecane-2,6,13-trione; (1S,4R,7S,8S,9R,11S)-9-tert-butyl-7,9-dihydroxy-3,5,12-trioxatetracyclo[6.6.0.0¹,¹¹.0⁴,⁸]tetradecane-2,6,13-trione; (1S,4R,9R,11S)-9-tert-butyl-7,9-dihydroxy-3,5,12-trioxatetracyclo[6.6.0.01,11.04,8]tetradecane-2,6,13-trione; 9-Tert-butyl-7,9-dihydroxy-3,5,12-trioxatetracyclo[6.6.0.01,11.04,8]tetradecane-2,6,13-trione; (-)-bilobalide; Bilobalide A; Bilobalide; Bilobalide; Bilobalide
数据库引用编号
18 个数据库交叉引用编号
- KEGG: C07605
- PubChem: 11875005
- PubChem: 25090658
- PubChem: 545839
- HMDB: HMDB0036735
- Metlin: METLIN73567
- KNApSAcK: C00011512
- foodb: FDB015672
- chemspider: 475104
- CAS: 33570-04-6
- PMhub: MS000010209
- ChEBI: CHEBI:3103
- PubChem: 9807
- NIKKAJI: J17.976K
- medchemexpress: HY-N0076
- LOTUS: LTS0000581
- wikidata: Q76422221
- KNApSAcK: 3103
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 3311 - Ginkgo biloba:
- 3311 - Ginkgo biloba: 10.1021/JA00743A051
- 3311 - Ginkgo biloba L.: -
- 9606 - Homo sapiens: -
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lars Wiklund, Aruna Sharma, Dafin F Muresanu, Zhiqiang Zhang, Cong Li, Z Ryan Tian, Anca D Buzoianu, José Vicente Lafuente, Ala Nozari, Lianyuan Feng, Hari Shanker Sharma. TiO2-Nanowired Delivery of Chinese Extract of Ginkgo biloba EGb-761 and Bilobalide BN-52021 Enhanced Neuroprotective Effects of Cerebrolysin Following Spinal Cord Injury at Cold Environment.
Advances in neurobiology.
2023; 32(?):353-384. doi:
10.1007/978-3-031-32997-5_9. [PMID: 37480466] - T-T Niu, B-Y Yuan, G-Z Liu. Ginkgolides and bilobalide for treatment of Alzheimer's disease and COVID-19: potential mechanisms of action.
European review for medical and pharmacological sciences.
2022 12; 26(24):9502-9510. doi:
10.26355/eurrev_202212_30702. [PMID: 36591860] - Qiang Su, Jing Dong, Donglei Zhang, Lu Yang, Rupak Roy. Protective Effects of the Bilobalide on Retinal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.
Applied biochemistry and biotechnology.
2022 Dec; 194(12):6407-6422. doi:
10.1007/s12010-022-04012-5. [PMID: 35932369] - Li-Juan Song, Ruo-Xuan Sui, Jing Wang, Qiang Miao, Yan He, Jun-Jun Yin, Jun An, Zhi-Bin Ding, Qing-Xian Han, Qing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma. Targeting the differentiation of astrocytes by Bilobalide in the treatment of Parkinson's disease model.
The International journal of neuroscience.
2022 Aug; ?(?):1-18. doi:
10.1080/00207454.2022.2100778. [PMID: 36037147] - Jiajia Zhao, Kun Li, Yingying Wang, Dan Li, Qianwen Wang, Shengsheng Xie, Jianxin Wang, Zhong Zuo. Enhanced anti-amnestic effect of donepezil by Ginkgo biloba extract (EGb 761) via further improvement in pro-cholinergic and antioxidative activities.
Journal of ethnopharmacology.
2021 Apr; 269(?):113711. doi:
10.1016/j.jep.2020.113711. [PMID: 33352242] - Yan Zhang, Hongyin Zhai. Bilobalide assuages morphine-induced addiction in hippocampal neuron cells through upregulation of microRNA-101.
Journal of biochemical and molecular toxicology.
