Nedaplatin (BioDeep_00000009396)
代谢物信息卡片
Nedaplatin
化学式: C2H8N2O3Pt (303.01827480000003)
中文名称: 奈达铂
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)O)O.[NH2-].[NH2-].[Pt+2]
InChI: +2
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent > C1450 - Platinum Compound
D000970 - Antineoplastic Agents
Same as: D01416
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:31898
- KEGG: C12862
- KEGGdrug: D01416
- PubChem: 72120
- PubChem: 24200453
- Metlin: METLIN69499
- CAS: 95734-82-0
- PMhub: MS000023176
- PubChem: 583251
- NIKKAJI: J1.844.106C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masaya Takahashi, Katsuyuki Takahashi, Kazuya Muguruma, Masaichi Ohira, Katsuya Nagayama. Establishment of nedaplatin safety dose formula based on renal function for combination chemotherapy with nedaplatin and 5-fluorouracil in patients with esophageal cancer.
International journal of clinical oncology.
2022 Feb; 27(2):348-353. doi:
10.1007/s10147-021-02057-w. [PMID: 34686932] - Lufeng Chen, Xuanxuan Zhu, Donglin Li, Xudong Cai. Effect of thoracic hyperthermic perfusion with recombinant human endostatin plus nedaplatin in treating pleural effusion in patients with advanced non-small cell lung cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2020 Nov; 25(6):2643-2649. doi:
. [PMID: 33455108] - Jun Fu, Sanyou Fang, Yin Wen, Yanbing Wang, Xin Yin, Daofeng Wang. The efficacy and safety of irinotecan combined with nedaplatin in the treatment of small cell lung cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2020 Jul; 25(4):1707-1713. doi:
. [PMID: 33099904] - Dongzhi Zuo, Guancheng Liu, Ming Deng, Yanyong Gao. Efficacy of nedaplatin combined with docetaxel in patients with nasopharyngeal carcinoma and its influence on ECRG4 and VEGF expressions.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2020 Jul; 25(4):1976-1981. doi:
. [PMID: 33099941] - Takumi Shiraishi, Terukazu Nakamura, Toshiya Takamura, Masakatsu Oishi, Takeshi Yamada, Yasuhiro Yamada, Takashi Ueda, Atsuko Fujihara, Fumiya Hongo, Koji Okihara, Osamu Ukimura. Less nephrotoxicity of paclitaxel and ifosfamide plus nedaplatin for refractory or relapsed germ cell tumors in patients with impaired renal function.
International journal of urology : official journal of the Japanese Urological Association.
2020 Feb; 27(2):134-139. doi:
10.1111/iju.14147. [PMID: 31701563] - Hongmei Zhang, Chenchen Chen, Shuyuan Wang, Xiaoxia Li, Tingting Fan. Efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2020 Jan; 25(1):80-86. doi:
. [PMID: 32277617] - Feng Sun, Jiajia Wang, Ximing Wu, Chung S Yang, Jinsong Zhang. Selenium nanoparticles act as an intestinal p53 inhibitor mitigating chemotherapy-induced diarrhea in mice.
Pharmacological research.
2019 11; 149(?):104475. doi:
10.1016/j.phrs.2019.104475. [PMID: 31593755] - Chunfeng Yu, Zhonghua Jiang, Aihua Hou, Yuejun Mu, Wei Liu, Song Tan. Shen-Cao granules formulated based on traditional Chinese medicine alleviates bone marrow suppression caused by platinum-based anticancer reagents.
Medicine.
2017 May; 96(19):e6818. doi:
10.1097/md.0000000000006818. [PMID: 28489759] - Risa Araki, Hidetaka Iwamizu, Tomomi Kataoka, Yasuo Kumakura, Masayuki Miyazaki, Taku Nagai, Yuichi Ando, Kiyofumi Yamada. [Analysis of Nedaplatin Dose in Patients with Impaired Renal Function].
Gan to kagaku ryoho. Cancer & chemotherapy.
2017 Feb; 44(2):143-147. doi:
. [PMID: 28223671] - Keita Kobayashi, Hideyasu Matsuyama, Kosuke Shimizu, Nakanori Fujii, Ryo Inoue, Yoshiaki Yamamoto, Hiroaki Matsumoto, Kazuhiro Nagao. Clinical significance of a second-line chemotherapy regimen with paclitaxel, ifosfamide and nedaplatin for metastatic urothelial carcinoma after failure of cisplatin-based chemotherapy.
