Lipid A (BioDeep_00000009657)

 

Secondary id: BioDeep_00000639469, BioDeep_00001080618

human metabolite


代谢物信息卡片


{[(2R,3S,4R,5R,6R)-5-[(3R)-3-(dodecanoyloxy)tetradecanamido]-6-{[(2R,3S,4R,5R,6R)-3-hydroxy-5-[(3R)-3-hydroxytetradecanamido]-4-{[(3R)-3-hydroxytetradecanoyl]oxy}-6-(phosphonooxy)oxan-2-yl]methoxy}-2-(hydroxymethyl)-4-{[(3R)-3-(tetradecanoyloxy)tetradecanoyl]oxy}oxan-3-yl]oxy}phosphonic acid

化学式: C94H178N2O25P2 (1797.2193278)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC
InChI: InChI=1S/C94H178N2O25P2/c1-7-13-19-25-31-37-38-44-50-56-62-68-84(103)115-78(66-60-54-48-42-35-29-23-17-11-5)72-86(105)119-92-88(96-82(101)71-77(65-59-53-47-41-34-28-22-16-10-4)114-83(102)67-61-55-49-43-36-30-24-18-12-6)93(116-79(73-97)90(92)120-122(107,108)109)113-74-80-89(106)91(118-85(104)70-76(99)64-58-52-46-40-33-27-21-15-9-3)87(94(117-80)121-123(110,111)112)95-81(100)69-75(98)63-57-51-45-39-32-26-20-14-8-2/h75-80,87-94,97-99,106H,7-74H2,1-6H3,(H,95,100)(H,96,101)(H2,107,108,109)(H2,110,111,112)/t75-,76-,77-,78-,79-,80-,87-,88-,89-,90-,91-,92-,93-,94-/m1/s1

描述信息

Lipid A is a lipid component of an endotoxin held responsible for toxicity of Gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS, also called endotoxin) molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. While its toxic effects can be damaging, the sensing of lipid A by the human immune system may also be critical for the onset of immune responses to Gram-negative infection, and for the subsequent successful fight against the infection. Many of the immune activating abilities of LPS can be attributed to the lipid A unit. It is a very potent stimulant of the immune system, activating cells (for example, monocytes or macrophages) at picogram per milliliter quantities. Lipid A has been found in Escherichia, Pseudomonas, Salmonella and meningococcus (PMID: 11948150; PMID: 12045108).
Lipid A is a lipid component of an endotoxin held responsible for toxicity of Gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS, also called endotoxin) molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. While its toxic effects can be damaging, the sensing of lipid A by the human immune system may also be critical for the onset of immune responses to Gram-negative infection, and for the subsequent successful fight against the infection.; Many of the immune activating abilities of LPS can be attributed to the lipid A unit. It is a very potent stimulant of the immune system, activating cells (for example, monocytes or macrophages) at picogram per milliliter quantities. [HMDB]

同义名列表

7 个代谢物同义名

{[(2R,3S,4R,5R,6R)-5-[(3R)-3-(dodecanoyloxy)tetradecanamido]-6-{[(2R,3S,4R,5R,6R)-3-hydroxy-5-[(3R)-3-hydroxytetradecanamido]-4-{[(3R)-3-hydroxytetradecanoyl]oxy}-6-(phosphonooxy)oxan-2-yl]methoxy}-2-(hydroxymethyl)-4-{[(3R)-3-(tetradecanoyloxy)tetradecanoyl]oxy}oxan-3-yl]oxy}phosphonic acid; Lipid A, diphosphoryl from Escherichia coli F583 (Rd mutant); Diphosphoryl hexaacyl lipid a; Synthetic e. coli lipid a; E. coli lipid a; a, Lipid; Lipid A



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Danyang Huang, Lingyan Chen, Yang Wang, Zhe Wang, Jianli Wang, Xiaoyuan Wang. Characterization of a secondary hydroxy-acyltransferase for lipid A in Vibrio parahaemolyticus. Microbiological research. 2024 Jun; 283(?):127712. doi: 10.1016/j.micres.2024.127712. [PMID: 38593580]
  • Ali Jalili, Fereshteh Shojaei-Ghahrizjani, Mohammad Amin Tabatabaiefar, Shima Rahmati. Decellularized skin pretreatment by monophosphoryl lipid A and lactobacillus casei supernatant accelerate skin recellularization. Molecular biology reports. 2024 May; 51(1):675. doi: 10.1007/s11033-024-09599-y. [PMID: 38787484]
  • Taigh Anderson, Hao Jiang, Aisling Ní Cheallaigh, Dennis Bengtsson, Stefan Oscarson, Chantelle Cairns, Frank St Michael, Andrew Cox, Michelle M Kuttel. Formation and immunological evaluation of Moraxella catarrhalis glycoconjugates based on synthetic oligosaccharides. Carbohydrate polymers. 2024 May; 332(?):121928. doi: 10.1016/j.carbpol.2024.121928. [PMID: 38431400]
  • Rajendra Rohokale, Jiatong Guo, Zhongwu Guo. Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants. Journal of medicinal chemistry. 2024 May; 67(9):7458-7469. doi: 10.1021/acs.jmedchem.3c02385. [PMID: 38634150]
  • Divyapriya Karthikeyan, Sanjit Kumar, N S Jayaprakash. A comprehensive review of recent developments in the gram-negative bacterial UDP-2,3-diacylglucosamine hydrolase (LpxH) enzyme. International journal of biological macromolecules. 2024 May; 267(Pt 2):131327. doi: 10.1016/j.ijbiomac.2024.131327. [PMID: 38574903]
