3,5-Diiodo-L-tyrosine (BioDeep_00000001505)

 

Secondary id: BioDeep_00000055175, BioDeep_00001868065

human metabolite Endogenous blood metabolite natural product BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid

化学式: C9H9I2NO3 (432.8671944)
中文名称: 3,5-二碘酪氨酸, 3,5-二碘-L-酪氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 10.87%

分子结构信息

SMILES: C1=C(C=C(C(=C1I)O)I)CC(C(=O)O)N
InChI: InChI=1S/C9H9I2NO3/c10-5-1-4(2-6(11)8(5)13)3-7(12)9(14)15/h1-2,7,13H,3,12H2,(H,14,15)/t7-/m0/s1

描述信息

3,5-Diiodo-L-tyrosine, also known as diiy or DIT, belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 3,5-Diiodo-L-tyrosine exists in all living organisms, ranging from bacteria to humans. In humans, 3,5-diiodo-L-tyrosine is involved in thyroid hormone synthesis. 3,5-Diiodo-L-tyrosine is a product from the iodination of monoiodotyrosine.
A product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones (thyroxine and triiodothyronine). [HMDB]
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03B - Antithyroid preparations
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
KEIO_ID D056

同义名列表

19 个代谢物同义名

(2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid; (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoate; 4-Hydroxy-3,5-diiodophenylalanine; 3,5-Diiodo-L-tyrosine; 3,5-L-Diiodotyrosine; L-3,5-Diiodotyrosine; 3,5-Diiodo-tyrosine; 3,5-Iodo-L-tyrosine; 3,5-Diiodotyrosine; 3,5-Diiodotyrocine; Acid, iodogorgoic; L-Diiodotyrosine; Iodogorgoic acid; Diiodotyrosine; 66-02-4; DiIY; DIT; 3,5-Diiodo-tyrosine; 3,5-Diiodo-L-tyrosine



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(4)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jesús Nicolás Carcelén, Juan Manuel Marchante-Gayón, Pablo Rodríguez-González, Alfredo Ballesteros, José M González, José Ángel Cocho de Juan, José Ignacio García Alonso. Determination of 3-monoiodotyrosine and 3,5-diiodotyrosine in newborn urine and dried urine spots by isotope dilution tandem mass spectrometry. The Analyst. 2022 Mar; 147(7):1329-1340. doi: 10.1039/d1an02203b. [PMID: 35262098]
  • Naoya Fujita, Yosuke Ono, Azusa Sano, Motohiro Kimata, Seigo Oyama, Kenichi Hashimoto, Ikuya Sato, Masahiko Kudo, Yoshimichi Miyashiro, Akira Fujikata, Yuji Tanaka. Serum diiodotyrosine - a biomarker to differentiate destructive thyroiditis from Graves' disease. European journal of endocrinology. 2022 Jan; 186(2):245-253. doi: 10.1530/eje-21-0901. [PMID: 34874894]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Salvatore Benvenga, Fabrizio Guarneri. Thyroid hormone binding motifs and iodination pattern of thyroglobulin. Frontiers in bioscience (Landmark edition). 2019 01; 24(2):212-230. doi: 10.2741/4714. [PMID: 30468652]
  • Chayanon Ngambenjawong, Meilyn Sylvestre, Heather H Gustafson, Julio Marco B Pineda, Suzie H Pun. Reversibly Switchable, pH-Dependent Peptide Ligand Binding via 3,5-Diiodotyrosine Substitutions. ACS chemical biology. 2018 04; 13(4):995-1002. doi: 10.1021/acschembio.8b00171. [PMID: 29481044]
  • L S Bolshakova, A B Lisitsyn, I M Chernukha, Yu N Zubtsov, D E Lukin, S L Lyublinsky. [The study of the metabolism of iodotyrosines included in the iodized milk protein in rats]. Voprosy pitaniia. 2018 ; 87(3):12-17. doi: 10.24411/0042-8833-2018-10037. [PMID: 30772969]
