Promegestone (BioDeep_00000009763)

   


代谢物信息卡片


Promegestone

化学式: C22H30O2 (326.224568)
中文名称: 普美孕酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(=O)C1(C)CCC2C3CCC4=CC(=O)CCC4=C3CCC21C
InChI: InChI=1S/C22H30O2/c1-4-20(24)22(3)12-10-19-18-7-5-14-13-15(23)6-8-16(14)17(18)9-11-21(19,22)2/h13,18-19H,4-12H2,1-3H3/t18-,19+,21+,22-/m1/s1

描述信息

G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DB - Pregnadien derivatives
Same as: D08431

同义名列表

2 个代谢物同义名

Promegestone; FT-0686408



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Oksana Shynlova, Lubna Nadeem, Anna Dorogin, Sam Mesiano, Stephen J Lye. The selective progesterone receptor modulator-promegestone-delays term parturition and prevents systemic inflammation-mediated preterm birth in mice. American journal of obstetrics and gynecology. 2022 02; 226(2):249.e1-249.e21. doi: 10.1016/j.ajog.2021.08.013. [PMID: 34418351]
  • Natalícia de Jesus Antunes, Raimundo Vieira de Oliveira Filho, Jaime de Oliveira Ilha, Ronilson A Moreno, André Felipe Nahoum, Ralph-Steven Wedemeyer, André Warnke, Gilberto De Nucci. Single-dose pharmacokinetics and pharmacodynamics assessment of oestriol and trimegestone containing vaginal rings in healthy women with childbearing potential. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2021 Jun; 26(3):184-194. doi: 10.1080/13625187.2021.1884219. [PMID: 33645377]
  • Ingrid J M Duijkers, Christine Klipping, Corinna Draeger, Barbara S Schug, Annika Dax, Maika Friedrich, Klaus Nickisch. Ovulation inhibition with a new vaginal ring containing trimegestone. Contraception. 2020 10; 102(4):237-242. doi: 10.1016/j.contraception.2020.06.006. [PMID: 32569678]
  • Thomas McFall, Mugdha Patki, Rayna Rosati, Manohar Ratnam. Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges. Oncotarget. 2015 Oct; 6(32):33146-64. doi: 10.18632/oncotarget.5082. [PMID: 26356672]
  • Grace B Flock, Xiemin Cao, Marlena Maziarz, Daniel J Drucker. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Diabetes. 2013 Jan; 62(1):283-90. doi: 10.2337/db12-0601. [PMID: 22933106]
  • Carlos J Baier, Jacques Fantini, Francisco J Barrantes. Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor. Scientific reports. 2011; 1(?):69. doi: 10.1038/srep00069. [PMID: 22355588]
  • Sarah J Santos, Mark D Aupperlee, Jianwei Xie, Srinivasan Durairaj, Richard Miksicek, Susan E Conrad, Jeffrey R Leipprandt, Ying S Tan, Richard C Schwartz, Sandra Z Haslam. Progesterone receptor A-regulated gene expression in mammary organoid cultures. The Journal of steroid biochemistry and molecular biology. 2009 Jul; 115(3-5):161-72. doi: 10.1016/j.jsbmb.2009.04.001. [PMID: 19383543]
  • M Hellgren, J Conard, L Norris, C Kluft. Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone. Maturitas. 2009 Mar; 62(3):287-93. doi: 10.1016/j.maturitas.2009.01.004. [PMID: 19268506]
  • Cherie E Bond, Martina Zimmermann, Susan A Greenfield. Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides. PloS one. 2009; 4(3):e4846. doi: 10.1371/journal.pone.0004846. [PMID: 19287501]
  • Kristen Evaul, Michelle Jamnongjit, Bala Bhagavath, Stephen R Hammes. Testosterone and progesterone rapidly attenuate plasma membrane Gbetagamma-mediated signaling in Xenopus laevis oocytes by signaling through classical steroid receptors. Molecular endocrinology (Baltimore, Md.). 2007 Jan; 21(1):186-96. doi: 10.1210/me.2006-0301. [PMID: 17021048]
  • Regine Sitruk-Ware. New progestagens for contraceptive use. Human reproduction update. 2006 Mar; 12(2):169-78. doi: 10.1093/humupd/dmi046. [PMID: 16291771]
  • Rebecca A Shirk, Zhiming Zhang, Richard C Winneker. Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat. The Journal of steroid biochemistry and molecular biology. 2005 Mar; 94(4):361-8. doi: 10.1016/j.jsbmb.2004.12.026. [PMID: 15857755]
