Daidzein (BioDeep_00000001454)

 

Secondary id: BioDeep_00000270070, BioDeep_00000859617

natural product human metabolite PANOMIX_OTCML-2023 blood metabolite Antitumor activity BioNovoGene_Lab2019


代谢物信息卡片


7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one

化学式: C15H10O4 (254.0579)
中文名称: 大豆苷元, 黄豆苷元, 大豆素, 大豆异黄酮
谱图信息: 最多检出来源 Homo sapiens(feces) 23.93%

Reviewed

Last reviewed on 2024-10-31.

Cite this Page

Daidzein. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/daidzein (retrieved 2024-12-12) (BioDeep RN: BioDeep_00000001454). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(ccc2c(c1)occ(c2=O)c1ccc(cc1)O)O
InChI: InChI=1/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

描述信息

Daidzein is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4. It has a role as an antineoplastic agent, a phytoestrogen, a plant metabolite, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor. It is a conjugate acid of a daidzein(1-).
Daidzein is a natural product found in Pericopsis elata, Thermopsis lanceolata, and other organisms with data available.
Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties. (NCI)
Daidzein is one of several known isoflavones. Isoflavones compounds are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Up until recently, daidzein was considered to be one of the most important and most studied isoflavones, however more recently attention has shifted to isoflavone metabolites. Equol represents the main active product of daidzein metabolism, produced via specific microflora in the gut. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity. However, not all individuals consuming daidzein produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This high variability in equol production is presumably attributable to interindividual differences in the composition of the intestinal microflora, which may play an important role in the mechanisms of action of isoflavones. But, the specific bacterial species in the colon involved in the production of equol are yet to be discovered. (A3191, A3189).
See also: Trifolium pratense flower (part of).
Daidzein is one of several known isoflavones. Isoflavones compounds are found in a number of plants, but soybeans and soy products like tofu and textured vegetable protein are the primary food source. Up until recently, daidzein was considered to be one of the most important and most studied isoflavones, however more recently attention has shifted to isoflavone metabolites. Equol represents the main active product of daidzein metabolism, produced via specific microflora in the gut. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic metabolite, equol, which may enhance the actions of soy isoflavones, owing to its greater affinity for estrogen receptors, unique antiandrogenic properties, and superior antioxidant activity. However, not all individuals consuming daidzein produce equol. Only approximately one-third to one-half of the population is able to metabolize daidzein to equol. This high variability in equol production is presumably attributable to interindividual differences in the composition of the intestinal microflora, which may play an important role in the mechanisms of action of isoflavones. But, the specific bacterial species in the colon involved in the production of equol are yet to be discovered. (PMID:18045128, 17579894). Daidzein is a biomarker for the consumption of soy beans and other soy products.
Widespread isoflavone in the Leguminosae, especies Phaseolus subspecies (broad beans, lima beans); also found in soy and soy products (tofu, miso), chick peas (Cicer arietinum) and peanuts (Arachis hypogaea). Nutriceutical with anticancer and bone protective props.
A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4894; ORIGINAL_PRECURSOR_SCAN_NO 4890
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3575; ORIGINAL_PRECURSOR_SCAN_NO 3572
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4858; ORIGINAL_PRECURSOR_SCAN_NO 4855
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7978; ORIGINAL_PRECURSOR_SCAN_NO 7973
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4898; ORIGINAL_PRECURSOR_SCAN_NO 4894
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4884; ORIGINAL_PRECURSOR_SCAN_NO 4881
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7989; ORIGINAL_PRECURSOR_SCAN_NO 7985
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7952; ORIGINAL_PRECURSOR_SCAN_NO 7950
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4852; ORIGINAL_PRECURSOR_SCAN_NO 4847
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7907; ORIGINAL_PRECURSOR_SCAN_NO 7904
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7956; ORIGINAL_PRECURSOR_SCAN_NO 7952
CONFIDENCE standard compound; INTERNAL_ID 937; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7917; ORIGINAL_PRECURSOR_SCAN_NO 7913
CONFIDENCE Reference Standard (Level 1); NaToxAq - Natural Toxins and Drinking Water Quality - From Source to Tap (https://natoxaq.ku.dk)
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2315
IPB_RECORD: 1801; CONFIDENCE confident structure
IPB_RECORD: 421; CONFIDENCE confident structure
CONFIDENCE standard compound; INTERNAL_ID 8828
CONFIDENCE standard compound; INTERNAL_ID 2874
CONFIDENCE standard compound; INTERNAL_ID 4239
CONFIDENCE standard compound; INTERNAL_ID 4163
CONFIDENCE standard compound; INTERNAL_ID 181
Daidzein is a soy isoflavone, which acts as a PPAR activator.
Daidzein is a soy isoflavone, which acts as a PPAR activator.
Daidzein is a soy isoflavone, which acts as a PPAR activator.

