Ethylene thiourea (BioDeep_00000002856)

 

Secondary id: BioDeep_00001873588

human metabolite blood metabolite


代谢物信息卡片


4,5-dihydro-1H-imidazole-2-thiol

化学式: C3H6N2S (102.02516759999999)
中文名称: 甲醇中乙撑硫脲溶液
谱图信息: 最多检出来源 Homo sapiens(blood) 2.86%

分子结构信息

SMILES: C1CNC(=S)N1
InChI: InChI=1S/C3H6N2S/c6-3-4-1-2-5-3/h1-2H2,(H2,4,5,6)

描述信息

CONFIDENCE standard compound; EAWAG_UCHEM_ID 271
CONFIDENCE standard compound; INTERNAL_ID 8704

同义名列表

9 个代谢物同义名

4,5-dihydro-1H-imidazole-2-thiol; imidazolidine-2-thione; 2-Imidazolidinethione; 2-Mercaptoimidazoline; 2 Mercaptoimidazoline; Imidazolidinethione; Ethylene thiourea; ethylenethiourea; Ethlenethiourea



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Katrina Stadler, Xueshu Li, Buyun Liu, Wei Bao, Kai Wang, Hans-Joachim Lehmler. Systematic review of human biomonitoring studies of ethylenethiourea, a urinary biomarker for exposure to dithiocarbamate fungicides. Environmental pollution (Barking, Essex : 1987). 2022 Jan; 292(Pt B):118419. doi: 10.1016/j.envpol.2021.118419. [PMID: 34751155]
  • Stefan Mandić-Rajčević, Federico Maria Rubino, Claudio Colosio. Establishing health-based biological exposure limits for pesticides: A proof of principle study using mancozeb. Regulatory toxicology and pharmacology : RTP. 2020 Aug; 115(?):104689. doi: 10.1016/j.yrtph.2020.104689. [PMID: 32544413]
  • Ana M Mora, Jane A Hoppin, Leonel Córdoba, Juan C Cano, Manuel Soto-Martínez, Brenda Eskenazi, Christian H Lindh, Berna van Wendel de Joode. Prenatal pesticide exposure and respiratory health outcomes in the first year of life: Results from the infants' Environmental Health (ISA) study. International journal of hygiene and environmental health. 2020 04; 225(?):113474. doi: 10.1016/j.ijheh.2020.113474. [PMID: 32066110]
  • Stefan Mandic-Rajcevic, Federico Maria Rubino, Eugenio Ariano, Danilo Cottica, Sara Negri, Claudio Colosio. Exposure duration and absorbed dose assessment in pesticide-exposed agricultural workers: Implications for risk assessment and modeling. International journal of hygiene and environmental health. 2019 04; 222(3):494-502. doi: 10.1016/j.ijheh.2019.01.006. [PMID: 30685193]
  • Stefan Mandic-Rajcevic, Federico M Rubino, Eugenio Ariano, Danilo Cottica, Sara Neri, Claudio Colosio. Environmental and biological monitoring for the identification of main exposure determinants in vineyard mancozeb applicators. Journal of exposure science & environmental epidemiology. 2018 05; 28(3):289-296. doi: 10.1038/jes.2017.14. [PMID: 28901326]
  • Emanuela Medda, Ferruccio Santini, Simona De Angelis, Fabrizio Franzellin, Carla Fiumalbi, Andrea Perico, Enzo Gilardi, Maria Teresa Mechi, Alessandro Marsili, Angela Citroni, Adaniele Leandri, Alberto Mantovani, Paolo Vitti, Antonella Olivieri. Iodine nutritional status and thyroid effects of exposure to ethylenebisdithiocarbamates. Environmental research. 2017 04; 154(?):152-159. doi: 10.1016/j.envres.2016.12.019. [PMID: 28073049]
  • Marcela Eugenia Varona-Uribe, Carlos H Torres-Rey, Sonia Díaz-Criollo, Ruth Marien Palma-Parra, Diana María Narváez, Sandra Patricia Carmona, Leonardo Briceño, Alvaro J Idrovo. Exposure to pesticide mixtures and DNA damage among rice field workers. Archives of environmental & occupational health. 2016; 71(1):3-9. doi: 10.1080/19338244.2014.910489. [PMID: 24972111]
  • Berna van Wendel de Joode, Ana María Mora, Leonel Córdoba, Juan Camilo Cano, Rosario Quesada, Moosa Faniband, Catharina Wesseling, Clemens Ruepert, Mattias Oberg, Brenda Eskenazi, Donna Mergler, Christian H Lindh. Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA). Environmental health perspectives. 2014 Dec; 122(12):1321-8. doi: 10.1289/ehp.1307679. [PMID: 25198283]
