Tramiprosate (BioDeep_00000000719)
Secondary id: BioDeep_00001867544
human metabolite PANOMIX_OTCML-2023 blood metabolite Marine Natural Products
代谢物信息卡片
化学式: C3H9NO3S (139.0303124)
中文名称: 高牛磺酸, 3-氨基丙烷磺酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 69.54%
分子结构信息
SMILES: C(CN)CS(=O)(=O)O
InChI: InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
描述信息
3-aminopropanesulfonic acid is an amino sulfonic acid that is the 3-amino derivative of propanesulfonic acid. It has a role as an algal metabolite, a nootropic agent, an anticonvulsant, a GABA agonist and an anti-inflammatory agent. It is a tautomer of a 3-aminopropanesulfonic acid zwitterion.
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
C26170 - Protective Agent > C1509 - Neuroprotective Agent
Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].
同义名列表
58 个代谢物同义名
Acamprosate impurity A, European Pharmacopoeia (EP) Reference Standard; ACAMPROSATE CALCIUM IMPURITY A [EP IMPURITY]; 3-Aminopropane-1-sulfonic Acid (Homotaurine); 3-Amino-1-propanesulfonic acid, 97\\%; 3-AMINOPROPANE SULFONIC ACID [INCI]; 1-Propanesulfonic acid, 3-amino-; 3-Amino-propane-1-sulfonic acid; 3-amino-1-propane sulfonic acid; 3-amino-1-propanesulphonic acid; 3-Aminopropane-1-sulphonic acid; 3-aminopropane-d6-sulfonic acid; 3-amino-1-propanesulfonic acid; 3-aminopropane-1-sulfonic acid; 3-aminopropane-1-sulfonicacid; 3-aminopropanesulphonic acid; 3-Aminopropane sulfonic acid; 3-ammoniopropane-1-sulfonate; 3-Aminopropane-1-sulphonate; 3-aminopropanesulfonic acid; SNKZJIOFVMKAOJ-UHFFFAOYSA-N; 3-Amino-1-propanesulphonate; 3-Aminopropane-1-sulfonate; 3-Amino-1-propanesulfonate; 3-aminopropylsulfonic acid; 3-Aminopropiosulfonic Acid; Tramiprosate [USAN:INN]; 3-Aminopropanesulfonate; Acamprosate impurity A; Aminopropanesulfonic-3; TRAMIPROSATE [WHO-DD]; Tramiprosate [USAN]; Tramiprosate (USAN); TRAMIPROSATE [INN]; TRAMIPROSATE [MI]; Spectrum5_001319; Spectrum3_000924; Spectrum2_001409; Spectrum4_001023; Tramiprosic acid; UNII-5K8EAX0G53; DivK1c_000348; Lopac0_000066; KBio2_006956; KBio2_004388; KBio3_001928; Tramiprosate; KBio1_000348; KBio2_001820; IDI1_000348; homotaurine; 5K8EAX0G53; AI3-52544; Cerebril; Alzhemed; 3-APS; 3APS; A20; 3-Aminopropanesulfonate
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:1457
- KEGG: C03349
- KEGGdrug: D06202
- PubChem: 1646
- HMDB: HMDB0253211
- Metlin: METLIN43475
- DrugBank: DB06527
- ChEMBL: CHEMBL149082
- Wikipedia: Homotaurine
- MeSH: tramiprosate
- ChemIDplus: 0003687181
- CAS: 3687-18-1
- medchemexpress: HY-14602
- PMhub: MS000017907
- PubChem: 6191
- PDB-CCD: A20
- NIKKAJI: J205.597J
- RefMet: Cerebril
- KNApSAcK: 1457
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elisa Toppi, Laura Sireno, Micaela Lembo, Nerisa Banaj, Beatrice Messina, Sedigheh Golesorkhtafti, Gianfranco Spalletta, Paola Bossù. IL-33 and IL-10 Serum Levels Increase in MCI Patients Following Homotaurine Treatment.
Frontiers in immunology.
2022; 13(?):813951. doi:
10.3389/fimmu.2022.813951. [PMID: 35515001] - Xingyuan Zou, Sebastian Himbert, Alix Dujardin, Janos Juhasz, Samantha Ros, Harald D H Stöver, Maikel C Rheinstädter. Curcumin and Homotaurine Suppress Amyloid-β25-35 Aggregation in Synthetic Brain Membranes.
ACS chemical neuroscience.
2021 04; 12(8):1395-1405. doi:
10.1021/acschemneuro.1c00057. [PMID: 33826295] - Jide Tian, Min Song, Daniel L Kaufman. Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.
Scientific reports.
2021 03; 11(1):5402. doi:
10.1038/s41598-021-84751-3. [PMID: 33686135] - Filippo Locri, Maurizio Cammalleri, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli. Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury.
