2,2',4,4',5,5'-Hexachlorobiphenyl (BioDeep_00000009758)

 

Secondary id: BioDeep_00001873676

human metabolite blood metabolite


代谢物信息卡片


1,2,4-trichloro-5-(2,4,5-trichlorophenyl)benzene

化学式: C12H4Cl6 (357.8444164)
中文名称: 六氯联苯
谱图信息: 最多检出来源 Homo sapiens(blood) 97.73%

分子结构信息

SMILES: C1=C(C(=CC(=C1Cl)Cl)Cl)C2=CC(=C(C=C2Cl)Cl)Cl
InChI: InChI=1S/C12H4Cl6/c13-7-3-11(17)9(15)1-5(7)6-2-10(16)12(18)4-8(6)14/h1-4H

描述信息

D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls

同义名列表

6 个代谢物同义名

1,2,4-trichloro-5-(2,4,5-trichlorophenyl)benzene; 2,2,4,4,5,5-Hexachlorobiphenyl; 2,4,5,2,4,5-Hexachlorobiphenyl; hexachlorobiphenyl; PCB 153; PCB-153



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Bo Yuan, Anders Bignert, Patrik L Andersson, Christina E West, Magnus Domellöf, Åke Bergman. Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study: Matrix dependent partitioning differences compared to legacy POPs. Environment international. 2024 Jan; 183(?):108440. doi: 10.1016/j.envint.2024.108440. [PMID: 38232504]
  • Jana Slováčková, Josef Slavík, Pavel Kulich, Josef Večeřa, Ondrej Kováč, Hana Paculová, Nicol Straková, Radek Fedr, João Pedro Silva, Félix Carvalho, Miroslav Machala, Jiřina Procházková. Polychlorinated environmental toxicants affect sphingolipid metabolism during neurogenesis in vitro. Toxicology. 2021 11; 463(?):152986. doi: 10.1016/j.tox.2021.152986. [PMID: 34627992]
  • Libin Liu, Haiyan Zhang, Can Chen, Ziguang Li, Yue Xu. Pilot study on long-term simulation of PCB-153 human body burden in the Tibetan Plateau. Chemosphere. 2021 Aug; 276(?):130184. doi: 10.1016/j.chemosphere.2021.130184. [PMID: 33725619]
  • Yuan Tian, Wei Gui, Bipin Rimal, Imhoi Koo, Philip B Smith, Robert G Nichols, Jingwei Cai, Qing Liu, Andrew D Patterson. Metabolic impact of persistent organic pollutants on gut microbiota. Gut microbes. 2020 11; 12(1):1-16. doi: 10.1080/19490976.2020.1848209. [PMID: 33295235]
  • Lingli Min, Yulang Chi, Sijun Dong. Gut microbiota health closely associates with PCB153-derived risk of host diseases. Ecotoxicology and environmental safety. 2020 Oct; 203(?):111041. doi: 10.1016/j.ecoenv.2020.111041. [PMID: 32888612]
  • Jonatan Axelsson, Kristin Scott, Joakim Dillner, Christian H Lindh, He Zhang, Lars Rylander, Anna Rignell-Hydbom. Exposure to polychlorinated compounds and cryptorchidism; A nested case-control study. PloS one. 2020; 15(7):e0236394. doi: 10.1371/journal.pone.0236394. [PMID: 32702712]
  • Qiong Wu, Hindrik Bouwman, Ryan C Uren, Carl D van der Lingen, Walter Vetter. Halogenated natural products and anthropogenic persistent organic pollutants in chokka squid (Loligo reynaudii) from three sites along the South Atlantic and Indian Ocean coasts of South Africa. Environmental pollution (Barking, Essex : 1987). 2019 Dec; 255(Pt 2):113282. doi: 10.1016/j.envpol.2019.113282. [PMID: 31563788]
  • Ling-Chuan Guo, Shengbing Yu, De Wu, Jinxu Huang, Tao Liu, Jianpeng Xiao, Weixiong Huang, Yanhong Gao, Xing Li, Weilin Zeng, Shannon Rutherford, Wenjun Ma, Yonghui Zhang, Lifeng Lin. Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region. Environmental pollution (Barking, Essex : 1987). 2019 Nov; 254(Pt B):112925. doi: 10.1016/j.envpol.2019.07.093. [PMID: 31454572]
  • Douglas I Walker, M Elizabeth Marder, Yukiko Yano, Metrecia Terrell, Yongliang Liang, Dana Boyd Barr, Gary W Miller, Dean P Jones, Michele Marcus, Kurt D Pennell. Multigenerational metabolic profiling in the Michigan PBB registry. Environmental research. 2019 05; 172(?):182-193. doi: 10.1016/j.envres.2019.02.018. [PMID: 30782538]
  • M W Dzierlenga, M Yoon, F Wania, P L Ward, J M Armitage, S A Wood, H J Clewell, M P Longnecker. Quantitative bias analysis of the association of type 2 diabetes mellitus with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153). Environment international. 2019 04; 125(?):291-299. doi: 10.1016/j.envint.2018.12.036. [PMID: 30735960]
  • Danielle Naville, Guillain Gaillard, Benoit Julien, Nathalie Vega, Claudie Pinteur, Stéphanie Chanon, Hubert Vidal, Brigitte Le Magueresse-Battistoni. Chronic exposure to a pollutant mixture at low doses led to tissue-specific metabolic alterations in male mice fed standard and high-fat high-sucrose diet. Chemosphere. 2019 Apr; 220(?):1187-1199. doi: 10.1016/j.chemosphere.2018.12.177. [PMID: 30722647]
