Penoxsulam (BioDeep_00000002236)

human metabolite blood metabolite

代谢物信息卡片

2-(2,2-difluoroethoxy)-N-{5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}-6-(trifluoromethyl)benzene-1-sulfonamide

化学式: C16H14F5N5O5S (483.06357740000004)
中文名称: 五氟磺草胺
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: COC1=CN=C(N2C1=NC(=N2)NS(=O)(=O)C3=C(C=CC=C3OCC(F)F)C(F)(F)F)OC
InChI: InChI=1S/C16H14F5N5O5S/c1-29-10-6-22-15(30-2)26-13(10)23-14(24-26)25-32(27,28)12-8(16(19,20)21)4-3-5-9(12)31-7-11(17)18/h3-6,11H,7H2,1-2H3,(H,24,25)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4005; ORIGINAL_PRECURSOR_SCAN_NO 4004
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8116; ORIGINAL_PRECURSOR_SCAN_NO 8114
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4018; ORIGINAL_PRECURSOR_SCAN_NO 4017
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8170; ORIGINAL_PRECURSOR_SCAN_NO 8166
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8176; ORIGINAL_PRECURSOR_SCAN_NO 8174
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4015; ORIGINAL_PRECURSOR_SCAN_NO 4014
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8118; ORIGINAL_PRECURSOR_SCAN_NO 8115
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4014; ORIGINAL_PRECURSOR_SCAN_NO 4012
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4004; ORIGINAL_PRECURSOR_SCAN_NO 4003
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3984; ORIGINAL_PRECURSOR_SCAN_NO 3983
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8080; ORIGINAL_PRECURSOR_SCAN_NO 8079
CONFIDENCE standard compound; INTERNAL_ID 462; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8164; ORIGINAL_PRECURSOR_SCAN_NO 8162

同义名列表

4 个代谢物同义名

2-(2,2-difluoroethoxy)-N-{5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}-6-(trifluoromethyl)benzene-1-sulfonamide; 2-(2,2-difluoroethoxy)-N-{5,8-dimethoxy-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}-6-(trifluoromethyl)benzenesulfonamide; Penoxsulam; Penoxsulam

数据库引用编号

25 个数据库交叉引用编号

ChEBI: CHEBI:81776
KEGG: C18481
KEGG: C13421
PubChem: 11784975
HMDB: HMDB0256242
Metlin: METLIN72287
ChEMBL: CHEMBL1895913
chemspider: 9959655
CAS: 219714-96-2
MoNA: LU046254
MoNA: LU046253
MoNA: LU046204
MoNA: LU046255
MoNA: LU046256
MoNA: LU046202
MoNA: LU046205
MoNA: LU046201
MoNA: LU046251
MoNA: LU046252
MoNA: LU046203
MoNA: LU046206
PMhub: MS000002193
PubChem: 124489155
PDB-CCD: PXD
KNApSAcK: 81776

