Scopoletin (BioDeep_00000000004)

 

Secondary id: BioDeep_00000397986, BioDeep_00000859325

natural product human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


7-hydroxy-6-methoxy-2H-chromen-2-one

化学式: C10H8O4 (192.0422568)
中文名称: 东莨菪内酯, 东莨菪亭, 东莨菪素, 莨菪亭
谱图信息: 最多检出来源 Viridiplantae(plant) 0.49%

Reviewed

Last reviewed on 2024-07-12.

Cite this Page

Scopoletin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/scopoletin (retrieved 2024-11-24) (BioDeep RN: BioDeep_00000000004). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COc(c1)c(O)cc(O2)c(C=CC(=O)2)1
InChI: InChI=1/C10H8O4/c1-13-9-4-6-2-3-10(12)14-8(6)5-7(9)11/h2-5,11H,1H3

描述信息

Scopoletin is a hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6. It has a role as a plant growth regulator and a plant metabolite. It is functionally related to an umbelliferone.
Scopoletin is a natural product found in Ficus auriculata, Haplophyllum cappadocicum, and other organisms with data available.
Scopoletin is a coumarin compound found in several plants including those in the genus Scopolia and the genus Brunfelsia, as well as chicory (Cichorium), redstem wormwood (Artemisia scoparia), stinging nettle (Urtica dioica), passion flower (Passiflora), noni (Morinda citrifolia fruit) and European black nightshade (Solanum nigrum) that is comprised of umbelliferone with a methoxy group substituent at position 6. Scopoletin is used to standardize and establish pharmacokinetic properties for products derived from the plants that produce it, such as noni extract. Although the mechanism(s) of action have not yet been established, this agent has potential antineoplastic, antidopaminergic, antioxidant, anti-inflammatory and anticholinesterase effects.
Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica.
See also: Arnica montana Flower (part of); Lycium barbarum fruit (part of); Viburnum opulus root (part of).
Isolated from Angelica acutiloba (Dong Dang Gui). Scopoletin is found in many foods, some of which are lambsquarters, lemon, sunflower, and sherry.
Scopoletin is found in anise. Scopoletin is isolated from Angelica acutiloba (Dong Dang Gui
A hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6.
Acquisition and generation of the data is financially supported in part by CREST/JST.
[Raw Data] CBA72_Scopoletin_pos_20eV.txt
[Raw Data] CBA72_Scopoletin_pos_40eV.txt
[Raw Data] CBA72_Scopoletin_neg_30eV.txt
[Raw Data] CBA72_Scopoletin_neg_50eV.txt
[Raw Data] CBA72_Scopoletin_pos_50eV.txt
[Raw Data] CBA72_Scopoletin_pos_10eV.txt
[Raw Data] CBA72_Scopoletin_neg_40eV.txt
[Raw Data] CBA72_Scopoletin_neg_10eV.txt
[Raw Data] CBA72_Scopoletin_pos_30eV.txt
[Raw Data] CBA72_Scopoletin_neg_20eV.txt

Scopoletin. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=92-61-5 (retrieved 2024-07-12) (CAS RN: 92-61-5). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Scopoletin is an inhibitor of acetylcholinesterase (AChE).
Scopoletin is an inhibitor of acetylcholinesterase (AChE).