  • Qing Chang, Yue'e Peng, Lifen Yun, Qingxin Zhu, Shenghong Hu, Qin Shuai. Rapid Identification of Unknown Organic Iodine in Small-Volume Complex Biological Samples Based on Nanospray Mass Spectrometry Coupled with in-Tube Solid Phase Microextraction. Analytical chemistry. 2017 04; 89(7):4147-4152. doi: 10.1021/acs.analchem.7b00037. [PMID: 28287711]
  • Ainhoa Iglesias, Laura García-Nimo, José A Cocho de Juan, José C Moreno. Towards the pre-clinical diagnosis of hypothyroidism caused by iodotyrosine deiodinase (DEHAL1) defects. Best practice & research. Clinical endocrinology & metabolism. 2014 Mar; 28(2):151-9. doi: 10.1016/j.beem.2013.10.009. [PMID: 24629858]
  • Kuan-Chung Chen, Wen-Yuan Lee, Hsin-Yi Chen, Calvin Yu-Chian Chen. In silico investigation of potential TRAF6 inhibitor from traditional Chinese medicine against cancers. BioMed research international. 2014; 2014(?):429486. doi: 10.1155/2014/429486. [PMID: 25089269]
  • Vanessa Romarís-Hortas, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. Ultrasound-assisted enzymatic hydrolysis for iodinated amino acid extraction from edible seaweed before reversed-phase high performance liquid chromatography-inductively coupled plasma-mass spectrometry. Journal of chromatography. A. 2013 Sep; 1309(?):33-40. doi: 10.1016/j.chroma.2013.08.022. [PMID: 23972456]
  • Gergo Tóth, Béla Noszál. [Thyroid hormones and their precursors I. Biochemical properties]. Acta pharmaceutica Hungarica. 2013; 83(2):35-45. doi: . [PMID: 23926648]
  • Vanessa Romarís-Hortas, Pilar Bermejo-Barrera, Jorge Moreda-Piñeiro, Antonio Moreda-Piñeiro. Speciation of the bio-available iodine and bromine forms in edible seaweed by high performance liquid chromatography hyphenated with inductively coupled plasma-mass spectrometry. Analytica chimica acta. 2012 Oct; 745(?):24-32. doi: 10.1016/j.aca.2012.07.035. [PMID: 22938602]
  • Vanessa Romarís-Hortas, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. Development of anion-exchange/reversed-phase high performance liquid chromatography-inductively coupled plasma-mass spectrometry methods for the speciation of bio-available iodine and bromine from edible seaweed. Journal of chromatography. A. 2012 May; 1236(?):164-76. doi: 10.1016/j.chroma.2012.03.019. [PMID: 22440665]
  • Enza Topo, George Fisher, Andrea Sorricelli, Francesco Errico, Alessandro Usiello, Antimo D'Aniello. Thyroid hormones and D-aspartic acid, D-aspartate oxidase, D-aspartate racemase, H2O2, and ROS in rats and mice. Chemistry & biodiversity. 2010 Jun; 7(6):1467-78. doi: 10.1002/cbdv.200900360. [PMID: 20564565]
  • Anupama A Mathi, Tekchand C Gaupale, Corinne Dupuy, Nishikant Subhedar, Shobha Bhargava. Expression pattern of iodotyrosine dehalogenase 1 (DEHAL1) during chick ontogeny. The International journal of developmental biology. 2010; 54(10):1503-8. doi: 10.1387/ijdb.092932am. [PMID: 21302259]
  • Eva D McLanahan, Melvin E Andersen, Jerry L Campbell, Jeffrey W Fisher. Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH. Environmental health perspectives. 2009 May; 117(5):731-8. doi: 10.1289/ehp.0800111. [PMID: 19479014]
  • Gijs Afink, Willem Kulik, Henk Overmars, Janine de Randamie, Truus Veenboer, Arno van Cruchten, Margarita Craen, Carrie Ris-Stalpers. Molecular characterization of iodotyrosine dehalogenase deficiency in patients with hypothyroidism. The Journal of clinical endocrinology and metabolism. 2008 Dec; 93(12):4894-901. doi: 10.1210/jc.2008-0865. [PMID: 18765512]
