napelline (BioDeep_00000001072)

 

Secondary id: BioDeep_00000410486, BioDeep_00001473736, BioDeep_00001734675

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,2R,4S,5S,7R,8R,9R,13R,16S,17R)-11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol

化学式: C22H33NO3 (359.2460308000001)
中文名称: 12-表-欧乌头碱, 12-表欧乌头碱
谱图信息: 最多检出来源 Viridiplantae(plant) 0.3%

分子结构信息

SMILES: C=C1C2CC3(C1O)C1CC4C5(C)CCC(O)C4(C1N(CC)C5)C3CC2O
InChI: InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3

描述信息

LSM-1634 is a kaurane diterpenoid.
Napelline is a natural product found in Aconitum karakolicum, Aconitum baicalense, and other organisms with data available.
12-Epinapelline is a kaurane diterpenoid.
12-Epinapelline is a natural product found in Aconitum napellus, Delphinium leroyi, and other organisms with data available.
Annotation level-1
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors[1][2].
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors[1][2].

同义名列表

10 个代谢物同义名

(1R,2R,4S,5S,7R,8R,9R,13R,16S,17R)-11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol; Prestwick3_000690; BPBio1_000901; napelline; 11-ethyl-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecane-4,7,16-triol; 12-epi-Napelline; 12-epinapelline; Oprea1_157914; Oprea1_176735; Napelline



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qi Wang, Jing Peng, Yang Liu, Yang Tian, Jie Li, Yao-Yao Ren, Jian Gu, Rui Tan. [Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(17):4715-4722. doi: 10.19540/j.cnki.cjcmm.20220207.704. [PMID: 36164879]
  • Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa. A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang. Natural product research. 2018 Oct; 32(19):2319-2324. doi: 10.1080/14786419.2017.1410814. [PMID: 29212360]
  • Yu V Nesterova, T N Povet'yeva, N I Suslov, G N Zyuz'kov, S V Pushkarskii, S G Aksinenko, E E Schultz, S S Kravtsova, A V Krapivin. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bulletin of experimental biology and medicine. 2014 Aug; 157(4):488-91. doi: 10.1007/s10517-014-2598-6. [PMID: 25110090]
  • Tivadar Kiss, Péter Orvos, Száva Bánsághi, Peter Forgo, Nikoletta Jedlinszki, László Tálosi, Judit Hohmann, Dezső Csupor. Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids. Fitoterapia. 2013 Oct; 90(?):85-93. doi: 10.1016/j.fitote.2013.07.010. [PMID: 23876370]
  • Yu V Nesterova, T N Povetieva, N I Suslov, V V Zhdanov, T Yu Hrichkova, E V Udut, A S Chaykovskiy, N N Gaydamovich, T I Andreeva, A M Dygai. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bulletin of experimental biology and medicine. 2012 Feb; 152(4):439-43. doi: 10.1007/s10517-012-1548-4. [PMID: 22803106]
  • Sang Hee Shim, Ju Sun Kim, Sam Sik Kang, Kun Ho Son, KiHwan Bae. Alkaloidal constituents from Aconitum jaluense. Archives of pharmacal research. 2003 Sep; 26(9):709-15. doi: 10.1007/bf02976678. [PMID: 14560917]