trimethyl-[(2S)-1-oxidanyl-1-oxidanylidene-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)propan-2-yl]azanium (BioDeep_00000003122)
Secondary id: BioDeep_00000018451
代谢物信息卡片
trimethyl-[(2S)-1-oxidanyl-1-oxidanylidene-3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)propan-2-yl]azanium
化学式: C9H16N3O2S+ (230.09631760000002)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 0.07%
分子结构信息
SMILES: C[N+](C)(C)C(CC1=CNC(=S)N1)C(=O)O
InChI: InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/p+1/t7-/m0/s1
数据库引用编号
9 个数据库交叉引用编号
- KEGG: C05570
- PubChem: 3037043
- ChEMBL: CHEMBL4303270
- ChEBI: CHEBI:4828
- PubChem: 7896
- CAS: 497-30-3
- PDB-CCD: LW8
- 3DMET: B00790
- NIKKAJI: J96.989C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nae-Cherng Yang, Hung-Chi Lin, Jhoa-Huei Wu, Hsiu-Chung Ou, Yu-Chin Chai, Chin-Yin Tseng, Jiunn-Wang Liao, Tuzz-Ying Song. Ergothioneine protects against neuronal injury induced by β-amyloid in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Nov; 50(11):3902-11. doi:
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Biochimica et biophysica acta.
2012 May; 1822(5):714-28. doi:
10.1016/j.bbadis.2011.11.004. [PMID: 22101076] - Dirk Gründemann. The ergothioneine transporter controls and indicates ergothioneine activity--a review.
Preventive medicine.
2012 May; 54 Suppl(?):S71-4. doi:
10.1016/j.ypmed.2011.12.001. [PMID: 22182480] - AuBrei J Weigand-Heller, Penny M Kris-Etherton, Robert B Beelman. The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation.
Preventive medicine.
2012 May; 54 Suppl(?):S75-8. doi:
10.1016/j.ypmed.2011.12.028. [PMID: 22230474] - Marco H Bello, Viviana Barrera-Perez, Dexter Morin, Lynn Epstein. The Neurospora crassa mutant NcΔEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination.
Fungal genetics and biology : FG & B.
2012 Feb; 49(2):160-72. doi:
10.1016/j.fgb.2011.12.007. [PMID: 22209968] - Takeo Nakanishi, Akimasa Fukushi, Masanobu Sato, Mayuko Yoshifuji, Tomoka Gose, Yoshiyuki Shirasaka, Kazuyo Ohe, Masato Kobayashi, Keiichi Kawai, Ikumi Tamai. Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.
Molecular pharmaceutics.
2011 Dec; 8(6):2142-50. doi:
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The Journal of pharmacology and experimental therapeutics.
2011 Aug; 338(2):537-47. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2011 Aug; 62(4):411-9. doi:
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Cryobiology.
2011 Aug; 63(1):1-6. doi:
10.1016/j.cryobiol.2011.04.001. [PMID: 21513707] - Marlène Klein, Laurent Ouerdane, Maïté Bueno, Florence Pannier. Identification in human urine and blood of a novel selenium metabolite, Se-methylselenoneine, a potential biomarker of metabolization in mammals of the naturally occurring selenoneine, by HPLC coupled to electrospray hybrid linear ion trap-orbital ion trap MS.
Metallomics : integrated biometal science.
2011 May; 3(5):513-20. doi:
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Chemical research in toxicology.
2011 Jan; 24(1):30-4. doi:
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Journal of toxicology.
2011; 2011(?):973172. doi:
10.1155/2011/973172. [PMID: 21776268] - Wai-Jiao Cai, Jian-Hua Huang, Su-Qin Zhang, Bin Wu, Pankaj Kapahi, Xin-Min Zhang, Zi-Yin Shen. Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.
PloS one.
2011; 6(12):e28835. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Dec; 48(12):3492-9. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2010 Oct; 38(10):1665-72. doi:
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Journal of cosmetic dermatology.
2010 Sep; 9(3):218-25. doi:
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Bioresource technology.