  • Jana Frýdlová, Zdenka Kucerová, Marie Tichá. Interaction of pepsin with aromatic amino acids and their derivatives immobilized to Sepharose. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Feb; 863(1):135-40. doi: 10.1016/j.jchromb.2008.01.021. [PMID: 18255363]
  • Sédami Gnidehou, Ludovic Lacroix, Alphonse Sezan, Renée Ohayon, Marie-Sophie Noël-Hudson, Stanislas Morand, Jacques Francon, Françoise Courtin, Alain Virion, Corinne Dupuy. Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B. Thyroid : official journal of the American Thyroid Association. 2006 Aug; 16(8):715-24. doi: 10.1089/thy.2006.16.715. [PMID: 16910871]
  • Anna M Giudetti, Monica Leo, Math J H Geelen, Gabriele V Gnoni. Short-term stimulation of lipogenesis by 3,5-L-diiodothyronine in cultured rat hepatocytes. Endocrinology. 2005 Sep; 146(9):3959-66. doi: 10.1210/en.2005-0345. [PMID: 15932927]
  • Helen G Gika, Victoria F Samanidou, Ioannis N Papadoyannis. Development of a validated HPLC method for the determination of iodotyrosines and iodothyronines in pharmaceuticals and biological samples using solid phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Jan; 814(1):163-72. doi: 10.1016/j.jchromb.2004.10.025. [PMID: 15607721]
  • Yoji Kato, Yoshichika Kawai, Hiroshi Morinaga, Hajime Kondo, Natsuko Dozaki, Noritoshi Kitamoto, Toshihiko Osawa. Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to dihalogenated tyrosine. Free radical biology & medicine. 2005 Jan; 38(1):24-31. doi: 10.1016/j.freeradbiomed.2004.09.013. [PMID: 15589368]
  • Hiroshi Shionoya, Yoshiki Sugihara, Kazuo Okano, Fumio Sagami, Takashi Mikami, Kouichi Katayama. Studies on experimental iodine allergy: 1. Antigen recognition of guinea pig anti-iodine antibody. The Journal of toxicological sciences. 2004 May; 29(2):131-6. doi: 10.2131/jts.29.131. [PMID: 15206581]
  • D H Haas, R M Murphy. Design of a pH-sensitive pore-forming peptide with improved performance. The journal of peptide research : official journal of the American Peptide Society. 2004 Jan; 63(1):9-16. doi: 10.1046/j.1399-3011.2004.00098.x. [PMID: 14984568]
  • R Simon, J E Tietge, B Michalke, S Degitz, K W Schramm. Iodine species and the endocrine system: thyroid hormone levels in adult Danio rerio and developing Xenopus laevis. Analytical and bioanalytical chemistry. 2002 Feb; 372(3):481-5. doi: 10.1007/s00216-001-1211-9. [PMID: 11939537]
  • J T Dunn, A D Dunn. Update on intrathyroidal iodine metabolism. Thyroid : official journal of the American Thyroid Association. 2001 May; 11(5):407-14. doi: 10.1089/105072501300176363. [PMID: 11396699]
  • B Michalke, P Schramel, H Witte. Method developments for iodine speciation by reversed-phase liquid chromatography-ICP-mass spectrometry. Biological trace element research. 2000; 78(1-3):67-79. doi: 10.1385/bter:78:1-3:67. [PMID: 11314989]
  • B Michalke, P Schramel, H Witte. Iodine speciation in human serum by reversed-phase liquid chromatography-ICP-mass spectrometry. Biological trace element research. 2000; 78(1-3):81-91. doi: 10.1385/bter:78:1-3:81. [PMID: 11314990]
  • R Wahl, M Breidt, E Kallee. Iodide supplementation: 200 micrograms daily or 1,500 micrograms weekly?. Zeitschrift fur Ernahrungswissenschaft. 1998 Mar; 37(1):18-22. doi: 10.1007/pl00007367. [PMID: 9556863]
