4-Chloro-3-methylphenol (BioDeep_00000002891)
Secondary id: BioDeep_00001871630
human metabolite blood metabolite
代谢物信息卡片
1-Chloro-2-methyl-4-hydroxybenzene
化学式: C7H7ClO (142.0185402)
中文名称: 4-氯-3-甲基苯酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)O)Cl
InChI: InChI=1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3
描述信息
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D016573 - Agrochemicals
D010575 - Pesticides
Same as: D03468
同义名列表
16 个代谢物同义名
1-Chloro-2-methyl-4-hydroxybenzene; 6-Chloro-3-hydroxytoluene; 2-Chloro-5-hydroxytoluene; Chlorocresol sodium salt; 4-Chloro-3-methylphenol; 4-Chloro-5-methylphenol; 3-Methyl-4-chlorophenol; Para-chloro-meta-cresol; 4-chloro-Meta-cresol; 4-chloro-3-Cresol; 4-Chloro-m-cresol; p-Chloro-m-cresol; p-Chlorocresol; Chlorocresol; baktol; 4-Chloro-m-cresol
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:34395
- KEGG: C14331
- PubChem: 1732
- HMDB: HMDB0246386
- Metlin: METLIN43538
- ChEMBL: CHEMBL1230222
- Wikipedia: P-Chlorocresol
- chemspider: 21106018
- CAS: 59-50-7
- PMhub: MS000006800
- PubChem: 17395331
- PDB-CCD: 43M
- NIKKAJI: J4.604C
- KNApSAcK: 34395
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Takashi Kondo, Toshimichi Yasuda, Keiko Mukaida, Sachiko Otsuki, Rieko Kanzaki, Hirotsugu Miyoshi, Hiroshi Hamada, Ichizo Nishino, Masashi Kawamoto. Genetic and functional analysis of the RYR1 mutation p.Thr84Met revealed a susceptibility to malignant hyperthermia.
Journal of anesthesia.
2018 04; 32(2):174-181. doi:
10.1007/s00540-018-2451-6. [PMID: 29344738] - Luigi Lopardo, Andrew Cummins, Axel Rydevik, Barbara Kasprzyk-Hordern. New Analytical Framework for Verification of Biomarkers of Exposure to Chemicals Combining Human Biomonitoring and Water Fingerprinting.
Analytical chemistry.
2017 07; 89(13):7232-7239. doi:
10.1021/acs.analchem.7b01527. [PMID: 28548845] - Anfei He, Jin Yuan, Jing Jiang, G Daniel Sheng. Suppression of chloromethylphenol accumulation in wheat seedlings by uptake-induced phytotoxicity.
Chemosphere.
2016 Dec; 164(?):263-270. doi:
10.1016/j.chemosphere.2016.08.104. [PMID: 27591377] - S Salvatico, C Feuillolay, Y Mas, F Verrière, C Roques. Bactericidal activity of 3 cutaneous/mucosal antiseptic solutions in the presence of interfering substances: Improvement of the NF EN 13727 European Standard?.
Medecine et maladies infectieuses.
2015 Mar; 45(3):89-94. doi:
10.1016/j.medmal.2015.01.006. [PMID: 25779009] - Tatiana Adasme, Andrea Paula-Lima, Cecilia Hidalgo. Inhibitory ryanodine prevents ryanodine receptor-mediated Ca²⁺ release without affecting endoplasmic reticulum Ca²⁺ content in primary hippocampal neurons.
Biochemical and biophysical research communications.
2015 Feb; 458(1):57-62. doi:
10.1016/j.bbrc.2015.01.065. [PMID: 25623539] - Stephan A van der Heijden, Joop L M Hermens, Theo L Sinnige, Philipp Mayer, Dorothea Gilbert, Michiel T O Jonker. Determining high-quality critical body residues for multiple species and chemicals by applying improved experimental design and data interpretation concepts.
Environmental science & technology.