同义名列表

74 个代谢物同义名

Scopoletin, United States Pharmacopeia (USP) Reference Standard; 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI); SCOPOLETIN (CONSTITUENT OF STINGING NETTLE) [DSC]; 5-18-03-00203 (Beilstein Handbook Reference); SCOPOLETIN (CONSTITUENT OF STINGING NETTLE); 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-; 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one; 7-hydroxy-6-methoxy-1-benzopyran-2-one; 7-Hydroxy-6-methoxy-2H-chromen-2-one #; 0B4B9FAA-686D-4977-AA08-65F8E4F1977C; 7-Hydroxy-6-methoxy-2H-chromen-2-one; 6-methoxy-7-oxidanyl-chromen-2-one; 7-hydroxy-6-methoxy-chromen-2-one; Gelseminic acid; 7-hydroxy-6-methoxychromen-2-one; Scopoletin, analytical standard; COUMARIN, 7-HYDROXY-6-METHOXY-; 7-hydroxy 6-methoxy coumarine; 7-hydroxy-6-methoxy-coumarin; 7-Hydroxy-5-methoxycoumarin; 7-Hydroxy-6-methoxycoumarin; 6-Methoxy-7-hydroxycoumarin; Aesculetin 6-methyl ether; Esculetin 6-methyl ether; Esculetin-6-methyl ether; 6-Methoxyumbelliferone; .beta.-Methylesculetin; beta -methylesculetin; beta-Methylesculetin; 6-O-Methylesculetin; SCOPOLETIN [USP-RS]; SCOPOLETIN (USP-RS); |A-Methylaesculetin; b-Methylaesculetin; Scopoletin, >=99\\%; Acid, Chrysotropic; Prestwick2_000962; 6-Methylesculetin; Chrysotropic Acid; Prestwick3_000962; Prestwick0_000962; Chrysatropic acid; Prestwick1_000962; Spectrum4_001054; Acid, Gelseminic; Spectrum2_001207; Spectrum5_000654; Spectrum3_001532; SCOPOLETIN [MI]; Gelseminic acid; UNII-KLF1HS0SXJ; Methylesculetin; BPBio1_001061; DivK1c_000720; Baogongteng B; MEGxp0_001192; KBio3_002444; ACon1_000143; KBio1_000720; NCI60_003834; IDI1_000720; Escopoletin; Scopoletine; CAS-92-61-5; KLF1HS0SXJ; Scopoletol; Scopoletin; Murrayetin; COPOLETIN; Buxuletin; T83; Chrysatropic acid; Scopoletin; Scopoletin



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(7)

