Phentermine (BioDeep_00000002652)

 

Secondary id: BioDeep_00000406247

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(alpha,alpha)-Dimethylphenethylamine

化学式: C10H15N (149.120443)
中文名称: 芬特明
谱图信息: 最多检出来源 Viridiplantae(plant) 93.75%

分子结构信息

SMILES: CC(C)(CC1=CC=CC=C1)N
InChI: InChI=1S/C10H15N/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8,11H2,1-2H3

描述信息

Phentermine is only found in individuals that have used or taken this drug. It is a central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]Phentermine is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. The drug seems to inhibit reuptake of noradrenaline, dopamine, and seratonin through inhibition or reversal of the reuptake transporters. It may also inhibit MAO enzymes leaving more neurotransmitter available at the synapse.Phentermine (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products
CONFIDENCE standard compound; INTERNAL_ID 7; HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
CONFIDENCE Reference Standard (Level 1); HBM4EU - science and policy for a healthy future (https://www.hbm4eu.eu)
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

17 个代谢物同义名

(alpha,alpha)-Dimethylphenethylamine; alpha,alpha-Dimethylphenethylamine; 2-methyl-1-phenylpropan-2-amine; a,a-Dimethylphenethylamine; Hydrochloride, phentermine; Α,α-dimethylphenethylamine; Phentermine Hydrochloride; Phenterminum; phentermine; Fentermina; Adipex-p; Ionamine; Duromine; Adipex p; AdipexP; Phentermine; Phentermine