Japanese journal of clinical oncology.
2016 Aug; 46(8):775-80. doi:
10.1093/jjco/hyw071. [PMID: 27272172] - Takashi Tachibana, Kazumasa Matsumoto, Shoji Nagi, Masahiro Hagiwara, Kentaro Kobayashi, Hideyasu Tsumura, Kazunari Yoshida, Masatsugu Iwamura. [Combined Chemotherapy with Radiation was Tolerable and Effective Treatment in Female Octogenarian Patients with Urethral Cancer -Two Case Reports].
Hinyokika kiyo. Acta urologica Japonica.
2016 Jul; 62(7):367-71. doi:
10.14989/actauroljap_62_7_367. [PMID: 27569355] - Hongfei Gao, Lijun Yuan, Yimin Han. Comparisons of the survival time of patients with ovarian cancer adopting post-operative chemotherapy by use of paclitaxel combined with carboplatin or nedaplatin.
World journal of surgical oncology.
2016 Jun; 14(1):168. doi:
10.1186/s12957-016-0930-5. [PMID: 27341795] - Masatomo Nishikawa, Hideaki Miyake, Masato Fujisawa. Irinotecan and nedaplatin as salvage therapy for patients with advanced germ cell tumors following intensive treatment with cisplatin-based combination chemotherapies.
International journal of clinical oncology.
2016 Feb; 21(1):162-7. doi:
10.1007/s10147-015-0861-0. [PMID: 26123313] - Hideomi Yamashita, Akihiro Haga, Ryousuke Takenaka, Tomoki Kiritoshi, Kae Okuma, Kuni Ohtomo, Keiichi Nakagawa. Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer.
Radiation oncology (London, England).
2016 Jan; 11(?):4. doi:
10.1186/s13014-016-0587-9. [PMID: 26781439] - Yuka Asami, Ryo Kitagawa, Moe Iiba, Asami Uenoyama, Kazunari Kondo, Nakako Sato, Kaoru Tadauchi, Masatoshi Sugita, Hajime Tsunoda. [A Patient with Recurrent Ovarian Cancer Who Was Hypersensitive to Carboplatin Exhibited Complete Response to Gemcitabine and Nedaplatin].
Gan to kagaku ryoho. Cancer & chemotherapy.
2015 Jul; 42(7):883-5. doi:
. [PMID: 26197756] - Terukazu Nakamura, Takashi Ueda, Masakatsu Oishi, Hiroyuki Nakanishi, Atsuko Fujihara, Yoshio Naya, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Tsuneharu Miki. Salvage combined chemotherapy with paclitaxel, ifosfamide and nedaplatin for patients with advanced germ cell tumors.
International journal of urology : official journal of the Japanese Urological Association.
2015 Mar; 22(3):288-93. doi:
10.1111/iju.12665. [PMID: 25393104] - Wu-Ju Li, Jia-Ying Jiang, Xian-Lian Wang. Nedaplatin salvage chemotherapy for cervical cancer.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(8):3159-62. doi:
10.7314/apjcp.2015.16.8.3159. [PMID: 25921114] - Zhongyu Liu, Jun Liu, Li Li, Dan Nie, Qilei Tao, Jian Wu, Jiajun Fan, Chen Lin, Shuwei Zhao, Dianwen Ju. Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells.
PloS one.
2015; 10(8):e0135236. doi:
10.1371/journal.pone.0135236. [PMID: 26288183] - Zhen-Qin Qiu, Kun Zhao. Expression of ERCC1, RRM1 and LRP in non-small cell lung cancers and their influence on chemotherapeutic efficacy of gemcitabine concomitant with nedaplatin.
Asian Pacific journal of cancer prevention : APJCP.
2014; 15(17):7303-7. doi:
10.7314/apjcp.2014.15.17.7303. [PMID: 25227833] - Shinya Sato, Hiroyuki Fujiwara, Tetsuro Oishi, Muneaki Shimada, Shizuo Machida, Yuji Takei, Hiroaki Itamochi, Mitsuaki Suzuki, Junzo Kigawa. Evaluation of a formula for individual dosage of nedaplatin based on renal function.
Cancer chemotherapy and pharmacology.
2012 Mar; 69(3):599-603. doi:
10.1007/s00280-011-1739-0. [PMID: 21918903] - Yasutaka Otsuki, Akira Kotani, Fumiyo Kusu. Capillary liquid chromatography with UV detection using N,N-diethyl dithiocarbamate for determining platinum-based antitumor drugs in plasma.