2010 Aug; 101(15):6248-55. doi:
10.1016/j.biortech.2010.03.026. [PMID: 20346651] - B D Paul, S H Snyder. The unusual amino acid L-ergothioneine is a physiologic cytoprotectant.
Cell death and differentiation.
2010 Jul; 17(7):1134-40. doi:
10.1038/cdd.2009.163. [PMID: 19911007] - Yumiko Yamashita, Michiaki Yamashita. Identification of a novel selenium-containing compound, selenoneine, as the predominant chemical form of organic selenium in the blood of bluefin tuna.
The Journal of biological chemistry.
2010 Jun; 285(24):18134-8. doi:
10.1074/jbc.c110.106377. [PMID: 20388714] - Angel B Encarnacion, Fernand Fagutao, Ikuo Hirono, Hideki Ushio, Toshiaki Ohshima. Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus).
Journal of agricultural and food chemistry.
2010 Feb; 58(4):2577-85. doi:
10.1021/jf903944y. [PMID: 20078077] - Elizabeth Turner, Jennifer A Brewster, Nigel A B Simpson, James J Walker, Julie Fisher. Imidazole-based erythrocyte markers of oxidative stress in preeclampsia--an NMR investigation.
Reproductive sciences (Thousand Oaks, Calif.).
2009 Nov; 16(11):1040-51. doi:
10.1177/1933719109340928. [PMID: 19657142] - Shikai Yan, Bin Wu, Zhongying Lin, Huizi Jin, Jianhua Huang, Yun Yang, Xinmin Zhang, Ziyin Shen, Weidong Zhang. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium.
Molecular bioSystems.
2009 Oct; 5(10):1204-13. doi:
10.1039/b816407j. [PMID: 19756310] - Nelli G Markova, Nevena Karaman-Jurukovska, Kelly K Dong, Niusha Damaghi, Kenneth A Smiles, Daniel B Yarosh. Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system.
Free radical biology & medicine.
2009 Apr; 46(8):1168-76. doi:
10.1016/j.freeradbiomed.2009.01.021. [PMID: 19439218] - H N D Bao, H Ushio, T Ohshima. Antioxidative activities of mushroom (Flammulina velutipes) extract added to bigeye tuna meat: dose-dependent efficacy and comparison with other biological antioxidants.
Journal of food science.
2009 Mar; 74(2):C162-9. doi:
10.1111/j.1750-3841.2009.01069.x. [PMID: 19323731] - Silke Grigat, Christian Fork, Markus Bach, Stefan Golz, Andreas Geerts, Edgar Schömig, Dirk Gründemann. The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Feb; 37(2):330-7. doi:
10.1124/dmd.108.023929. [PMID: 18981167] - Huynh N D Bao, Hideki Ushio, Toshiaki Ohshima. Antioxidative activity and antidiscoloration efficacy of ergothioneine in mushroom (Flammulina velutipes) extract added to beef and fish meats.
Journal of agricultural and food chemistry.
2008 Nov; 56(21):10032-40. doi:
10.1021/jf8017063. [PMID: 18841979] - Omer Sakrak, Mustafa Kerem, Abdulkadir Bedirli, Hatice Pasaoglu, Nalan Akyurek, Ebru Ofluoglu, Fatma Ayça Gültekin. Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury.
The Journal of surgical research.
2008 Jan; 144(1):36-42. doi:
10.1016/j.jss.2007.04.020. [PMID: 17603080] - Thomas J Urban, Chen Yang, Leah L Lagpacan, Chaline Brown, Richard A Castro, Travis R Taylor, Conrad C Huang, Douglas Stryke, Susan J Johns, Michiko Kawamoto, Elaine J Carlson, Thomas E Ferrin, Esteban G Burchard, Kathleen M Giacomini. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4).
Pharmacogenetics and genomics.
2007 Sep; 17(9):773-82. doi:
10.1097/fpc.0b013e3281c6d08e.. [PMID: 17700366] - Kelly K Dong, Niusha Damaghi, Jeannie Kibitel, Matthew T Canning, Kenneth A Smiles, Daniel B Yarosh. A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.
Journal of cosmetic dermatology.
