Adenophostin A (BioDeep_00000009533)
代谢物信息卡片
化学式: C16H26N5O18P3 (669.0485686000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)OP(=O)(O)O)O[C@@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)OP(=O)(O)O)OP(=O)(O)O)O)O
InChI: InChI=1S/C16H26N5O18P3/c17-13-7-14(19-3-18-13)21(4-20-7)15-12(39-42(31,32)33)9(5(1-22)34-15)36-16-8(24)11(38-41(28,29)30)10(6(2-23)35-16)37-40(25,26)27/h3-6,8-12,15-16,22-24H,1-2H2,(H2,17,18,19)(H2,25,26,27)(H2,28,29,30)(H2,31,32,33)/t5-,6-,8-,9-,10-,11-,12-,15-,16-/m1/s1
描述信息
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D002120 - Calcium Channel Agonists
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:34524
- KEGG: C13727
- PubChem: 123695
- PubChem: 2023
- Metlin: METLIN69662
- ChEMBL: CHEMBL204385
- KNApSAcK: C00016901
- CAS: 149091-92-9
- PMhub: MS000023326
- PubChem: 586316
- NIKKAJI: J569.664J
- RefMet: Adenophostin a
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cecilia I Lopez, Leonardo E Pelletán, Laila Suhaiman, Gerardo A De Blas, Nicolas Vitale, Luis S Mayorga, Silvia A Belmonte. Diacylglycerol stimulates acrosomal exocytosis by feeding into a PKC- and PLD1-dependent positive loop that continuously supplies phosphatidylinositol 4,5-bisphosphate.
Biochimica et biophysica acta.
2012 Sep; 1821(9):1186-99. doi:
10.1016/j.bbalip.2012.05.001. [PMID: 22609963] - Guiling Zhao, Zachary P Neeb, M Dennis Leo, Judith Pachuau, Adebowale Adebiyi, Kunfu Ouyang, Ju Chen, Jonathan H Jaggar. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.
The Journal of general physiology.
2010 Sep; 136(3):283-91. doi:
10.1085/jgp.201010453. [PMID: 20713546] - Colin W Taylor, David L Prole, Taufiq Rahman. Ca(2+) channels on the move.
Biochemistry.
2009 Dec; 48(51):12062-80. doi:
10.1021/bi901739t. [PMID: 19928968] - Yuansong Yu, Guillaume Halet, F Anthony Lai, Karl Swann. Regulation of diacylglycerol production and protein kinase C stimulation during sperm- and PLCzeta-mediated mouse egg activation.
Biology of the cell.
2008 Nov; 100(11):633-43. doi:
10.1042/bc20080033. [PMID: 18471090] - Genevieve B Wortzman-Show, Manabu Kurokawa, Rafael A Fissore, Janice P Evans. Calcium and sperm components in the establishment of the membrane block to polyspermy: studies of ICSI and activation with sperm factor.
Molecular human reproduction.
2007 Aug; 13(8):557-65. doi:
10.1093/molehr/gam042. [PMID: 17575288] - Elizabeth S Erickson, Olivia L Mooren, David Moore, Jeffrey R Krogmeier, Robert C Dunn. The role of nuclear envelope calcium in modifying nuclear pore complex structure.
Canadian journal of physiology and pharmacology.
2006 Mar; 84(3-4):309-18. doi:
10.1139/y05-109. [PMID: 16902578] - Olivia L Mooren, Elizabeth S Erickson, David Moore-Nichols, Robert C Dunn. Nuclear side conformational changes in the nuclear pore complex following calcium release from the nuclear membrane.
Physical biology.
2004 Jun; 1(1-2):125-34. doi:
10.1088/1478-3967/1/2/008. [PMID: 16204829] - Forrest L Smith, Scott J LeBlanc, Richard Carter. Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.
European journal of pain (London, England).
2004 Apr; 8(2):153-61. doi:
10.1016/s1090-3801(03)00089-2. [PMID: 14987625] - Hervé Cadiou, Gérard Molle. Adenophostin A and imipramine are two activators of the olfactory inositol 1,4,5-trisphosphate-gated channel in fish olfatory cilia.
European biophysics journal : EBJ.
2003 May; 32(2):106-12. doi:
10.1007/s00249-002-0271-x. [PMID: 12734698] - L B Silverman-Gavrila, R R Lew. Regulation of the tip-high [Ca2+] gradient in growing hyphae of the fungus Neurospora crassa.
European journal of cell biology.
2001 Jun; 80(6):379-90. doi:
10.1078/0171-9335-00175. [PMID: 11484929] - K Ukhanov, S J Mills, B V Potter, B Walz. InsP(3)-induced Ca(2+) release in permeabilized invertebrate photoreceptors: a link between phototransduction and Ca(2+) stores.
Cell calcium.
2001 May; 29(5):335-45. doi:
10.1054/ceca.2001.0195. [PMID: 11292390] - S DeLisle, E W Marksberry, C Bonnett, D J Jenkins, B V Potter, M Takahashi, K Tanzawa. Adenophostin A can stimulate Ca2+ influx without depleting the inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in the Xenopus oocyte.
The Journal of biological chemistry.
1997 Apr; 272(15):9956-61. doi:
10.1074/jbc.272.15.9956. [PMID: 9092535] - H C Hartzell, K Machaca, Y Hirayama. Effects of adenophostin-A and inositol-1,4,5-trisphosphate on Cl- currents in Xenopus laevis oocytes.
Molecular pharmacology.
1997 Apr; 51(4):683-92. doi:
10.1124/mol.51.4.683. [PMID: 9106635] - R A Wilcox, C Erneux, W U Primrose, R Gigg, S R Nahorski. 2-Hydroxyethyl-alpha-D-glucopyranoside-2,3',4'-trisphosphate, a novel, metabolically resistant, adenophostin A and myo-inositol-1,4,5-trisphosphate analogue, potently interacts with the myo-inositol-1,4,5-trisphosphate receptor.
Molecular pharmacology.
1995 Jun; 47(6):1204-11. doi:
. [PMID: 7603461] - M Takahashi, K Tanzawa, S Takahashi. Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry.
1994 Jan; 269(1):369-72. doi:
. [PMID: 8276820]