2020 Jul; 34(7):e22493. doi:
10.1002/jbt.22493. [PMID: 32319158] - Qiang Miao, Xiao-Xue Zhang, Qing-Xian Han, Si-Si Ren, Ruo-Xuan Sui, Jing-Wen Yu, Jing Wang, Qing Wang, Jie-Zhong Yu, Liang Cao, Wei Xiao, Bao-Guo Xiao, Cun-Gen Ma. The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice.
Metabolic brain disease.
2020 06; 35(5):793-807. doi:
10.1007/s11011-020-00555-w. [PMID: 32215835] - Hai-Li Dong, Shan Lin, Qiu-Ling Wu, Ri-Xin Su, Zhi-Li Wu, Hong-Yuan Dong, Hui-Liang Li, Wei-Dong Zhang. A new bilobalide isomer and two cis-coumaroylated flavonol glycosides from Ginkgo biloba leaves.
Fitoterapia.
2020 Apr; 142(?):104516. doi:
10.1016/j.fitote.2020.104516. [PMID: 32081701] - Shohei Nishimon, Mai Yamaguchi, Hisae Muraki, Noriaki Sakai, Seiji Nishino. Intraperitoneal injection of ginkgolide B, a major active compound of Ginkgo biloba, dose-dependently increases the amount of wake and decreases non-rapid eye movement sleep in C57BL/6 mice.
Neuroscience letters.
2020 03; 722(?):134832. doi:
10.1016/j.neulet.2020.134832. [PMID: 32050100] - Dongmei Mao, Hong Li, Lei Zhang, Jian Xu, Chunyan Yu, Qi Zhang. Bilobalide alleviates IL-17-induced inflammatory injury in ATDC5 cells by downregulation of microRNA-125a.
Journal of biochemical and molecular toxicology.
2019 Dec; 33(12):e22405. doi:
10.1002/jbt.22405. [PMID: 31593333] - Meghan A Baker, Robert M Demoret, Masaki Ohtawa, Ryan A Shenvi. Concise asymmetric synthesis of (-)-bilobalide.
Nature.
2019 11; 575(7784):643-646. doi:
10.1038/s41586-019-1690-5. [PMID: 31618759] - Haihua Zhang, Qiumei Shi, Weixiao Nan, Yaqi Wang, Shiyong Wang, Fuhe Yang, Guangyu Li. Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.
BioFactors (Oxford, England).
2019 Nov; 45(6):950-958. doi:
10.1002/biof.1562. [PMID: 31520488] - Peter Yaro, Jing Nie, Mingcheng Xu, Kui Zeng, Houhong He, Jianbiao Yao, Ruwei Wang, Su Zeng. Influence of organic anion transporter 1/3 on the pharmacokinetics and renal excretion of ginkgolides and bilobalide.
Journal of ethnopharmacology.
2019 Oct; 243(?):112098. doi:
10.1016/j.jep.2019.112098. [PMID: 31325605] - Jun Xiang, Jingsi Zhang, Xiaofang Cai, Feng Yang, Wen Zhu, Wen Zhang, Min Cai, Zhonghai Yu, Xiangting Li, Ting Wu, Guohua Wang, Dingfang Cai. Bilobalide protects astrocytes from oxygen and glucose deprivation-induced oxidative injury by upregulating manganese superoxide dismutase.
Phytotherapy research : PTR.
2019 Sep; 33(9):2329-2336. doi:
10.1002/ptr.6414. [PMID: 31243840] - Ruo-Xuan Sui, Qiang Miao, Jing Wang, Qing Wang, Li-Juan Song, Jing-Wen Yu, Liang Cao, Wei Xiao, Bao-Guo Xiao, Cun-Gen Ma. Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
International immunopharmacology.
2019 Jan; 66(?):69-81. doi:
10.1016/j.intimp.2018.09.041. [PMID: 30445309] - Lu Xiaoyan, Chen Li, Ting Liu, Han Ke, Xingchu Gong, Qingqing Wang, Jianbing Zhang, Xiaohui Fan. Chemical analysis, pharmacological activity and process optimization of the proportion of bilobalide and ginkgolides in Ginkgo biloba extract.