同义名列表

76 个代谢物同义名

Daidzein, Pharmaceutical Secondary Standard; Certified Reference Material; Daidzein, United States Pharmacopeia (USP) Reference Standard; 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxyphenyl)-; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one; Daidzein, primary pharmaceutical reference standard; 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; DAIDZEIN (CONSTITUENT OF SOY ISOFLAVONES) [DSC]; 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 7-Hydroxy-3-(4-hydroxy-phenyl)-chromen-4-one; 5-18-04-00089 (Beilstein Handbook Reference); 7-hydroxy-3-(4-hydroxyphenyl)-chromen-4-one; 7-Hydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; DAIDZEIN (CONSTITUENT OF ASTRAGALUS) [DSC]; 7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one; DAIDZEIN (CONSTITUENT OF RED CLOVER) [DSC]; DAIDZEIN (CONSTITUENT OF SOY ISOFLAVONES); 7-Hydroxy-3-(4-hydroxy-phenyl)-chromone; 80E3ED75-D852-4D97-9BD6-B5ADE7EA25A1; DAIDZEIN (CONSTITUENT OF ASTRAGALUS); DAIDZEIN (CONSTITUENT OF RED CLOVER); Daidzein (4,7-Dihydroxyisoflavone); 7-hydroxy-3-(4-hydroxyphenyl)-4H-; Daidzein, purum, >=98.0\\% (TLC); d-(+)-alpha-methylbenzyl amine; d-(+)-alpha-methylbenzylamine; Daidzein, analytical standard; 7,4-Dihydroxy-isoflavone (3a); Daidzein, >=98\\%, synthetic; Isoflavone, 4,7-dihydroxy-; 4,7-Dihydroxy-iso-flavone; 4,7-dihydroxy isoflavone; 4,7-dihydroxy-Isoflavone; 7,4-Dihydroxyisoflavone; 4,7-Dihydroxyisoflavone; Daidzein (Standard); DAIDZEIN [USP-RS]; Daidzein-3,5,8-d3; DAIDZEIN (USP-RS); DAIDZEIN [WHO-DD]; Spectrum5_000857; BiomolKI2_000066; DAIDZEIN [MART.]; Spectrum2_000053; DAIDZEIN (MART.); Spectrum4_001964; Spectrum3_000191; DAIDZEIN [INCI]; Daidzein (DAI); Oprea1_305345; DAIDZEIN [MI]; Oprea1_182317; DivK1c_001023; Isoaurostatin; Lopac0_000412; MEGxm0_000123; KBio2_003303; KBio3_001241; Daidzein,(S); KBio2_000735; Tox21_201444; KBio1_001023; Tox21_303650; ACon1_000543; ACon0_001477; Tox21_500412; KBio2_005871; SMP1_000089; IDI1_001023; BMK1-F12; Daidzeol; diadzein; Daidzein; C15H10O4; ZF1; 4 7-dihydroxyisoflavone; Daidzein



数据库引用编号

114 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(6)

代谢反应

54 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(8)

WikiPathways(0)