分类词条

Benzenesulfonamides

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Xiaoyue Yu, Jinqiu Sun, Yongjie Yang, Jianping Zhang, Yongliang Lu, Wei Tang. Enhanced Herbicide Metabolism and Target Site Mutation Enabled the Multiple Resistance to Cyhalofop-butyl, Florpyrauxifen-benzyl, and Penoxsulam in Echinochloa crus-galli. Journal of agricultural and food chemistry. 2024 May; 72(20):11405-11414. doi: 10.1021/acs.jafc.4c02450. [PMID: 38717990]
Haitao Gao, Jiaxing Yu, Jinyi Chen, Hao Wang, Shaoqi Liang, Zhike Feng, Yucheng Gu, Liyao Dong. Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Late Watergrass (Echinochloa phyllopogon) in China. Journal of agricultural and food chemistry. 2023 Nov; ?(?):. doi: 10.1021/acs.jafc.3c05921. [PMID: 37934576]
Xianyan Chen, Yonglin Ma, Mengge Huang, Weisheng Li, Dongqiang Zeng, Jingbo Li, Yanhui Wang. Multiple herbicide resistance in a Cyperus difformis population in rice field from China. Pesticide biochemistry and physiology. 2023 Sep; 195(?):105576. doi: 10.1016/j.pestbp.2023.105576. [PMID: 37666602]
Huan-Huan Zhao, Hong-Yu Li, Chui-Hua Kong. Penoxsulam-resistant barnyardgrass-mediated rhizosphere microbial communities affect the growth of rice. Pest management science. 2023 Aug; 79(8):2664-2674. doi: 10.1002/ps.7445. [PMID: 36883589]
Lulu Zhang, Weijing Wang, Ying Du, Yunyan Deng, Tianlang Bai, Mingshan Ji. Multiple resistance of Echinochloa phyllopogon to synthetic auxin, ALS-, and ACCase-inhibiting herbicides in Northeast China. Pesticide biochemistry and physiology. 2023 Jun; 193(?):105450. doi: 10.1016/j.pestbp.2023.105450. [PMID: 37248019]
Alex R Ceseski, Amar S Godar, Sara Ohadi, Kassim Al-Khatib. Target and nontarget mechanisms of AHAS inhibitor cross-resistance patterns in Cyperus difformis. Pesticide biochemistry and physiology. 2023 Jun; 193(?):105444. doi: 10.1016/j.pestbp.2023.105444. [PMID: 37248013]
Ali Acar, Divya Singh. Monitoring genotoxic, biochemical and morphotoxic potential of penoxsulam and the protective role of European blueberry (Vaccinium myrtillus L.) extract. Scientific reports. 2023 Apr; 13(1):6787. doi: 10.1038/s41598-023-34068-0. [PMID: 37101000]
Hanna Barchanska, Klaudia Pszczolińska, Ingus Perkons, Vadims Bartkevics, Sławomir Drzewiecki, Nasir Shakeel, Joanna Płonka. The metabolic processes of selected pesticides and their influence on plant metabolism. A case study of two field-cultivated wheat varieties. The Science of the total environment. 2023 Mar; 875(?):162709. doi: 10.1016/j.scitotenv.2023.162709. [PMID: 36907395]
Yuhua Zhang, Haitao Gao, Jiapeng Fang, Hao Wang, Jinyi Chen, Jun Li, Liyao Dong. Up-regulation of bZIP88 transcription factor is involved in resistance to three different herbicides in both Echinochloa crus-galli and E. glabrescens. Journal of experimental botany. 2022 11; 73(19):6916-6930. doi: 10.1093/jxb/erac319. [PMID: 35867472]
Dengtan Li, Jingwen Zhang, Chao Cheng, Kaixuan Hou, Xiaole Wang, Lusheng Zhu, Bing Li, Zhongkun Du, Jinhua Wang, Jun Wang. Effects of ecotoxicity of penoxsulam single and co-exposure with AgNPs on Eisenia fetida. Chemosphere. 2022 Nov; 307(Pt 4):136134. doi: 10.1016/j.chemosphere.2022.136134. [PMID: 36028129]
Tangqi Feng, Qian Peng, Lei Wang, Yuanli Xie, Kang Ouyang, Feile Li, Huazhong Zhou, Hongju Ma. Multiple resistance mechanisms to penoxsulam in Echinochloa crus-galli from China. Pesticide biochemistry and physiology. 2022 Oct; 187(?):105211. doi: 10.1016/j.pestbp.2022.105211. [PMID: 36127055]
Jiapeng Fang, Dongchen Yang, Zerui Zhao, Jinyi Chen, Liyao Dong. A novel Phe-206-Leu mutation in acetolactate synthase confers resistance to penoxsulam in barnyardgrass (Echinochloa crus-galli (L.) P. Beauv). Pest management science. 2022 Jun; 78(6):2560-2570. doi: 10.1002/ps.6887. [PMID: 35334143]
