gomisin B (BioDeep_00000000217)

 

Secondary id: BioDeep_00000276674

PANOMIX_OTCML-2023


代谢物信息卡片


2-Butenoic acid, 2-methyl-, 5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-5-yl ester, (5S-(5.alpha.(Z),6.beta.,7.beta.))-

化学式: C28H34O9 (514.2202714)
中文名称: 五味子酯乙
谱图信息: 最多检出来源 unclassified Codonopsis(otcml) 55.56%

分子结构信息

SMILES: CC=C(C)C(=O)OC1C2=CC(=C(C(=C2C3=C(C4=C(C=C3CC(C1(C)O)C)OCO4)OC)OC)OC)OC
InChI: InChI=1S/C28H34O9/c1-9-14(2)27(29)37-26-17-12-18(31-5)22(32-6)25(34-8)21(17)20-16(10-15(3)28(26,4)30)11-19-23(24(20)33-7)36-13-35-19/h9,11-12,15,26,30H,10,13H2,1-8H3/b14-9-/t15-,26-,28-/m0/s1

描述信息

Gomisin B is a tannin.
Schisantherin B is a natural product found in Kadsura angustifolia, Schisandra rubriflora, and other organisms with data available.
See also: Schisandra chinensis fruit (part of).
Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.
Schisantherin B (Gomisin-B; Wuweizi ester-B; Schisantherin-B) is a natural product.

同义名列表

22 个代谢物同义名

2-Butenoic acid, 2-methyl-, 5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-5-yl ester, (5S-(5.alpha.(Z),6.beta.,7.beta.))-; 2-Butenoic acid, 2-methyl-, 5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-5-yl ester, (5S-(5alpha(Z),6beta,7beta))-; [(8S,9S,10S)-9-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-8-yl] (Z)-2-methylbut-2-enoate; 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,8-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO(3,4)CYCLOOCTA(1,2-F)(1,3)BENZODIOXOL-5-YL ESTER, (2Z)-; 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,8-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)-; 2-BUTENOICACID,2-METHYL-,(5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YLESTER,(2Z)-; (5S,6S,7S)-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3,4]cycloocta[1,2:4,5]benzo[1,2-d][1,3]dioxol-5-yl (Z)-2-methylbut-2-enoate; (hydroxy-tetramethoxy-dimethyl-[?]yl) (Z)-2-methylbut-2-enoate; Schisantherin B; Schisantherin C; Wuweizi ester-B; Wuweizi ester B; Schizantherin-B; UNII-97ZTC185XV; Schizantherin B; schisandrer B; Schizandrol; 97ZTC185XV; gomisin B; Gomisin-B; Schisantherin-B; Gomisin B