Journal of pharmaceutical and biomedical analysis.
2018 Oct; 160(?):46-54. doi:
10.1016/j.jpba.2018.07.037. [PMID: 30071391] - Szilvia Czigle, Jaroslav Tóth, Nikoletta Jedlinszki, Erzsébet Háznagy-Radnai, Dezső Csupor, Daniela Tekeľová. Ginkgo biloba Food Supplements on the European Market - Adulteration Patterns Revealed by Quality Control of Selected Samples.
Planta medica.
2018 Apr; 84(6-07):475-482. doi:
10.1055/a-0581-5203. [PMID: 29506293] - Lei-Lei Gong, Hui-Jun Yuan, Lan Wang, Xiao-Jie Yin, Hai-Yu Xu, Ri-Xin Liang, Hong-Jun Yang. [Simultaneous determination of seven bioactive compounds and pharmacokinetics in rat plasma after oral administration of Yindan Xinnaotong Ruanjiaonang by UPLC-MS/MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Dec; 42(23):4665-4673. doi:
10.19540/j.cnki.cjcmm.2017.0204. [PMID: 29376269] - Jingjing Liu, Yan He, Shuo Chen, Ming Ma, Shouzuo Yao, Bo Chen. New urea-modified paper substrate for enhanced analytical performance of negative ion mode paper spray mass spectrometry.
Talanta.
2017 May; 166(?):306-314. doi:
10.1016/j.talanta.2017.01.076. [PMID: 28213239] - Ruiyong Wu, Li Shui, Siyang Wang, Zhenzhen Song, Fadao Tai. Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice.
Behavioural pharmacology.
2016 10; 27(7):596-605. doi:
10.1097/fbp.0000000000000252. [PMID: 27509313] - Z Yan-Yan, G Li-Li, S Guo-Ming, R Rong, T Jing-Zhen. Determination of Ginkgolides A, B, C, J and Bilobalide in Plasma by LC-ESI (-)/MS/MS (QQQ) and its Application to the Pharmacokinetic Study of Ginkgo Biloba Extract in Rats.
Drug research.
2016 Oct; 66(10):520-526. doi:
10.1055/s-0042-111904. [PMID: 27490936] - Yi-Xin Qian, Ji-Chuan Kang, Yi-Kai Luo, Jun-Jie Zhao, Jun He, Kun Geng. A Bilobalide-Producing Endophytic Fungus, Pestalotiopsis uvicola from Medicinal Plant Ginkgo biloba.
Current microbiology.
2016 Aug; 73(2):280-6. doi:
10.1007/s00284-016-1060-6. [PMID: 27155842] - L Lu, S Wang, L Fu, D Liu, Y Zhu, A Xu. Bilobalide protection of normal human melanocytes from hydrogen peroxide-induced oxidative damage via promotion of antioxidase expression and inhibition of endoplasmic reticulum stress.
Clinical and experimental dermatology.
2016 Jan; 41(1):64-73. doi:
10.1111/ced.12664. [PMID: 26178968] - Hai-hong Si, Ting Geng, Xiao-ping Sun, Jie Zhao, Jia Xue. [Absolute bioavailability of ginkgolide compounds in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2015 Jul; 40(14):2882-6. doi:
NULL. [PMID: 26666044] - Wenping Wang, Qian Kang, Na Liu, Qing Zhang, Yewen Zhang, Hui Li, Bochen Zhao, Yanyan Chen, Yi Lan, Qiang Ma, Qing Wu. Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion.
Fitoterapia.
2015 Apr; 102(?):189-97. doi:
10.1016/j.fitote.2014.10.004. [PMID: 25446043] - A Priyanka, V M Nisha, S S Anusree, K G Raghu. Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Free radical research.
2014 Oct; 48(10):1206-17. doi:
10.3109/10715762.2014.945442. [PMID: 25039303] - Wei-Zu Li, Wang-Yang Wu, Huan Huang, Yang-Yang Wu, Yan-Yan Yin. Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia.
Molecular medicine reports.