  • Panagiotis Filis, Natasha Walker, Linda Robertson, Emily Eaton-Turner, Lauma Ramona, Michelle Bellingham, Maria R Amezaga, Zulin Zhang, Beatrice Mandon-Pepin, Neil P Evans, Richard M Sharpe, Corinne Cotinot, William D Rees, Peter O'Shaughnessy, Paul A Fowler. Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males. Environment international. 2019 03; 124(?):98-108. doi: 10.1016/j.envint.2019.01.003. [PMID: 30641261]
  • Juan Pedro Arrebola, Juan José Ramos, Mónica Bartolomé, Marta Esteban, Olga Huetos, Ana I Cañas, Ana López-Herranz, Eva Calvo, Beatriz Pérez-Gómez, Argelia Castaño. Associations of multiple exposures to persistent toxic substances with the risk of hyperuricemia and subclinical uric acid levels in BIOAMBIENT.ES study. Environment international. 2019 02; 123(?):512-521. doi: 10.1016/j.envint.2018.12.030. [PMID: 30622076]
  • J D Rasinger, T S Carroll, F Maranghi, R Tassinari, G Moracci, I Altieri, A Mantovani, A-K Lundebye, C Hogstrand. Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice. Reproductive toxicology (Elmsford, N.Y.). 2018 09; 80(?):105-116. doi: 10.1016/j.reprotox.2018.06.010. [PMID: 29935226]
  • B González-Alzaga, M Lacasaña, A F Hernández, J P Arrebola, I López-Flores, F Artacho-Cordón, J P Bonde, N Olea, C Aguilar-Garduño. Serum concentrations of organochlorine compounds and predictors of exposure in children living in agricultural communities from South-Eastern Spain. Environmental pollution (Barking, Essex : 1987). 2018 Jun; 237(?):685-694. doi: 10.1016/j.envpol.2017.10.109. [PMID: 29129429]
  • Aina Jansen, Anuschka Polder, Mette H B Müller, Eystein Skjerve, Jan Aaseth, Jan L Lyche. Increased levels of persistent organic pollutants in serum one year after a great weight loss in humans: Are the levels exceeding health based guideline values?. The Science of the total environment. 2018 May; 622-623(?):1317-1326. doi: 10.1016/j.scitotenv.2017.11.241. [PMID: 29890598]
  • Josiah E Hardesty, Laila Al-Eryani, Banrida Wahlang, K Cameron Falkner, Hongxue Shi, Jian Jin, Brad J Vivace, Brian P Ceresa, Russell A Prough, Matthew C Cave. Epidermal Growth Factor Receptor Signaling Disruption by Endocrine and Metabolic Disrupting Chemicals. Toxicological sciences : an official journal of the Society of Toxicology. 2018 04; 162(2):622-634. doi: 10.1093/toxsci/kfy004. [PMID: 29329451]
  • Eliezer Brown Mwakalapa, Aviti John Mmochi, Mette Helen Bjorge Müller, Robinson Hammerthon Mdegela, Jan Ludvig Lyche, Anuschka Polder. Occurrence and levels of persistent organic pollutants (POPs) in farmed and wild marine fish from Tanzania. A pilot study. Chemosphere. 2018 Jan; 191(?):438-449. doi: 10.1016/j.chemosphere.2017.09.121. [PMID: 29054084]
  • Kelly A Heys, Richard F Shore, M Glória Pereira, Francis L Martin. Vibrational biospectroscopy characterizes biochemical differences between cell types used for toxicological investigations and identifies alterations induced by environmental contaminants. Environmental toxicology and chemistry. 2017 11; 36(11):3127-3137. doi: 10.1002/etc.3890. [PMID: 28627759]
  • Aske Hess Rosenquist, Birgit Bjerre Høyer, Jordi Julvez, Jordi Sunyer, Henning Sloth Pedersen, Virissa Lenters, Bo A G Jönsson, Jens Peter Bonde, Gunnar Toft. Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5–9 Years of Age among Children in Greenland and Ukraine. Environmental health perspectives. 2017 10; 125(10):107002. doi: 10.1289/ehp553. [PMID: 28974479]
  • Matthew Lorber, Leisa-Maree L Toms. Use of a simple pharmacokinetic model to study the impact of breast-feeding on infant and toddler body burdens of PCB 153, BDE 47, and DDE. Chemosphere. 2017 Oct; 185(?):1081-1089. doi: 10.1016/j.chemosphere.2017.07.118. [PMID: 28764132]
  • D Mullerova, M Pesta, J Dvorakova, M Cedikova, V Kulda, P Dvorak, V Bouchalová, M Kralickova, V Babuska, J Kuncova, J Langmajerova, L Muller. Polychlorinated biphenyl 153 in lipid medium modulates differentiation of human adipocytes. Physiological research. 2017 09; 66(4):653-662. doi: 10.33549/physiolres.933280. [PMID: 28406693]
  • Hui Zhang, Yun Teng, Tra Thi Thanh Doan, Yun Wei Yat, Sheot Harn Chan, Barry C Kelly. Stable nitrogen and carbon isotopes in sediments and biota from three tropical marine food webs: Application to chemical bioaccumulation assessment. Environmental toxicology and chemistry. 2017 09; 36(9):2521-2532. doi: 10.1002/etc.3796. [PMID: 28300282]
