Testosterone Propionate (BioDeep_00000002308)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate

化学式: C22H32O3 (344.23513219999995)
中文名称: 丙酸睾丸素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI: InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1

描述信息

Testosterone Propionate is only found in individuals that have used or taken this drug. It is an ester of testosterone with a propionate substitution at the 17-beta position. [PubChem]The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

14 个代谢物同义名

(1S,2R,10R,11S,14S,15S)-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl propanoate; 17-propionyl-17beta-hydroxyandrost-4-en-3-one; Eifelfango brand OF testosterone propionate; Ferring brand OF testosterone propionate; Propionat eifelfango, testosteron; Eifelfango, testosteron propionat; Testosteron propionat eifelfango; Testosterone propionic acid; Testosterone propionate; ChemDiv1_020720; Virormone; Agovirin; Testex; Testosterone propionate

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:9466
KEGG: C08158
KEGGdrug: D00959
PubChem: 5410
PubChem: 5995
HMDB: HMDB0015489
Metlin: METLIN2783
DrugBank: DB01420
ChEMBL: CHEMBL1170
Wikipedia: Testosterone propionate
MeSH: Testosterone Propionate
chemspider: 5774
CAS: 57-85-2
PMhub: MS000002318
PubChem: 10358
LipidMAPS: LMST02020076
3DMET: B02149
NIKKAJI: J4.584E
KNApSAcK: 9466