代谢反应

339 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(9)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(330)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1969 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Salihu, L G Hassan, U Z Faruq, A J Yusuf. Deciphering the interactions of scopoletin and scopolin from Catunaregam nilotica roots against Naja nigricollis phospholipase A2 enzyme. Toxicon : official journal of the International Society on Toxinology. 2024 May; 243(?):107732. doi: 10.1016/j.toxicon.2024.107732. [PMID: 38642905]
  • Sourav Kundu, Sitara Ghosh, Bidya Dhar Sahu. Scopoletin alleviates high glucose-induced toxicity in human renal proximal tubular cells via inhibition of oxidative damage, epithelial-mesenchymal transition, and fibrogenesis. Molecular biology reports. 2024 May; 51(1):620. doi: 10.1007/s11033-024-09579-2. [PMID: 38709349]
  • Jing Wang, Peitao Chen, Tengfei Zhao, Xianhui Huang, Jikai Zong, Qingqing Luo, Chao Peng, Xiaoyan Wu, Fei Qiu, Dongchao Zhao, Lien Xiang, Yan Zhang, Chunxian Yang, Fangyuan Zhang, Zhihua Liao, Yufan Fu, Junlan Zeng. Biosynthesis of Scopoletin in Sweet Potato Confers Resistance against Fusarium oxysporum. Journal of agricultural and food chemistry. 2024 Apr; 72(14):7749-7764. doi: 10.1021/acs.jafc.3c09389. [PMID: 38537104]
  • Hong Zhou, Yeshuang Ning, Yufan Jian, Miao Zhang, Matthana Klakong, Fuyou Guo, Qingyi Shao, Yanhong Li, Pinglong Yang, Zongquan Li, Liang Yang, Shili Li, Wei Ding. Functional analysis of a down-regulated transcription factor-SoxNeuroA gene involved in the acaricidal mechanism of scopoletin against spider mites. Pest management science. 2023 Nov; ?(?):. doi: 10.1002/ps.7892. [PMID: 37986233]
  • Na Song, Jinsong Wu. Synergistic induction of phytoalexins in Nicotiana attenuata by JA and ethylene signaling mediated by NaWRKY70. Journal of experimental botany. 2023 Oct; ?(?):. doi: 10.1093/jxb/erad415. [PMID: 37870145]
  • Vincent Lebot, Floriane Lawac, Ismaël Muñoz-Cuervo, Pierre-Edouard Mercier, Laurent Legendre. Metabolite fingerprinting of cassava (Manihot esculenta Crantz) landraces assessed for post-harvest physiological deterioration (PPD). Food chemistry. 2023 Sep; 421(?):136217. doi: 10.1016/j.foodchem.2023.136217. [PMID: 37121018]
  • Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Amol N Patil, Dibyajyoti Banerjee. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats. Journal of complementary & integrative medicine. 2023 Sep; ?(?):. doi: 10.1515/jcim-2023-0168. [PMID: 37732506]
  • Alexander Beesley, Sebastian F Beyer, Verena Wanders, Sophie Levecque, Sandra Bredenbruch, Samer S Habash, A Sylvia S Schleker, Jochem Gätgens, Marco Oldiges, Holger Schultheiss, Uwe Conrath, Caspar J G Langenbach. Engineered coumarin accumulation reduces mycotoxin-induced oxidative stress and disease susceptibility. Plant biotechnology journal. 2023 Aug; ?(?):. doi: 10.1111/pbi.14144. [PMID: 37578146]
  • Nishit D Patel, Samir G Patel, Amit A Patel, Manan A Raval. Estimation of Scopoletin from Roots of Argyreia nervosa (Burm. fill.) Bojer Using a Validated HPLC-Fluorescence Method Optimized Using the Design of Experiment Approach. Journal of AOAC International. 2023 Jul; 106(4):992-1002. doi: 10.1093/jaoacint/qsad018. [PMID: 36707989]
  • Qinggang Yin, Tianze Wu, Ranran Gao, Lan Wu, Yuhua Shi, Xingwen Wang, Mengyue Wang, Zhichao Xu, Yueliang Zhao, Xiaojia Su, Yanyan Su, Xiaoyan Han, Ling Yuan, Li Xiang, Shilin Chen. Multi-omics reveal key enzymes involved in the formation of phenylpropanoid glucosides in Artemisia annua. Plant physiology and biochemistry : PPB. 2023 Jun; 201(?):107795. doi: 10.1016/j.plaphy.2023.107795. [PMID: 37301186]