Chemical & pharmaceutical bulletin.
2012; 60(5):665-9. doi:
10.1248/cpb.60.665. [PMID: 22689405] - Hiroshi Kitamura, Keisuke Taguchi, Yasuharu Kunishima, Masahiro Yanase, Atsushi Takahashi, Masanori Shigyo, Toshiaki Tanaka, Masatoshi Mutoh, Fumimasa Fukuta, Naoya Masumori, Taiji Tsukamoto. Paclitaxel, ifosfamide, and nedaplatin as second-line treatment for patients with metastatic urothelial carcinoma: a phase II study of the SUOC group.
Cancer science.
2011 Jun; 102(6):1171-5. doi:
10.1111/j.1349-7006.2011.01909.x. [PMID: 21323791] - Atsushi Yonezawa, Ken-Ichi Inui. Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents.
Biochemical pharmacology.
2011 Mar; 81(5):563-8. doi:
10.1016/j.bcp.2010.11.016. [PMID: 21144842] - Hiroshige Saito, Kiyohiko Shuto, Takumi Ota, Takayuki Toma, Gaku Ohira, Toshiyuki Natsume, Masaya Uesato, Yasunori Akutsu, Tsuguaki Kono, Hisahiro Matsubara. [A case of long-term survival after resection for postoperative solitary adrenal metastasis from esophageal adenocarcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
2010 Nov; 37(12):2406-8. doi:
. [PMID: 21224588] - Hideo Fukuhara, Kenji Tamura, Ichiro Yamasaki, Masayuki Kamada, Hiroshi Nishikawa, Manabu Matumoto, Keiji Inoue, Taro Shuin. [Granulocyte-colony stimulating factor producing squamous cell carcinoma of the renal pelvis: a case report].
Hinyokika kiyo. Acta urologica Japonica.
2010 Sep; 56(9):505-8. doi:
NULL. [PMID: 20940525] - Yasunori Matsuda, Shigeru Lee, Satoru Kishida, Kazuhiko Mori, Noriyuki Isohata, Hiroshi Iwasaki, Ryoya Hashiba, Ken Gyobu, Harushi Osugi. [A case of SIADH developed during neoadjuvant chemotherapy using nedaplatin and 5-fluorouracil in a patient with esophageal cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2010 Sep; 37(9):1787-90. doi:
. [PMID: 20841948] - Y Hamada, H Naitoh, Y Niibe, A Kotani, R Takayanagi, S Tsunoda, N Unno, K Hayakawa, F Kusu, K Yago, Y Yamada. Initial analysis of relationship between plasma platinum concentration and hematological adverse reaction associated with weekly chemotherapy using nedaplatin in combination with radiotherapy for cervical carcinoma.
European journal of gynaecological oncology.
2010; 31(5):517-21. doi:
NULL. [PMID: 21061792] - Noboru Yamamoto, Tomohide Tamura, Takayasu Kurata, Nobuyuki Yamamoto, Ikuo Sekine, Hideo Kunitoh, Yuichiro Ohe, Nagahiro Saijo. A dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer.
Cancer chemotherapy and pharmacology.
2009 Dec; 65(1):79-88. doi:
10.1007/s00280-009-1006-9. [PMID: 19396598] - Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda. Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.
International journal of medical sciences.
2009 Sep; 6(6):305-11. doi:
10.7150/ijms.6.305. [PMID: 19834547] - Yutaka Tokairin, Michio Iida, Shigeru Yamazaki. [Effective combination chemotherapy with gemcitabine hydrochloride, S-1 and nedaplatin for recurrent pancreatic cancer--a case report].
Gan to kagaku ryoho. Cancer & chemotherapy.
2008 Nov; 35(12):2123-5. doi:
NULL. [PMID: 19106544] - Kazuhisa Tokunou, Shigeru Takeda, Shigefumi Yoshino, Taku Nishimura, Masaaki Oka. [A case of esophageal cancer patient who developed tumor lysis syndrome after chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2008 Nov; 35(12):2030-2. doi:
NULL. [PMID: 19106513] - Takeki Uehara, Noriko Tsuchiya, Aki Masuda, Mikinori Torii, Masuhisa Nakamura, Jyoji Yamate, Toshiyuki Maruyama. Time course of the change and amelioration of nedaplatin-induced nephrotoxicity in rats.
Journal of applied toxicology : JAT.