  • F Al-Azzawi, M Wahab, S Sami, A J Proudler, J Thompson, J Stevenson. Randomized trial of effects of estradiol in combination with either norethisterone acetate or trimegestone on lipids and lipoproteins in postmenopausal women. Climacteric : the journal of the International Menopause Society. 2004 Sep; 7(3):292-300. doi: 10.1080/13697130400001364. [PMID: 15669554]
  • Jorge R Pasqualini. The selective estrogen enzyme modulators in breast cancer: a review. Biochimica et biophysica acta. 2004 Jun; 1654(2):123-43. doi: 10.1016/j.bbcan.2004.03.001. [PMID: 15172700]
  • H Fernandez, C Lucas, B Hédon, J L Meyer, J M Mayenga, C Roux. One year comparison between two add-back therapies in patients treated with a GnRH agonist for symptomatic endometriosis: a randomized double-blind trial. Human reproduction (Oxford, England). 2004 Jun; 19(6):1465-71. doi: 10.1093/humrep/deh250. [PMID: 15105403]
  • Lise Warming, Pernille Ravn, Danièle Spielman, Pierre Delmas, Claus Christiansen. Trimegestone in a low-dose, continuous-combined hormone therapy regimen prevents bone loss in osteopenic postmenopausal women. Menopause (New York, N.Y.). 2004 May; 11(3):337-42. doi: 10.1097/01.gme.0000097846.95550.aa. [PMID: 15167314]
  • Kathrin A Dunlap, Fredrick Stormshak. Nongenomic inhibition of oxytocin binding by progesterone in the ovine uterus. Biology of reproduction. 2004 Jan; 70(1):65-9. doi: 10.1095/biolreprod.103.020180. [PMID: 12954727]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • Marinka S Post, Marieke O Verhoeven, Marius J van der Mooren, Peter Kenemans, Coen D A Stehouwer, Tom Teerlink. Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women. The Journal of clinical endocrinology and metabolism. 2003 Sep; 88(9):4221-6. doi: 10.1210/jc.2003-030584. [PMID: 12970290]
  • Renee F Slade, Dirk A Hunt, Mildred M Pochet, Virginia J Venema, Randolph A Hennigar. Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. Anticancer research. 2003 Mar; 23(2B):1235-43. doi: . [PMID: 12820377]
  • C Bumke-Vogt, V Bähr, S Diederich, S M Herrmann, I Anagnostopoulos, W Oelkers, M Quinkler. Expression of the progesterone receptor and progesterone- metabolising enzymes in the female and male human kidney. The Journal of endocrinology. 2002 Nov; 175(2):349-64. doi: 10.1677/joe.0.1750349. [PMID: 12429033]
  • N Sunil, Jessica M Bennett, Sandra Z Haslam. Hepatocyte growth factor is required for progestin-induced epithelial cell proliferation and alveolar-like morphogenesis in serum-free culture of normal mammary epithelial cells. Endocrinology. 2002 Aug; 143(8):2953-60. doi: 10.1210/endo.143.8.8971. [PMID: 12130561]
  • Ingrid Garbus, Ana M Roccamo, Francisco J Barrantes. Identification of threonine 422 in transmembrane domain alpha M4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone. Neuropharmacology. 2002 Jul; 43(1):65-73. doi: 10.1016/s0028-3908(02)00068-0. [PMID: 12213260]
  • J H J M Meuwissen, L Beijers-De Bie, T Vihtamaki, R Tuimala, N Siseles, C Magaril, H S The, P W H Houben, M Murga, D Spielmann, T J De Villiers. Assessment of the metabolic tolerance in postmenopausal women over a 1-year period of two hormone replacement therapies containing estradiol in combination with either norgestrel or trimegestone. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2002 Apr; 16(2):155-62. doi: . [PMID: 12012627]
  • M S Post, D F Hendriks, M J Van Der Mooren, W M Van Baal, J R Leurs, J J Emeis, P Kenemans, C D A Stehouwer. Oral oestradiol/trimegestone replacement reduces procarboxypeptidase U (TAFI): a randomized, placebo- controlled, 12-week study in early postmenopausal women. Journal of internal medicine. 2002 Mar; 251(3):245-51. doi: 10.1046/j.1365-2796.2002.00960.x. [PMID: 11886484]