Plant Reactome(3)

INOH(0)

PlantCyc(43)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

407 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xuemei Yang, Xinhui Jiang, Changqing Liu, Chuang Yang, Sheng Yao, Hongmei Qiu, Junxia Yang, Ke Wu, Hong Liao, Qingsong Jiang. Daidzein protects endothelial cells against high glucose-induced injury through the dual-activation of PPARα and PPARγ. General physiology and biophysics. 2024 Mar; 43(2):153-162. doi: 10.4149/gpb_2023041. [PMID: 38477605]
  • Iskandar Azmy Harahap, Maciej Kuligowski, Adam Cieslak, Paweł A Kołodziejski, Joanna Suliburska. Effect of Tempeh and Daidzein on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in Ovariectomized Rats. Nutrients. 2024 Feb; 16(5):. doi: 10.3390/nu16050651. [PMID: 38474779]
  • Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad127. [PMID: 38215001]
  • Carlos Eduardo Iglesias-Aguirre, María Romo-Vaquero, María Victoria Selma, Juan Carlos Espín. Unveiling metabotype clustering in resveratrol, daidzein, and ellagic acid metabolism: Prevalence, associated gut microbiomes, and their distinctive microbial networks. Food research international (Ottawa, Ont.). 2023 Nov; 173(Pt 2):113470. doi: 10.1016/j.foodres.2023.113470. [PMID: 37803793]
  • Yi-Hui Wang, Xiao-Hui Gao, Xuan Li, Yu-Jie Ding, Qing Shi, Zhi-Yu Yang, Dian Peng, Hao-Ran Liu. Design, synthesis and the evaluation of cholinesterase inhibition and blood-brain permeability of daidzein derivatives or analogs. Chemical biology & drug design. 2023 10; 102(4):718-729. doi: 10.1111/cbdd.14279. [PMID: 37291745]
  • Yong-Mei Guan, Sheng-Hang Ye, Xiang Zhou, Zhen-Zhong Zang, Li-Hua Chen, Wei-Feng Zhu. [Preparation and in vitro property evaluation of β-cyclodextrin-daidzein/PEG_(20000)/Carbomer_(940) nanocrystals]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jun; 48(11):2949-2957. doi: 10.19540/j.cnki.cjcmm.20230329.302. [PMID: 37381955]
  • Yunong Zeng, Rong Wu, Fangzhao Wang, Shan Li, Lei Li, Yanru Li, Ping Qin, Mingyuan Wei, Junhao Yang, Jie Wu, Ali Chen, Guibao Ke, Zhengzheng Yan, Hong Yang, Zhongqing Chen, Zhang Wang, Wei Xiao, Yong Jiang, Xia Chen, Zhenhua Zeng, Xiaoshan Zhao, Peng Chen, Shenhai Gong. Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice. Cell host & microbe. 2023 Apr; ?(?):. doi: 10.1016/j.chom.2023.04.002. [PMID: 37100057]
  • Jiayan Liu, Yuxin Fu, Shuaishuai Zhou, Pengyu Zhao, Jian Zhao, Qinglin Yang, Hao Wu, Manyi Ding, Yao Li. Comparison of the effect of quercetin and daidzein on production performance, anti-oxidation, hormones, and cecal microflora in laying hens during the late laying period. Poultry science. 2023 Mar; 102(6):102674. doi: 10.1016/j.psj.2023.102674. [PMID: 37104906]
  • Sukhbir Singh, Sonam Grewal, Neelam Sharma, Tapan Behl, Sumeet Gupta, Md Khalid Anwer, Celia Vargas-De-La-Cruz, Syam Mohan, Simona Gabriela Bungau, Adrian Bumbu. Unveiling the Pharmacological and Nanotechnological Facets of Daidzein: Present State-of-the-Art and Future Perspectives. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041765. [PMID: 36838751]
