Methylone (BioDeep_00000002042)
Secondary id: BioDeep_00000408445
human metabolite blood metabolite
代谢物信息卡片
1-(2H-1,3-benzodioxol-5-yl)-2-(methylamino)propan-1-one
化学式: C11H13NO3 (207.0895388)
中文名称: 亚甲基二氧基甲卡西酮
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC(C(=O)C1=CC2=C(C=C1)OCO2)NC
InChI: InChI=1S/C11H13NO3/c1-7(12-2)11(13)8-3-4-9-10(5-8)15-6-14-9/h3-5,7,12H,6H2,1-2H3
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:182618
- KEGG: C20126
- PubChem: 45789647
- HMDB: HMDB0254656
- Metlin: METLIN73543
- ChEMBL: CHEMBL3604010
- CAS: 186028-79-5
- PMhub: MS000001730
- PubChem: 135626586
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Courtney Gearlds, Jessica Brooke Bouldin, Mariah McKinney, Shannon Schreiner, Stacy D Brown, Brooks B Pond. Pharmacokinetics of Synthetic Cathinones Found in Bath Salts in Mouse Brain and Plasma Using High-Pressure Liquid Chromatography-Tandem Mass Spectrometry.
European journal of drug metabolism and pharmacokinetics.
2021 Nov; 46(6):771-778. doi:
10.1007/s13318-021-00712-1. [PMID: 34427910] - Fernando B de Moura, Alexander Sherwood, Thomas E Prisinzano, Carol A Paronis, Jack Bergman, Stephen J Kohut. Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses.
Pharmacology, biochemistry, and behavior.
2021 03; 202(?):173112. doi:
10.1016/j.pbb.2021.173112. [PMID: 33444603] - I Vaz, T Carvalho, M J Valente, A Castro, A M Araújo, M L Bastos, M Carvalho. The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells.
Toxicology letters.
2020 Oct; 331(?):42-52. doi:
10.1016/j.toxlet.2020.05.025. [PMID: 32464236] - Eulalia Olesti, Jose Antonio Pascual, Mireia Ventura, Esther Papaseit, Magí Farré, Rafael de la Torre, Oscar J Pozo. LC-MS/MS method for the quantification of new psychoactive substances and evaluation of their urinary detection in humans for doping control analysis.
Drug testing and analysis.
2020 Jun; 12(6):785-797. doi:
10.1002/dta.2768. [PMID: 31950617] - Bárbara Silva, Renata Silva, Carla Fernandes, Paula Guedes de Pinho, Fernando Remião. Enantioselectivity on the absorption of methylone and pentedrone using Caco-2 cell line: Development and validation of an UHPLC method for cathinones quantification.
Toxicology and applied pharmacology.
2020 05; 395(?):114970. doi:
10.1016/j.taap.2020.114970. [PMID: 32234388] - Dino Luethi, Karolina E Kolaczynska, Melanie Walter, Masaki Suzuki, Kenner C Rice, Bruce E Blough, Marius C Hoener, Michael H Baumann, Matthias E Liechti. Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems.
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2019 07; 33(7):831-841. doi:
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2019 Mar; 236(3):953-962. doi:
10.1007/s00213-018-5075-5. [PMID: 30345459] - Lilian H J Richter, Andreas Beck, Veit Flockerzi, Hans H Maurer, Markus R Meyer. Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.
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Bioorganic & medicinal chemistry.
2015 Sep; 23(17):5574-9. doi:
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Behavioural pharmacology.
2015 Jun; 26(4):345-52. doi:
10.1097/fbp.0000000000000135. [PMID: 25794333] - John H Anneken, Mariana Angoa-Pérez, Donald M Kuhn. 3,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter.
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2015 Apr; 133(2):211-22. doi:
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2013 Aug; 45(?):64-72. doi:
10.1016/j.pnpbp.2013.04.007. [PMID: 23603357] - Christine M Murphy, Anna R Dulaney, Michael C Beuhler, Sherri Kacinko. 'Bath salts' and 'plant food' products: the experience of one regional US poison center.
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10.1007/s13181-012-0243-1. [PMID: 22733603] - Peter N Carbone, David L Carbone, Shaun D Carstairs, Scott A Luzi. Sudden cardiac death associated with methylone use.
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