  • Kripa Shankar Nainawat, Sarita Singh, Karishma Agarwal, Hina Iqbal, Poonam Rani, Divya Bhatt, Sana Khan, Debabrata Chanda, Dnyaneshwar Umrao Bawankule, Sudeep Tandon, Feroz Khan, Anil Kumar Gupta, Atul Gupta. Synthesis of 6-alkoxy and 6-hydroxy-alkyl amine derivatives of braylin as vasorelaxing agents. Bioorganic & medicinal chemistry letters. 2023 06; 89(?):129311. doi: 10.1016/j.bmcl.2023.129311. [PMID: 37149230]
  • Jieren Liao, Guangxin Sun, Elisabeth Kurze, Wieland Steinchen, Timothy D Hoffmann, Chuankui Song, Zhiwei Zou, Thomas Hoffmann, Wilfried G Schwab. Subfunctionalization of a monolignol to a phytoalexin glucosyltransferase is accompanied by substrate inhibition. Plant communications. 2023 05; 4(3):100506. doi: 10.1016/j.xplc.2022.100506. [PMID: 36566353]
  • Siqi Liu, Pengmin Ding, Mengjiao Wu, Zhihao Zhu, Jiayue Tao, Jing Wang, Zhe Xue, Rufeng Wang. Screening quality markers (Q-markers) of Xiaoer Chaige Tuire Oral Liquid by in vitro sequential metabolism and in vivo biopharmaceutical analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Apr; 116(?):154844. doi: 10.1016/j.phymed.2023.154844. [PMID: 37163902]
  • Kunpeng Yu, Cheng Peng, Yanling Lin, Lijun Li, Hui Ni, Qingbiao Li. [Expression of β-glucosidase An-bgl3 from Aspergillus niger for conversion of scopolin]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2023 Mar; 39(3):1232-1246. doi: 10.13345/j.cjb.220709. [PMID: 36994584]
  • Yifan Sun, Guangxi Ren, Qijin Shi, Hongyu Zhu, Na Zhou, Xianghe Kong, Dan Jiang, Chunsheng Liu. Identification of a Novel Coumarins Biosynthetic Pathway in the Endophytic Fungus Fusarium oxysporum GU-7 with Antioxidant Activity. Applied and environmental microbiology. 2023 01; 89(1):e0160122. doi: 10.1128/aem.01601-22. [PMID: 36598487]
  • Zhong Wang, Lanxin Ma, Pingping Liu, Zhaopeng Luo, Zefeng Li, Mingzhu Wu, Xin Xu, Wenxuan Pu, Pingjun Huang, Jun Yang. Transcription factor NtWRKY33a modulates the biosynthesis of polyphenols by targeting NtMYB4 and NtHCT genes in tobacco. Plant science : an international journal of experimental plant biology. 2023 Jan; 326(?):111522. doi: 10.1016/j.plantsci.2022.111522. [PMID: 36332766]
  • Israt Jahan, Shahenur Alam Sakib, Najmul Alam, Mohuya Majumder, Sanjida Sharmin, A S M Ali Reza. Pharmacological insights into Chukrasia velutina bark: Experimental and computer-aided approaches. Animal models and experimental medicine. 2022 12; 5(4):377-388. doi: 10.1002/ame2.12268. [PMID: 36047481]
  • Jia Sun, Jian Gou, Li-Qin Liu, Chun-Hua Liu, Jie Pan, Yue-Ting Li, Zi-Peng Gong. [Excretion of Cynanchum auriculatum extract in urine and feces of normal and functional dyspepsia rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6355-6364. doi: 10.19540/j.cnki.cjcmm.20220621.202. [PMID: 36604880]
  • Jia Sun, Li-Qin Liu, Jian Gou, Si-Ying Chen, Zi-Peng Gong, Ting Liu, Yong-Jun Li, Yuan Lu. [Differences in intestinal absorption characteristics of Cynanchum auriculatum extract based on in situ intestinal circulation perfusion model in two states]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6340-6347. doi: 10.19540/j.cnki.cjcmm.20220621.203. [PMID: 36604878]
  • Farah Naz, Mukesh Kumar, Tirthankar Koley, Priyanka Sharma, Muhammad Anzarul Haque, Arti Kapil, Manoj Kumar, Punit Kaur, Abdul Samath Ethayathulla. Screening of plant-based natural compounds as an inhibitor of FtsZ from Salmonella Typhi using the computational, biochemical and in vitro cell-based studies. International journal of biological macromolecules. 2022 Oct; 219(?):428-437. doi: 10.1016/j.ijbiomac.2022.07.241. [PMID: 35932806]
  • Joana L Rodrigues, Daniela Gomes, Lígia R Rodrigues. Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217230. [PMID: 36364054]