  • P J Blower, M R Puncher, A G Kettle, S George, S Dorsch, A Leak, L H Naylor, M J O'Doherty. Iodine-123 salmon calcitonin, an imaging agent for calcitonin receptors: synthesis, biodistribution, metabolism and dosimetry in humans. European journal of nuclear medicine. 1998 Feb; 25(2):101-8. doi: 10.1007/s002590050200. [PMID: 9473255]
  • D R Doerge, R L Divi, J Deck, A Taurog. Mechanism for the anti-thyroid action of minocycline. Chemical research in toxicology. 1997 Jan; 10(1):49-58. doi: 10.1021/tx960150g. [PMID: 9074802]
  • B Gancedo, A L Alonso-Gómez, N de Pedro, M J Delgado, M Alonso-Bedate. Daily changes in thyroid activity in the frog Rana perezi: variation with season. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1996 May; 114(1):79-87. doi: 10.1016/0742-8413(96)00009-6. [PMID: 8689532]
  • L M Thienpont, V I De Brabandere, D Stöckl, A P De Leenheer. Development of a new method for the determination of thyroxine in serum based on isotope dilution gas chromatography mass spectrometry. Biological mass spectrometry. 1994 Aug; 23(8):475-82. doi: 10.1002/bms.1200230804. [PMID: 7918690]
  • P R Kootstra, R Wever, J J de Vijlder. Thyroid peroxidase: kinetics, pH optima and substrate dependency. Acta endocrinologica. 1993 Oct; 129(4):328-31. doi: 10.1530/acta.0.1290328. [PMID: 8237251]
  • P Lakatos, P H Stern. Evidence for direct non-genomic effects of triiodothyronine on bone rudiments in rats: stimulation of the inositol phosphate second messenger system. Acta endocrinologica. 1991 Nov; 125(5):603-8. doi: 10.1530/acta.0.1250603. [PMID: 1759547]
  • H Meinhold, H J Gramm, W Meissner, J Zimmermann, J Schwander, R Dennhardt, K Voigt. Elevated serum diiodotyrosine (DIT) in severe infections and sepsis: DIT, a possible new marker of leukocyte activity. The Journal of clinical endocrinology and metabolism. 1991 Apr; 72(4):945-53. doi: 10.1210/jcem-72-4-945. [PMID: 2005222]
  • J Noh, N Hamada, H Saito, M Yoshimoto, H Iwasaki, O Ozaki, Y Okamoto, K Ito, H Morii. Inhibition by immunoglobulin G of synthesis of thyroid hormone in thyroid cultures from hypothyroid patients with goitrous Hashimoto's thyroiditis. Acta endocrinologica. 1990 Nov; 123(5):511-8. doi: 10.1530/acta.0.1230511. [PMID: 1979465]
  • S A Tan, J E Lewis, L S Berk, R B Wilcox. Extrathyroidal physiology of monoiodotyrosine in humans. Clinical physiology and biochemistry. 1990; 8(3):109-15. doi: . [PMID: 2225717]
  • V K Mazo, N F Samenkova. [Binding of 3H-alanine and 125I-diiodotyrosine with serum proteins in vitro and in vivo]. Voprosy meditsinskoi khimii. 1989 Nov; 35(6):69-73. doi: NULL. [PMID: 2629243]
  • F Tietze, L D Kohn, A D Kohn, I Bernardini, H C Andersson, M D Adamson, G S Harper, W A Gahl. Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes. The Journal of biological chemistry. 1989 Mar; 264(9):4762-5. doi: . [PMID: 2925666]
  • P R Koostra, H H van den Broek, E A Hogendoorn, C E Goewie, J J de Vijlder. Automated high-performance liquid chromatographic method for the determination of iodotyrosines and iodothyronines. Journal of chromatography. 1988 Dec; 458(?):175-83. doi: 10.1016/s0021-9673(00)90562-4. [PMID: 3235633]