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinman Liu, Qihui Wu, Qiqing Wu, Guangcheng Zhong, Yong Liang, Yong Gu, Yunhui Hu, Wenjia Wang, Ning Hao, Shuhuan Fang, Weirong Li, Huafeng Pan, Qi Wang, Jiansong Fang. Modulating endoplasmic reticulum stress in APP/PS1 mice by Gomisin B and Osthole in Bushen-Yizhi formula: Synergistic effects and therapeutic implications for Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155023. doi: 10.1016/j.phymed.2023.155023. [PMID: 37586159]
  • Yinpeng Wang, Jingbo Zhu, Xinxin Du, Yumei Li. Simultaneous Extraction and Determination of Lignans from Schisandra chinensis (Turcz.) Baill. via Diol-Based Matrix Solid-Phase Dispersion with High-Performance Liquid Chromatography. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186448. [PMID: 37764224]
  • Li-Jing Du, Xin-Ning Zhang, Sha-Sha Li, Yuan-Fang Sun, Hui-Zi Jin, Shi-Kai Yan, Chuan-Gang Han. Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression. Metabolic brain disease. 2022 12; 37(8):2903-2914. doi: 10.1007/s11011-022-01067-5. [PMID: 36070047]
  • Jin-Man Liu, Jun-Mei Chen, Ming-Jun Lin, Fan-Chang Wu, Cui-Ru Ma, Xue Zuo, Wen-Qian Yu, Ming-Jun Huang, Jian-Song Fang, Wei-Rong Li, Qi Wang, Yong Liang. Screening and verification of CYP3A4 inhibitors from Bushen-Yizhi formula to enhance the bioavailability of osthole in rat plasma. Journal of ethnopharmacology. 2022 Jan; 282(?):114643. doi: 10.1016/j.jep.2021.114643. [PMID: 34534597]
  • B Poornima, Bandi Siva, A Venkanna, G Shankaraiah, Nishant Jain, Dharmendra Kumar Yadav, Sanjeev Misra, K Suresh Babu. Novel Gomisin B analogues as potential cytotoxic agents: Design, synthesis, biological evaluation and docking studies. European journal of medicinal chemistry. 2017 Oct; 139(?):441-453. doi: 10.1016/j.ejmech.2017.07.076. [PMID: 28818768]
  • Mengjie Xu, Yan Dong, Shutong Wan, Tingxu Yan, Jingdi Cao, Lidan Wu, Kaishun Bi, Ying Jia. Schisantherin B ameliorates Aβ1-42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer's disease. Physiology & behavior. 2016 12; 167(?):265-273. doi: 10.1016/j.physbeh.2016.09.018. [PMID: 27660034]
  • Lian-lin Su, Xue Cheng, De Ji, Li-jun Wang, Xi-yan Ding, Tu-lin Lu, Chun-qin Mao, Ji Zhang. [Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 10; 51(10):1600-8. doi: . [PMID: 29932608]
  • Rong Sun, Hong-Chuan Song, Chun-Ren Wang, Kai-Ze Shen, Yao-Bo Xu, Yan-Xiu Gao, Ye-Gao Chen, Jin-Yan Dong. Compounds from Kadsura angustifolia with anti-HIV activity. Bioorganic & medicinal chemistry letters. 2011 Feb; 21(3):961-5. doi: 10.1016/j.bmcl.2010.12.055. [PMID: 21232955]
  • Hiroshi Iwata, Yasuhiro Tezuka, Shigetoshi Kadota, Akira Hiratsuka, Tadashi Watabe. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug metabolism and disposition: the biological fate of chemicals. 2004 Dec; 32(12):1351-8. doi: 10.1124/dmd.104.000646. [PMID: 15342469]
  • K T Liu, P Lesca. Pharmacological properties of Dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae Chinensis III. Inhibitory effects on carbon tetrachloride-induced lipid peroxidation, metabolism and covalent binding of carbon tetrachloride to lipids. Chemico-biological interactions. 1982 Jul; 41(1):39-47. doi: 10.1016/0009-2797(82)90015-1. [PMID: 7094143]
  • K T Liu, P Lesca. Pharmacological properties of dibenzo[a,c]cyclooctene derivatives isolated from Fructus Schizandrae chinensis. I. Interaction with rat liver cytochrome P-450 and inhibition of xenobiotic metabolism and mutagenicity. Chemico-biological interactions. 1982 Apr; 39(3):301-14. doi: 10.1016/0009-2797(82)90047-3. [PMID: 7082441]
  • Y Ikeya, H Taguchi, I Yosioka, H Kobayashi. The constituents of Schizandra chinensis Baill. I. Isolation and structure determination of five new lignans, gomisin A, B, C, F and G, and the absolute structure of schizandrin. Chemical & pharmaceutical bulletin. 1979 Jun; 27(6):1383-94. doi: 10.1248/cpb.27.1383. [PMID: 544051]
  • C S Liu, S D Fang, M F Huang, Y L Kao, J S Hsu. Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds. Scientia Sinica. 1978 Jul; 21(4):483-502. doi: . [PMID: 233922]