ppads (BioDeep_00000009549)
代谢物信息卡片
Pyridoxalphosphate-6-azophenyl-2,4-disulfonic acid
化学式: C14H14N3O12PS2 (510.97565340000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=C(C(=N1)N=NC2=C(C=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)COP(=O)(O)O)C=O)O
InChI: InChI=1S/C14H14N3O12PS2/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28)
描述信息
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34941
- KEGG: C13745
- PubChem: 4881
- Metlin: METLIN69677
- ChEMBL: CHEMBL3305983
- ChEMBL: CHEMBL1437958
- ChEMBL: CHEMBL69234
- PMhub: MS000023342
- PubChem: 586334
- CAS: 149017-66-3
- PDB-CCD: UO6
- NIKKAJI: J508.318D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Peter Cuthbertson, Nicholas J Geraghty, Sam R Adhikary, Sienna Casolin, Debbie Watson, Ronald Sluyter. P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model.
Clinical science (London, England : 1979).
2021 02; 135(3):495-513. doi:
10.1042/cs20201352. [PMID: 33463682] - Norichika Ueda, Makoto Kondo, Kentaro Takezawa, Hiroshi Kiuchi, Yosuke Sekii, Yusuke Inagaki, Tetsuji Soda, Shinichiro Fukuhara, Kazutoshi Fujita, Motohide Uemura, Ryoichi Imamura, Yasushi Miyagawa, Norio Nonomura, Shoichi Shimada. Bladder urothelium converts bacterial lipopolysaccharide information into neural signaling via an ATP-mediated pathway to enhance the micturition reflex for rapid defense.
Scientific reports.
2020 12; 10(1):21167. doi:
10.1038/s41598-020-78398-9. [PMID: 33273625] - Markus Schwiering, Matthias Husmann, Nadja Hellmann. P2X-Receptor Antagonists Inhibit the Interaction of S. aureus Hemolysin A with Membranes.
Toxins.
2017 10; 9(10):. doi:
10.3390/toxins9100332. [PMID: 29048353] - Peng Huang, Yuanjie Zou, Xi Zoë Zhong, Qi Cao, Kexin Zhao, Michael X Zhu, Ruth Murrell-Lagnado, Xian-Ping Dong. P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.
The Journal of biological chemistry.
2014 Jun; 289(25):17658-67. doi:
10.1074/jbc.m114.552158. [PMID: 24817123] - Jiri Masin, Radovan Fiser, Irena Linhartova, Radim Osicka, Ladislav Bumba, Erik L Hewlett, Roland Benz, Peter Sebo. Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size.
Infection and immunity.
2013 Dec; 81(12):4571-82. doi:
10.1128/iai.00711-13. [PMID: 24082076] - Kerstin Birke, Erion Lipo, Marco T Birke, Rajendra Kumar-Singh. Topical application of PPADS inhibits complement activation and choroidal neovascularization in a model of age-related macular degeneration.
PloS one.
2013; 8(10):e76766. doi:
10.1371/journal.pone.0076766. [PMID: 24130789] - Robert Kowalski, Ewelina Kreft, Malgorzata Kasztan, Maciej Jankowski, Miroslawa Szczepanska-Konkel. Chronic renal denervation increases renal tubular response to P2X receptor agonists in rats: implication for renal sympathetic nerve ablation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Sep; 27(9):3443-8. doi:
10.1093/ndt/gfs087. [PMID: 22516625] - Youichirou Higashi, Shohei Segawa, Takaaki Matsuo, Shogo Nakamura, Yukiko Kikkawa, Kentaro Nishida, Kazuki Nagasawa. Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia.
Glia.
2011 Dec; 59(12):1933-45. doi:
10.1002/glia.21235. [PMID: 22253048] - Jiaming Yang, Paul S P Ip, John H K Yeung, Chun-Tao Che. Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Aug; 18(11):998-1005. doi:
10.1016/j.phymed.2011.02.014. [PMID: 21514126] - Greg Clark, Devin Fraley, Iris Steinebrunner, Andrew Cervantes, James Onyirimba, Angela Liu, Jonathan Torres, Wenqiang Tang, Joshua Kim, Stanley J Roux. Extracellular nucleotides and apyrases regulate stomatal aperture in Arabidopsis.
Plant physiology.