2015 Feb; 49(3):1879-87. doi:
10.1021/es505078r. [PMID: 25594358] - Ruth Fiechter, Peter Deplazes, Manuela Schnyder. Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel.
Veterinary parasitology.
2012 Jun; 187(1-2):93-8. doi:
10.1016/j.vetpar.2011.12.023. [PMID: 22240238] - Kathryn M Onesios, Edward J Bouwer. Biological removal of pharmaceuticals and personal care products during laboratory soil aquifer treatment simulation with different primary substrate concentrations.
Water research.
2012 May; 46(7):2365-75. doi:
10.1016/j.watres.2012.02.001. [PMID: 22374299] - Toshiaki Haraki, Toshimichi Yasuda, Keiko Mukaida, Takako Migita, Hiroshi Hamada, Masashi Kawamoto. Mutated p.4894 RyR1 function related to malignant hyperthermia and congenital neuromuscular disease with uniform type 1 fiber (CNMDU1).
Anesthesia and analgesia.
2011 Dec; 113(6):1461-7. doi:
10.1213/ane.0b013e318232053e. [PMID: 21926372] - Ian McLaren, Andrew Wales, Mark Breslin, Robert Davies. Evaluation of commonly-used farm disinfectants in wet and dry models of Salmonella farm contamination.
Avian pathology : journal of the W.V.P.A.
2011 Feb; 40(1):33-42. doi:
10.1080/03079457.2010.537303. [PMID: 21331946] - Christian Rosker, Gargi Meur, Emily J A Taylor, Colin W Taylor. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells.
The Journal of biological chemistry.
2009 Feb; 284(8):5186-94. doi:
10.1074/jbc.m805587200. [PMID: 19116207] - Takako Migita, Keiko Mukaida, Hiroshi Hamada, Toshimichi Yasuda, Toshiaki Haraki, Ichizo Nishino, Nobuyuki Murakami, Masashi Kawamoto. Functional analysis of ryanodine receptor type 1 p.R2508C mutation in exon 47.
Journal of anesthesia.
2009; 23(3):341-6. doi:
10.1007/s00540-009-0746-3. [PMID: 19685112] - R A Bannister, H M Colecraft, K G Beam. Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.
Biophysical journal.
2008 Apr; 94(7):2631-8. doi:
10.1529/biophysj.107.116467. [PMID: 18192376] - Alexander V Zhdanov, Manus W Ward, Jochen H M Prehn, Dmitri B Papkovsky. Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.
The Journal of biological chemistry.
2008 Feb; 283(9):5650-61. doi:
10.1074/jbc.m706439200. [PMID: 18086678] - Yu-An Zhang, Richard A Tuft, Lawrence M Lifshitz, Kevin E Fogarty, Joshua J Singer, Hui Zou. Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance.
American journal of physiology. Heart and circulatory physiology.
2007 Oct; 293(4):H2448-61. doi:
10.1152/ajpheart.00032.2007. [PMID: 17483243] - Héctor Rojas, Claudia Colina, Magaly Ramos, Gustavo Benaim, Erica H Jaffe, Carlo Caputo, Reinaldo DiPolo. Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers Ca(i)2+-induced Ca2+ release in rat cerebellar Type-1 astrocytes.
Journal of neurochemistry.
2007 Mar; 100(5):1188-202. doi:
10.1111/j.1471-4159.2006.04303.x. [PMID: 17316398] - Bruno Allard, Harold Couchoux, Sandrine Pouvreau, Vincent Jacquemond. Sarcoplasmic reticulum Ca2+ release and depletion fail to affect sarcolemmal ion channel activity in mouse skeletal muscle.
The Journal of physiology.
2006 Aug; 575(Pt 1):69-81. doi:
10.1113/jphysiol.2006.112367. [PMID: 16777939] - Saiid Bina, George Cowan, John Karaian, Sheila Muldoon, Paul Mongan, Rolf Bünger. Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.
Anesthesiology.
