Matenon (BioDeep_00000009791)

Main id: BioDeep_00000855555

 


代谢物信息卡片


17-beta-Hydroxy-7-alpha,17-dimethylestr-4-en-3-one

化学式: C20H30O2 (302.224568)
中文名称: 米勃龙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2=CC(=O)CCC2C2CCC3(C)C(CCC3(C)O)C12
InChI: InChI=1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Same as: D05025

同义名列表

3 个代谢物同义名

17-beta-Hydroxy-7-alpha,17-dimethylestr-4-en-3-one; Mibolerone; Matenon



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Maslama Bidosee, Rachel Karry, Esther Weiss-Messer, Ronnie J Barkey. Regulation of growth hormone receptors in human prostate cancer cell lines. Molecular and cellular endocrinology. 2009 Oct; 309(1-2):82-92. doi: 10.1016/j.mce.2009.06.004. [PMID: 19540305]
  • Wuhan Xiao, Qiuheng Zhang, Feng Jiang, Michael Pins, James M Kozlowski, Zhou Wang. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Cancer research. 2003 Aug; 63(15):4698-704. doi: NULL. [PMID: 12907652]
  • A Kumar, S D Mikolajczyk, T M Hill, L S Millar, M S Saedi. Different proportions of various prostate-specific antigen (PSA) and human kallikrein 2 (hK2) forms are present in noninduced and androgen-induced LNCaP cells. The Prostate. 2000 Aug; 44(3):248-54. doi: 10.1002/1097-0045(20000801)44:3<248::aid-pros10>3.0.co;2-d. [PMID: 10906742]
  • T M Williams, A J Kind, W G Hyde, D W Hill. Characterization of urinary metabolites of testosterone, methyltestosterone, mibolerone and boldebone in greyhound dogs. Journal of veterinary pharmacology and therapeutics. 2000 Jun; 23(3):121-9. doi: 10.1046/j.1365-2885.2000.00267.x. [PMID: 11110098]
  • N Kumar, A Crozat, F Li, J F Catterall, C W Bardin, K Sundaram. 7alpha-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens. The Journal of steroid biochemistry and molecular biology. 1999 Dec; 71(5-6):213-22. doi: 10.1016/s0960-0760(99)00143-0. [PMID: 10704910]
  • C Spitzweg, S Zhang, E R Bergert, M R Castro, B McIver, A E Heufelder, D J Tindall, C Y Young, J C Morris. Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines. Cancer research. 1999 May; 59(9):2136-41. doi: NULL. [PMID: 10232600]
  • J Szelei, J Jimenez, A M Soto, M F Luizzi, C Sonnenschein. Androgen-induced inhibition of proliferation in human breast cancer MCF7 cells transfected with androgen receptor. Endocrinology. 1997 Apr; 138(4):1406-12. doi: 10.1210/endo.138.4.5047. [PMID: 9075695]
  • J V Swinnen, M Esquenet, K Goossens, W Heyns, G Verhoeven. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer research. 1997 Mar; 57(6):1086-90. doi: ". [PMID: 9067276]
  • A E Lemus, J Enríquez, G A García, I Grillasca, G Pérez-Palacios. 5alpha-reduction of norethisterone enhances its binding affinity for androgen receptors but diminishes its androgenic potency. The Journal of steroid biochemistry and molecular biology. 1997 Jan; 60(1-2):121-9. doi: 10.1016/s0960-0760(96)00172-0. [PMID: 9182866]
  • A E Summerfield, P J Diaz Cruz, M P Dolenga, H E Smith, C D Strader, J H Toney. Tissue-specific pharmacology of testosterone and 5 alpha-dihydrotestosterone analogues: characterization of a novel canine liver androgen-binding protein. Molecular pharmacology. 1995 May; 47(5):1080-8. doi: NULL. [PMID: 7746275]
  • M S Fitzpatrick, W L Gale, C B Schreck. Binding characteristics of an androgen receptor in the ovaries of coho salmon, Oncorhynchus kisutch. General and comparative endocrinology. 1994 Sep; 95(3):399-408. doi: 10.1006/gcen.1994.1139. [PMID: 7821777]