  • J Faber, C Kirkegaard, H Meinhold, C Bregengaard. Metabolic clearance and production of diiodotyrosine in healthy man. Scandinavian journal of clinical and laboratory investigation. 1988 Dec; 48(8):747-50. doi: 10.3109/00365518809088755. [PMID: 3238320]
  • H Meinhold, J Schwander, H J Gramm. [Ether bond cleavage of thyroxine to diiodotyrosine (DIT). DIT in serum, a possible new marker of leukocyte activity in sepsis and severe infections]. Acta medica Austriaca. 1988; 15 Suppl 1(?):25-30. doi: . [PMID: 3051831]
  • H Meinhold, R Finke, U Bogner, H Schleusener. Pharmacokinetics and urinary excretion of orally administered diiodotyrosine. Acta endocrinologica. 1987 Nov; 116(3):395-8. doi: 10.1530/acta.0.1160395. [PMID: 3687324]
  • H Meinhold, T Olbricht, D Schwartz-Porsche. Turnover and urinary excretion of circulating diiodotyrosine. The Journal of clinical endocrinology and metabolism. 1987 Apr; 64(4):794-800. doi: 10.1210/jcem-64-4-794. [PMID: 3818904]
  • W K Chan, C H Tan. Inhibition of follicle-stimulating hormone induction of aromatase activity in porcine granulosa cells by thyroxine and triiodothyronine. Endocrinology. 1986 Nov; 119(5):2353-9. doi: 10.1210/endo-119-5-2353. [PMID: 3095107]
  • G Benker, H Rasche, T Olbricht, H Meinhold, J Teuber, D Reinwein. Response of total and 'free' thyroid hormones and diiodotyrosine to bovine TSH in subclinical hypothyroidism. Acta endocrinologica. 1986 Aug; 112(4):509-16. doi: 10.1530/acta.0.1120509. [PMID: 3751463]
  • H Meinhold, R Buchholz. In vivo formation of diiodotyrosine by extrathyroidal thyroxine ether-link cleavage and effects of mononitrotyrosine on this pathway in the rat. Endocrinology. 1986 Jun; 118(6):2305-11. doi: 10.1210/endo-118-6-2305. [PMID: 3698915]
  • D B Ramsden, M Farmer, M N Mohammed, R S McGonigle, M C Sheppard. 3,5-Diiodotyrosine and thyronine in the urine of patients with chronic renal disease. Clinical endocrinology. 1986 May; 24(5):491-5. doi: 10.1111/j.1365-2265.1986.tb03277.x. [PMID: 3098453]
  • D Bernard, J C Maurizis, C Nicolas, J Michelot, G Bétail, G Meyniel. IgG purification to measure the level of an iodinated thyroglobulin peptide, the 3,5,3',5' tetraiodo-l-tyrosyl-l-tyrosine in human serum. Experientia. 1985 Mar; 41(3):385-7. doi: 10.1007/bf02004519. [PMID: 3972086]
  • R A Peterfreund, P E Sawchenko, W Vale. Thyroid hormones reversibly suppress somatostatin secretion and immunoreactivity in cultured neocortical cells. Brain research. 1985 Mar; 328(2):259-70. doi: 10.1016/0006-8993(85)91037-6. [PMID: 2859080]
  • G Benker, C Splittstösser, H Meinhold, T Olbricht, D Reinwein. Effects of small doses of bovine TSH on serum levels of free and total thyroid hormones, their degradation products, and diiodotyrosine. Acta endocrinologica. 1985 Feb; 108(2):211-6. doi: 10.1530/acta.0.1080211. [PMID: 3969815]
  • J E Zull, J Chuang. Preparation and characterization of radioactive monoiodotyrosine and diiodotyrosine derivatives of parathyroid hormone. Analytical biochemistry. 1984 Jul; 140(1):214-22. doi: 10.1016/0003-2697(84)90157-x. [PMID: 6486408]
  • I A Krasnovskaia, T V Tavrovskaia. [Function of the posterior lobe of the hypophysis in rats under long-term thyroliberin administration]. Problemy endokrinologii. 1984 May; 30(3):72-5. doi: NULL. [PMID: 6204330]