  • Hao Wu, Weihua Yu, Fansen Meng, Jie Mi, Jie Peng, Jiangzheng Liu, Xiaodi Zhang, Chunxu Hai, Xin Wang. Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS/NF-κB signaling via downregulation of HNF1b. Redox biology. 2017 08; 12(?):300-310. doi: 10.1016/j.redox.2017.02.026. [PMID: 28285191]
  • Emmanuel Labaronne, Claudie Pinteur, Nathalie Vega, Sandra Pesenti, Benoit Julien, Emmanuelle Meugnier-Fouilloux, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse-Battistoni. Low-dose pollutant mixture triggers metabolic disturbances in female mice leading to common and specific features as compared to a high-fat diet. The Journal of nutritional biochemistry. 2017 07; 45(?):83-93. doi: 10.1016/j.jnutbio.2017.04.001. [PMID: 28433925]
  • Maria Wielsøe, Peder Kern, Eva Cecilie Bonefeld-Jørgensen. Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit: a case control study. Environmental health : a global access science source. 2017 06; 16(1):56. doi: 10.1186/s12940-017-0269-6. [PMID: 28610584]
  • Kelly A Fader, Rance Nault, Mathew P Kirby, Gena Markous, Jason Matthews, Timothy R Zacharewski. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicology and applied pharmacology. 2017 04; 321(?):1-17. doi: 10.1016/j.taap.2017.02.006. [PMID: 28213091]
  • Fekadu Yadetie, Eystein Oveland, Anne Døskeland, Frode Berven, Anders Goksøyr, Odd André Karlsen. Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153. Aquatic toxicology (Amsterdam, Netherlands). 2017 Apr; 185(?):19-28. doi: 10.1016/j.aquatox.2017.01.014. [PMID: 28183064]
  • Kristen Lyall, Lisa A Croen, Andreas Sjödin, Cathleen K Yoshida, Ousseny Zerbo, Martin Kharrazi, Gayle C Windham. Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability. Environmental health perspectives. 2017 03; 125(3):474-480. doi: 10.1289/ehp277. [PMID: 27548254]
  • F Pierucci, A Frati, R Squecco, E Lenci, C Vicenti, J Slavik, F Francini, M Machala, E Meacci. Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. Archives of toxicology. 2017 Feb; 91(2):749-760. doi: 10.1007/s00204-016-1750-7. [PMID: 27318803]
  • Yoshihisa Kato, Aki Fujii, Koichi Haraguchi, Yukiko Fujii, Kazutaka Atobe, Tetsuya Endo, Osamu Kimura, Nobuyuki Koga, Chiho Ohta, Shizuo Yamada, Masakuni Degawa. Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats. The Journal of toxicological sciences. 2017; 42(6):663-669. doi: 10.2131/jts.42.663. [PMID: 29142165]
  • Ľubica Palkovičová Murínová, Arturo Moleti, Renata Sisto, Soňa Wimmerová, Todd A Jusko, Juraj Tihányi, Dana Jurečková, Ján Kováč, Vladimíra Koštiaková, Beata Drobná, Tomáš Trnovec. PCB exposure and cochlear function at age 6 years. Environmental research. 2016 Nov; 151(?):428-435. doi: 10.1016/j.envres.2016.08.017. [PMID: 27552711]
  • Mohammad H Rahbar, Maureen Samms-Vaughan, Manouchehr Hessabi, Aisha S Dickerson, MinJae Lee, Jan Bressler, Sara E Tomechko, Emily K Moreno, Katherine A Loveland, Charlene Coore Desai, Sydonnie Shakespeare-Pellington, Jody-Ann Reece, Renee Morgan, Matthew J Geiger, Michael E O'Keefe, Megan L Grove, Eric Boerwinkle. Concentrations of Polychlorinated Biphenyls and Organochlorine Pesticides in Umbilical Cord Blood Serum of Newborns in Kingston, Jamaica. International journal of environmental research and public health. 2016 10; 13(10):. doi: 10.3390/ijerph13101032. [PMID: 27775677]
  • M Elizabeth Marder, Parinya Panuwet, Ronald E Hunter, P Barry Ryan, Michele Marcus, Dana Boyd Barr. Quantification of Polybrominated and Polychlorinated Biphenyls in Human Matrices by Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry. Journal of analytical toxicology. 2016 Sep; 40(7):511-8. doi: 10.1093/jat/bkw041. [PMID: 27445313]
  • Lian-Jun Bao, Xiaoqin Wu, Fang Jia, Eddy Y Zeng, Jay Gan. Isotopic exchange on solid-phase micro extraction fiber in sediment under stagnant conditions: Implications for field application of performance reference compound calibration. Environmental toxicology and chemistry. 2016 08; 35(8):1978-85. doi: 10.1002/etc.3345. [PMID: 26678218]
  • Şafak Ulusoy, Özkan Özden, Olaf Päpke. Distribution of OCPs and PCBs in Mussels (Mytilus galloprovincialis) from the Marmara Sea Coastal Sites. Bulletin of environmental contamination and toxicology. 2016 Aug; 97(2):191-7. doi: 10.1007/s00128-016-1848-x. [PMID: 27329111]
  • Todd A Jusko, Anneclaire J De Roos, Sue Y Lee, Kelly Thevenet-Morrison, Stephen M Schwartz, Marc-André Verner, Lubica Palkovicova Murinova, Beata Drobná, Anton Kočan, Anna Fabišiková, Kamil Čonka, Tomas Trnovec, Irva Hertz-Picciotto, B Paige Lawrence. A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination. Environmental health perspectives. 2016 06; 124(6):813-21. doi: 10.1289/ehp.1510101. [PMID: 26649893]