2006 Jan; 104(1):90-100. doi:
10.1097/00000542-200601000-00015. [PMID: 16394695] - Alan Andersen. Final report on the safety assessment of sodium p-chloro-m-cresol, p-chloro-m-cresol, chlorothymol, mixed cresols, m-cresol, o-cresol, p-cresol, isopropyl cresols, thymol, o-cymen-5-ol, and carvacrol.
International journal of toxicology.
2006; 25 Suppl 1(?):29-127. doi:
10.1080/10915810600716653. [PMID: 16835130] - Dali Luo, Hongli Sun, Rui Ping Xiao, Qide Han. Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells.
European journal of pharmacology.
2005 Feb; 509(2-3):109-15. doi:
10.1016/j.ejphar.2004.12.038. [PMID: 15733545] - Forrest L Smith, Scott J LeBlanc, Richard Carter. Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.
European journal of pain (London, England).
2004 Apr; 8(2):153-61. doi:
10.1016/s1090-3801(03)00089-2. [PMID: 14987625] - Toshiharu Oba, Chieko Kurono, Ritsuko Nakajima, Tetsuo Takaishi, Kazuto Ishida, Geraldine A Fuller, Wuthichai Klomkleaw, Mamoru Yamaguchi. H2O2 activates ryanodine receptor but has little effect on recovery of releasable Ca2+ content after fatigue.
Journal of applied physiology (Bethesda, Md. : 1985).
2002 Dec; 93(6):1999-2008. doi:
10.1152/japplphysiol.00097.2002. [PMID: 12391105] - J D Fessenden, Y Wang, R A Moore, S R Chen, P D Allen, I N Pessah. Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line.
Biophysical journal.
2000 Nov; 79(5):2509-25. doi:
10.1016/s0006-3495(00)76492-7. [PMID: 11053126] - M Anetseder, L Ritter, H Horbaschek, E Hartung, N Roewer. The impact of 4-chloro-m-cresol in heparin formulas on malignant hyperthermia: in vitro and in vivo.
Acta anaesthesiologica Scandinavica.
2000 Mar; 44(3):338-42. doi:
10.1034/j.1399-6576.2000.440321.x. [PMID: 10714851] - P A Iaizzo, B A Johnson, K Nagao, W J Gallagher. 4-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations.
Anesthesiology.
1999 Jun; 90(6):1723-32. doi:
10.1097/00000542-199906000-00030. [PMID: 10360872] - G Li, C B Wollheim, W F Pralong. Oscillations of cytosolic free calcium in bombesin-stimulated HIT-T15 cells.
Cell calcium.
1996 Jun; 19(6):535-46. doi:
10.1016/s0143-4160(96)90063-9. [PMID: 8842521] - A Herrmann-Frank, M Richter, S Sarközi, U Mohr, F Lehmann-Horn. 4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor.
Biochimica et biophysica acta.
1996 Feb; 1289(1):31-40. doi:
10.1016/0304-4165(95)00131-x. [PMID: 8605229] - K Jaschonek, C Faul, W Daiss, H Weisenberger. Effects of heparin on prostacyclin binding and platelet adenylate cyclase activity stimulated by iloprost and forskolin.
Prostaglandins, leukotrienes, and medicine.
1986 Oct; 24(2-3):199-206. doi:
10.1016/0262-1746(86)90127-7. [PMID: 2432618] - L Zahradnícek, M Vidová, V Chromý. Determination of serum glucose by a continuous-flow technique using glucose oxidase and 4-chlor-3-methylphenol as a color reagent.
Clinica chimica acta; international journal of clinical chemistry.
1983 Jan; 127(1):127-30. doi:
10.1016/0009-8981(83)90082-7. [PMID: 6825305] - J D Cooper, D C Turnell, C P Price. The estimation of serum acid phosphatase using alpha-naphthyl phosphate as substrate: observations on the use of Fast Red TR salt in the assay.
Clinica chimica acta; international journal of clinical chemistry.
1982 Dec; 126(3):297-306. doi:
10.1016/0009-8981(82)90304-7. [PMID: 7151283]