  • Yuka Horio, Yuji Isegawa, Mototada Shichiri. Daidzein phosphorylates and activates 5-lipoxygenase via the MEK/ERK pathway: a mechanism for inducing the production of 5-lipoxygenase metabolite that inhibit influenza virus intracellular replication. The Journal of nutritional biochemistry. 2023 Jan; 114(?):109276. doi: 10.1016/j.jnutbio.2023.109276. [PMID: 36682398]
  • Baoping Zhang, Xiaohan Wei, Mengze Ding, Zhenye Luo, Xiaomei Tan, Zezhong Zheng. Daidzein Protects Caco-2 Cells against Lipopolysaccharide-Induced Intestinal Epithelial Barrier Injury by Suppressing PI3K/AKT and P38 Pathways. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248928. [PMID: 36558058]
  • Abhay Punia, Nalini Singh Chauhan. Effect of daidzein on growth, development and biochemical physiology of insect pest, Spodoptera litura (Fabricius). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Dec; 262(?):109465. doi: 10.1016/j.cbpc.2022.109465. [PMID: 36103973]
  • Matheus Luís Oliveira Cunha, Lara Caroline Alves de Oliveira, Vinicius Martins Silva, Gabriel Sgarbiero Montanha, André Rodrigues Dos Reis. Selenium increases photosynthetic capacity, daidzein biosynthesis, nodulation and yield of peanuts plants (Arachis hypogaea L.). Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):231-239. doi: 10.1016/j.plaphy.2022.08.006. [PMID: 36137309]
  • Chengjian Zhou, Ping Li, Meihong Han, Xuejun Gao. Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway. Animal biotechnology. 2022 Oct; 33(5):851-863. doi: 10.1080/10495398.2020.1842749. [PMID: 33164657]
  • Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang. Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway. Food & function. 2022 Sep; 13(18):9576-9588. doi: 10.1039/d2fo00772j. [PMID: 36000402]
  • Floriberta Solano, Eunice Hernández, Lizbeth Juárez-Rojas, Susana Rojas-Maya, Gabriela López, Carlos Romero, Fahiel Casillas, Miguel Betancourt, Alma López, Reza Heidari, Mohammad Mehdi Ommati, Socorro Retana-Márquez. Reproductive disruption in adult female and male rats prenatally exposed to mesquite pod extract or daidzein. Reproductive biology. 2022 Sep; 22(3):100683. doi: 10.1016/j.repbio.2022.100683. [PMID: 35932513]
  • Ajay Guru, Gokul Sudhakaran, Manikandan Velayutham, Raghul Murugan, Raman Pachaiappan, Ramzi A Mothana, Omar M Noman, Annie Juliet, Jesu Arockiaraj. Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Aug; 258(?):109364. doi: 10.1016/j.cbpc.2022.109364. [PMID: 35523404]
  • Raffaella Alò, Gilda Fazzari, Merylin Zizza, Ennio Avolio, Anna Di Vito, Ilaria Olvito, Rosalinda Bruno, Marcello Canonaco, Rosa Maria Facciolo. Emotional and Spontaneous Locomotor Behaviors Related to cerebellar Daidzein-dependent TrkB Expression Changes in Obese Hamsters. Cerebellum (London, England). 2022 Jul; ?(?):. doi: 10.1007/s12311-022-01432-1. [PMID: 35794426]
  • Ankit P Laddha, S Murugesan, Yogesh A Kulkarni. In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy. Drug and chemical toxicology. 2022 May; 45(3):1408-1416. doi: 10.1080/01480545.2020.1833906. [PMID: 33059469]
  • Esra Demirtürk, Afife Büşra Ugur Kaplan, Meltem Cetin, Kübra Akıllıoğlu, Meltem Dönmez Kutlu, Seda Köse, Fazilet Aksu. Assessment of Pharmacokinetic Parameters of Daidzein-Containing Nanosuspension and Nanoemulsion Formulations After Oral Administration to Rats. European journal of drug metabolism and pharmacokinetics. 2022 Mar; 47(2):247-257. doi: 10.1007/s13318-021-00746-5. [PMID: 35018554]