  • Dong-Ha Lee, Jueun Lee, So Yeon Ahn, Thi Len Ho, Kiyeon Kim, Eun-Ju Ko. Monophosphoryl lipid A and poly I:C combination enhances immune responses of equine influenza virus vaccine. Veterinary immunology and immunopathology. 2024 May; 271(?):110743. doi: 10.1016/j.vetimm.2024.110743. [PMID: 38522410]
  • Molly Dorothy Pither, Emanuela Andretta, Giuseppe Rocca, Fabio Balzarini, Alejandra Matamoros-Recio, Roberta Colicchio, Paola Salvatore, Yvette van Kooyk, Alba Silipo, Francesca Granucci, Sonsoles Martin-Santamaria, Fabrizio Chiodo, Antonio Molinaro, Flaviana Di Lorenzo. Deciphering the Chemical Language of the Immunomodulatory Properties of Veillonella parvula Lipopolysaccharide. Angewandte Chemie (International ed. in English). 2024 Apr; 63(17):e202401541. doi: 10.1002/anie.202401541. [PMID: 38393988]
  • Joshua A Mettlach, Melina B Cian, Medha Chakraborty, Zachary D Dalebroux. Signaling through the Salmonella PbgA-LapB regulatory complex activates LpxC proteolysis and limits lipopolysaccharide biogenesis during stationary-phase growth. Journal of bacteriology. 2024 Apr; 206(4):e0030823. doi: 10.1128/jb.00308-23. [PMID: 38534107]
  • ZhangFei Su, Aicheng Chen, Jacek Lipkowski. Electrochemical and Infrared Studies of a Model Bilayer of the Outer Membrane of Gram-Negative Bacteria and its Interaction with polymyxin─the Last-Resort Antibiotic. Langmuir : the ACS journal of surfaces and colloids. 2024 Apr; 40(15):8248-8259. doi: 10.1021/acs.langmuir.4c00480. [PMID: 38578277]
  • Emanuela Andretta, Stefania De Chiara, Chiara Pagliuca, Roberta Cirella, Elena Scaglione, Martina Di Rosario, Maxim S Kokoulin, Olga I Nedashkovskaya, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo. Increasing outer membrane complexity: the case of the lipopolysaccharide lipid A from marine Cellulophaga pacifica. Glycoconjugate journal. 2024 Apr; 41(2):119-131. doi: 10.1007/s10719-024-10149-8. [PMID: 38642279]
  • Kishore R Alugupalli. Monophosphoryl Lipid A-based Adjuvant to Promote the Immunogenicity of Multivalent Meningococcal Polysaccharide Conjugate Vaccines. ImmunoHorizons. 2024 Apr; 8(4):317-325. doi: 10.4049/immunohorizons.2400013. [PMID: 38625118]
  • Saugata Majumder, Shreya Das, Peng Li, Nicole Yang, Hazel Dellario, Haixin Sui, Ziqiang Guan, Wei Sun. Pneumonic Plague Protection Induced by a Monophosphoryl Lipid A Decorated Yersinia Outer-Membrane-Vesicle Vaccine. Small (Weinheim an der Bergstrasse, Germany). 2024 Apr; 20(15):e2307066. doi: 10.1002/smll.202307066. [PMID: 38009518]
  • Flavien Dardelle, Capucine Phelip, Maryam Darabi, Tatiana Kondakova, Xavier Warnet, Edyta Combret, Eugenie Juranville, Alexey Novikov, Jerome Kerzerho, Martine Caroff. Diversity, Complexity, and Specificity of Bacterial Lipopolysaccharide (LPS) Structures Impacting Their Detection and Quantification. International journal of molecular sciences. 2024 Mar; 25(7):. doi: 10.3390/ijms25073927. [PMID: 38612737]
  • Katherine R Hummels. mSphere of Influence: Celebrating exceptions to the rule of lipid A essentiality. mSphere. 2024 Mar; 9(3):e0063323. doi: 10.1128/msphere.00633-23. [PMID: 38421175]
  • Hyunjung Jin, Yuhyun Ji, Jinsu An, Da Hui Ha, Ye-Ram Lee, Hye-Ji Kim, Choon Geun Lee, Wooyeon Jeong, Ick Chan Kwon, Eun Gyeong Yang, Ki Hun Kim, Chankyu Lee, Hak Suk Chung. Engineering Escherichia coli for constitutive production of monophosphoryl lipid A vaccine adjuvant. Biotechnology and bioengineering. 2024 Mar; 121(3):1144-1162. doi: 10.1002/bit.28638. [PMID: 38184812]
  • Kanchi Baijal, Iryna Abramchuk, Carmen M Herrera, Thien-Fah Mah, M Stephen Trent, Mathieu Lavallée-Adam, Michael Downey. Polyphosphate kinase regulates LPS structure and polymyxin resistance during starvation in E. coli. PLoS biology. 2024 Mar; 22(3):e3002558. doi: 10.1371/journal.pbio.3002558. [PMID: 38478588]
  • Jeongik Cho, Hye-Won Hong, Kyungah Park, Heejoon Myung, Hyunjin Yoon. Unveiling the mechanism of bactericidal activity of a cecropin A-fused endolysin LNT113. International journal of biological macromolecules. 2024 Mar; 260(Pt 1):129493. doi: 10.1016/j.ijbiomac.2024.129493. [PMID: 38224804]
  • L López-Valencia, M Moya, B Escudero, B García-Bueno, L Orio. Bacterial lipopolysaccharide forms aggregates with apolipoproteins in male and female rat brains after ethanol binges. Journal of lipid research. 2024 03; 65(3):100509. doi: 10.1016/j.jlr.2024.100509. [PMID: 38295984]