2011 Aug; 156(4):1740-53. doi:
10.1104/pp.111.174466. [PMID: 21636723] - Jurgen Schnermann. Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice.
American journal of physiology. Renal physiology.
2011 Feb; 300(2):F339-44. doi:
10.1152/ajprenal.00637.2010. [PMID: 21147842] - John P Davies, Louise Robson. Pharmacological properties and physiological function of a P2X-like current in single proximal tubule cells isolated from frog kidney.
The Journal of membrane biology.
2010 Oct; 237(2-3):79-91. doi:
10.1007/s00232-010-9308-8. [PMID: 20972559] - Markus Tölle, Mirjam Schuchardt, Annette Wiedon, Tao Huang, Lars Klöckel, Joachim Jankowski, Vera Jankowski, Walter Zidek, Markus van der Giet. Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.
British journal of pharmacology.
2010 Oct; 161(3):530-40. doi:
10.1111/j.1476-5381.2010.00914.x. [PMID: 20880394] - David A Osmond, Edward W Inscho. P2X(1) receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo.
American journal of physiology. Renal physiology.
2010 Jun; 298(6):F1360-8. doi:
10.1152/ajprenal.00016.2010. [PMID: 20335318] - Luz María G Carrasquero, Esmerilda G Delicado, Lucía Sánchez-Ruiloba, Teresa Iglesias, Maria Teresa Miras-Portugal. Mechanisms of protein kinase D activation in response to P2Y(2) and P2X7 receptors in primary astrocytes.
Glia.
2010 Jun; 58(8):984-95. doi:
10.1002/glia.20980. [PMID: 20222145] - C Csölle, B Sperlágh. Peripheral origin of IL-1beta production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X(7) receptors.
Journal of neuroimmunology.
2010 Feb; 219(1-2):38-46. doi:
10.1016/j.jneuroim.2009.11.011. [PMID: 20022387] - Akiko Shitara, Akihiko Tanimura, Atsuko Sato, Yosuke Tojyo. Spontaneous oscillations in intracellular Ca(2+) concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Dec; 297(6):G1198-205. doi:
10.1152/ajpgi.00168.2009. [PMID: 19779019] - Kenneth A Jacobson, Andrei A Ivanov, Sonia de Castro, T Kendall Harden, Hyojin Ko. Development of selective agonists and antagonists of P2Y receptors.
Purinergic signalling.
2009 Mar; 5(1):75-89. doi:
10.1007/s11302-008-9106-2. [PMID: 18600475] - Akiko Shitara, Akihiko Tanimura, Atsuko Sato, Yosuke Tojyo. Spontaneous Ca2+ oscillations via purinergic receptors elicit transient cell swelling in rat parotid ducts.
The journal of medical investigation : JMI.
2009; 56 Suppl(?):377-80. doi:
10.2152/jmi.56.377. [PMID: 20224231] - Katsuaki Ito, Akihito Iwami, Hiromi Katsura, Masahiro Ikeda. Therapeutic effects of the putative P2X3/P2X2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2008 Jun; 377(4-6):483-90. doi:
10.1007/s00210-007-0197-z. [PMID: 17917716] - Shu-Jing Wu, Yuan-Shuai Liu, Jian-Yong Wu. The signaling role of extracellular ATP and its dependence on Ca2+ flux in elicitation of Salvia miltiorrhiza hairy root cultures.
Plant & cell physiology.
2008 Apr; 49(4):617-24. doi:
10.1093/pcp/pcn033. [PMID: 18325935] - Miguel L Graciano, Akira Nishiyama, Keith Jackson, Dale M Seth, Rudy M Ortiz, Minolfa C Prieto-Carrasquero, Hiroyuki Kobori, L Gabriel Navar. Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension.
American journal of physiology. Renal physiology.
2008 Jan; 294(1):F161-9. doi:
10.1152/ajprenal.00281.2007. [PMID: 17989111] - Tsuneo Takenaka, Tsutomu Inoue, Yoshihiko Kanno, Hirokazu Okada, Caryl E Hill, Hiromichi Suzuki. Connexins 37 and 40 transduce purinergic signals mediating renal autoregulation.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jan; 294(1):R1-11. doi:
10.1152/ajpregu.00269.2007. [PMID: 17928514] - L Dobrowolski, A Walkowska, E Kompanowska-Jezierska, M Kuczeriszka, J Sadowski. Effects of ATP on rat renal haemodynamics and excretion: role of sodium intake, nitric oxide and cytochrome P450.