  • Mengmeng Yu, Hao Qi, Xuejun Gao. Daidzein promotes milk synthesis and proliferation of mammary epithelial cells via the estrogen receptor α-dependent NFκB1 activation. Animal biotechnology. 2022 Feb; 33(1):43-52. doi: 10.1080/10495398.2020.1763376. [PMID: 32401613]
  • Jinyue Liu, Wenbo Jiang. Identification and characterization of unique 5-hydroxyisoflavonoid biosynthetic key enzyme genes in Lupinus albus. Plant cell reports. 2022 Feb; 41(2):415-430. doi: 10.1007/s00299-021-02818-x. [PMID: 34851457]
  • Qianrui Wang, Bert Spenkelink, Rungnapa Boonpawa, Ivonne M C M Rietjens. Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol. Journal of agricultural and food chemistry. 2022 Jan; 70(1):343-352. doi: 10.1021/acs.jafc.1c03950. [PMID: 34855380]
  • Majid Askaripour, Hamid Najafipour, Shadan Saberi, Elham Jafari, Soodeh Rajabi. Daidzein Mitigates Oxidative Stress and Inflammation in the Injured Kidney of Ovariectomized Rats: AT1 and Mas Receptor Functions. Iranian journal of kidney diseases. 2022 Jan; 1(1):32-43. doi: . [PMID: 35271498]
  • Rina Agustina, Yusuke Masuo, Yasuto Kido, Kyosuke Shinoda, Takahiro Ishimoto, Yukio Kato. Identification of Food-Derived Isoflavone Sulfates as Inhibition Markers for Intestinal Breast Cancer Resistance Proteins. Drug metabolism and disposition: the biological fate of chemicals. 2021 11; 49(11):972-984. doi: 10.1124/dmd.121.000534. [PMID: 34413161]
  • Ankit P Laddha, Yogesh A Kulkarni. Daidzein mitigates myocardial injury in streptozotocin-induced diabetes in rats. Life sciences. 2021 Nov; 284(?):119664. doi: 10.1016/j.lfs.2021.119664. [PMID: 34090859]
  • Zhao-Min Liu, Di Zhang, Guoyi Li, Suzanne C Ho, Yu-Ming Chen, Jing Ma, Qi Huang, Shuyi Li, Wen-Hua Ling. The 6-month effect of whole soy and purified isoflavones daidzein on thyroid function-A double-blind, randomized, placebo controlled trial among Chinese equol-producing postmenopausal women. Phytotherapy research : PTR. 2021 Oct; 35(10):5838-5846. doi: 10.1002/ptr.7244. [PMID: 34494323]
  • Yingchao Li, Farong Lu, Yawei Zhang, Xiaoyu Liu, Longyi Lin, Qikun Jiang, Tianhong Zhang. A rapid ultra high performance liquid chromatography-tandem mass spectrometry method for the quantification of daidzein, its valine carbamate prodrug, and glucuronide in rat plasma samples: Comparison of the pharmacokinetic behavior of daidzine valine carbamate prodrugs. Journal of separation science. 2021 Oct; 44(19):3691-3699. doi: 10.1002/jssc.202100331. [PMID: 34347375]
  • Yan-Bin Ye, Kai-Yin He, Wan-Lin Li, Shu-Yu Zhuo, Yu-Ming Chen, Wei Lu, Shang-Ling Wu, Juan Liu, Yan-Bing Li, Fang-Fang Zeng. Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: a double-blind, randomized, placebo-controlled trial. Food & function. 2021 Sep; 12(17):7997-8006. doi: 10.1039/d1fo00712b. [PMID: 34263280]
  • Sulagna Gupta, Wei Ning Chen. A metabolomics approach to evaluate post-fermentation enhancement of daidzein and genistein in a green okara extract. Journal of the science of food and agriculture. 2021 Sep; 101(12):5124-5131. doi: 10.1002/jsfa.11158. [PMID: 33608899]
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