  • Meiwei Zhao, Lan Ma, Na Song, Junbin Cheng, Zhengxiong Zhao, Jinsong Wu. The regulation of Alternaria alternata resistance by LRR-RK4 through ERF109, defensin19 and phytoalexin scopoletin in Nicotiana attenuata. Plant science : an international journal of experimental plant biology. 2022 Oct; 323(?):111414. doi: 10.1016/j.plantsci.2022.111414. [PMID: 35963495]
  • Théodora K Kowa, Olivia Jansen, Allison Ledoux, Lucia Mamede, Hippolyte K Wabo, Alembert T Tchinda, Gregory Genta-Jouve, Michel Frédérich. Bioassay-guided isolation of vilasinin-type limonoids and phenyl alkene from the leaves of Trichilia gilgiana and their antiplasmodial activities. Natural product research. 2022 Oct; 36(19):5039-5047. doi: 10.1080/14786419.2021.1920017. [PMID: 33951995]
  • Muqeet Wahid, Fatima Saqib, Muhammad Qamar, Zyta M Ziora. Antispasmodic activity of the ethanol extract of Citrullus lanatus seeds: Justifying ethnomedicinal use in Pakistan to treat asthma and diarrhea. Journal of ethnopharmacology. 2022 Sep; 295(?):115314. doi: 10.1016/j.jep.2022.115314. [PMID: 35490899]
  • Qiuxiang Ma, Jia Xu, Yancai Feng, Xiaoyun Wu, Xinlu Lu, Peng Zhang. Knockdown of p-Coumaroyl Shikimate/Quinate 3'-Hydroxylase Delays the Occurrence of Post-Harvest Physiological Deterioration in Cassava Storage Roots. International journal of molecular sciences. 2022 Aug; 23(16):. doi: 10.3390/ijms23169231. [PMID: 36012496]
  • Lucia Dwi Antika, Aprilia Nur Tasfiyati, Hikmat Hikmat, Abdi Wira Septama. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2022 Jul; 77(7-8):303-316. doi: 10.1515/znc-2021-0193. [PMID: 35218175]
  • Li-Qin Liu, Jing-Ya Zhang, Yuan Lu, Chun-Hua Liu, Jian Gou, Zhu-Jun Li, Ai-Min Wang, Jia Sun. [Intestinal absorption characteristics of root tuber of Cynanchum auriculatum extract in normal and functional dyspepsia model rats via everted intestine sac model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jul; 47(14):3915-3922. doi: 10.19540/j.cnki.cjcmm.20220215.201. [PMID: 35850850]
  • Meng Xu, Zhang-Xin Yu, Bin Zhang, Xiao-Bao Li, Mu-Yuan Li, Wei Xu, Guang-Ying Chen. [Chemical constituents with α-glucosidase inhibitory activities from seeds of Morinda citrifolia (Noni)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jul; 47(13):3519-3525. doi: 10.19540/j.cnki.cjcmm.20211228.201. [PMID: 35850804]
  • Dey Parama, Sosmitha Girisa, Elina Khatoon, Aviral Kumar, Mohammed S Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B Kunnumakkara. An overview of the pharmacological activities of scopoletin against different chronic diseases. Pharmacological research. 2022 05; 179(?):106202. doi: 10.1016/j.phrs.2022.106202. [PMID: 35378275]
  • Xiaoyun Wu, Jia Xu, Qiuxiang Ma, Sulaiman Ahmed, Xinlu Lu, Erjun Ling, Peng Zhang. Lysozyme inhibits postharvest physiological deterioration of cassava. Journal of integrative plant biology. 2022 Mar; 64(3):621-624. doi: 10.1111/jipb.13219. [PMID: 35195347]
  • Aprilia Nur Tasfiyati, Lucia Dwi Antika, Rizna Triana Dewi, Abdi Wira Septama, Akhmad Sabarudin, Teni Ernawati. An experimental design approach for the optimization of scopoletin extraction from Morinda citrifolia L. using accelerated solvent extraction. Talanta. 2022 Feb; 238(Pt 1):123010. doi: 10.1016/j.talanta.2021.123010. [PMID: 34857344]
  • Zongmei Wu, Yana Geng, Manon Buist-Homan, Han Moshage. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress. Toxicology and applied pharmacology. 2022 02; 436(?):115858. doi: 10.1016/j.taap.2021.115858. [PMID: 34979142]