  • M N Mohammed, M Farmer, D B Ramsden. 3,5-Diiodotyrosine excretion in human urine in individuals of differing thyroidal status. Biomedical mass spectrometry. 1983 Sep; 10(9):507-11. doi: 10.1002/bms.1200100906. [PMID: 6640076]
  • H Meinhold, R Buchholz. Effects of iodotyrosine deiodinase inhibition on serum concentrations and turnover of diiodotyrosine (DIT) and thyroxine (T4) in the rat. Acta endocrinologica. 1983 Aug; 103(4):521-7. doi: 10.1530/acta.0.1030521. [PMID: 6613496]
  • D Bernard, C Nicolas, J C Maurizis, G Betail. A new method of preparing hapten-carrier immunogens by coupling with Saccharomyces cerevisiae by periodate oxidation. Journal of immunological methods. 1983 Jul; 61(3):351-7. doi: 10.1016/0022-1759(83)90231-4. [PMID: 6308098]
  • A G Burger, D Engler, U Buergi, M Weissel, G Steiger, S H Ingbar, R E Rosin, B M Babior. Ether link cleavage is the major pathway of iodothyronine metabolism in the phagocytosing human leukocyte and also occurs in vivo in the rat. The Journal of clinical investigation. 1983 Apr; 71(4):935-49. doi: 10.1172/jci110848. [PMID: 6833495]
  • J M Michelot, D J Bernard, C M Nicolas, J C Maurizis, G F Betail, G Meyniel. A radioimmunoassay of an iodinated fraction of thyroglobulin: mean serum concentration in the euthyroid human. Clinica chimica acta; international journal of clinical chemistry. 1982 Sep; 124(3):251-5. doi: 10.1016/0009-8981(82)90419-3. [PMID: 7127841]
  • H Meinhold, A Beckert, K W Wenzel. Circulating diiodotyrosine: studies of its serum concentration, source, and turnover using radioimmunoassay after immunoextraction. The Journal of clinical endocrinology and metabolism. 1981 Dec; 53(6):1171-8. doi: 10.1210/jcem-53-6-1171. [PMID: 7028774]
  • S Suzuki, M Suzuki. Changes in thyroidal and plasma iodine compounds during and after metamorphosis of the bullfrog, Rana catesbeiana. General and comparative endocrinology. 1981 Sep; 45(1):74-81. doi: 10.1016/0016-6480(81)90171-4. [PMID: 6974676]
  • K Hartmann, C Voss, G Hübner, N Hartmann. [Effectors and products of enzymatic diiodotyrosine deiodination by a plasmatic fraction from pig liver]. Acta biologica et medica Germanica. 1981; 40(3):265-74. doi: . [PMID: 7304042]
  • A Van Zyl, A Louw. Inhibition of peroxidase activity by some non-steroidal anti-inflammatory drugs. Biochemical pharmacology. 1979 Sep; 28(18):2753-9. doi: 10.1016/0006-2952(79)90559-8. [PMID: 497025]
  • V Boonnamsiri, J C Kermode, B D Thompson. Prolonged intravenous infusion of labelled iodocompounds in the rat: [125I]iodide metabolism and effects of moderate dietary iodine deficiency. The Journal of endocrinology. 1979 Aug; 82(2):227-34. doi: 10.1677/joe.0.0820227. [PMID: 490078]
  • A Van Zyl, S Lubbe, A Potgieter, J Van Zyl. The influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1979 Jun; 55(26):1082-7. doi: . [PMID: 89704]
  • L G Davis, N L Sass, B Manna, M L Nusynowitz. Gas-liquid chromatographic determination of mono- and diiodotyrosines in serum. Clinical chemistry. 1979 Feb; 25(2):218-20. doi: . [PMID: 759018]
  • N S Salakhova, T D Saipov, F Ia Turakulova, Ia Kh Turakulov. [Thyroid hormone metabolism and the functional activity of the thyroid gland in mother and fetus]. Ontogenez. 1978; 9(6):594-600. doi: NULL. [PMID: 724204]