  • Chandran Sivasankar, Khristine Kaith Sison Lloren, John Hwa Lee. Deciphering the Interrelationship of arnT Involved in Lipid-A Alteration with the Virulence of Salmonella Typhimurium. International journal of molecular sciences. 2024 Feb; 25(5):. doi: 10.3390/ijms25052760. [PMID: 38474006]
  • Saranya Vijayakumar, Rayapadi G Swetha, Yamuna Devi Bakthavatchalam, Karthick Vasudevan, Baby Abirami Shankar, Agilandeeswari Kirubananthan, Kamini Walia, Sudha Ramaiah, Indranil Biswas, Balaji Veeraraghavan, Anand Anbarasu. Genomic investigation unveils colistin resistance mechanism in carbapenem-resistant Acinetobacter baumannii clinical isolates. Microbiology spectrum. 2024 Feb; 12(2):e0251123. doi: 10.1128/spectrum.02511-23. [PMID: 38214512]
  • Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Azusa Saika, Haruki Yamaura, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue. International immunology. 2024 Jan; 36(1):33-43. doi: 10.1093/intimm/dxad045. [PMID: 38006376]
  • Hyojik Yang, Victoria I Verhoeve, Courtney E Chandler, Shreeram Nallar, Greg A Snyder, Robert K Ernst, Joseph J Gillespie. Structural determination of Rickettsia lipid A without chemical extraction confirms shorter acyl chains in later-evolving spotted fever group pathogens. mSphere. 2024 Jan; ?(?):e0060923. doi: 10.1128/msphere.00609-23. [PMID: 38259062]
  • Casey E Hofstaedter, Courtney E Chandler, Charles M Met, Joseph J Gillespie, Janette M Harro, David R Goodlett, David A Rasko, Robert K Ernst. Divergent Pseudomonas aeruginosa LpxO enzymes perform site-specific lipid A 2-hydroxylation. mBio. 2023 Dec; ?(?):e0282323. doi: 10.1128/mbio.02823-23. [PMID: 38131669]
  • Jesús Pérez-Ortega, Ria van Boxtel, Michel Plisnier, Dominique Ingels, Nathalie Devos, Steven Sijmons, Jan Tommassen. Biosynthesis of the Inner Core of Bordetella pertussis Lipopolysaccharides: Effect of Mutations on LPS Structure, Cell Division, and Toll-like Receptor 4 Activation. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417313. [PMID: 38139140]
  • Lujie Liang, Lan-Lan Zhong, Lin Wang, Dianrong Zhou, Yaxin Li, Jiachen Li, Yong Chen, Wanfei Liang, Wenjing Wei, Chenchen Zhang, Hui Zhao, Lingxuan Lyu, Nicole Stoesser, Yohei Doi, Fang Bai, Siyuan Feng, Guo-Bao Tian. A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide. PLoS biology. 2023 Dec; 21(12):e3002433. doi: 10.1371/journal.pbio.3002433. [PMID: 38091366]
  • Suyeon Park, Jihyun Choi, Dongwoo Shin, Ki Tae Kwon, Si-Ho Kim, Yu Mi Wi, Kwan Soo Ko. Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy. International journal of antimicrobial agents. 2023 Oct; ?(?):107017. doi: 10.1016/j.ijantimicag.2023.107017. [PMID: 37884228]
  • Melanie N Hurst, Connor J Beebout, Alexis Hollingsworth, Kirsten R Guckes, Alexandria Purcell, Tomas A Bermudez, Diamond Williams, Seth A Reasoner, M Stephen Trent, Maria Hadjifrangiskou. The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS. mSphere. 2023 10; 8(5):e0005923. doi: 10.1128/msphere.00059-23. [PMID: 37676915]
  • Alejandra Matamoros-Recio, Javier Merino, Alicia Gallego-Jiménez, Raquel Conde-Alvarez, Manuel Fresno, Sonsoles Martín-Santamaría. Immune evasion through Toll-like receptor 4: The role of the core oligosaccharides from α2-Proteobacteria atypical lipopolysaccharides. Carbohydrate polymers. 2023 Oct; 318(?):121094. doi: 10.1016/j.carbpol.2023.121094. [PMID: 37479429]
  • Yukihiro Hiramatsu, Takashi Nishida, Natsuko Ota, Yuki Tamaki, Dendi K Nugraha, Yasuhiko Horiguchi. DAT, deacylating autotransporter toxin, from Bordetella parapertussis demyristoylates Gαi GTPases and contributes to cough. Proceedings of the National Academy of Sciences of the United States of America. 2023 10; 120(40):e2308260120. doi: 10.1073/pnas.2308260120. [PMID: 37748060]
  • Daniel Muñoz-Escudero, Steven D Breazeale, Myeongseon Lee, Ziqiang Guan, Christian R H Raetz, Marcelo C Sousa. Structure and Function of ArnD. A Deformylase Essential for Lipid A Modification with 4-Amino-4-deoxy-l-arabinose and Polymyxin Resistance. Biochemistry. 2023 Oct; ?(?):. doi: 10.1021/acs.biochem.3c00293. [PMID: 37782650]
  • Zhen Wang, Aizhen Zhao, Jun Qiao, Jing Yu, Fenfang He, Yibing Bi, Letong Yu, Xiaoyuan Wang. Engineering Escherichia coli MG1655 to Efficiently Produce 3-Deacyl-4'-monophosphoryl Lipid A. Journal of agricultural and food chemistry. 2023 Sep; 71(36):13376-13390. doi: 10.1021/acs.jafc.3c00681. [PMID: 37656614]