2013 Sep; 8(3):935-41. doi:
10.3892/mmr.2013.1573. [PMID: 23835946] - Hui Zhao, Yuhong Wang, Fang Liu, Yan Wang, Xue Gu, Chao Yan. [Microfluidic evaporative light scattering detector coupled with capillary liquid chromatography and its application to Ginkgo biloba extract analysis].
Se pu = Chinese journal of chromatography.
2013 Aug; 31(8):795-9. doi:
10.3724/sp.j.1123.2012.12043. [PMID: 24369616] - Leige Ma, Shiyan Wang, Fadao Tai, Gang Yuan, Ruiyong Wu, Xiao Liu, Bin Wei, Xiangping Yang. Effects of bilobalide on anxiety, spatial learning, memory and levels of hippocampal glucocorticoid receptors in male Kunming mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Dec; 20(1):89-96. doi:
10.1016/j.phymed.2012.09.015. [PMID: 23083816] - Yuko Taki, Kaori Yokotani, Shizuo Yamada, Kazumasa Shinozuka, Yoko Kubota, Yasuo Watanabe, Keizo Umegaki. Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Jan; 19(2):177-82. doi:
10.1016/j.phymed.2011.06.020. [PMID: 21802929] - Maciej A Pszczolkowski, Kevin Durden, Samantha Sellars, Brian Cowell, John J Brown. Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
Journal of agricultural and food chemistry.
2011 Oct; 59(20):10879-86. doi:
10.1021/jf202386c. [PMID: 21905729] - Andrew J Thompson, Gavin E Jarvis, Rujee K Duke, Graham A R Johnston, Sarah C R Lummis. Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.
Neuropharmacology.
2011 Feb; 60(2-3):488-95. doi:
10.1016/j.neuropharm.2010.11.003. [PMID: 21059362] - Soo Lim, Ji Won Yoon, Seon Mee Kang, Sung Hee Choi, Bong Jun Cho, Min Kim, Ho Seon Park, Hyun Ju Cho, Hayley Shin, Young-Bum Kim, Hyo Soo Kim, Hak Chul Jang, Kyong Soo Park. EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes.
PloS one.
2011; 6(6):e20301. doi:
10.1371/journal.pone.0020301. [PMID: 21655098] - Chun Shi, Fengming Wu, David T Yew, Jie Xu, Yonghong Zhu. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells.
Apoptosis : an international journal on programmed cell death.
2010 Jun; 15(6):715-27. doi:
10.1007/s10495-010-0492-x. [PMID: 20333467] - Vamsi L M Madgula, Bharathi Avula, Young-Beob Yu, Yan-Hong Wang, Flaubert Tchantchou, Scott Fisher, Yuan Luo, Ikhlas A Khan, Shabana I Khan. Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches.
Planta medica.
2010 Apr; 76(6):599-606. doi:
10.1055/s-0029-1240601. [PMID: 19937548] - Karin Woelkart, Elisabeth Feizlmayr, Peter Dittrich, Eckhard Beubler, Fritz Pinl, Andy Suter, Rudolf Bauer. Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.
Phytotherapy research : PTR.
2010 Mar; 24(3):445-50. doi:
10.1002/ptr.3074. [PMID: 20041430] - T Yoshitake, S Yoshitake, J Kehr. The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.
British journal of pharmacology.
2010 Feb; 159(3):659-68. doi:
10.1111/j.1476-5381.2009.00580.x. [PMID: 20105177] - Dorothee Lang, Christian Ude, Mario Wurglics, Manfred Schubert-Zsilavecz, Jochen Klein. Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2010; 13(4):607-14. doi:
10.18433/j31c7q. [PMID: 21486534] - Pushpinder Kaur, Abha Chaudhary, Bikram Singh, Gopichand. Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.
Journal of pharmaceutical and biomedical analysis.
2009 Dec; 50(5):1060-4. doi:
10.1016/j.jpba.2009.06.036. [PMID: 19616398] - Rossana Rossi, Fabrizio Basilico, Giuseppe Rossoni, Antonella Riva, Paolo Morazzoni, Pier Luigi Mauri. Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex.
Journal of pharmaceutical and biomedical analysis.