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Shedrach C Kanu, Fidelis E Ejezie, Chioma S Ejezie, Chinedum O Eleazu. Effect of methanol extract of Plectranthus esculentus N.E.Br tuber and its fractions on indices of benign prostatic hyperplasia in Wistar rats. Journal of ethnopharmacology. 2024 Sep; 331(?):118301. doi: 10.1016/j.jep.2024.118301. [PMID: 38735419]
Young-Jin Choi, Nishala Erandi Wedamulla, Seok-Hee Kim, Mirae Oh, Kang Sik Seo, Jeong Su Han, Eun Joo Lee, Young Ho Park, Young Jin Park, Eun-Kyung Kim. Salvia miltiorrhiza Bunge Ameliorates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress via Nrf-2/HO-1 Activation. Journal of microbiology and biotechnology. 2024 May; 34(5):1059-1072. doi: 10.4014/jmb.2308.08053. [PMID: 37994101]
Seong Min Lee, Sang Mok Lee, Jungbin Song. Effects of Taraxaci Herba (Dandelion) on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Rats. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081189. [PMID: 38674879]
Misaki Kojima, Masakuni Degawa. Causes of Sex Differences in Serum Cholesterol and Triglyceride Levels in Meishan Pigs. Biological & pharmaceutical bulletin. 2024; 47(3):606-610. doi: 10.1248/bpb.b23-00895. [PMID: 38462492]
Y Y Han, Q H Zhang, W S Chen, Z L Li, D Xie, S L Zhang, H Lu, L W Wang, Z H Xu, L Z Zhang. Fermented rape pollen powder can alleviate benign prostatic hyperplasia in rats by reducing hormone content and changing gut microbiota. Beneficial microbes. 2023 Nov; 14(5):503-524. doi: 10.1163/18762891-20230039. [PMID: 38656098]
Guo-Yu Gong, Sheng-Yan Xi, Cheng-Chen Li, Wen-Li Tang, Xue-Ming Fu, Yuan-Peng Huang. Bushen Tongluo formula ameliorated testosterone propionate-induced benign prostatic hyperplasia in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 120(?):155048. doi: 10.1016/j.phymed.2023.155048. [PMID: 37651753]
Shanshan Wang, Wenjiang He, Wenzhi Li, Jin-Rong Zhou, Zhiyun Du. Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28134900. [PMID: 37446563]
Deusdedit Tusubira, Patrick M Aja, Jonasi Munezero, Frank Ssedyabane, Nathim Namale, Josiah E Ifie, Peter C Agu, Clement O Ajayi, Joash Okoboi. Safety profile of colocasia esculenta tuber extracts in benign prostate hyperplasia. BMC complementary medicine and therapies. 2023 Jun; 23(1):187. doi: 10.1186/s12906-023-04018-4. [PMID: 37286957]
Jie Kang, Jixing Yan, Wensheng Yan. Testosterone ameliorated the behavioural deficits of gonadectomised rats and counteracted free radicals in a dosage-dependent manner. Behavioural brain research. 2023 May; 450(?):114501. doi: 10.1016/j.bbr.2023.114501. [PMID: 37207980]
Akansha Bisht, Ritika Gururani, Smita Jain, Rahul Shukla, Jaya Dwivedi, Swapnil Sharma. Cedrus deodara (Roxb. ex D.Don) G.Don bark fraction ameliorates metabolic, endocrine and ovarian dynamics in rats experiencing polycystic ovarian syndrome. Journal of ethnopharmacology. 2023 Apr; 306(?):116206. doi: 10.1016/j.jep.2023.116206. [PMID: 36690306]
Ebenezer O Farombi, Babajide O Ajayi, Edward K Opata, Abisoye O Fafioye, Adetomilola T Akinade. Kolaviron modulates angiogenesis, apoptosis and inflammatory signaling in rat model of testosterone propionate-induced benign prostate hyperplasia. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01171-7. [PMID: 36881348]
Myunghee Kim, Phuong Tran, Jun Yin, Jungbin Song, Hocheol Kim. Cinnamomum cassia and Rosa laevigata Mixture Improves Benign Prostatic Hyperplasia in Rats by Regulating Androgen Receptor Signaling and Apoptosis. Nutrients. 2023 Feb; 15(4):. doi: 10.3390/nu15040818. [PMID: 36839177]
Young-Jin Choi, Meiqi Fan, Nishala Erandi Wedamulla, Yujiao Tang, Sung Mun Bae, Ji-Young Hwang, Eun-Kyung Kim. Inhibitory effects of Centella asiatica (L.) Urban on enlarged prostate through androgen receptor and PI3K/Akt signaling pathways. Food & function. 2022 Oct; 13(19):10235-10247. doi: 10.1039/d2fo00841f. [PMID: 36124918]
Ja Yeon Park, Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Jun Hee Lee, Hyun Jeong Kwak, Jae-Young Um. Therapeutic role of Glycyrrhiza Uralensis fisher on benign prostatic hyperplasia through 5 alpha reductase regulation and apoptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Oct; 105(?):154371. doi: 10.1016/j.phymed.2022.154371. [PMID: 35964456]
Kate Eleazu, Patrick Maduabuchi Aja, Chinedum Ogbonnaya Eleazu. Cocoyam (Colocasia esculenta) modulates some parameters of testosterone propionate-induced rat model of benign prostatic hyperplasia. Drug and chemical toxicology. 2022 Sep; 45(5):1923-1933. doi: 10.1080/01480545.2021.1892956. [PMID: 33641553]
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jinbong Park, Jun Hee Lee, Jae-Young Um. Ellagic acid improves benign prostate hyperplasia by regulating androgen signaling and STAT3. Cell death & disease. 2022 06; 13(6):554. doi: 10.1038/s41419-022-04995-3. [PMID: 35715415]
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An. Purple Corn Extract Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis. Journal of agricultural and food chemistry. 2022 May; 70(18):5561-5569. doi: 10.1021/acs.jafc.1c07955. [PMID: 35466676]
Basma H Marghani, Alaa Fehaid, Ahmed I Ateya, Mohamed Aboul Ezz, Rasha M Saleh. Photothermal therapeutic potency of plasmonic silver nanoparticles for apoptosis and anti-angiogenesis in testosterone induced benign prostate hyperplasia in rats. Life sciences. 2022 Feb; 291(?):120240. doi: 10.1016/j.lfs.2021.120240. [PMID: 34942164]