2008 Apr; 28(3):388-98. doi:
10.1002/jat.1292. [PMID: 17685399] - Kazuhiko Hanada, Kunihito Asano, Takako Nishimura, Tomomi Chimata, Yusuke Matsuo, Maki Tsuchiya, Hiroyasu Ogata. Use of a toxicity factor to explain differences in nephrotoxicity and myelosuppression among the platinum antitumour derivatives cisplatin, carboplatin and nedaplatin in rats.
The Journal of pharmacy and pharmacology.
2008 Mar; 60(3):317-22. doi:
10.1211/jpp.60.3.0006. [PMID: 18284811] - Takeki Uehara, Takako Miyoshi, Noriko Tsuchiya, Koichi Masuno, Manabu Okada, Satoshi Inoue, Mikinori Torii, Jyoji Yamate, Toshiyuki Maruyama. Comparative analysis of gene expression between renal cortex and papilla in nedaplatin-induced nephrotoxicity in rats.
Human & experimental toxicology.
2007 Oct; 26(10):767-80. doi:
10.1177/0960327107084069. [PMID: 18025048] - Norio Nonomura, Daizo Oka, Kazuo Nishimura, Masashi Nakayama, Hitoshi Inoue, Yoichi Mizutani, Tsuneharu Miki, Akihiko Okuyama. Paclitaxel, ifosfamide, and nedaplatin (TIN) salvage chemotherapy for patients with advanced germ cell tumors.
International journal of urology : official journal of the Japanese Urological Association.
2007 Jun; 14(6):527-31. doi:
10.1111/j.1442-2042.2006.01702.x. [PMID: 17593098] - Shimpei Sugiura, Kazuhide Makiyama, Noboru Nakaigawa, Masahiro Yao, Yoshinobu Kubota, Hisashi Oshiro. Collecting duct carcinoma producing granulocyte-colony-stimulating factor (G-CSF).
International journal of urology : official journal of the Japanese Urological Association.
2007 Jun; 14(6):555-7. doi:
10.1111/j.1442-2042.2006.01711.x. [PMID: 17593104] - Yusuke Hattori, Akitoshi Takizawa, Takeshi Kishida, Manabu Kakizoe, Naoya Fujikawa, Jun-Ichi Teranishi, Keiichi Kondo, Kazuo Saito, Kazumi Noguchi, Noboru Nakaigawa, Yoshinobu Kubota. [Clinical study of combination chemotherapy of methotrexate, epirubicin and nedaplatin (MEN) in patients with advanced urothelial carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
2007 May; 34(5):739-43. doi:
. [PMID: 17496448] - Takenori Niioka, Tsukasa Uno, Norio Yasui-Furukori, Takenori Takahata, Mikiko Shimizu, Kazunobu Sugawara, Tomonori Tateishi. Pharmacokinetics of low-dose nedaplatin and validation of AUC prediction in patients with non-small-cell lung carcinoma.
Cancer chemotherapy and pharmacology.
2007 Apr; 59(5):575-80. doi:
10.1007/s00280-006-0298-2. [PMID: 16912889] - Gabriel W Loh, Lillian S L Ting, Mary H H Ensom. A systematic review of limited sampling strategies for platinum agents used in cancer chemotherapy.
Clinical pharmacokinetics.
2007; 46(6):471-94. doi:
10.2165/00003088-200746060-00002. [PMID: 17518507] - Atsushi Yonezawa, Satohiro Masuda, Sachiko Yokoo, Toshiya Katsura, Ken-Ichi Inui. Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).
The Journal of pharmacology and experimental therapeutics.
2006 Nov; 319(2):879-86. doi:
10.1124/jpet.106.110346. [PMID: 16914559] - Akinori Harada, Yasuyo Yamamoto, Ryuichi Taue, Tomoteru Kishimoto, Shuji Tanimoto, Hirofumi Izaki, Masayuki Takahashi, Tomoharu Fukumori, Masa-aki Nishitani, Hiro-omi Kanayama, Hideki Hayashi. [A non-seminomatous extra-gonadal germ cell tumor responding to intensive treatment: a case report].
Hinyokika kiyo. Acta urologica Japonica.
2006 Aug; 52(8):651-4. doi:
. [PMID: 16972631] - Hideki Takemura, Sei Kobayashi, Masahiro Katsuno, Rie Asano, Masato Morimoto, Shinya Tachibana, Hayato Kubota, Masaki Iida, Yoshiyuki Kadokura, Takeyuki Sanbe. [Clinical phase trial of concurrent chemoradiotherapy combined TS-1 and nedaplatin].