  • J L Codaccioni, J P Rinaldi, J Bismuth. The test of overloading L-diiodotyrosine (DIT) in the screening of iodotyrosine dehalogenase deficiency. Acta endocrinologica. 1978 Jan; 87(1):95-105. doi: 10.1530/acta.0.0870095. [PMID: 579538]
  • M J Ellis, R H Jones, J H Thomas, R Geiger, V Teetz, P H Sönksen. B1-3,5-diiodotyrosine insulin: a valid tracer for insulin. Diabetologia. 1977 May; 13(3):257-61. doi: 10.1007/bf01219709. [PMID: 873092]
  • F Ismail-Beigi, M Rahimifar. A variant of iodotyrosine-dehalogenase deficiency. The Journal of clinical endocrinology and metabolism. 1977 Mar; 44(3):499-506. doi: 10.1210/jcem-44-3-499. [PMID: 838849]
  • B V Segre, P D'Amour, J T Potts. Metabolism of radioiodinated bovine parathyroid hormone in the rat. Endocrinology. 1976 Dec; 99(6):1645-52. doi: 10.1210/endo-99-6-1645. [PMID: 1001258]
  • N Okabe, N Manabe, R Tokuoka, K Tomita. Interaction of diiodo-L-tyrosine and triiodophenol with bovine serum albumin. Circular dichroism and fluorescence studies. Journal of biochemistry. 1976 Sep; 80(3):455-61. doi: 10.1093/oxfordjournals.jbchem.a131298. [PMID: 10286]
  • S Bhattacharya, R H Das, A G Datta. Iodine metabolism in dispersed pharyngeal and head kidney teleostean thyroid cells obtained by continuous trypsinization. General and comparative endocrinology. 1976 Sep; 30(1):128-30. doi: 10.1016/0016-6480(76)90073-3. [PMID: 992326]
  • J Bismuth, M Castay, S Lissitzky. Binding of 3,5-diiodotyrosine to serum proteins. Clinica chimica acta; international journal of clinical chemistry. 1976 Jun; 69(3):417-22. doi: 10.1016/0009-8981(76)90113-3. [PMID: 59643]
  • A L Golub, T J Mende. Studies on the action mechanism of the antihemostatic effect of lodopeptides. Thrombosis and haemostasis. 1976 Apr; 35(2):437-46. doi: . [PMID: 9704]
  • C H Voss, K Pflugradt, G Hübner. [In vitro study on effect of body weight on deiodination of L-diiodotyrosine and L-thyroxine in liver and kidney of rats on standard diets]. Die Nahrung. 1976; 20(1):57-61. doi: 10.1002/food.19760200111. [PMID: 958320]
  • W L Green. Induction of a coupling defect in rats during inhibition of tyrosine dehalogenase. Endocrinology. 1976 Jan; 98(1):10-9. doi: 10.1210/endo-98-1-10. [PMID: 1248438]
  • G Hübner, N Hartmann, W D Jülich, W Weuffen. [Activity of thiosulfate: cyanide-sulfurtransferase and the 3,5-diiodotyrosine-plasma deiodase in relation to the immunization and administration of rhodanides]. Acta biologica et medica Germanica. 1976; 35(5):687-90. doi: NULL. [PMID: 983617]
  • J C Nelson, R M Weiss, F J Palmer, J E Lewis, R B Wilcox. Serum diiodotyrosine. The Journal of clinical endocrinology and metabolism. 1975 Dec; 41(06):1118-24. doi: 10.1210/jcem-41-6-1118. [PMID: 1243141]
  • C Voss, K Hartmann, N Hartmann, L Ratzmann. [Deiodination in the kidney and thyroid function)]. Endokrinologie. 1975 Dec; 66(3):313-8. doi: NULL. [PMID: 1212993]
  • C Voss, N Hartmann, G Hübner. [Deiodase activity in rats following an overdose of thyroid hormone]. Endokrinologie. 1975 Aug; 65(3):320-7. doi: NULL. [PMID: 1222735]
  • O V Molotkov, N B Kozlov. [Thyroid gland function in heatstroke]. Biulleten' eksperimental'noi biologii i meditsiny. 1975 Jul; 80(7):21-4. doi: NULL. [PMID: 1227640]
  • B E Belshaw, T B Cooper, D V Becker. The iodine requirement and influence of iodine intake on iodine metabolism and thyroid function in the adult beagle. Endocrinology. 1975 May; 96(5):1280-91. doi: 10.1210/endo-96-5-1280. [PMID: 1122886]