  • G A Montoya, V Strauss, E Fabian, H Kamp, W Mellert, T Walk, R Looser, M Herold, G Krennrich, E Peter, B van Ravenzwaay. Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance. Toxicology letters. 2014 Mar; 225(2):240-51. doi: 10.1016/j.toxlet.2013.12.010. [PMID: 24370789]
  • O López-Fernández, R Rial-Otero, A Cid, J Simal-Gándara. Combined determination and confirmation of ethylenethiourea and propylenethiourea residues in fruits at low levels of detection. Food chemistry. 2014 Feb; 145(?):1002-10. doi: 10.1016/j.foodchem.2013.09.023. [PMID: 24128576]
  • Jennifer D Runkle, J Antonio Tovar-Aguilar, Eugenia Economos, Joan Flocks, Bryan Williams, Juan F Muniz, Marie Semple, Linda McCauley. Pesticide risk perception and biomarkers of exposure in Florida female farmworkers. Journal of occupational and environmental medicine. 2013 Nov; 55(11):1286-92. doi: 10.1097/jom.0b013e3182973396. [PMID: 24164757]
  • Eva Ekman, Margaretha Maxe, Margareta Littorin, Bo A G Jönsson, Christian H Lindh. High-throughput method for the analysis of ethylenethiourea with direct injection of hydrolysed urine using online on-column extraction liquid chromatography and triple quadrupole mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Sep; 934(?):53-9. doi: 10.1016/j.jchromb.2013.06.035. [PMID: 23896430]
  • Csaba Vágvölgyi, Enikő Sajben-Nagy, Bettina Bóka, Mónika Vörös, Adrienn Berki, Andrea Palágyi, Judit Krisch, Biljana Skrbić, N Durišić-Mladenović, László Manczinger. Isolation and characterization of antagonistic Bacillus strains capable to degrade ethylenethiourea. Current microbiology. 2013 Mar; 66(3):243-50. doi: 10.1007/s00284-012-0263-8. [PMID: 23143288]
  • Kate Jones, Katan Patel, John Cocker, Ruth Bevan, Len Levy. Determination of ethylenethiourea in urine by liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry for monitoring background levels in the general population. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(27):2563-6. doi: 10.1016/j.jchromb.2009.10.028. [PMID: 19914152]
  • Renato Polimanti, Sara Piacentini, Maria Barone, Flavia Porreca, Maria Fuciarelli. Serum proteins and work habits in a group of farm-workers exposed to EBDCs. Annals of human biology. 2010 Jun; 37(3):440-50. doi: 10.3109/03014461003702195. [PMID: 20377494]
  • S Fustinoni, L Campo, J Liesivuori, S Pennanen, T Vergieva, Lgpm van Amelsvoort, C Bosetti, H Van Loveren, C Colosio. Biological monitoring and questionnaire for assessing exposure to ethylenebisdithiocarbamates in a multicenter European field study. Human & experimental toxicology. 2008 Sep; 27(9):681-91. doi: 10.1177/0960327108100003. [PMID: 19042950]
  • D Boers, L van Amelsvoort, C Colosio, E Corsini, S Fustinoni, L Campo, C Bosetti, C La Vecchia, T Vergieva, M Tarkowski, J Liesivuori, P Steerenberg, H van Loveren. Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies. Human & experimental toxicology. 2008 Sep; 27(9):721-7. doi: 10.1177/0960327108100001. [PMID: 19042955]
  • Lgpm van Amelsvoort, Dcl Mohren, Jj Slangen, G Swaen, E Corsini, S Fustinoni, T Vergieva, C Bosetti, J Liesivuori, M Tarkowski, C Colosio, H van Loveren. Immune effects and exposure to ethylenebisdithiocarbamate pesticides in re-entry workers in the Netherlands. Human & experimental toxicology. 2008 Sep; 27(9):693-9. doi: 10.1177/0960327108100000. [PMID: 19042951]