  • Yiqin Chen, Michael S McLachlan, Sarit Kaserzon, Xianyu Wang, Liesbeth Weijs, Michael Gallen, Leisa-Maree L Toms, Yan Li, Lesa L Aylward, Peter D Sly, Jochen F Mueller. Monthly variation in faeces:blood concentration ratio of persistent organic pollutants over the first year of life: a case study of one infant. Environmental research. 2016 May; 147(?):259-68. doi: 10.1016/j.envres.2016.02.017. [PMID: 26918839]
  • Claudia Consales, Gunnar Toft, Giorgio Leter, Jens Peter E Bonde, Raffaella Uccelli, Francesca Pacchierotti, Patrizia Eleuteri, Bo A G Jönsson, Aleksander Giwercman, Henning S Pedersen, Paweł Struciński, Katarzyna Góralczyk, Valentyna Zviezdai, Marcello Spanò. Exposure to persistent organic pollutants and sperm DNA methylation changes in Arctic and European populations. Environmental and molecular mutagenesis. 2016 Apr; 57(3):200-9. doi: 10.1002/em.21994. [PMID: 26801515]
  • Virissa Lenters, Lützen Portengen, Anna Rignell-Hydbom, Bo A G Jönsson, Christian H Lindh, Aldert H Piersma, Gunnar Toft, Jens Peter Bonde, Dick Heederik, Lars Rylander, Roel Vermeulen. Prenatal Phthalate, Perfluoroalkyl Acid, and Organochlorine Exposures and Term Birth Weight in Three Birth Cohorts: Multi-Pollutant Models Based on Elastic Net Regression. Environmental health perspectives. 2016 Mar; 124(3):365-72. doi: 10.1289/ehp.1408933. [PMID: 26115335]
  • Emilie Lund Egsmose, Elvira Vaclavik Bräuner, Marie Frederiksen, Thit Aarøe Mørck, Volkert Dirk Siersma, Pernille Winton Hansen, Flemming Nielsen, Philippe Grandjean, Lisbeth E Knudsen. Associations between plasma concentrations of PCB 28 and possible indoor exposure sources in Danish school children and mothers. Environment international. 2016 Feb; 87(?):13-9. doi: 10.1016/j.envint.2015.11.005. [PMID: 26638015]
  • Aleksandra Szczepkowska, Christine Lagaraine, Vincent Robert, Jarosław Młynarczuk, Laurence Dufourny, Jean-Claude Thiéry, Janina Skipor. PCB153 (2,2',4,4',5,5'-hexachlorobiphenyl) differentially affects the VEGF/VEGFR system depending on photoperiod in the ovine choroid plexus. Ecotoxicology and environmental safety. 2016 Feb; 124(?):303-308. doi: 10.1016/j.ecoenv.2015.11.007. [PMID: 26580897]
  • Hua Shen, Larry W Robertson, Gabriele Ludewig. Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3. Environmental science and pollution research international. 2016 Feb; 23(3):2108-18. doi: 10.1007/s11356-015-4722-1. [PMID: 26006071]
  • Kimberlee B Beckmen, Mandy J Keogh, Kathleen A Burek-Huntington, Gina M Ylitalo, Brian S Fadely, Kenneth W Pitcher. Organochlorine contaminant concentrations in multiple tissues of free-ranging Steller sea lions (Eumetopias jubatus) in Alaska. The Science of the total environment. 2016 Jan; 542(Pt A):441-52. doi: 10.1016/j.scitotenv.2015.10.119. [PMID: 26524270]
  • François-Gaël Michalec, Markus Holzner, Anissa Souissi, Stefka Stancheva, Alexandre Barras, Rabah Boukherroub, Sami Souissi. Lipid nanocapsules for behavioural testing in aquatic toxicology: Time-response of Eurytemora affinis to environmental concentrations of PAHs and PCB. Aquatic toxicology (Amsterdam, Netherlands). 2016 Jan; 170(?):310-322. doi: 10.1016/j.aquatox.2015.08.010. [PMID: 26362585]
  • Nadeem Ali, Lulwa Naseer Ali, Syed Ali Musstjab Akber Shah Eqani, Iqbal Mohammad Ibrahim Ismail, Govindan Malarvannan, Mohammad W Kadi, Jalal Mohammed Al-Badry Basahi, Adrian Covaci. Organohalogenated contaminants in sediments and bivalves from the Northern Arabian Gulf. Ecotoxicology and environmental safety. 2015 Dec; 122(?):432-9. doi: 10.1016/j.ecoenv.2015.09.013. [PMID: 26386334]
  • Rachel G Felton, Cynthia C Steiner, Barbara S Durrant, Duane H Keisler, Matthew R Milnes, Christopher W Tubbs. Identification of California Condor Estrogen Receptors 1 and 2 and Their Activation by Endocrine Disrupting Chemicals. Endocrinology. 2015 Dec; 156(12):4448-57. doi: 10.1210/en.2015-1448. [PMID: 26372180]
  • Sung Yong Eum, Dima Jaraki, Ibolya E András, Michal Toborek. Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2. Toxicology and applied pharmacology. 2015 Sep; 287(3):258-66. doi: 10.1016/j.taap.2015.06.011. [PMID: 26080028]