  • A Liu, K E Carlson, J A Katzenellenbogen. Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography. Journal of medicinal chemistry. 1992 May; 35(11):2113-29. doi: 10.1021/jm00089a024. [PMID: 1597861]
  • G Pérez-Palacios, M A Cerbón, A M Pasapera, J I Castro, J Enríquez, F Vilchis, G A García, G Moralí, A E Lemus. Mechanisms of hormonal and antihormonal action of contraceptive progestins at the molecular level. The Journal of steroid biochemistry and molecular biology. 1992 Mar; 41(3-8):479-85. doi: 10.1016/0960-0760(92)90373-q. [PMID: 1562519]
  • K Wrogemann, G Podolsky, J Gu, E Rosenmann. A 63-kDa protein with androgen-binding activity is not from the androgen receptor. Biochemistry and cell biology = Biochimie et biologie cellulaire. 1991 Oct; 69(10-11):695-701. doi: 10.1139/o91-104. [PMID: 1799435]
  • J Steinsapir, R Socci, P Reinach. Effects of androgen on intracellular calcium of LNCaP cells. Biochemical and biophysical research communications. 1991 Aug; 179(1):90-6. doi: 10.1016/0006-291x(91)91338-d. [PMID: 1883394]
  • J Steinsapir, T G Muldoon. Role of microsomal receptors in steroid hormone action. Steroids. 1991 Feb; 56(2):66-71. doi: 10.1016/0039-128x(91)90126-g. [PMID: 2020980]
  • C Y Young, S D Qiu, J L Prescott, D J Tindall. Overexpression of a partial human androgen receptor in E. coli: characterization of steroid binding, DNA binding, and immunological properties. Molecular endocrinology (Baltimore, Md.). 1990 Dec; 4(12):1841-9. doi: 10.1210/mend-4-12-1841. [PMID: 2127955]
  • N Olea, K Sakabe, A M Soto, C Sonnenschein. The proliferative effect of "anti-androgens" on the androgen-sensitive human prostate tumor cell line LNCaP. Endocrinology. 1990 Mar; 126(3):1457-63. doi: 10.1210/endo-126-3-1457. [PMID: 2307113]
  • C J Kemp, N R Drinkwater. Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer research. 1989 Sep; 49(18):5044-7. doi: NULL. [PMID: 2766275]
  • A M Traish, D F Williams, N D Hoffman, H H Wotiz. Validation of the exchange assay for the measurement of androgen receptors in human and dog prostates. Progress in clinical and biological research. 1988; 262(?):145-60. doi: NULL. [PMID: 3375279]
  • S Liao, D Witte. Autoimmune anti-androgen-receptor antibodies in human serum. Proceedings of the National Academy of Sciences of the United States of America. 1985 Dec; 82(24):8345-8. doi: 10.1073/pnas.82.24.8345. [PMID: 3866227]
  • J K Bhanushali, W L Ragland. Chickens bursectomized with mibolerone have Ig-positive cells which lack bursal cell specific antigens. Veterinary immunology and immunopathology. 1985 Nov; 10(2-3):189-203. doi: 10.1016/0165-2427(85)90046-7. [PMID: 2417401]
  • J K Bhanushali, K K Murthy, W L Ragland. Delayed development of humoral immunity in chickens following in ovo treatment with mibolerone. Developmental and comparative immunology. 1985; 9(3):453-63. doi: 10.1016/0145-305x(85)90008-4. [PMID: 3930306]
  • K Schilling, S Liao. The use of radioactive 7 alpha, 17 alpha-dimethyl-19-nortestosterone (mibolerone) in the assay of androgen receptors. The Prostate. 1984; 5(6):581-8. doi: 10.1002/pros.2990050603. [PMID: 6333679]
  • T J Lobl, N A Musto, G L Gunsalus, C W Bardin. Medroxyprogesterone acetate has opposite effects on the androgen binding protein concentrations in serum and epididymis. Biology of reproduction. 1983 Oct; 29(3):697-712. doi: 10.1095/biolreprod29.3.697. [PMID: 6226325]
  • B Lucio, S B Hitchner. Response of mibolerone-treated chickens to infectious bursal disease virus. Avian diseases. 1980 Apr; 24(2):334-44. doi: 10.2307/1589701. [PMID: 6254486]