Thuy Doan Minh, Tuan Nguyen Thanh Ha, Thuan Nguyen Duy, Ngan Nguyen Hoang, Dung PhamTien, Hung Pham Thai, Hoa Nguyen Thi, Phuong Dang Thi Lan, Binh Pham Quoc, D Y Ivkin, M N Povydysh, Bang Nguyen Cong, M V Krasnova. Linh Phu Khang Tue Tinh inhibited prostate proliferation in rats induced benign prostatic hyperplasia by testosterone propionate. Journal of ethnopharmacology. 2021 Oct; 279(?):114388. doi: 10.1016/j.jep.2021.114388. [PMID: 34224813]
Linghe Zang, Yuwei Zhang, Jing Zhao, Yunxia Yuan, Yi Wen, Jiaxin Lian, Shuailong Chen, Yiran Chen, Weiyi Liu, Ze Niu, Xinyue Wang, Chunlin Peng, Wenxin Zhang, Zhaoqing Meng, Jincai Lu. A metabolomics study of Qianliexin capsule treatment of benign prostatic hyperplasia induced by testosterone propionate in the rat model. Analytical biochemistry. 2021 09; 628(?):114258. doi: 10.1016/j.ab.2021.114258. [PMID: 34081927]
Hyo-Jung Kim, Bo-Ram Jin, Hyo-Jin An. Psoralea corylifolia L. extract ameliorates benign prostatic hyperplasia by regulating prostate cell proliferation and apoptosis. Journal of ethnopharmacology. 2021 Jun; 273(?):113844. doi: 10.1016/j.jep.2021.113844. [PMID: 33485982]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Fangfang Wang, Ningning Xie, Yan Wu, Qing Zhang, Yuhang Zhu, Minchen Dai, Jue Zhou, Jiexue Pan, Mengling Tang, Qi Cheng, Biwei Shi, Qinyuan Guo, Xinling Li, Lifeng Xie, Bing Wang, Dongxia Yang, Qing Weng, Lanzhong Guo, Jisheng Ye, Mingwo Pan, Shuyi Zhang, Hua Zhou, Cailan Zhen, Ping Liu, Ke Ning, Lisa Brackenridge, Paul J Hardiman, Fan Qu. Association between circadian rhythm disruption and polycystic ovary syndrome. Fertility and sterility. 2021 03; 115(3):771-781. doi: 10.1016/j.fertnstert.2020.08.1425. [PMID: 33358334]
Patience N Ogbu, Lawrence U S Ezeanyika, Victor N Eji Ogugua, Ikechukwu M Ogbu, Chinyere Aloke, Gertrude N Ony. Sphenostylis stenocarpa Seed Extract Attenuates Dyslipidemia in Testosterone Propionate-induced Benign Prostatic Hyperplasia in Rats. Pakistan journal of biological sciences : PJBS. 2021 Jan; 24(1):151-157. doi: 10.3923/pjbs.2021.151.157. [PMID: 33683042]
Misaki Kojima, Masakuni Degawa. Androgen-Dependent Differences in the Amounts of CYP mRNAs in the Pig Kidney. Biological & pharmaceutical bulletin. 2021; 44(8):1120-1128. doi: 10.1248/bpb.b21-00333. [PMID: 34334497]
Asmaa Mohamed Abdel-Aziz, Nashwa Fathy Gamal El-Tahawy, Medhat Atta Salah Abdel Haleem, Mostafa Mouard Mohammed, Ahmed Issam Ali, Yasmine F Ibrahim. Amelioration of testosterone-induced benign prostatic hyperplasia using febuxostat in rats: The role of VEGF/TGFβ and iNOS/COX-2. European journal of pharmacology. 2020 Dec; 889(?):173631. doi: 10.1016/j.ejphar.2020.173631. [PMID: 33031799]
Patience N Ogbu, Evelyn O Ugota, Rita U Onwuka, Ikechukwu M Ogbu, Chinyere Aloke. Effect of acetogenin fraction of Annona muricata leaves on antioxidant status and some indices of benign prostatic hyperplasia in rats. Redox report : communications in free radical research. 2020 Dec; 25(1):80-86. doi: 10.1080/13510002.2020.1804711. [PMID: 32878595]
Diego G Rocha, Mary Ane G Lana, Débora C S de Assis, Rodinei Augusti, Adriana F Faria. Determination of Steroids in Bovine Serum: Validation of a Reliable LC-MS/MS Method and In Vivo Studies with Boldenone Undecylenate and Testosterone Propionate. Journal of agricultural and food chemistry. 2020 Oct; 68(41):11545-11552. doi: 10.1021/acs.jafc.0c03621. [PMID: 32960588]
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Jinhyung Rho, Chang-Seob Seo, Hee-Seon Park, Hye-Yun Jeong, Og-Sung Moon, Young-Won Seo, Hwa-Young Son, Young-Suk Won, Hyo-Jung Kwun. Asteris Radix et Rhizoma suppresses testosterone-induced benign prostatic hyperplasia in rats by regulating apoptosis and inflammation. Journal of ethnopharmacology. 2020 Jun; 255(?):112779. doi: 10.1016/j.jep.2020.112779. [PMID: 32209388]
Xi Jin, Tianhai Lin, Guang Yang, Huawei Cai, Bo Tang, Xinyang Liao, Huifang Li, Xiaoting Chen, Lina Gong, Hang Xu, Yi Sun, Ping Tan, Jianqiong Yin, Hongwen Ma, Jianzhong Ai, Kunjie Wang, Qiang Wei, Lu Yang, Hong Li. Use of Tregs as a cell-based therapy via CD39 for benign prostate hyperplasia with inflammation. Journal of cellular and molecular medicine. 2020 05; 24(9):5082-5096. doi: 10.1111/jcmm.15137. [PMID: 32191396]
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Jinhyung Rho, Chang-Seob Seo, Hee-Seon Park, Charith Ub Wijerathne, Hye-Yun Jeong, Og-Sung Moon, Young-Won Seo, Hwa-Young Son, Young-Suk Won, Hyo-Jung Kwun. Ulmus macrocarpa Hance improves benign prostatic hyperplasia by regulating prostatic cell apoptosis. Journal of ethnopharmacology. 2019 Apr; 233(?):115-122. doi: 10.1016/j.jep.2018.11.042. [PMID: 30508623]
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Joabel Tonellotto Dos Santos, Jandui Escarião da Nóbrega, Lady Katerine Serrano Mujica, Carolina Dos Santos Amaral, Fabrício Amadori Machado, Manuela W Manta, Tiele Medianeira Rizzetti, Renato Zanella, Rafael Fighera, Alfredo Quites Antoniazzi, Paulo Bayard Dias Gonçalves, Fabio Vasconcellos Comim. Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome. Endocrinology. 2018 12; 159(12):4056-4064. doi: 10.1210/en.2018-00781. [PMID: 30376052]
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