  • I Nejad, J Bollinger, M A Mitnick, P Sullivan, S Reichlin. Measurement of plasma and tissue triiodothyronine concentration in the rat by radioimmunoassay. Endocrinology. 1975 Mar; 96(3):773-80. doi: 10.1210/endo-96-3-773. [PMID: 1116483]
  • C Voss, N Hartmann, L Ratzmann, G Hübner. [Deiodase activity in hypothyroid rats]. Acta biologica et medica Germanica. 1975; 34(1):143-8. doi: NULL. [PMID: 1179918]
  • V V'rbanov. [Deiodase deficiency--clinical significance and diagnosis]. Vutreshni bolesti. 1975; 14(1):23-9. doi: NULL. [PMID: 1189393]
  • A G Vagenakis, S H Ingbar, L E Braverman. The relationship between thyroglobulin synthesis and intrathyroid iodine metabolism as indicated by the effects of cycloheximide in the rat. Endocrinology. 1974 Jun; 94(6):1669-80. doi: 10.1210/endo-94-6-1669. [PMID: 4831130]
  • K L Wong, K W Chiu. The snake thyroid gland. I. Seasonal variation of thyroidal and serum iodoamino acids. General and comparative endocrinology. 1974 May; 23(1):63-70. doi: 10.1016/0016-6480(74)90054-9. [PMID: 4828881]
  • E E Gussakovskii, T Saatov, T A Babaev. The fluorescence of iodine-containing amino acids and proteins. I. Iodotyrosines and iodothyronines in solution and in iodinated human serum albumin. Molecular biology. 1974 Mar; 7(5):598-602. doi: NULL. [PMID: 4825846]
  • J C Nelson, R M Weiss, J E Lewis, R B Wilcox, F J Palmer. A multiple ligand-binding radioimmunoassay of diiodotyrosine. The Journal of clinical investigation. 1974 Feb; 53(2):416-22. doi: 10.1172/jci107575. [PMID: 11344555]
  • P Rochiccioli, G Dutau. [Thyroid hormonosynthesis disorders due to iodotyrosine-dehalogenase deficiency. Value of the D.I.T. test for the detection of heterozygotes]. Archives francaises de pediatrie. 1974 Jan; 31(1):25-36. doi: . [PMID: 4135480]
  • P Dasgupta, S Bhattacharya. Iodotyrosine synthesis by fish (Anabas testudineus) kidney soluble supernatant. Indian journal of experimental biology. 1974 Jan; 12(1):49-51. doi: NULL. [PMID: 4426650]
  • P R Larsen, J Dockalova, D Sipula, F M Wu. Immunoassay of thyroxine in unextracted human serum. The Journal of clinical endocrinology and metabolism. 1973 Aug; 37(2):177-82. doi: 10.1210/jcem-37-2-177. [PMID: 4198255]
  • G Knapp. [Rapid determination of iodoamino acid iodine in blood serum]. Clinica chimica acta; international journal of clinical chemistry. 1973 Jul; 46(3):261-6. doi: 10.1016/0009-8981(73)90181-2. [PMID: 4125150]
  • P K Ray, R K Banerjee, A G Datta. A new biochemical effect of erythropoietin. Biochemical and biophysical research communications. 1973 Jun; 52(4):1320-8. doi: 10.1016/0006-291x(73)90645-1. [PMID: 4736911]
  • C Godard, T Lemarchand-Béraud. Plasma thyrotropin levels in severe infantile malnutrition. Hormone research. 1973; 4(1):43-52. doi: 10.1159/000178289. [PMID: 4201256]
  • M L Wellby, K Powell, M Carman, B S Hetzel. Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter. The Journal of clinical endocrinology and metabolism. 1972 Nov; 35(5):762-3. doi: 10.1210/jcem-35-5-762. [PMID: 5071345]
  • E Siegel. Enhancement of the response of T-1 human kidney cells to thyroidal hormones by diminishing serum content of the growth medium. Endocrinology. 1972 Aug; 91(2):580-5. doi: 10.1210/endo-91-2-580. [PMID: 4566298]