Gan to kagaku ryoho. Cancer & chemotherapy.
2005 Dec; 32(13):2065-9. doi:
. [PMID: 16352930] - Yoshiko Kawai, Saburo Taniuchi, Shigeki Okahara, Masuhisa Nakamura, Munekazu Gemba. Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation.
Biological & pharmaceutical bulletin.
2005 Aug; 28(8):1385-8. doi:
10.1248/bpb.28.1385. [PMID: 16079479] - Takeki Uehara, Hiroshi Watanabe, Fumio Itoh, Satoshi Inoue, Hikaru Koshida, Masuhisa Nakamura, Jyoji Yamate, Toshiyuki Maruyama. Nephrotoxicity of a novel antineoplastic platinum complex, nedaplatin: a comparative study with cisplatin in rats.
Archives of toxicology.
2005 Aug; 79(8):451-60. doi:
10.1007/s00204-005-0648-6. [PMID: 15856183] - Manabu Okuyama, Satoru Motoyama, Kiyotomi Maruyama, Hideki Ohta, Norihiko Tsuchiya, Jinko Oyake, Jun-ichi Ogawa. [Chemotherapy for an esophageal cancer patient undergoing continuous ambulatory peritoneal dialysis for chronic renal failure and measurement of plasma concentration of the drug].
Gan to kagaku ryoho. Cancer & chemotherapy.
2005 Jul; 32(7):1029-32. doi:
NULL. [PMID: 16044967] - Toru Ishibashi, Yoshitaka Yano, Takayoshi Oguma. Determination of optimal dosage for nedaplatin based on pharmacokinetic and toxicodynamic analysis.
Anticancer research.
2005 Mar; 25(2B):1273-81. doi:
NULL. [PMID: 15865078] - Toru Ishibashi, Kazuya Fukumura, Yoshitaka Yano, Takayoshi Oguma. Optimal sampling and limited sampling strategies for estimation of unbound platinum AUC after nedaplatin infusion.
Anticancer research.
2005 Mar; 25(2B):1283-9. doi:
NULL. [PMID: 15865079] - Yuji Yoshiyama, Kazue Yamaguchi, Kazuhiro Matsuo, Minoru Kurokawa, Motoko Kanke. The effect of fosfomycin on nedaplatin-induced nephrotoxicity in rats.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2005 Feb; 11(1):14-7. doi:
10.1007/s10156-004-0361-z. [PMID: 15729482] - Takamichi Matsui, Makoto Kano. [Pharmacodynamics of tongue tissue and plasma after intraarterial infusion of cis-diammine glycolato platinum (CDGP)].
Nihon Jibiinkoka Gakkai kaiho.
2004 Nov; 107(11):990-7. doi:
10.3950/jibiinkoka.107.990. [PMID: 15624504] - Yimin Cui, Koh-Ichi Sugimoto, Yoshiko Kawai, Toshiaki Sudoh, Munekazu Gemba, Akio Fujimura. Chronotoxicity of nedaplatin in rats.
Chronobiology international.
2004 Jul; 21(4-5):601-11. doi:
10.1081/cbi-120039814. [PMID: 15470957] - Toru Ishibashi, Yoshitaka Yano, Takayoshi Oguma. Population pharmacokinetics of platinum after nedaplatin administration and model validation in adult patients.
British journal of clinical pharmacology.
2003 Aug; 56(2):205-13. doi:
10.1046/j.1365-2125.2003.01871.x. [PMID: 12895194] - Ryouhei Futami, Takashi Tajiri, Masao Miyashita, Hiroshi Maruyama, Hiroshi Makino, Tsutomu Nomura, Atsushi Tateno, Tsuguhiro Miyashita, Koji Sasajima. [Effect of nedaplatin, 5-FU, and leucovorin combined with radiation therapy in unresectable esophageal carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
2003 May; 30(5):681-4. doi:
. [PMID: 12795101] - Hidenori Umeki, Yumiko Yamaguchi, Mikiko Tsugata, Kimio Wakana, Yoshiaki Somekawa, Kouji Shimabukuro, Motohiro Ohara, Tomoko Terauchi, Mikio Ichimura, Isao Otsuka, Takeshi Aso. [Neoadjuvant intraarterial chemotherapy with nedaplatin, peplomycin and mitomycin C for advanced cervical cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2003 Mar; 30(3):377-82. doi:
NULL. [PMID: 12669397] - Shizuo Machida, Michitaka Ohwada, Hiroyuki Fujiwara, Ryo Konno, Masashi Takano, Tsunekazu Kita, Yoshihiro Kikuchi, Shinichi Komiyama, Mikio Mikami, Mitsuaki Suzuki. Phase I study of combination chemotherapy using irinotecan hydrochloride and nedaplatin for advanced or recurrent cervical cancer.