  • Rakesh Vaiwala, K Ganapathy Ayappa. Martini-3 Coarse-Grained Models for the Bacterial Lipopolysaccharide Outer Membrane of Escherichia coli. Journal of chemical theory and computation. 2023 Sep; ?(?):. doi: 10.1021/acs.jctc.3c00471. [PMID: 37676287]
  • Vanessa Rogga, Ivan Kosalec. Untying the anchor for the lipopolysaccharide: lipid A structural modification systems offer diagnostic and therapeutic options to tackle polymyxin resistance. Arhiv za higijenu rada i toksikologiju. 2023 Sep; 74(3):145-166. doi: 10.2478/aiht-2023-74-3717. [PMID: 37791675]
  • Jinshi Zhao, C Skyler Cochrane, Javaria Najeeb, David Gooden, Carly Sciandra, Ping Fan, Nadine Lemaitre, Kate Newns, Robert A Nicholas, Ziqiang Guan, Joshua T Thaden, Vance G Fowler, Ivan Spasojevic, Florent Sebbane, Eric J Toone, Clayton Duncan, Richard Gammans, Pei Zhou. Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Science translational medicine. 2023 Aug; 15(708):eadf5668. doi: 10.1126/scitranslmed.adf5668. [PMID: 37556556]
  • Alessio Borio, Aurora Holgado, Christina Passegger, Herbert Strobl, Rudi Beyaert, Holger Heine, Alla Zamyatina. Exploring Species-Specificity in TLR4/MD-2 Inhibition with Amphiphilic Lipid A Mimicking Glycolipids. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28165948. [PMID: 37630200]
  • Marco Tamborrini, Anja Schäfer, Julia Hauser, Linghui Zou, Daniel H Paris, Gerd Pluschke. The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals. Malaria journal. 2023 Jul; 22(1):210. doi: 10.1186/s12936-023-04638-8. [PMID: 37454145]
  • Daniela P Lage, Vívian T Martins, Danniele L Vale, Camila S Freitas, Breno L Pimenta, Gabriel J L Moreira, Fernanda F Ramos, Isabela A G Pereira, Raquel S Bandeira, Marcelo M de Jesus, Fernanda Ludolf, Grasiele S V Tavares, Miguel A Chávez-Fumagalli, Bruno M Roatt, Myron Christodoulides, Eduardo A F Coelho. The association between rLiHyp1 protein plus adjuvant and amphotericin B is an effective immunotherapy against visceral leishmaniasis in mice. Acta tropica. 2023 Jul; ?(?):106986. doi: 10.1016/j.actatropica.2023.106986. [PMID: 37453579]
  • Jing Lu, Meiling Han, Heidi H Yu, Phillip J Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov. Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae. Microbiology spectrum. 2023 Jul; ?(?):e0085223. doi: 10.1128/spectrum.00852-23. [PMID: 37432123]
  • Valeria Castelletto, Jani Seitsonen, Ian W Hamley. Effect of Glycosylation on Self-Assembly of Lipid A Lipopolysaccharides in Aqueous Solutions. Langmuir : the ACS journal of surfaces and colloids. 2023 Jun; 39(24):8516-8522. doi: 10.1021/acs.langmuir.3c00828. [PMID: 37289534]
  • Negar Mozaheb, Paria Rasouli, Mandeep Kaur, Patrick Van Der Smissen, Gerald Larrouy-Maumus, Marie-Paule Mingeot-Leclercq. A Mildly Acidic Environment Alters Pseudomonas aeruginosa Virulence and Causes Remodeling of the Bacterial Surface. Microbiology spectrum. 2023 Jun; ?(?):e0483222. doi: 10.1128/spectrum.04832-22. [PMID: 37278652]
  • Huangdu Hu, Qiucheng Shi, Ping Zhang, Jingjing Quan, Xinhong Han, Dongdong Zhao, Huichuan Zhang, Qian Wang, Yan Jiang, Yunsong Yu. Prevalence and molecular characteristics of colistin-resistant isolates among clinically isolated carbapenem-resistant Klebsiella pneumoniae in China. International journal of antimicrobial agents. 2023 Jun; ?(?):106873. doi: 10.1016/j.ijantimicag.2023.106873. [PMID: 37276893]
  • Sun Ju Kim, Jeongwoo Jo, Kwan Soo Ko. Lipid A modification-induced colistin-resistant Klebsiella variicola from healthy adults. Journal of medical microbiology. 2023 Jun; 72(6):. doi: 10.1099/jmm.0.001680. [PMID: 37261959]
  • Ramin Baghaee, Shima Rahmati, Mehdi Banitalebi, Lotfollah Afzali. Comparison of human acellular amniotic membranes with acellular amniotic membranes pretreated with MPLA for repair of fascia in rats. Cell and tissue banking. 2023 Jun; 24(2):495-501. doi: 10.1007/s10561-022-10049-x. [PMID: 36434168]
  • Maryia Khomich, Huang Lin, Andrei Malinovschi, Susanne Brix, Lucia Cestelli, Shyamal Peddada, Ane Johannessen, Carsten Eriksen, Francisco Gomez Real, Cecilie Svanes, Randi Jacobsen Bertelsen. Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort. Journal of translational medicine. 2023 May; 21(1):354. doi: 10.1186/s12967-023-04199-z. [PMID: 37246224]
  • Hyojik Yang, Matthew E Sherman, Caitlyn J Koo, Logan M Treaster, Joseph P Smith, Shawn G Gallaher, David R Goodlett, Charles R Sweet, Robert K Ernst. Structure Determination of Lipid A with Multiple Glycosylation Sites by Tandem MS of Lithium-Adducted Negative Ions. Journal of the American Society for Mass Spectrometry. 2023 May; ?(?):. doi: 10.1021/jasms.3c00014. [PMID: 37184080]