Acta physiologica (Oxford, England).
2007 Jan; 189(1):77-85. doi:
10.1111/j.1748-1716.2006.01627.x. [PMID: 17280559] - Srdjan M Vlajkovic, Carol J H Wang, Christian Soeller, Herbert Zimmermann, Peter R Thorne, Gary D Housley. Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells.
The international journal of biochemistry & cell biology.
2007; 39(4):810-7. doi:
10.1016/j.biocel.2007.01.003. [PMID: 17307380] - T Hafting, T M Haug, S Ellefsen, O Sand. Hypotonic stress activates BK channels in clonal kidney cells via purinergic receptors, presumably of the P2Y subtype.
Acta physiologica (Oxford, England).
2006 Sep; 188(1):21-31. doi:
10.1111/j.1748-1716.2006.01601.x. [PMID: 16911250] - Léa Emonnot, Charles Bakhos, Bruno Chapuis, Valérie Oréa, Christian Barrès, Claude Julien. Role of purinergic cotransmission in the sympathetic control of arterial pressure variability in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2006 Sep; 291(3):R736-41. doi:
10.1152/ajpregu.00088.2006. [PMID: 16513767] - C Y Chiang, S Zhang, Y F Xie, J W Hu, J O Dostrovsky, M W Salter, B J Sessle. Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn).
Journal of neurophysiology.
2005 Sep; 94(3):1751-60. doi:
10.1152/jn.00223.2005. [PMID: 15901761] - Edward C Y Wang, Jey-Myung Lee, Wily G Ruiz, Elena M Balestreire, Maximilian von Bodungen, Stacey Barrick, Debra A Cockayne, Lori A Birder, Gerard Apodaca. ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells.
The Journal of clinical investigation.
2005 Sep; 115(9):2412-22. doi:
10.1172/jci24086. [PMID: 16110327] - Alexander V Gourine, Dmitry M Poputnikov, Nikolai Zhernosek, Ekaterina V Melenchuk, Rüdiger Gerstberger, K Michael Spyer, Valery N Gourine. P2 receptor blockade attenuates fever and cytokine responses induced by lipopolysaccharide in rats.
British journal of pharmacology.
2005 Sep; 146(1):139-45. doi:
10.1038/sj.bjp.0706287. [PMID: 15965498] - Ricardo J Rodrigues, Teresa Almeida, Peter J Richardson, Catarina R Oliveira, Rodrigo A Cunha. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2005 Jul; 25(27):6286-95. doi:
10.1523/jneurosci.0628-05.2005. [PMID: 16000618] - Matt J Sylte, Chris J Kuckleburg, Thomas J Inzana, Paul J Bertics, Charles J Czuprynski. Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells.
Journal of leukocyte biology.
2005 Jun; 77(6):958-65. doi:
10.1189/jlb.1004597. [PMID: 15728716] - Jeffrey F Hiken, Thomas H Steinberg. ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells.
American journal of physiology. Cell physiology.
2004 Aug; 287(2):C403-12. doi:
10.1152/ajpcell.00361.2003. [PMID: 15070812] - Hervé Le Stunff, Rodolphe Auger, Jean Kanellopoulos, Marie-Noëlle Raymond. The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes.
The Journal of biological chemistry.
2004 Apr; 279(17):16918-26. doi:
10.1074/jbc.m313064200. [PMID: 14761980] - Nick J Spencer, Grant W Hennig, Terence K Smith. A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon.
The Journal of physiology.
2002 12; 545(2):629-48. doi:
10.1113/jphysiol.2002.028647. [PMID: 12456839] - Sylvia Rost, Christoph Daniel, Eckhard Schulze-Lohoff, Hans G Bäumert, Günter Lambrecht, Christian Hugo. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangial proliferative glomerulonephritis.
Kidney international.
2002 Nov; 62(5):1659-71. doi:
10.1046/j.1523-1755.2002.00621.x. [PMID: 12371966] - Kenneth A Jacobson, Michael F Jarvis, Michael Williams. Purine and pyrimidine (P2) receptors as drug targets.
Journal of medicinal chemistry.
2002 Sep; 45(19):4057-93. doi:
10.1021/jm020046y. [PMID: 12213051] - Valeria Spelta, Lin-Hua Jiang, Annmarie Surprenant, R Alan North. Kinetics of antagonist actions at rat P2X2/3 heteromeric receptors.