  • P Steerenberg, L van Amelsvoort, C Colosio, E Corsini, S Fustinoni, T Vergieva, C Zaikov, S Pennanen, J Liesivuori, H Van Loveren. Toxicological evaluation of the immune function of pesticide workers, a European wide assessment. Human & experimental toxicology. 2008 Sep; 27(9):701-7. doi: 10.1177/0960327108095993. [PMID: 19042952]
  • Gmh Swaen, Lgpm van Amelsvoort, D Boers, E Corsini, S Fustinoni, T Vergieva, C Bosetti, S Pennanen, J Liesivuori, C Colosio, H van Loveren. Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy: results from the EUROPIT field study. Human & experimental toxicology. 2008 Sep; 27(9):715-20. doi: 10.1177/0960327108097433. [PMID: 19042954]
  • Christian H Lindh, Margareta Littorin, Gunvor Johannesson, Bo A G Jönsson. Analysis of ethylenethiourea as a biomarker in human urine using liquid chromatography/triple quadrupole mass spectrometry. Rapid communications in mass spectrometry : RCM. 2008 Aug; 22(16):2573-9. doi: 10.1002/rcm.3647. [PMID: 18651716]
  • Claudio Colosio, Silvia Fustinoni, Emanuela Corsini, Cristina Bosetti, Sarah Birindelli, Daisy Boers, Laura Campo, Carlo La Vecchia, Jyrki Liesivuori, Sirpa Pennanen, Tatjana Vergieva, Ludovic G P M Van Amelsvoort, Peter Steerenberg, Gerard M H Swaen, Christo Zaikov, Henk Van Loveren. Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: an Italian study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2007 Nov; 12(6):574-88. doi: 10.1080/13547500701441315. [PMID: 17852083]
  • M Angela Montesano, Anders O Olsson, Peter Kuklenyik, Larry L Needham, A S A Bradman, Dana B Barr. Method for determination of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea and propylenethiourea in human urine using high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Journal of exposure science & environmental epidemiology. 2007 Jul; 17(4):321-30. doi: 10.1038/sj.jes.7500550. [PMID: 17440487]
  • Francesca Mattioli, Antonietta Martelli, Marzia Gosmar, Claudia Garbero, Valeria Manfredi, Emanuela Varaldo, Gian Carlo Torre, Giovanni Brambilla. DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by chemicals carcinogenic to the rat thyroid. Mutation research. 2006 Oct; 609(2):146-53. doi: 10.1016/j.mrgentox.2006.06.028. [PMID: 16942904]
  • Claudio Colosio, Sara Visentin, Sarah Birindelli, Laura Campo, Silvia Fustinoni, Franco Mariani, Manuela Tiramani, Michele Tommasini, Gabri Brambilla, Marco Maroni. Reference values for ethylenethiourea in urine in Northern Italy: results of a pilot study. Toxicology letters. 2006 Apr; 162(2-3):153-7. doi: 10.1016/j.toxlet.2005.09.031. [PMID: 16257147]
  • Emanuela Corsini, Sarah Birindelli, Silvia Fustinoni, Gioia De Paschale, Teresa Mammone, Sara Visentin, Corrado L Galli, Marina Marinovich, Claudio Colosio. Immunomodulatory effects of the fungicide Mancozeb in agricultural workers. Toxicology and applied pharmacology. 2005 Oct; 208(2):178-85. doi: 10.1016/j.taap.2005.02.011. [PMID: 15893782]
  • Souleiman El Balkhi, Pierre Sandouk, Martine Galliot-Guilley. Determination of ethylene thiourea in urine by HPLC-DAD. Journal of analytical toxicology. 2005 May; 29(4):229-33. doi: 10.1093/jat/29.4.229. [PMID: 15975251]
  • Silvia Fustinoni, Laura Campo, Claudio Colosio, Sarah Birindelli, Vito Foà. Application of gas chromatography-mass spectrometry for the determination of urinary ethylenethiourea in humans. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Jan; 814(2):251-8. doi: 10.1016/j.jchromb.2004.10.042. [PMID: 15639446]