  • Antonio De Nicola, Costanza Montis, Greta Donati, Antonio Molinaro, Alba Silipo, Arianna Balestri, Debora Berti, Flaviana Di Lorenzo, You-Liang Zhu, Giuseppe Milano. Bacterial lipids drive compartmentalization on the nanoscale. Nanoscale. 2023 May; ?(?):. doi: 10.1039/d3nr00559c. [PMID: 37144495]
  • Qiwei Chen, Heng Quan, Yongfeng Yu, Donghui Liu, Caiyu Li, Yuefeng Chu, Xiaowei Gong. EptA of Riemerella anatipestifer mediates phenotypes involved in colistin resistance and virulence. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023 05; 37(5):e22928. doi: 10.1096/fj.202300215r. [PMID: 37071453]
  • Siru Wu, Cong Zhang, Yibo Wang, Penghui Li, Xiubo Du, Xiaohui Wang. Dissecting the species-specific recognition of Neoseptin 3 by TLR4/MD2 via molecular dynamics simulations. Physical chemistry chemical physics : PCCP. 2023 Apr; ?(?):. doi: 10.1039/d3cp00949a. [PMID: 37102696]
  • Chamith Hewawaduge, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee. The impact of lipid A modification on biofilm and related pathophysiological phenotypes, endotoxicity, immunogenicity, and protection of Salmonella Typhimurium. Veterinary microbiology. 2023 Apr; 282(?):109759. doi: 10.1016/j.vetmic.2023.109759. [PMID: 37104940]
  • Monika Adori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquin Castro Dopico, Gunilla B Karlsson Hedestam. Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells. Cells. 2023 04; 12(9):. doi: 10.3390/cells12091229. [PMID: 37174629]
  • Alexandria B Purcell, Brent W Simpson, M Stephen Trent. Impact of the cAMP-cAMP Receptor Protein Regulatory Complex on Lipopolysaccharide Modifications and Polymyxin B Resistance in Escherichia coli. Journal of bacteriology. 2023 Apr; ?(?):e0006723. doi: 10.1128/jb.00067-23. [PMID: 37070977]
  • Renate Frantz, Konrad Gwozdzinski, Nicolas Gisch, Swapnil Prakash Doijad, Martina Hudel, Maria Wille, Mobarak Abu Mraheil, Dominik Schwudke, Can Imirzalioglu, Linda Falgenhauer, Michael Ehrmann, Trinad Chakraborty. A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience. Microbiology spectrum. 2023 Apr; ?(?):e0359222. doi: 10.1128/spectrum.03592-22. [PMID: 37071007]
  • Roberta Cirella, Chiara Pagliuca, Molly Dorothy Pither, Elena Scaglione, Olga I Nedashkovskaya, Oleg V Chernikov, Kuo-Feng Hua, Roberta Colicchio, Mariateresa Vitiello, Maxim S Kokoulin, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo. Pushing the Boundaries of Structural Heterogeneity with the Lipid A of Marine Bacteria Cellulophaga. Chembiochem : a European journal of chemical biology. 2023 Apr; ?(?):e202300183. doi: 10.1002/cbic.202300183. [PMID: 37042436]
  • Cristina González-Fernández, Christoph Öhlknecht, Matthias Diem, Yerko Escalona, Eugenio Bringas, Gabriel Moncalián, Chris Oostenbrink, Inmaculada Ortiz. Insights into the Binding Mode of Lipid A to the Anti-lipopolysaccharide Factor ALFPm3 from Penaeus monodon: An In Silico Study through MD Simulations. Journal of chemical information and modeling. 2023 Apr; ?(?):. doi: 10.1021/acs.jcim.3c00173. [PMID: 37026789]
  • Seung-Hwa Kwak, C Skyler Cochrane, Jae Cho, Patrick A Dome, Amanda F Ennis, Jea Hyun Kim, Pei Zhou, Jiyong Hong. Development of LpxH inhibitors chelating the active site di-manganese metal cluster of LpxH. ChemMedChem. 2023 Apr; ?(?):e202300023. doi: 10.1002/cmdc.202300023. [PMID: 37014664]
  • Fan Ji, Danyang Huang, Xin Tan, Yong Guo, Zhen Wang, Qing Zhou, Xiaoyuan Wang. Structure analysis of lipid A species in Vibrio parahaemolyticus by constructing mutants lacking multiple secondary acyltransferases of lipid A. Biotechnology and applied biochemistry. 2023 Apr; 70(2):716-729. doi: 10.1002/bab.2393. [PMID: 35913040]
  • Ya Gao, Göran Widmalm, Wonpil Im. Modeling and Simulation of Bacterial Outer Membranes with Lipopolysaccharides and Capsular Polysaccharides. Journal of chemical information and modeling. 2023 03; 63(5):1592-1601. doi: 10.1021/acs.jcim.3c00072. [PMID: 36802606]
  • Masafumi Sakuma, Masahito Hashimoto, Kanako Nishi, Mari Tohya, Tomomi Hishinuma, Masahiro Shimojima, Tatsuya Tada, Teruo Kirikae. Emergence of colistin-resistant Acinetobacter modestus harbouring the intrinsic phosphoethanolamine transferase EptA. Journal of global antimicrobial resistance. 2023 Mar; 33(?):101-108. doi: 10.1016/j.jgar.2023.02.023. [PMID: 36906175]