2009 Sep; 50(2):224-7. doi:
10.1016/j.jpba.2009.04.026. [PMID: 19473802] - Li Zhang, Ji-Qu Xu, Shuang Rong, Bi-Jun Xie, Zhi-Da Sun, Yun-Jian Zhang, Lie-Gang Liu. The mixture of procyanidins extracted from the lotus seed pod and bilobalide ameliorates scopolamine-induced memory impairment in mice.
Neuroscience bulletin.
2009 Aug; 25(4):203-8. doi:
10.1007/s12264-009-0309-5. [PMID: 19633702] - Yuko Taki, Yuko Yamazaki, Fumio Shimura, Shizuo Yamada, Keizo Umegaki. Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.
Journal of pharmacological sciences.
2009 Mar; 109(3):459-62. doi:
10.1254/jphs.08198sc. [PMID: 19276617] - Bharathi Avula, Yan-Hong Wang, Troy J Smillie, Ikhlas A Khan. Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements.
Journal of AOAC International.
2009 Mar; 92(2):645-52. doi:
. [PMID: 19485226] - Flaubert Tchantchou, Pascale N Lacor, Zhiming Cao, Lixing Lao, Yan Hou, Changhai Cui, William L Klein, Yuan Luo. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.
Journal of Alzheimer's disease : JAD.
2009; 18(4):787-98. doi:
10.3233/jad-2009-1189. [PMID: 19661619] - Sofiyan Saleem, Hean Zhuang, Shyam Biswal, Yves Christen, Sylvain Doré. Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.
Stroke.
2008 Dec; 39(12):3389-96. doi:
10.1161/strokeaha.108.523480. [PMID: 18845796] - Y Deng, H-C Bi, L-Z Zhao, F He, Y-Q Liu, J-J Yu, Z-M Ou, L Ding, X Chen, Z-Y Huang, M Huang, S-F Zhou. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2008 May; 38(5):465-81. doi:
10.1080/00498250701883233. [PMID: 18421621] - Jiashu Xie, Cungang Ding, Qinghua Ge, Zhen Zhou, Xiaojin Zhi. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 864(1-2):87-94. doi:
10.1016/j.jchromb.2008.01.045. [PMID: 18295555] - Ying Deng, Hui-chang Bi, Li-zi Zhao, Xue-ding Wang, Jie Chen, Zhi-min Ou, Liang Ding, Le-jia Xu, Su Guan, Xiao Chen, Shu-Feng Zhou, Min Huang. Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes.
Drug metabolism letters.
2008 Jan; 2(1):60-6. doi:
10.2174/187231208783478489. [PMID: 19356072] - Jan Krzek, Janusz S Czekaj, Włodzimierz Rzeszutko, Radosław J Ekiert. Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.
Acta poloniae pharmaceutica.
2007 Jul; 64(4):303-10. doi:
. [PMID: 18536155] - Keizo Umegaki, Yuko Taki, Kaori Endoh, Kyoko Taku, Hiroki Tanabe, Kazumasa Shinozuka, Tomomi Sugiyama. Bilobalide in Ginkgo biloba extract is a major substance inducing hepatic CYPs.
The Journal of pharmacy and pharmacology.
2007 Jun; 59(6):871-7. doi:
10.1211/jpp.59.6.0014. [PMID: 17637180] - Thomas K H Chang, Jie Chen, Xiao Wei Teng. Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Feb; 34(2):234-42. doi:
10.1124/dmd.105.005751. [PMID: 16258077] - Shujing Ding, Ed Dudley, Sue Plummer, Jiandong Tang, Russell P Newton, A Gareth Brenton. Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2006; 20(18):2753-60. doi:
10.1002/rcm.2646. [PMID: 16921563] - S H Huang, R K Duke, M Chebib, K Sasaki, K Wada, G A R Johnston. Mixed antagonistic effects of bilobalide at rho1 GABAC receptor.
Neuroscience.