  • Lynn Panganiban, Nelia Cortes-Maramba, Carissa Dioquino, Maria Lurenda Suplido, Herbert Ho, Ana Francisco-Rivera, Ailyn Manglicmot-Yabes. Correlation between blood ethylenethiourea and thyroid gland disorders among banana plantation workers in the Philippines. Environmental health perspectives. 2004 Jan; 112(1):42-5. doi: 10.1289/ehp.6499. [PMID: 14698929]
  • Cristina Sottani, Maurizio Bettinelli, Maria Lorena Fiorentino, Claudio Minoia. Analytical method for the quantitative determination of urinary ethylenethiourea by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2003; 17(20):2253-9. doi: 10.1002/rcm.1171. [PMID: 14558122]
  • C Aprea, G Catenacci. [Environmental and biological reference values of plant pesticides]. Giornale italiano di medicina del lavoro ed ergonomia. 2003 Jan; 25(1):37-60. doi: NULL. [PMID: 12696485]
  • Claudio Colosio, S Fustinoni, S Birindelli, I Bonomi, G De Paschale, T Mammone, M Tiramani, F Vercelli, S Visentin, M Maroni. Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers. Toxicology letters. 2002 Aug; 134(1-3):133-40. doi: 10.1016/s0378-4274(02)00182-0. [PMID: 12191871]
  • Ikram Debbarh, Nicholas Moore. A simple method for the determination of ethylene-thiourea (ETU) in biological samples. Journal of analytical toxicology. 2002 May; 26(4):216-21. doi: 10.1093/jat/26.4.216. [PMID: 12054362]
  • Clifford R Elcombe, Jenny Odum, John R Foster, Susan Stone, Susan Hasmall, Anthony R Soames, Ian Kimber, John Ashby. Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens. Environmental health perspectives. 2002 Apr; 110(4):363-75. doi: 10.1289/ehp.02110363. [PMID: 11940454]
  • C Aprea, G Sciarra, P Sartorelli, R Mancini, V Di Luca. Environmental and biological monitoring of exposure to mancozeb, ethylenethiourea, and dimethoate during industrial formulation. Journal of toxicology and environmental health. Part A. 1998 Feb; 53(4):263-81. doi: 10.1080/009841098159277. [PMID: 9490325]
  • C Aprea, A Betta, G Catenacci, A Colli, A Lotti, C Minoia, P Olivieri, V Passini, I Pavan, C Roggi, R Ruggeri, G Sciarra, R Turci, P Vannini, V Vitalone. Urinary excretion of ethylenethiourea in five volunteers on a controlled diet (multicentric study). The Science of the total environment. 1997 Sep; 203(2):167-79. doi: 10.1016/s0048-9697(97)00145-9. [PMID: 9281842]
  • P C do Nascimento, D Bohrer, S Garcia, A F Ritzel. Liquid chromatography with ultraviolet absorbance detection of ethylenethiourea in blood serum after microwave irradiation as an auxiliary cleanup step. The Analyst. 1997 Aug; 122(8):733-5. doi: 10.1039/a701011g. [PMID: 9338983]
  • Y F Sasaki, F Izumiyama, E Nishidate, N Matsusaka, S Tsuda. Detection of rodent liver carcinogen genotoxicity by the alkaline single-cell gel electrophoresis (Comet) assay in multiple mouse organs (liver, lung, spleen, kidney, and bone marrow). Mutation research. 1997 Jul; 391(3):201-14. doi: 10.1016/s1383-5718(97)00072-7. [PMID: 9268046]
  • T Iwase, M Yamamoto, M Shirai, F Akahori, T Masaoka, T Takizawa, K Arishima, Y Eguchi. Time course of ethylene thiourea in maternal plasma, amniotic fluid and embryos in rats following single oral dosing. The Journal of veterinary medical science. 1996 Dec; 58(12):1235-6. doi: 10.1292/jvms.58.12_1235. [PMID: 8996709]
  • C Aprea, A Betta, G Catenacci, A Lotti, C Minoia, W Passini, I Pavan, F Saverio Robustelli della Cuna, C Roggi, R Ruggeri, C Soave, G Sciarra, P Vannini, V Vitalone. Reference values of urinary ethylenethiourea in four regions of Italy (multicentric study). The Science of the total environment. 1996 Nov; 192(1):83-93. doi: 10.1016/0048-9697(96)05300-4. [PMID: 8921624]
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