数据库引用编号

83 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qingyang Shi, Yang Wang, Qiukui Hao, Per Olav Vandvik, Gordon Guyatt, Jing Li, Zhe Chen, Shishi Xu, Yanjiao Shen, Long Ge, Feng Sun, Ling Li, Jiajie Yu, Kailei Nong, Xinyu Zou, Siyi Zhu, Cong Wang, Shengzhao Zhang, Zhi Qiao, Zhongyu Jian, Ya Li, Xinyi Zhang, Kerun Chen, Furong Qu, Yuan Wu, Yazhou He, Haoming Tian, Sheyu Li. Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials. Lancet (London, England). 2024 04; 403(10434):e21-e31. doi: 10.1016/s0140-6736(24)00351-9. [PMID: 38582569]
  • Yu-Jin Kwon, Go Eun Kwon, Hye Sun Lee, Man Ho Choi, Ji-Won Lee. The Effect of Orlistat on Sterol Metabolism in Obese Patients. Frontiers in endocrinology. 2022; 13(?):824269. doi: 10.3389/fendo.2022.824269. [PMID: 35282441]
  • Michael E Hall, Jordana B Cohen, Jamy D Ard, Brent M Egan, John E Hall, Carl J Lavie, Jun Ma, Chiadi E Ndumele, Philip R Schauer, Daichi Shimbo. Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement From the American Heart Association. Hypertension (Dallas, Tex. : 1979). 2021 11; 78(5):e38-e50. doi: 10.1161/hyp.0000000000000202. [PMID: 34538096]
  • Karen E Elkind-Hirsch, N Chappell, Ericka Seidemann, John Storment, Drake Bellanger. Exenatide, Dapagliflozin, or Phentermine/Topiramate Differentially Affect Metabolic Profiles in Polycystic Ovary Syndrome. The Journal of clinical endocrinology and metabolism. 2021 09; 106(10):3019-3033. doi: 10.1210/clinem/dgab408. [PMID: 34097062]
  • Ernesto Limón-Bernal, José E Roa-Coria, Ángel Zúñiga-Romero, Juan C Huerta-Cruz, Irma R C Ruíz-Velasco, Francisco J Flores-Murrieta, Eleazar Lara-Padilla, Juan G Reyes-García, Héctor I Rocha-González. Anorectic interaction and safety of 5-hydroxytryptophan/carbidopa plus phentermine or diethylpropion in rat. Behavioural pharmacology. 2021 08; 32(5):368-381. doi: 10.1097/fbp.0000000000000625. [PMID: 33660661]
  • Marvin Wei Jie Chua, Boon Cheok Lai. Phentermine-Induced Acute Kidney Injury Secondary to Uncontrolled Hypertension in a Patient with Weight Regain Post-bariatric Surgery. Obesity surgery. 2021 08; 31(8):3874-3879. doi: 10.1007/s11695-021-05438-2. [PMID: 33890226]
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  • Xiang-Guo Lei, Jia-Qi Ruan, Chen Lai, Ziyi Sun, Xi Yang. Efficacy and Safety of Phentermine/Topiramate in Adults with Overweight or Obesity: A Systematic Review and Meta-Analysis. Obesity (Silver Spring, Md.). 2021 06; 29(6):985-994. doi: 10.1002/oby.23152. [PMID: 33864346]
  • Sundeep Kumar, Akhil Mogalapalli, Ruthvik Srinivasamurthy, Sayed T Hussain, Philip L Mar. Supraventricular tachycardia with the use of phentermine: case report and review of literature. Postgraduate medicine. 2021 May; 133(4):454-457. doi: 10.1080/00325481.2021.1901476. [PMID: 33686912]
  • Yun Jeong Choi, Arum Sim, Min Kyung Kim, Sunglll Suh, Moon Kyo In, Jin Young Kim. Determination of phentermine, N-hydroxyphentermine and mephentermine in urine using dilute and shoot liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Sep; 1029-1030(?):22-27. doi: 10.1016/j.jchromb.2016.06.045. [PMID: 27398632]
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  • David B Allison, Kishore M Gadde, William Timothy Garvey, Craig A Peterson, Michael L Schwiers, Thomas Najarian, Peter Y Tam, Barbara Troupin, Wesley W Day. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity (Silver Spring, Md.). 2012 Feb; 20(2):330-42. doi: 10.1038/oby.2011.330. [PMID: 22051941]
  • Kelly E Steidl, William Darko, Luke A Probst, John A Noviasky, Samer Nasser. Rhabdomyolysis associated with phentermine. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2010 Nov; 67(22):1929-32. doi: 10.2146/ajhp090395. [PMID: 21048209]
  • J G Kang, C-Y Park, J H Kang, Y-W Park, S W Park. Randomized controlled trial to investigate the effects of a newly developed formulation of phentermine diffuse-controlled release for obesity. Diabetes, obesity & metabolism. 2010 Oct; 12(10):876-82. doi: 10.1111/j.1463-1326.2010.01242.x. [PMID: 20920040]
  • Leveriza F Arenas, Benilda S Ebarvia, Fortunato B Sevilla. Enantioselective piezoelectric quartz crystal sensor for d-methamphetamine based on a molecularly imprinted polymer. Analytical and bioanalytical chemistry. 2010 Aug; 397(7):3155-8. doi: 10.1007/s00216-010-3865-7. [PMID: 20526767]
  • Wei-Hsun Huang, Chin-Hung Liu, Ray H Liu, Ying Lung Tseng. Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis. Journal of analytical toxicology. 2010 Mar; 34(2):73-7. doi: 10.1093/jat/34.2.73. [PMID: 20223098]
  • Raquel Ferrer-Lorente, Cristina Cabot, José-Antonio Fernández-López, Marià Alemany. Comparative effects of oleoyl-estrone and a specific beta3-adrenergic agonist (CL316, 243) on the expression of genes involved in energy metabolism of rat white adipose tissue. Nutrition & metabolism. 2010 Feb; 7(?):15. doi: 10.1186/1743-7075-7-15. [PMID: 20184727]
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  • Mei-Chich Hsu, Su-Fan Lin, Cheng-Ping Kuan, Wei-Lan Chu, Kuei-Hui Chan, Guo-Ping Chang-Chien. Oxethazaine as the source of mephentermine and phentermine in athlete's urine. Forensic science international. 2009 Mar; 185(1-3):e1-5. doi: 10.1016/j.forsciint.2008.12.009. [PMID: 19157735]
  • Mark Waterlow, Paul Chrisp. Rimonabant: the evidence for its use in the treatment of obesity and the metabolic syndrome. Core evidence. 2008 Feb; 2(3):173-87. doi: ". [PMID: 21221184]
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  • Dorota Zolkowska, Richard B Rothman, Michael H Baumann. Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. The Journal of pharmacology and experimental therapeutics. 2006 Aug; 318(2):604-10. doi: 10.1124/jpet.106.101618. [PMID: 16644904]
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  • Tatyana D Sotnikova, Jean-Martin Beaulieu, Larry S Barak, William C Wetsel, Marc G Caron, Raul R Gainetdinov. Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. PLoS biology. 2005 Aug; 3(8):e271. doi: 10.1371/journal.pbio.0030271. [PMID: 16050778]
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  • Maria Luz Fernandez, Shiva Metghalchi, Sonia Vega-López, Karin Conde-Knape, Timothy G Lohman, Zaida R Cordero-Macintyre. Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women. The Journal of nutritional biochemistry. 2004 Dec; 15(12):717-21. doi: 10.1016/j.jnutbio.2004.07.001. [PMID: 15607644]
  • Amal Kaddoumi, Mihoko N Nakashima, Toshihide Maki, Yoshihiro Matsumura, Junzo Nakamura, Kenichiro Nakashima. Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 791(1-2):291-303. doi: 10.1016/s1570-0232(03)00231-9. [PMID: 12798189]
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