  • A M Pasapera, R Gutiérrez-Sagal, R García-Becerra, A Ulloa-Aguirre, J F Savouret. Transactivation of progestin- and estrogen-responsive promoters by 19-nor progestins in African Green Monkey Kidney CV1 cells. Endocrine. 2001 Dec; 16(3):217-25. doi: 10.1385/endo:16:3:217. [PMID: 11954666]
  • P Alban, C Hurd, S Dinda, N Khattree, V K Moudgil. Differential regulation of retinoblastoma protein by hormonal and antihormonal agents in T47D breast cancer cells. The Journal of steroid biochemistry and molecular biology. 2001 May; 77(2-3):135-41. doi: 10.1016/s0960-0760(01)00043-7. [PMID: 11377979]
  • G Giannoukos, D Szapary, C L Smith, J E Meeker, S S Simons. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Molecular endocrinology (Baltimore, Md.). 2001 Feb; 15(2):255-70. doi: 10.1210/mend.15.2.0596. [PMID: 11158332]
  • M O Joly-Pharaboz, A Ruffion, A Roch, L Michel-Calemard, J André, J Chantepie, B Nicolas, G Panaye. Inhibition of growth and induction of apoptosis by androgens of a variant of LNCaP cell line. The Journal of steroid biochemistry and molecular biology. 2000 Jul; 73(5):237-49. doi: 10.1016/s0960-0760(00)00076-5. [PMID: 11070352]
  • C L Smith, R G Wolford, T B O'Neill, G L Hager. Characterization of transiently and constitutively expressed progesterone receptors: evidence for two functional states. Molecular endocrinology (Baltimore, Md.). 2000 Jul; 14(7):956-71. doi: 10.1210/mend.14.7.0482. [PMID: 10894147]
  • W M Van Baal, J J Emeis, P Kenemans, H Kessel, E R Peters-Muller, C G Schalkwijk, M J van der Mooren, C D Stehouwer. Short-term hormone replacement therapy: reduced plasma levels of soluble adhesion molecules. European journal of clinical investigation. 1999 Nov; 29(11):913-21. doi: 10.1046/j.1365-2362.1999.00565.x. [PMID: 10583435]
  • W M van Baal, R G Smolders, M J van der Mooren, T Teerlink, P Kenemans. Hormone replacement therapy and plasma homocysteine levels. Obstetrics and gynecology. 1999 Oct; 94(4):485-91. doi: 10.1016/s0029-7844(99)00412-3. [PMID: 10511346]
  • C Hurd, K Nag, N Khattree, P Alban, S Dinda, V K Moudgil. Agonist and antagonist-induced qualitative and quantitative alterations of progesterone receptor from breast cancer cells. Molecular and cellular biochemistry. 1999 Sep; 199(1-2):49-56. doi: 10.1023/a:1006982528297. [PMID: 10544951]
  • M P Blanton, Y Xie, L J Dangott, J B Cohen. The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface. Molecular pharmacology. 1999 Feb; 55(2):269-78. doi: 10.1124/mol.55.2.269. [PMID: 9927618]
  • S Dinda, S Kodali-Gali, L Sevilla, M Burkley, C Hurd, V K Moudgil. Inhibition of proliferation of T47D human breast cancer cells: alterations in progesterone receptor and p53 tumor suppressor protein. Molecular and cellular biochemistry. 1997 Oct; 175(1-2):81-9. doi: 10.1023/a:1006841413053. [PMID: 9350037]
  • J Xie, S Z Haslam. Extracellular matrix regulates ovarian hormone-dependent proliferation of mouse mammary epithelial cells. Endocrinology. 1997 Jun; 138(6):2466-73. doi: 10.1210/endo.138.6.5211. [PMID: 9165037]
  • A Pecci, A Scholz, D Pelster, M Beato. Progestins prevent apoptosis in a rat endometrial cell line and increase the ratio of bcl-XL to bcl-XS. The Journal of biological chemistry. 1997 May; 272(18):11791-8. doi: 10.1074/jbc.272.18.11791. [PMID: 9115235]
  • G A Morrill, G Y Ma, A Kostellow. Progesterone binding to plasma membrane and cytosol receptors in the amphibian oocyte. Biochemical and biophysical research communications. 1997 Mar; 232(1):213-7. doi: 10.1006/bbrc.1997.6190. [PMID: 9125134]