  • Jesús Pérez-Ortega, Roel M van Harten, Henk P Haagsman, Jan Tommassen. Physiological consequences of inactivation of lgmB and lpxL1, two genes involved in lipid A synthesis in Bordetella bronchiseptica. Research in microbiology. 2023 Mar; ?(?):104049. doi: 10.1016/j.resmic.2023.104049. [PMID: 36871896]
  • Hamdullah Khadim Sheikh, Tanzila Arshad, Uzma Habib, Seyedeh Zahra Mirmohammadi, Rafia Usman, Muhammad Mohtasheemul Hassan. Arresting the biosynthesis of Lipid A to hinder Escherichia coli and Pseudomonas aeruginosa through fatty diglyceride. Pakistan journal of pharmaceutical sciences. 2023 Mar; 36(2):409-415. doi: ". [PMID: 37530147]
  • Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Ken J Ishii, Shizuo Akira, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. International immunopharmacology. 2023 Feb; 117(?):109852. doi: 10.1016/j.intimp.2023.109852. [PMID: 36806039]
  • Hwanjin Joo, Hyunuk Eom, Youna Cho, Mina Rho, Woon Ju Song. Discovery and Characterization of Polymyxin-Resistance Genes pmrE and pmrF from Sediment and Seawater Microbiome. Microbiology spectrum. 2023 Feb; 11(1):e0273622. doi: 10.1128/spectrum.02736-22. [PMID: 36602384]
  • Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana E Adade, Dervla T D Kenna, Beverley C Millar, John E Moore, José Ramos Vivas, Antonio Molinaro, Miguel A Valvano. Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide. Microbiology spectrum. 2023 Feb; 11(1):e0372922. doi: 10.1128/spectrum.03729-22. [PMID: 36519943]
  • Yong Guo, Fan Ji, Jun Qiao, Xiaofei Dong, Yuanming Wu, Xiaoyuan Wang. Overexpression of the key genes in the biosynthetic pathways of lipid A and peptidoglycan in Escherichia coli. Biotechnology and applied biochemistry. 2023 Feb; 70(1):374-386. doi: 10.1002/bab.2364. [PMID: 35644907]
  • Ximin Zeng, Atsushi Hinenoya, Ziqiang Guan, Fuzhou Xu, Jun Lin. Critical role of the RpoE stress response pathway in polymyxin resistance of Escherichia coli. The Journal of antimicrobial chemotherapy. 2023 Jan; ?(?):. doi: 10.1093/jac/dkad003. [PMID: 36658759]
  • Zhen Wang, Aizhen Zhao, Chenhui Wang, Danyang Huang, Jing Yu, Letong Yu, Yuanming Wu, Xiaoyuan Wang. Metabolic engineering of Escherichia coli to efficiently produce monophosphoryl lipid A. Biotechnology and applied biochemistry. 2023 Jan; ?(?):. doi: 10.1002/bab.2443. [PMID: 36659840]
  • George Necula, Mihaela Bacalum, Mihai Radu. Interaction of Tryptophan- and Arginine-Rich Antimicrobial Peptide with E. coli Outer Membrane-A Molecular Simulation Approach. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032005. [PMID: 36768325]
  • Xue Li Guan, Johnathan Yi-Xiong Loh, Marco Lizwan, Sharon Cui Mun Chan, Jeric Mun Chung Kwan, Tze Peng Lim, Tse Hsien Koh, Li-Yang Hsu, Bernett Teck Kwong Lee. LipidA-IDER to Explore the Global Lipid A Repertoire of Drug-Resistant Gram-Negative Bacteria. Analytical chemistry. 2023 01; 95(2):602-611. doi: 10.1021/acs.analchem.1c03566. [PMID: 36599414]
  • Swapnil Prakash Doijad, Nicolas Gisch, Renate Frantz, Bajarang Vasant Kumbhar, Jane Falgenhauer, Can Imirzalioglu, Linda Falgenhauer, Alexander Mischnik, Jan Rupp, Michael Behnke, Michael Buhl, Simone Eisenbeis, Petra Gastmeier, Hanna Gölz, Georg Alexander Häcker, Nadja Käding, Winfried V Kern, Axel Kola, Evelyn Kramme, Silke Peter, Anna M Rohde, Harald Seifert, Evelina Tacconelli, Maria J G T Vehreschild, Sarah V Walker, Janine Zweigner, Dominik Schwudke, Trinad Chakraborty. Resolving colistin resistance and heteroresistance in Enterobacter species. Nature communications. 2023 Jan; 14(1):140. doi: 10.1038/s41467-022-35717-0. [PMID: 36627272]
  • Ibrahim Aissa, Ágnes Dörnyei, Viktor Sándor, Anikó Kilár. Complete Structural Elucidation of Monophosphorylated Lipid A by CID Fragmentation of Protonated Molecule and Singly Charged Sodiated Adducts. Journal of the American Society for Mass Spectrometry. 2023 Jan; 34(1):92-100. doi: 10.1021/jasms.2c00269. [PMID: 36539922]
  • Ming Yang, Yingying Su, Yanlong Jiang, Xin Huang, Qing Liu, Qingke Kong. Reducing the endotoxic activity or enhancing the vaccine immunogenicity by altering the length of lipid A acyl chain in Salmonella. International immunopharmacology. 2023 Jan; 114(?):109575. doi: 10.1016/j.intimp.2022.109575. [PMID: 36700768]
  • Atsushi Shimoyama, Koichi Fukase. Chemical Synthesis and Immunomodulatory Functions of Bacterial Lipid As. Methods in molecular biology (Clifton, N.J.). 2023; 2613(?):33-53. doi: 10.1007/978-1-0716-2910-9_4. [PMID: 36587069]