2006; 137(2):607-17. doi:
10.1016/j.neuroscience.2005.08.071. [PMID: 16300902] - Xin Zhou, Xue-Qin Zhang, Mu Yuan, Dao-Ping Wang. [Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2005 Dec; 30(24):1915-8. doi:
". [PMID: 16494022] - Hiroyasu Satoh. Suppression of pacemaker activity by Ginkgo biloba extract and its main constituent, bilobalide in rat sino-atrial nodal cells.
Life sciences.
2005 Nov; 78(1):67-73. doi:
10.1016/j.lfs.2005.04.081. [PMID: 16182317] - Seiichiro Nishida, Hiroyasu Satoh. Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.
Clinica chimica acta; international journal of clinical chemistry.
2005 Apr; 354(1-2):141-6. doi:
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Se pu = Chinese journal of chromatography.
2005 Jan; 23(1):46-51. doi:
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Phytochemistry.
2004 Nov; 65(21):2897-902. doi:
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Cancer letters.
2004 Jul; 210(2):159-69. doi:
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Analytical and bioanalytical chemistry.
2004 Jun; 379(3):445-8. doi:
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Canadian journal of physiology and pharmacology.
2004 Jan; 82(1):57-64. doi:
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Journal of pharmaceutical and biomedical analysis.
2003 Nov; 33(4):811-7. doi:
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Journal of natural products.
2003 Oct; 66(10):1333-7. doi:
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Pharmacopsychiatry.
2003 Jun; 36 Suppl 1(?):S89-94. doi:
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Pharmacopsychiatry.
2003 Jun; 36 Suppl 1(?):S32-7. doi:
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Pharmacopsychiatry.
2003 Jun; 36 Suppl 1(?):S68-77. doi:
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Pharmacopsychiatry.
2003 Jun; 36 Suppl 1(?):S8-14. doi:
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Life sciences.
2003 Apr; 72(23):2659-67. doi:
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Chemical & pharmaceutical bulletin.
2003 Feb; 51(2):158-61. doi:
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Journal of chromatography. A.
2003 Jan; 986(1):121-7. doi:
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Arzneimittel-Forschung.
2003; 53(6):407-13. doi:
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Pharmacological research.
2002 Dec; 46(6):565-8. doi:
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The Journal of pharmacy and pharmacology.
2002 Nov; 54(11):1507-14. doi:
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Journal of natural products.
2002 Oct; 65(10):1501-4. doi:
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Journal of chromatographic science.
2002 Oct; 40(9):519-22. doi:
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Cellular and molecular biology (Noisy-le-Grand, France).
2002 Sep; 48(6):663-9. doi:
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The Analyst.
2002 May; 127(5):641-6. doi:
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Neurochemical research.
2002 Apr; 27(4):319-23. doi:
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Journal of agricultural and food chemistry.
2002 Mar; 50(7):1840-4. doi:
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Life sciences.
2002 Feb; 70(14):1657-67. doi:
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Phytochemical analysis : PCA.
2002 Jan; 13(1):31-8. doi:
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Brain research.
2001 Dec; 922(2):282-92. doi:
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Rapid communications in mass spectrometry : RCM.
2001; 15(12):929-34. doi:
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Acta pharmacologica Sinica.
2000 May; 21(5):415-20. doi:
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Acta pharmacologica Sinica.
2000 Jan; 21(1):75-9. doi:
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Journal of mass spectrometry : JMS.
1999 Dec; 34(12):1361-7. doi:
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Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1999 Nov; 124(3):315-21. doi:
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Planta medica.
1999 Mar; 65(2):192-3. doi:
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European journal of pharmacology.
1999 Feb; 367(2-3):423-30. doi:
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Chemico-biological interactions.
1997 Oct; 106(3):183-90. doi:
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Brain research.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
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Journal of molecular and cellular cardiology.
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Biochemical pharmacology.
1995 Sep; 50(7):991-9. doi:
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Therapie.
1995 Mar; 50(2):137-44. doi:
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General pharmacology.
1994 Jan; 25(1):31-46. doi:
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Antimicrobial agents and chemotherapy.
1993 Jul; 37(7):1492-6. doi:
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Biological & pharmaceutical bulletin.
1993 Feb; 16(2):210-2. doi:
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Bioorganicheskaia khimiia.
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