2007 Sep; 6(3):183-8. doi:
10.1111/j.1473-2165.2007.00330.x. [PMID: 17760697] - Janine Ey, Edgar Schömig, Dirk Taubert. Dietary sources and antioxidant effects of ergothioneine.
Journal of agricultural and food chemistry.
2007 Aug; 55(16):6466-74. doi:
10.1021/jf071328f. [PMID: 17616140] - Claus Jacob. A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms.
Natural product reports.
2006 Dec; 23(6):851-63. doi:
10.1039/b609523m. [PMID: 17119635] - F Franzoni, R Colognato, F Galetta, I Laurenza, M Barsotti, R Di Stefano, R Bocchetti, F Regoli, A Carpi, A Balbarini, L Migliore, G Santoro. An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2006 Sep; 60(8):453-7. doi:
10.1016/j.biopha.2006.07.015. [PMID: 16930933] - Jose Luis Santiago, Alfonso Martínez, Hermenegildo de la Calle, Miguel Fernández-Arquero, M Angeles Figueredo, Emilio G de la Concha, Elena Urcelay. Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.
BMC medical genetics.
2006 Jun; 7(?):54. doi:
10.1186/1471-2350-7-54. [PMID: 16796743] - Irfan Rahman, Iain Kilty. Antioxidant therapeutic targets in COPD.
Current drug targets.
2006 Jun; 7(6):707-20. doi:
10.2174/138945006777435254. [PMID: 16787173] - M A Soobrattee, V S Neergheen, A Luximon-Ramma, O I Aruoma, T Bahorun. Phenolics as potential antioxidant therapeutic agents: mechanism and actions.
Mutation research.
2005 Nov; 579(1-2):200-13. doi:
10.1016/j.mrfmmm.2005.03.023. [PMID: 16126236] - S Choudhary, T Xiao, S Srivastava, W Zhang, L L Chan, L A Vergara, F J G M Van Kuijk, N H Ansari. Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells.
Toxicology and applied pharmacology.
2005 Apr; 204(2):122-34. doi:
10.1016/j.taap.2004.08.023. [PMID: 15808518] - Abdulkadir Bedirli, Omer Sakrak, Sebahattin Muhtaroglu, Isin Soyuer, Ilkay Guler, Ali Riza Erdogan, Erdogan M Sozuer. Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70.
The Journal of surgical research.
2004 Nov; 122(1):96-102. doi:
10.1016/j.jss.2004.06.016. [PMID: 15522321] - Monica Deiana, Antonella Rosa, Viviana Casu, Rosaria Piga, M Assunta Dessì, Okezie I Aruoma. L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids.
Clinical nutrition (Edinburgh, Scotland).
2004 Apr; 23(2):183-93. doi:
10.1016/s0261-5614(03)00108-0. [PMID: 15030958] - Jung-Hee Jang, Okezie I Aruoma, Ling-Sun Jen, Hae Young Chung, Young-Joon Surh. Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death.
Free radical biology & medicine.
2004 Feb; 36(3):288-99. doi:
10.1016/j.freeradbiomed.2003.11.005. [PMID: 15036348] - M V Guijarro, A Indart, O I Aruoma, M Viana, B Bonet. Effects of ergothioneine on diabetic embryopathy in pregnant rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2002 Dec; 40(12):1751-5. doi:
10.1016/s0278-6915(02)00177-1. [PMID: 12419688] - Pierantonio Menna, Emanuela Salvatorelli, Rossella Giampietro, Giovanni Liberi, Giovanni Teodori, Antonio M Calafiore, Giorgio Minotti. Doxorubicin-dependent reduction of ferrylmyoglobin and inhibition of lipid peroxidation: implications for cardiotoxicity of anticancer anthracyclines.
Chemical research in toxicology.
2002 Sep; 15(9):1179-89. doi:
10.1021/tx020055+. [PMID: 12230412] - F Misiti, M Castagnola, C Zuppi, B Giardina, I Messana. Role of ergothioneine on S-nitrosoglutathione catabolism.
The Biochemical journal.
2001 Jun; 356(Pt 3):799-804. doi:
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