  • Kine S N Dervola, Espen B Johansen, S Ivar Walaas, Frode Fonnum. Gender-dependent and genotype-sensitive monoaminergic changes induced by polychlorinated biphenyl 153 in the rat brain. Neurotoxicology. 2015 Sep; 50(?):38-45. doi: 10.1016/j.neuro.2015.07.004. [PMID: 26215117]
  • Sunmi Kim, Jeongim Park, Hai-Joong Kim, Jeong Jae Lee, Gyuyeon Choi, Sooran Choi, Sungjoo Kim, Su Young Kim, Duk Hee Lee, Hyo-Bang Moon, Sungkyoon Kim, Kyungho Choi. Association between Several Persistent Organic Pollutants in Serum and Adipokine Levels in Breast Milk among Lactating Women of Korea. Environmental science & technology. 2015 Jul; 49(13):8033-40. doi: 10.1021/acs.est.5b00520. [PMID: 26054256]
  • Katrin S Hoydal, Robert J Letcher, David A D Blair, Maria Dam, Christina Lockyer, Bjørn M Jenssen. Legacy and emerging organic pollutants in liver and plasma of long-finned pilot whales (Globicephala melas) from waters surrounding the Faroe Islands. The Science of the total environment. 2015 Jul; 520(?):270-85. doi: 10.1016/j.scitotenv.2015.03.056. [PMID: 25817764]
  • Katarzyna Góralczyk, Paweł Struciński, Bogdan Wojtyniak, Daniel Rabczenko, Christian H Lindh, Bo A G Jönsson, Gunnar Toft, Virissa Lenters, Katarzyna Czaja, Agnieszka Hernik, Jens Peter Bonde, Henning S Pedersen, Valentyna Zvyezday, Jan K Ludwicki. Is the fact of parenting couples cohabitation affecting the serum levels of persistent organohalogen pollutants?. International journal of hygiene and environmental health. 2015 Jun; 218(4):392-400. doi: 10.1016/j.ijheh.2015.03.005. [PMID: 25836759]
  • Marc-André Verner, Pierrich Plusquellec, Justine Laura Desjardins, Chloé Cartier, Sami Haddad, Pierre Ayotte, Éric Dewailly, Gina Muckle. Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers. Environment international. 2015 May; 78(?):90-94. doi: 10.1016/j.envint.2015.02.004. [PMID: 25796081]
  • Yi Qian, Shuping Zhang, Wenli Guo, Juan Ma, Yue Chen, Lei Wang, Meirong Zhao, Sijin Liu. Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis. Chemical research in toxicology. 2015 Apr; 28(4):629-40. doi: 10.1021/tx500428r. [PMID: 25686467]
  • Kinga Lancz, Irva Hertz-Picciotto, Todd A Jusko, Lubica Murínová, Soňa Wimmerová, Eva Sovčíková, Ladislav Dedík, Maximilián Strémy, Beata Drobná, Dana Farkašová, Tomáš Trnovec. Duration of breastfeeding and serum PCB 153 concentrations in children. Environmental research. 2015 Jan; 136(?):35-9. doi: 10.1016/j.envres.2014.09.036. [PMID: 25460618]
  • Aurélia Mesnier, Serge Champion, Laurence Louis, Christophe Sauzet, Phealay May, Henri Portugal, Karim Benbrahim, Joelle Abraldes, Marie-Christine Alessi, Marie-Josephe Amiot-Carlin, Franck Peiretti, Philippe Piccerelle, Gilles Nalbone, Pierre-Henri Villard. The Transcriptional Effects of PCB118 and PCB153 on the Liver, Adipose Tissue, Muscle and Colon of Mice: Highlighting of Glut4 and Lipin1 as Main Target Genes for PCB Induced Metabolic Disorders. PloS one. 2015; 10(6):e0128847. doi: 10.1371/journal.pone.0128847. [PMID: 26086818]
  • Changjiang Liu, Lianbing Li, Mei Ha, Suqin Qi, Peng Duan, Kedi Yang. The PI3K/Akt and ERK pathways elevate thyroid hormone receptor β1 and TRH receptor to decrease thyroid hormones after exposure to PCB153 and p,p'-DDE. Chemosphere. 2015 Jan; 118(?):229-38. doi: 10.1016/j.chemosphere.2014.09.023. [PMID: 25278044]
  • Juan P Arrebola, Ricardo Ocaña-Riola, Antonio L Arrebola-Moreno, María Fernández-Rodríguez, Piedad Martin-Olmedo, Mariana F Fernández, Nicolás Olea. Associations of accumulated exposure to persistent organic pollutants with serum lipids and obesity in an adult cohort from Southern Spain. Environmental pollution (Barking, Essex : 1987). 2014 Dec; 195(?):9-15. doi: 10.1016/j.envpol.2014.08.003. [PMID: 25173983]
  • L J S Brokken, P J Lundberg, M Spanò, G C Manicardi, H S Pedersen, P Struciński, K Góralczyk, V Zviezdai, B A G Jönsson, J P Bonde, G Toft, Y Lundberg Giwercman, A Giwercman. Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality. Reproductive toxicology (Elmsford, N.Y.). 2014 Nov; 49(?):65-73. doi: 10.1016/j.reprotox.2014.07.073. [PMID: 25084496]
  • Todd A Jusko, Renata Sisto, Ana-Maria Iosif, Arturo Moleti, Sonˇa Wimmerová, Kinga Lancz, Juraj Tihányi, Eva Sovčiková, Beata Drobná, L'ubica Palkovičová, Dana Jurečková, Kelly Thevenet-Morrison, Marc-André Verner, Dean Sonneborn, Irva Hertz-Picciotto, Tomáš Trnovec. Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age. Environmental health perspectives. 2014 Nov; 122(11):1246-52. doi: 10.1289/ehp.1307473. [PMID: 25051575]