  • Danyang Huang, Fan Ji, Xin Tan, Jun Qiao, Hedan Li, Zhen Wang, Xiaoyuan Wang. Free lipid A and full-length lipopolysaccharide coexist in Vibrio parahaemolyticus ATCC33846. Microbial pathogenesis. 2023 Jan; 174(?):105889. doi: 10.1016/j.micpath.2022.105889. [PMID: 36435436]
  • Matthew E Sherman, Richard D Smith, Francesca M Gardner, David R Goodlett, Robert K Ernst. A Sensitive GC-MS Method for Quantitation of Lipid A Backbone Components and Terminal Phosphate Modifications. Journal of the American Society for Mass Spectrometry. 2022 Dec; 33(12):2301-2309. doi: 10.1021/jasms.2c00266. [PMID: 36326685]
  • Annaleise Wilson, Narelle Fegan, Mark S Turner. Co-culture with Acinetobacter johnsonii enhances benzalkonium chloride resistance in Salmonella enterica via triggering lipid A modifications. International journal of food microbiology. 2022 Nov; 381(?):109905. doi: 10.1016/j.ijfoodmicro.2022.109905. [PMID: 36095868]
  • Juan Felipe Franco-Gonzalez, Alejandra Matamoros-Recio, Angel Torres-Mozas, Blanca Rodrigo-Lacave, Sonsoles Martin-Santamaria. Lipid-A-dependent and cholesterol-dependent dynamics properties of liposomes from gram-negative bacteria in ESKAPE. Scientific reports. 2022 11; 12(1):19474. doi: 10.1038/s41598-022-22886-7. [PMID: 36376343]
  • Kang Liang, Zhenyuan Tian, Xin Chen, Mengru Li, Xiaofen Zhang, Xiaoping Bian, Md Kaisar Ali, Qingke Kong. Attenuated Salmonella Typhimurium with truncated LPS and outer membrane-displayed RGD peptide for cancer therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113682. doi: 10.1016/j.biopha.2022.113682. [PMID: 36095964]
  • Amal Senevirathne, Chamith Hewawaduge, Chandran Sivasankar, John Hwa Lee. Prospective lipid-A altered live attenuated Salmonella Gallinarum confers protectivity, DIVA capability, safety and low endotoxicity against fowl typhoid. Veterinary microbiology. 2022 Nov; 274(?):109572. doi: 10.1016/j.vetmic.2022.109572. [PMID: 36113357]
  • Seyyedeh Maryam Afshani, Reihaneh Mirhassani, Hamed Hosseini, Reihaneh Hosseini, Afsaneh Tehranian, Reza Malekzadeh, Afshin Ostovar, Amir Hossein Abdolghaffari, Mohammad Amin Ghobadi, Behnaz Hedayatjoo, Delara Hazegh Fetratjoo, Zahra Rezagholi, AmirHossein Anari, Ashraf Moini. Immunogenicity and safety of a bivalent, adjuvant system 04-adjuvanted human papillomavirus vaccine in healthy female volunteers aged 15-25: a randomized, double-blind, phase III, noninferiority clinical trial. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2022 11; 31(6):558-567. doi: 10.1097/cej.0000000000000753. [PMID: 35352698]
  • Neeltje Steeghs, Aaron R Hansen, Glenn J Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L Washburn, Christopher Matheny, Sarina A Piha-Paul. Manufacturing-dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development. Clinical and translational science. 2022 11; 15(11):2625-2639. doi: 10.1111/cts.13387. [PMID: 36097345]
  • Siyu Liu, Tianyu Wei, Hongyun Lu, Xiayu Liu, Ying Shi, Qihe Chen. Interactions between Mannosylerythritol Lipid-A and Heat-Induced Soy Glycinin Aggregates: Physical and Chemical Characteristics, Functional Properties, and Structural Effects. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217393. [PMID: 36364220]
  • Diship Srivastava, Niladri Patra. Self-Uptake Mechanism of Polymyxin-Based Lipopeptide against Gram-Negative Bacterial Membrane: Role of the First Adsorbed Lipopeptide. The journal of physical chemistry. B. 2022 10; 126(41):8222-8232. doi: 10.1021/acs.jpcb.2c03827. [PMID: 36126341]
  • Kristina Klobucar, Emily Jardine, Maya A Farha, Marc R MacKinnon, Meghan Fragis, Brenda Nkonge, Timsy Bhando, Louis Borrillo, Caressa N Tsai, Jarrod W Johnson, Brian K Coombes, Jakob Magolan, Eric D Brown. Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria. ACS infectious diseases. 2022 10; 8(10):2187-2197. doi: 10.1021/acsinfecdis.2c00357. [PMID: 36098580]
  • Laura Galazzo, Gianmarco Meier, Dovile Januliene, Kristian Parey, Dario De Vecchis, Bianca Striednig, Hubert Hilbi, Lars V Schäfer, Ilya Kuprov, Arne Moeller, Enrica Bordignon, Markus A Seeger. The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells. Science advances. 2022 10; 8(41):eabn6845. doi: 10.1126/sciadv.abn6845. [PMID: 36223470]
  • Denys E S Santos, Kaline Coutinho, Thereza A Soares. Surface Assessment via Grid Evaluation (SuAVE) for Every Surface Curvature and Cavity Shape. Journal of chemical information and modeling. 2022 10; 62(19):4690-4701. doi: 10.1021/acs.jcim.2c00673. [PMID: 35946873]