Nutrients.
2019 Dec; 11(12):. doi:
10.3390/nu11122931. [PMID: 31816880] - John A Hey, Jeremy Y Yu, Mark Versavel, Susan Abushakra, Petr Kocis, Aidan Power, Paul L Kaplan, John Amedio, Martin Tolar. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease.
Clinical pharmacokinetics.
2018 03; 57(3):315-333. doi:
10.1007/s40262-017-0608-3. [PMID: 29063518] - Avner Schlessinger, Matthias B Wittwer, Amber Dahlin, Natalia Khuri, Massimiliano Bonomi, Hao Fan, Kathleen M Giacomini, Andrej Sali. High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.
The Journal of biological chemistry.
2012 Nov; 287(45):37745-56. doi:
10.1074/jbc.m112.388157. [PMID: 22932902] - R Nageswara Rao, Pawan K Maurya, Dhananjay D Shinde, Sachin B Agwane. Reversed-phase liquid chromatographic determination of tramiprosate in rat plasma using evaporative light scattering detector.
Biomedical chromatography : BMC.
2011 Aug; 25(8):925-9. doi:
10.1002/bmc.1546. [PMID: 21154641] - R Nageswara Rao, Pawan K Maurya, Dhananjay D Shinde, Sara Khalid. Precolumn derivatization followed by liquid chromatographic separation and determination of tramiprosate in rat plasma by fluorescence detector: application to pharmacokinetics.
Journal of pharmaceutical and biomedical analysis.
2011 May; 55(2):282-7. doi:
10.1016/j.jpba.2011.01.013. [PMID: 21324628] - Ronald W Irwin, Jun Ming Wang, Shuhua Chen, Roberta Diaz Brinton. Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease.
Frontiers in endocrinology.
2011; 2(?):117. doi:
10.3389/fendo.2011.00117. [PMID: 22654847] - Jian-Ping Guo, Sheng Yu, Patrick L McGeer. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.
Journal of Alzheimer's disease : JAD.
2010; 19(4):1359-70. doi:
10.3233/jad-2010-1331. [PMID: 20061605] - Davekanand Gossai, Cesar A Lau-Cam. The effects of taurine, taurine homologs and hypotaurine on cell and membrane antioxidative system alterations caused by type 2 diabetes in rat erythrocytes.
Advances in experimental medicine and biology.
2009; 643(?):359-68. doi:
10.1007/978-0-387-75681-3_37. [PMID: 19239167] - Francine Gervais, Julie Paquette, Céline Morissette, Pascale Krzywkowski, Mathilde Yu, Mounia Azzi, Diane Lacombe, Xianqi Kong, Ahmed Aman, Julie Laurin, Walter A Szarek, Patrick Tremblay. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.
Neurobiology of aging.
2007 Apr; 28(4):537-47. doi:
10.1016/j.neurobiolaging.2006.02.015. [PMID: 16675063] - P S Aisen, D Saumier, R Briand, J Laurin, F Gervais, P Tremblay, D Garceau. A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.
Neurology.
2006 Nov; 67(10):1757-63. doi:
10.1212/01.wnl.0000244346.08950.64. [PMID: 17082468] - Tamsin M Wright. Tramiprosate.
Drugs of today (Barcelona, Spain : 1998).
2006 May; 42(5):291-8. doi:
10.1358/dot.2006.42.5.973584. [PMID: 16801992] - M Mäkinen, L Ahtee, K Rosenqvist, R K Tuominen, P Männistö. Effects of intraventricular taurine, homotaurine and GABA on serum prolactin and thyrotropin levels in female and in male rats.
Journal of neural transmission. General section.
1993; 94(3):155-63. doi:
10.1007/bf01277021. [PMID: 8123228] - E Panula-Lehto, L Ahtee, R K Tuominen, P T Männistö. Comparison of the effects of intraventricular taurine, GABA and homotaurine on serum prolactin levels in male rats.
Pharmacology & toxicology.
1989 Aug; 65(2):152-6. doi:
10.1111/j.1600-0773.1989.tb01146.x. [PMID: 2813286] - G M Anderson, T A Durkin, M Chakraborty, D J Cohen. Liquid chromatographic determination of taurine in whole blood, plasma and platelets.
Journal of chromatography.
1988 Oct; 431(2):400-5. doi:
10.1016/s0378-4347(00)83109-6. [PMID: 3243795] - M Masuda, K Horisaka. Effect of taurine and homotaurine on bile acid metabolism in dietary hyperlipidemic rats.
Journal of pharmacobio-dynamics.
1986 Nov; 9(11):934-40. doi:
10.1248/bpb1978.9.934. [PMID: 3559883]