  • Changjiang Liu, Mei Ha, Lianbing Li, Kedi Yang. PCB153 and p,p'-DDE disorder thyroid hormones via thyroglobulin, deiodinase 2, transthyretin, hepatic enzymes and receptors. Environmental science and pollution research international. 2014 Oct; 21(19):11361-9. doi: 10.1007/s11356-014-3093-3. [PMID: 24878560]
  • M J Cascaes, R T Oliveira, M M Ubarana, R M Sato, P Baldassin, F I Colabuono, J Leonel, S Taniguchi, R R Weber. Persistent organic pollutants in liver of Brazilian sharpnose shark (Rhizoprionodon lalandii) from southeastern coast of Brazil. Marine pollution bulletin. 2014 Sep; 86(1-2):591-593. doi: 10.1016/j.marpolbul.2014.05.032. [PMID: 25127497]
  • Maria C Ferrante, Paola Amero, Anna Santoro, Anna Monnolo, Raffaele Simeoli, Francesca Di Guida, Giuseppina Mattace Raso, Rosaria Meli. Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes. Toxicology and applied pharmacology. 2014 Sep; 279(3):401-408. doi: 10.1016/j.taap.2014.06.016. [PMID: 24978599]
  • L L Aylward, J J Collins, K M Bodner, M Wilken, C M Bodnar. 'Intrinsic' elimination rate and dietary intake estimates for selected indicator PCBs: toxicokinetic modeling using serial sampling data in US subjects, 2005-2010. Chemosphere. 2014 Sep; 110(?):48-52. doi: 10.1016/j.chemosphere.2014.03.070. [PMID: 24880598]
  • Andreas Sjödin, Arnold Schecter, Richard Jones, Lee-Yang Wong, Justin A Colacino, Noor Malik-Bass, Yalin Zhang, Sarah Anderson, Cheryl McClure, Wayman Turner, Antonia M Calafat. Polybrominated diphenyl ethers, 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentrations in sera collected in 2009 from Texas children. Environmental science & technology. 2014 Jul; 48(14):8196-202. doi: 10.1021/es5016907. [PMID: 24911286]
  • Nicholas A Warner, Therese H Nøst, Hector Andrade, Guttorm Christensen. Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic cod. Environmental pollution (Barking, Essex : 1987). 2014 Jul; 190(?):109-14. doi: 10.1016/j.envpol.2014.03.031. [PMID: 24747104]
  • Fekadu Yadetie, Odd André Karlsen, Marta Eide, Christer Hogstrand, Anders Goksøyr. Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism. BMC genomics. 2014 Jun; 15(?):481. doi: 10.1186/1471-2164-15-481. [PMID: 24939016]
  • Caroline Louis, Carine Van den Daelen, Gilles Tinant, Sophie Bourez, Jean-Pierre Thomé, Isabelle Donnay, Yvan Larondelle, Cathy Debier. Efficient in vitro adipocyte model of long-term lipolysis: a tool to study the behavior of lipophilic compounds. In vitro cellular & developmental biology. Animal. 2014 Jun; 50(6):507-18. doi: 10.1007/s11626-014-9733-6. [PMID: 24477563]
  • Sihem Ben Hassine, Bechir Hammami, Walid Ben Ameur, Yassine El Megdiche, Badriddine Barhoumi, Rached El Abidi, Mohamed Ridha Driss. Concentrations of organochlorine pesticides and polychlorinated biphenyls in human serum and their relation with age, gender, and BMI for the general population of Bizerte, Tunisia. Environmental science and pollution research international. 2014 May; 21(10):6303-13. doi: 10.1007/s11356-013-1480-9. [PMID: 23338993]
  • Natalie Rosenfelder, Walter Vetter. Polychlorinated terphenyl patterns and levels in selected marine mammals and a river fish from different continents. Environment international. 2014 Jan; 62(?):119-24. doi: 10.1016/j.envint.2013.10.008. [PMID: 24211498]
  • Jayanta K Das, Quentin Felty. PCB153-induced overexpression of ID3 contributes to the development of microvascular lesions. PloS one. 2014; 9(8):e104159. doi: 10.1371/journal.pone.0104159. [PMID: 25090023]
  • Andreas Sjödin, Richard S Jones, Samuel P Caudill, Lee-Yang Wong, Wayman E Turner, Antonia M Calafat. Polybrominated diphenyl ethers, polychlorinated biphenyls, and persistent pesticides in serum from the national health and nutrition examination survey: 2003-2008. Environmental science & technology. 2014; 48(1):753-60. doi: 10.1021/es4037836. [PMID: 24298999]
  • Farrukh Aqil, Hua Shen, Jeyaprakash Jeyabalan, Xing Xin, Hans-Joachim Lehmler, Gabriele Ludewig, Larry W Robertson, Ramesh C Gupta. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicology reports. 2014 Jan; 1(?):820-833. doi: 10.1016/j.toxrep.2014.09.010. [PMID: 25530946]
  • Therese Haugdahl Nøst, Knut Breivik, Ole-Martin Fuskevåg, Evert Nieboer, Jon Øyvind Odland, Torkjel Manning Sandanger. Persistent organic pollutants in Norwegian men from 1979 to 2007: intraindividual changes, age-period-cohort effects, and model predictions. Environmental health perspectives. 2013 Nov; 121(11-12):1292-8. doi: 10.1289/ehp.1206317. [PMID: 24007675]