  • E Epstein, J Silver, G Almogi, N Livni, T Naveh-Many. Parathyroid hormone mRNA levels are increased by progestins and vary during rat estrous cycle. The American journal of physiology. 1996 Jan; 270(1 Pt 1):E158-63. doi: 10.1152/ajpendo.1996.270.1.e158. [PMID: 8772488]
  • C Hurd, N Khattree, P Alban, K Nag, S C Jhanwar, S Dinda, V K Moudgil. Hormonal regulation of the p53 tumor suppressor protein in T47D human breast carcinoma cell line. The Journal of biological chemistry. 1995 Dec; 270(48):28507-10. doi: 10.1074/jbc.270.48.28507. [PMID: 7499360]
  • G Giannoukos, I P Callard. Reptilian (Chrysemys picta) hepatic progesterone receptors: relationship to plasma steroids and the vitellogenic cycle. The Journal of steroid biochemistry and molecular biology. 1995 Oct; 55(1):93-106. doi: 10.1016/0960-0760(95)00149-t. [PMID: 7577726]
  • E K Asem, M D Conkright. Role of progesterone in luteinizing hormone-induced fibronectin production and deposition by chicken granulosa cells in vitro. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1995 Oct; 112(2):247-55. doi: 10.1016/0742-8413(95)02018-7. [PMID: 8788593]
  • M M Singh, M Fähnrich, S H Hasan, W Elger. Reversibility of antigestagenic action of antiprogestin onapristone by exogenous progestagens during early pregnancy in guinea pig. Contraception. 1995 Sep; 52(3):187-93. doi: 10.1016/0010-7824(95)00152-z. [PMID: 7587191]
  • F A Trémollieres, J M Pouilles, C A Ribot. A prospective two-year study of progestin given alone in postmenopausal women: effect on lipid and metabolic parameters. American journal of obstetrics and gynecology. 1995 Jul; 173(1):85-9. doi: 10.1016/0002-9378(95)90174-4. [PMID: 7631732]
  • M D Conkright, E K Asem. Intracrine role of progesterone in follicle-stimulating hormone- and cyclic adenosine 3',5'-monophosphate-induced fibronectin production and deposition by chicken granulosa cells: influence of follicular development. Endocrinology. 1995 Jun; 136(6):2641-51. doi: 10.1210/endo.136.6.7750488. [PMID: 7750488]
  • O D Slayden, M B Zelinski-Wooten, R L Stouffer, R M Brenner. Radioligand binding assay of progesterone receptors in the primate corpus luteum after in vivo treatment with the 3 beta-hydroxysteroid dehydrogenase inhibitor, trilostane. The Journal of clinical endocrinology and metabolism. 1994 Aug; 79(2):620-6. doi: 10.1210/jcem.79.2.8045986. [PMID: 8045986]
  • J Botella, E Duranti, I Duc, A M Cognet, R Delansorne, J Paris. Inhibition by nomegestrol acetate and other synthetic progestins on proliferation and progesterone receptor content of T47-D human breast cancer cells. The Journal of steroid biochemistry and molecular biology. 1994 Jul; 50(1-2):41-7. doi: 10.1016/0960-0760(94)90170-8. [PMID: 8049131]
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  • F Trémollières, J M Pouilles, C Ribot. Effect of long-term administration of progestogen on post-menopausal bone loss: result of a two-year, controlled randomized study. Clinical endocrinology. 1993 Jun; 38(6):627-31. doi: 10.1111/j.1365-2265.1993.tb02145.x. [PMID: 8334749]
  • D Di Lorenzo, M Giannì, G F Savoldi, F Ferrari, A Albertini, E Garattini. Progesterone induced expression of alkaline phosphatase is associated with a secretory phenotype in T47D breast cancer cells. Biochemical and biophysical research communications. 1993 May; 192(3):1066-72. doi: 10.1006/bbrc.1993.1525. [PMID: 8507182]
  • C Lobaccaro-Henri, M Saintot, F Laffargue, H P Zahradnik, B Descomps, H Thaler-Dao. Effect of the progesterone antagonist RU486 on human myometrial spontaneous contractility and PGI2 release. Prostaglandins. 1992 Nov; 44(5):443-55. doi: 10.1016/0090-6980(92)90139-k. [PMID: 1470683]
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