  • David J Diemert, Maria Zumer, Doreen Campbell, Shannon Grahek, Guangzhao Li, Jin Peng, Maria Elena Bottazzi, Peter Hotez, Jeffrey Bethony. Safety and immunogenicity of the Na-APR-1 hookworm vaccine in infection-naïve adults. Vaccine. 2022 10; 40(42):6084-6092. doi: 10.1016/j.vaccine.2022.09.017. [PMID: 36114129]
  • Ram Prasad Aganja, Chandran Sivasankar, Chamith Hewawaduge, John Hwa Lee. Safety assessment of compliant, highly invasive, lipid A-altered, O-antigen-defected Salmonella strains as prospective vaccine delivery systems. Veterinary research. 2022 Oct; 53(1):76. doi: 10.1186/s13567-022-01096-z. [PMID: 36183131]
  • Molly Dorothy Pither, Mei-Ling Sun, Immacolata Speciale, Alba Silipo, Yu-Zhong Zhang, Antonio Molinaro, Flaviana Di Lorenzo. Structural determination of the lipid A from the deep-sea bacterium Zunongwangia profunda SM-A87: a small-scale approach. Glycoconjugate journal. 2022 10; 39(5):565-578. doi: 10.1007/s10719-022-10076-6. [PMID: 35930130]
  • Jenisha Ghimire, Shantanu Guha, Benjamin J Nelson, Lisa A Morici, William C Wimley. The Remarkable Innate Resistance of Burkholderia bacteria to Cationic Antimicrobial Peptides: Insights into the Mechanism of AMP Resistance. The Journal of membrane biology. 2022 10; 255(4-5):503-511. doi: 10.1007/s00232-022-00232-2. [PMID: 35435452]
  • Yoshihiro Saito, Tomoya Yamashita, Naofumi Yoshida, Takuo Emoto, Shintaro Takeda, Tokiko Tabata, Masakazu Shinohara, Shigenobu Kishino, Yuta Sugiyama, Nahoko Kitamura, Hiroyuki Yamamoto, Tomofumi Takaya, Jun Ogawa, Ken-Ichi Hirata. Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils. Atherosclerosis. 2022 10; 358(?):1-11. doi: 10.1016/j.atherosclerosis.2022.08.009. [PMID: 36049289]
  • Alice Ascari, Elizabeth Ngoc Hoa Tran, Bart A Eijkelkamp, Renato Morona. Identification of the Shigella flexneri Wzy Domain Modulating WzzpHS-2 Interaction and Detection of the Wzy/Wzz/Oag Complex. Journal of bacteriology. 2022 Sep; 204(9):e0022422. doi: 10.1128/jb.00224-22. [PMID: 35980183]
  • Lang Sun, Youwen Zhang, Tanxi Cai, Xue Li, Na Li, Zhensheng Xie, Fuquan Yang, Xuefu You. CrrAB regulates PagP-mediated glycerophosphoglycerol palmitoylation in the outer membrane of Klebsiella pneumoniae. Journal of lipid research. 2022 09; 63(9):100251. doi: 10.1016/j.jlr.2022.100251. [PMID: 35841948]
  • Su-Hyun Kim, Sohyeon Yun, Woojun Park. Constitutive Phenotypic Modification of Lipid A in Clinical Acinetobacter baumannii Isolates. Microbiology spectrum. 2022 08; 10(4):e0129522. doi: 10.1128/spectrum.01295-22. [PMID: 35861511]
  • Christopher Mullally, Keith A Stubbs, Van C Thai, Anandhi Anandan, Stephanie Bartley, Martin J Scanlon, Gary A Jarvis, Constance M John, Katherine Y L Lim, Courtney M Sullivan, Mitali Sarkar-Tyson, Alice Vrielink, Charlene M Kahler. Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase. The Journal of antimicrobial chemotherapy. 2022 08; 77(9):2441-2447. doi: 10.1093/jac/dkac204. [PMID: 35770844]
  • Erin M Harberts, Daniel Grubaugh, Daniel C Akuma, Sunny Shin, Robert K Ernst, Igor E Brodsky. Position-Specific Secondary Acylation Determines Detection of Lipid A by Murine TLR4 and Caspase-11. Infection and immunity. 2022 08; 90(8):e0020122. doi: 10.1128/iai.00201-22. [PMID: 35862717]
  • Jasmine Alexander-Floyd, Antonia R Bass, Erin M Harberts, Daniel Grubaugh, Joseph D Buxbaum, Igor E Brodsky, Robert K Ernst, Sunny Shin. Lipid A Variants Activate Human TLR4 and the Noncanonical Inflammasome Differently and Require the Core Oligosaccharide for Inflammasome Activation. Infection and immunity. 2022 08; 90(8):e0020822. doi: 10.1128/iai.00208-22. [PMID: 35862709]
  • Mrunal Gosavi, Harshad P Patil. Evaluation of monophosphoryl lipid A as an adjuvanted for inactivated chikungunya virus. Vaccine. 2022 08; 40(34):5060-5068. doi: 10.1016/j.vaccine.2022.07.018. [PMID: 35871870]
  • Bakar A Hassan, Zhiqi A Liu, Jozafina Milicaj, Mia S Kim, Meka Tyson, Yuk Y Sham, Erika A Taylor. Kinetic Characterization and Computational Modeling of Escherichia coli Heptosyltransferase II: Exploring the Role of Protein Dynamics in Catalysis for GT-B Glycosyltransferase. Biochemistry. 2022 08; 61(15):1572-1584. doi: 10.1021/acs.biochem.2c00329. [PMID: 35861590]
  • Michael D Sacco, Kyle Defrees, Xiujun Zhang, William Lawless, Emeka Nwanochie, Amelia Balsizer, Sophie E Darch, Adam R Renslo, Yu Chen. Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis. ACS infectious diseases. 2022 07; 8(7):1231-1240. doi: 10.1021/acsinfecdis.1c00650. [PMID: 35653508]