  • Jan O Bustnes, Bård J Bårdsen, Dorte Herzke, Trond V Johnsen, Igor Eulaers, Manuel Ballesteros, Sveinn A Hanssen, Adrian Covaci, Veerle L B Jaspers, Marcel Eens, Christian Sonne, Duncan Halley, Truls Moum, Therese Haugdal Nøst, Kjell E Erikstad, Rolf Anker Ims. Plasma concentrations of organohalogenated pollutants in predatory bird nestlings: associations to growth rate and dietary tracers. Environmental toxicology and chemistry. 2013 Nov; 32(11):2520-7. doi: 10.1002/etc.2329. [PMID: 23861300]
  • Khaled Abass, Antti Huusko, Pentti Nieminen, Päivi Myllynen, Olavi Pelkonen, Kirsi Vahakangas, Arja Rautio. Estimation of health risk by using toxicokinetic modelling: a case study of polychlorinated biphenyl PCB153. Journal of hazardous materials. 2013 Oct; 261(?):1-10. doi: 10.1016/j.jhazmat.2013.07.011. [PMID: 23911823]
  • Marc-André Verner, Robin McDougall, Anders Glynn, Melvin E Andersen, Harvey J Clewell, Matthew P Longnecker. Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics?. Environmental health perspectives. 2013 Oct; 121(10):1219-24. doi: 10.1289/ehp.1206457. [PMID: 23934733]
  • Jennifer M Daley, Ross J Norstrom, Ken G Drouillard. Tissue distribution kinetics of 2,2',4,4',5,5'-hexachlorobiphenyl in ringdoves after oral dosing. Bulletin of environmental contamination and toxicology. 2013 Oct; 91(4):367-71. doi: 10.1007/s00128-013-1069-5. [PMID: 23892364]
  • Danielle Naville, Claudie Pinteur, Nathalie Vega, Yoan Menade, Michèle Vigier, Alexandre Le Bourdais, Emmanuel Labaronne, Cyrille Debard, Céline Luquain-Costaz, Martine Bégeot, Hubert Vidal, Brigitte Le Magueresse-Battistoni. Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013 Sep; 27(9):3860-70. doi: 10.1096/fj.13-231670. [PMID: 23756648]
  • Banrida Wahlang, K Cameron Falkner, Bonnie Gregory, Douglas Ansert, David Young, Daniel J Conklin, Aruni Bhatnagar, Craig J McClain, Matt Cave. Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. The Journal of nutritional biochemistry. 2013 Sep; 24(9):1587-95. doi: 10.1016/j.jnutbio.2013.01.009. [PMID: 23618531]
  • Jessica A O'Neil, Timothy B Johnson, Ken G Drouillard. Validation of rapid assimilation of PCBs following IP dosing in the round goby (Neogobius melanostomus). Bulletin of environmental contamination and toxicology. 2013 Aug; 91(2):135-40. doi: 10.1007/s00128-013-1038-z. [PMID: 23771313]
  • Jie Zhang, Jiren Liang, Hongyan Zhu, Cuizhen Li, Qing Wu. PFOS and PCB 153 have direct adverse effects on neonatal testis modeled using a coculture of primary gonocyte and sertoli cells. Environmental toxicology. 2013 Jun; 28(6):322-31. doi: 10.1002/tox.20723. [PMID: 21544924]
  • Aleksandra Szczepkowska, Christine Lagaraine, Vincent Robert, Laurence Dufourny, Jean-Claude Thiéry, Janina Skipor. Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods. Neurotoxicology and teratology. 2013 May; 37(?):63-7. doi: 10.1016/j.ntt.2013.03.061. [PMID: 23567221]
  • Chao Han, Senbiao Fang, Huiming Cao, Yan Lu, Yaqiong Ma, Dongfeng Wei, Xiaoyun Xie, Xiaohua Liu, Xin Li, Dongqing Fei, Chunyan Zhao. Molecular interaction of PCB153 to human serum albumin: insights from spectroscopic and molecular modeling studies. Journal of hazardous materials. 2013 Mar; 248-249(?):313-21. doi: 10.1016/j.jhazmat.2012.12.056. [PMID: 23416474]
  • Karin E Zimmer, Marianne Kraugerud, Mona Aleksandersen, Arno C Gutleb, Gunn C Østby, Ellen Dahl, Vidar Berg, Janneche U Skaare, Ingrid Olsaker, Erik Ropstad. Fetal adrenal development: comparing effects of combined exposures to PCB 118 and PCB 153 in a sheep model. Environmental toxicology. 2013 Mar; 28(3):164-77. doi: 10.1002/tox.20703. [PMID: 21544918]
  • Changjiang Liu, Mei Ha, Yushan Cui, Chengmin Wang, Maosheng Yan, Wenjuan Fu, Chao Quan, Jun Zhou, Kedi Yang. JNK pathway decreases thyroid hormones via TRH receptor: a novel mechanism for disturbance of thyroid hormone homeostasis by PCB153. Toxicology. 2012 Dec; 302(1):68-76. doi: 10.1016/j.tox.2012.07.016. [PMID: 22889935]
  • Marianne Kraugerud, Mona Aleksandersen, Jens Randel Nyengaard, Gunn C Ostby, Arno C Gutleb, Ellen Dahl, Vidar Berg, Wenche Farstad, Tore Schweder, Janneche U Skaare, Erik Ropstad. In utero and lactational exposure to PCB 118 and PCB 153 alter ovarian follicular dynamics and GnRH-induced luteinizing hormone secretion in female lambs. Environmental toxicology. 2012 Nov; 27(11):623-34. doi: 10.1002/tox.20679. [PMID: 21344607]