  • Zhongxiang Fan, Dan Tang, Qiang Wu, Qun Huang, Jie Song, Qiping Long. Scopoletin inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by regulating NF-κB signaling pathway. Allergologia et immunopathologia. 2022; 50(1):92-98. doi: 10.15586/aei.v50i1.517. [PMID: 34965643]
  • Seon Gyeong Bak, Hyung-Jin Lim, Yeong-Seon Won, Soyoung Lee, Sun Hee Cheong, Seong Jin Lee, Eun Young Bae, Seung Woong Lee, Seung Jae Lee, Mun-Chual Rho. Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation. BioMed research international. 2022; 2022(?):2475699. doi: 10.1155/2022/2475699. [PMID: 36158872]
  • Darille Claudia Ngnokam Jouogo, Jean-De-Dieu Tamokou, Rémy Bertrand Teponno, Germaine Matsuete-Takongmo, Laurence Voutquenne-Nazabadioko, Léon Azefack Tapondjou, David Ngnokam. Chemotaxonomy and Antibacterial Activity of the Extracts and Chemical Constituents of Psychotria succulenta Hiern. (Rubiaceae). BioMed research international. 2022; 2022(?):7856305. doi: 10.1155/2022/7856305. [PMID: 35757466]
  • Marwa M Khalaf, Samar M Hassan, Ahmed M Sayed, Amira M Abo-Youssef. Ameliorate impacts of scopoletin against vancomycin-induced intoxication in rat model through modulation of Keap1-Nrf2/HO-1 and IκBα-P65 NF-κB/P38 MAPK signaling pathways: Molecular study, molecular docking evidence and network pharmacology analysis. International immunopharmacology. 2022 Jan; 102(?):108382. doi: 10.1016/j.intimp.2021.108382. [PMID: 34848155]
  • Preksha Patel, Manan Raval, Nidhi Patel, Samir Patel, Niraj Vyas, Amit Patel. Quantification of Scopoletin from the Roots of Argyreia Speciosa (Linn. F) Sweet Using HPLC Through the Concept of Design of Experiment. Journal of AOAC International. 2021 Aug; 104(4):1167-1180. doi: 10.1093/jaoacint/qsab013. [PMID: 33515243]
  • Marco Cosme, Iván Fernández, Stéphane Declerck, Marcel G A van der Heijden, Corné M J Pieterse. A coumarin exudation pathway mitigates arbuscular mycorrhizal incompatibility in Arabidopsis thaliana. Plant molecular biology. 2021 Jul; 106(4-5):319-334. doi: 10.1007/s11103-021-01143-x. [PMID: 33825084]
  • Ankita R Rane, Harshad Paithankar, Ramakrishna V Hosur, Sinjan Choudhary. Modulation of α-synuclein fibrillation by plant metabolites, daidzein, fisetin and scopoletin under physiological conditions. International journal of biological macromolecules. 2021 Jul; 182(?):1278-1291. doi: 10.1016/j.ijbiomac.2021.05.071. [PMID: 33991558]
  • Jiranan Chaingam, Thaweesak Juengwatanatrakul, Gorawit Yusakul, Tripetch Kanchanapoom, Waraporn Putalun. HPLC-UV-Based Simultaneous Determination of Canthin-6-One Alkaloids, Quassinoids, and Scopoletin: The Active Ingredients in Eurycoma Longifolia Jack and Eurycoma Harmandiana Pierre, and Their Anti-Inflammatory Activities. Journal of AOAC International. 2021 Jun; 104(3):802-810. doi: 10.1093/jaoacint/qsaa141. [PMID: 33064798]
  • Qilei Chen, Lin Zhu, Ka Man Yip, Yancheng Tang, Yi Liu, Tao Jiang, Jianye Zhang, Zhongzhen Zhao, Tao Yi, Hubiao Chen. A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz. Journal of ethnopharmacology. 2021 May; 271(?):113849. doi: 10.1016/j.jep.2021.113849. [PMID: 33485983]
  • Yijun Liang, Xuxin Zeng, Jialiang Guo, Hui Liu, Bao He, Renyu Lai, Quan Zhu, Zhaoguang Zheng. Scopoletin and umbelliferone from Cortex Mori as protective agents in high glucose-induced mesangial cell as in vitro model of diabetic glomerulosclerosis. The Chinese journal of physiology. 2021 May; 64(3):150-158. doi: 10.4103/cjp.cjp_9_21. [PMID: 34169921]
  • Chong Yuan, Meng-Heng Wang, Fei Wang, Peng-Yu Chen, Xin-Ge Ke, Bing Yu, Yan-Fang Yang, Peng-Tao You, He-Zhen Wu. Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer. Life sciences. 2021 Apr; 270(?):119105. doi: 10.1016/j.lfs.2021.119105. [PMID: 33497736]
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