British journal of pharmacology.
2002 Mar; 135(6):1524-30. doi:
10.1038/sj.bjp.0704591. [PMID: 11906966] - K G Fischer, U Saueressig, C Jacobshagen, A Wichelmann, H Pavenstädt. Extracellular nucleotides regulate cellular functions of podocytes in culture.
American journal of physiology. Renal physiology.
2001 Dec; 281(6):F1075-81. doi:
10.1152/ajprenal.2001.281.6.f1075. [PMID: 11704558] - Y Kobayashi, K Hoshikuma, Y Nakano, Y Yokoo, T Kamiya. The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.
Planta medica.
2001 Apr; 67(3):244-8. doi:
10.1055/s-2001-12008. [PMID: 11345696] - E W Inscho. Renal microvascular effects of P2 receptor stimulation.
Clinical and experimental pharmacology & physiology.
2001 Apr; 28(4):332-9. doi:
10.1046/j.1440-1681.2001.03450.x. [PMID: 11339210] - A D Hibell, K M Thompson, M Xing, P P Humphrey, A D Michel. Complexities of measuring antagonist potency at P2X(7) receptor orthologs.
The Journal of pharmacology and experimental therapeutics.
2001 Mar; 296(3):947-57. doi:
NULL. [PMID: 11181928] - Y C Kim, S G Brown, T K Harden, J L Boyer, G Dubyak, B F King, G Burnstock, K A Jacobson. Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.
Journal of medicinal chemistry.
2001 Feb; 44(3):340-9. doi:
10.1021/jm9904203. [PMID: 11462975] - J R Kapoor, C D Sladek. Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2000 Dec; 20(23):8868-75. doi:
10.1523/jneurosci.20-23-08868.2000. [PMID: 11102496] - G G Yegutkin, G Burnstock. Inhibitory effects of some purinergic agents on ecto-ATPase activity and pattern of stepwise ATP hydrolysis in rat liver plasma membranes.
Biochimica et biophysica acta.
2000 Jun; 1466(1-2):234-44. doi:
10.1016/s0005-2736(00)00165-6. [PMID: 10825445] - C Chen, M S Parker, A P Barnes, P Deininger, R P Bobbin. Functional expression of three P2X(2) receptor splice variants from guinea pig cochlea.
Journal of neurophysiology.
2000 Mar; 83(3):1502-9. doi:
10.1152/jn.2000.83.3.1502. [PMID: 10712475] - D Shehnaz, B Torres, M A Balboa, P A Insel. Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonate (PPADS), a putative P2Y(1) receptor antagonist, blocks signaling at a site distal to the receptor in Madin-Darby canine kidney-D(1) cells.
The Journal of pharmacology and experimental therapeutics.
2000 Jan; 292(1):346-50. doi:
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Neuropharmacology.
1999 Sep; 38(9):1335-42. doi:
10.1016/s0028-3908(99)00034-9. [PMID: 10471087] - M van der Giet, O Cinkilic, J Jankowski, M Tepel, W Zidek, H Schlüter. Evidence for two different P2X-receptors mediating vasoconstriction of Ap5A and Ap6A in the isolated perfused rat kidney.
British journal of pharmacology.
1999 Jul; 127(6):1463-9. doi:
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Journal of neurochemistry.
1999 Feb; 72(2):826-34. doi:
10.1046/j.1471-4159.1999.0720826.x. [PMID: 9930759] - M van der Giet, J Jankowski, H Schlüter, W Zidek, M Tepel. Mediation of the vasoactive properties of diadenosine tetraphosphate via various purinoceptors.
Journal of hypertension.
1998 Dec; 16(12 Pt 2):1939-43. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998 Sep; 18(18):7152-9. doi:
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Journal of medicinal chemistry.
1998 Jun; 41(13):2201-6. doi:
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The EMBO journal.
1998 Jun; 17(11):3016-28. doi:
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Biochemistry. Biokhimiia.
1997 Jun; 62(6):619-22. doi:
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The Biochemical journal.
1997 May; 323 ( Pt 3)(?):677-84. doi:
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Biochemical and biophysical research communications.
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The American journal of physiology.
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Arzneimittel-Forschung.
1995 Sep; 45(9):994-7. doi:
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Molecular pharmacology.
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