  • Evy Van Ael, Adrian Covaci, Ronny Blust, Lieven Bervoets. Persistent organic pollutants in the Scheldt estuary: environmental distribution and bioaccumulation. Environment international. 2012 Nov; 48(?):17-27. doi: 10.1016/j.envint.2012.06.017. [PMID: 22832186]
  • Jan Ove Bustnes, Børge Moe, Sveinn Are Hanssen, Dorte Herzke, Anette A Fenstad, Tore Nordstad, Katrine Borgå, Geir W Gabrielsen. Temporal dynamics of circulating persistent organic pollutants in a fasting seabird under different environmental conditions. Environmental science & technology. 2012 Sep; 46(18):10287-94. doi: 10.1021/es301746j. [PMID: 22938172]
  • Fadheela Al-Salman, Nick Plant. Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner. Toxicology and applied pharmacology. 2012 Aug; 263(1):7-13. doi: 10.1016/j.taap.2012.05.016. [PMID: 22664347]
  • Thomas Schettgen, A Alt, D Preim, D Keller, T Kraus. Biological monitoring of indoor-exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building. Toxicology letters. 2012 Aug; 213(1):116-21. doi: 10.1016/j.toxlet.2011.06.005. [PMID: 21699966]
  • Lars Rylander, Carl-Magnus Björkdahl, Anna Axmon, Aleksander Giwercman, Bo A G Jönsson, Christian Lindh, Anna Rignell-Hydbom. Very high correlations between fresh weight and lipid-adjusted PCB-153 serum concentrations: irrespective of fasting status, age, body mass index, gender, or exposure distributions. Chemosphere. 2012 Aug; 88(7):828-31. doi: 10.1016/j.chemosphere.2012.03.089. [PMID: 22546635]
  • Charlotta Rylander, Eiliv Lund, Livar Frøyland, Torkjel M Sandanger. Predictors of PCP, OH-PCBs, PCBs and chlorinated pesticides in a general female Norwegian population. Environment international. 2012 Aug; 43(?):13-20. doi: 10.1016/j.envint.2012.02.008. [PMID: 22459059]
  • Xue Shi, Banrida Wahlang, Xiaoli Wei, Xinmin Yin, K Cameron Falkner, Russell A Prough, Seong Ho Kim, Eugene G Mueller, Craig J McClain, Matthew Cave, Xiang Zhang. Metabolomic analysis of the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease. Journal of proteome research. 2012 Jul; 11(7):3805-15. doi: 10.1021/pr300297z. [PMID: 22686559]
  • Agung Dhamar Syakti, Laurence Asia, Fehmi Kanzari, Halikkudin Umasangadji, Laure Malleret, Yann Ternois, Gilbert Mille, Pierre Doumenq. Distribution of organochlorine pesticides (OCs) and polychlorinated biphenyls (PCBs) in marine sediments directly exposed to wastewater from Cortiou, Marseille. Environmental science and pollution research international. 2012 Jun; 19(5):1524-35. doi: 10.1007/s11356-011-0640-z. [PMID: 22051976]
  • Olivier Boucher, Matthew J Burden, Gina Muckle, Dave Saint-Amour, Pierre Ayotte, Éric Dewailly, Charles A Nelson, Sandra W Jacobson, Joseph L Jacobson. Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury. Environmental health perspectives. 2012 Apr; 120(4):608-15. doi: 10.1289/ehp.1103828. [PMID: 22142904]
  • Janina Skipor, Jarosław Młynarczuk, Aleksandra Szczepkowska, Christine Lagaraine, Adam Grochowalski, Daniel Guillaume, Laurence Dufourny, Jean-Claude Thiéry. Photoperiod modulates access of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) to the brain and its effect on gonadotropin and thyroid hormones in adult ewes. Ecotoxicology and environmental safety. 2012 Apr; 78(?):336-43. doi: 10.1016/j.ecoenv.2011.11.042. [PMID: 22197259]
  • Eva Govarts, Mark Nieuwenhuijsen, Greet Schoeters, Ferran Ballester, Karolien Bloemen, Michiel de Boer, Cécile Chevrier, Merete Eggesbø, Mònica Guxens, Ursula Krämer, Juliette Legler, David Martínez, Lubica Palkovicova, Evridiki Patelarou, Ulrich Ranft, Arja Rautio, Maria Skaalum Petersen, Rémy Slama, Hein Stigum, Gunnar Toft, Tomas Trnovec, Stéphanie Vandentorren, Pál Weihe, Nynke Weisglas Kuperus, Michael Wilhelm, Jürgen Wittsiepe, Jens Peter Bonde. Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts. Environmental health perspectives. 2012 Feb; 120(2):162-70. doi: 10.1289/ehp.1103767. [PMID: 21997443]
  • Sophie Bourez, Soazig Le Lay, Carine Van den Daelen, Caroline Louis, Yvan Larondelle, Jean-Pierre Thomé, Yves-Jacques Schneider, Isabelle Dugail, Cathy Debier. Accumulation of polychlorinated biphenyls in adipocytes: selective targeting to lipid droplets and role of caveolin-1. PloS one. 2012; 7(2):e31834. doi: 10.1371/journal.pone.0031834. [PMID: 22363745]