Jiapeng Fang, Yuhua Zhang, Tingting Liu, Bojun Yan, Jun Li, Liyao Dong. Target-Site and Metabolic Resistance Mechanisms to Penoxsulam in Barnyardgrass (Echinochloa crus-galli (L.) P. Beauv). Journal of agricultural and food chemistry. 2019 Jul; 67(29):8085-8095. doi: 10.1021/acs.jafc.9b01641. [PMID: 31265279]
Bojun Yan, Yuhua Zhang, Jun Li, Jiapeng Fang, Tingting Liu, Liyao Dong. Transcriptome profiling to identify cytochrome P450 genes involved in penoxsulam resistance in Echinochloa glabrescens. Pesticide biochemistry and physiology. 2019 Jul; 158(?):112-120. doi: 10.1016/j.pestbp.2019.04.017. [PMID: 31378345]
Xue-Fang Yang, Kang Lei, Chui-Hua Kong, Xiao-Hua Xu. Effect of allelochemical tricin and its related benzothiazine derivative on photosynthetic performance of herbicide-resistant barnyardgrass. Pesticide biochemistry and physiology. 2017 Nov; 143(?):224-230. doi: 10.1016/j.pestbp.2017.08.010. [PMID: 29183596]
Xue-Fang Yang, Chui-Hua Kong, Xia Yang, Yong-Feng Li. Interference of allelopathic rice with penoxsulam-resistant barnyardgrass. Pest management science. 2017 Nov; 73(11):2310-2317. doi: 10.1002/ps.4617. [PMID: 28523765]
Geovane B Reimche, Sérgio L O Machado, Maria Angélica Oliveira, Renato Zanella, Valderi Luiz Dressler, Erico M M Flores, Fábio F Gonçalves, Filipe F Donato, Matheus A G Nunes. Imazethapyr and imazapic, bispyribac-sodium and penoxsulam: zooplankton and dissipation in subtropical rice paddy water. The Science of the total environment. 2015 May; 514(?):68-76. doi: 10.1016/j.scitotenv.2015.01.055. [PMID: 25659307]
Camila Rebellatto Murussi, Maria Luiza Thorstenberg, Jossiele Leitemperger, Maiara Costa, Bárbara Clasen, Adriana Santi, Charlene Menezes, Vanessa Kruger Engers, Vania Lucia Loro. Toxic effects of penoxsulam herbicide in two fish species reared in southern Brazil. Bulletin of environmental contamination and toxicology. 2014 Jan; 92(1):81-4. doi: 10.1007/s00128-013-1137-x. [PMID: 24189995]
Jhoana L Opeña, Bhagirath S Chauhan, Aurora M Baltazar. Seed germination ecology of Echinochloa glabrescens and its implication for management in rice (Oryza sativa L.). PloS one. 2014; 9(3):e92261. doi: 10.1371/journal.pone.0092261. [PMID: 24642568]
Xia Yang, Xin-Yan Yu, Yong-Feng Li. De novo assembly and characterization of the Barnyardgrass (Echinochloa crus-galli) transcriptome using next-generation pyrosequencing. PloS one. 2013; 8(7):e69168. doi: 10.1371/journal.pone.0069168. [PMID: 23874903]
Junghyun Kim, Abolfazl Zarjou, Amie M Traylor, Subhashini Bolisetty, Edgar A Jaimes, Travis D Hull, James F George, Fady M Mikhail, Anupam Agarwal. In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice. Kidney international. 2012 Aug; 82(3):278-91. doi: 10.1038/ki.2012.102. [PMID: 22495295]
Harindra Karunatilake. Acute renal failure following penoxsulam poisoning. Clinical toxicology (Philadelphia, Pa.). 2012 Jan; 50(1):79. doi: 10.3109/15563650.2011.633492. [PMID: 22115055]
Roberta Cattaneo, Bárbara Clasen, Vania Lucia Loro, Charlene Cavalheiro de Menezes, Bibiana Moraes, Adriana Santi, Candida Toni, Luis Antonio de Avila, Renato Zanella. Toxicological responses of Cyprinus carpio exposed to the herbicide penoxsulam in rice field conditions. Journal of applied toxicology : JAT. 2011 Oct; 31(7):626-32. doi: 10.1002/jat.1606. [PMID: 21204108]
Hagai Yasuor, Maria D Osuna, Aida Ortiz, Néstor E Saldaín, James W Eckert, Albert J Fischer. Mechanism of resistance to penoxsulam in late watergrass [ Echinochloa phyllopogon (Stapf) Koss.]. Journal of agricultural and food chemistry. 2009 May; 57(9):3653-60. doi: 10.1021/jf8039999. [PMID: 19323496]