Oncology.
2003; 65(2):102-7. doi:
10.1159/000072333. [PMID: 12931014] - Nobukazu Fuwa, Takeshi Kodaira, Minoru Kamata, Akira Matsumoto, Kazuhisa Furutani, Hiroyuki Tachibana, Yoshiyuki Ito. Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
American journal of clinical oncology.
2002 Dec; 25(6):565-9. doi:
10.1097/00000421-200212000-00006. [PMID: 12477999] - T Ishibashi, Y Yano, T Oguma. A formula for predicting optimal dosage of nedaplatin based on renal function in adult cancer patients.
Cancer chemotherapy and pharmacology.
2002 Sep; 50(3):230-6. doi:
10.1007/s00280-002-0488-5. [PMID: 12203105] - Yasubumi Maruoka, Tomohiro Ando, Makoto Hoshino, Yosuke Ogiuchi, Noboru Nishihara, Toshihiro Okamoto, Kenji Fukada, Takaho Kuwazawa, Hideki Ogiuchi. [Combination chemotherapy with nedaplatin (CDGP) and 5-FU for oral cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2002 Mar; 29(3):421-5. doi:
NULL. [PMID: 11915732] - Masatoshi Adachi, Akihiko Shibata, Munehiro Hayashi, Daigo Satoh, Takahiro Miyasaka, Chie Yanai, Noritoshi Kawatsu, Hideo Yagishita, Yasuhito Ogino, Noriaki Yamashita, Munekazu Suzuki. [Combined preoperative therapy for oral cancer with nedaplatin and radiation].
Gan to kagaku ryoho. Cancer & chemotherapy.
2002 Mar; 29(3):465-7. doi:
NULL. [PMID: 11915741] - Y Matsumoto, O Ishiko, E Nakagawa, T Sumi, Y Hyun, Y Ando, S Ogita. Pharmacokinetics and pharmacodynamics of serum platinum of gynecologic cancer patients treated with nedaplatin.
Oncology reports.
2001 Nov; 8(6):1269-73. doi:
10.3892/or.8.6.1269. [PMID: 11605047] - K Kawanishi, Y Miyagi, J Yamamoto, Y Miyagi, K Nakamura, J Kodama, A Hongo, M Yoshinouchi, T Kudo. Cytocidal effect and DNA damage of nedaplatin in vitro by simulating pharmacokinetic parameters.
Cancer chemotherapy and pharmacology.
2001 Apr; 47(4):303-8. doi:
10.1007/s002800000238. [PMID: 11345646] - A Iwasaki, A Tanizaki, Y Ohbayashi, M Miyake, S Nagahata, N Takahashi. [Chemotherapy with nedaplatin for an oral floor cancer patient undergoing chronic hemodialysis].
Gan to kagaku ryoho. Cancer & chemotherapy.
2000 Dec; 27(14):2231-4. doi:
NULL. [PMID: 11142167] - N Takigawa, Y Segawa, H Ueoka, K Kiura, M Tabata, T Shibayama, I Takata, H Miyamoto, K Eguchi, M Harada. Combination of nedaplatin and vindesine for treatment of relapsed or refractory non-small-cell lung cancer.
Cancer chemotherapy and pharmacology.
2000; 46(4):272-8. doi:
10.1007/s002800000153. [PMID: 11052624] - N Uchida, H Yoshida, H Yamada, T Wada, K Daikatsu, I Ikeuchi, R Maekawa, K Sugita, T Yoshioka. Combination chemotherapy with nedaplatin and cyclophosphamide in human ovarian cancer model.
Japanese journal of cancer research : Gann.
1999 Aug; 90(8):887-94. doi:
10.1111/j.1349-7006.1999.tb00831.x. [PMID: 10543262] - Y Nishioka, O Kitada, T Meguro, K Aragane, T Tanimukai, H Nakamura, H Nakahama, T Matsuyama, M Sugita, T Yano, Y Takenaka, Y Takamitsu. [Nedaplatin and etoposide combination chemotherapy in a patient with small cell carcinoma undergoing hemodialysis].
Gan to kagaku ryoho. Cancer & chemotherapy.
1999 Mar; 26(4):527-30. doi:
NULL. [PMID: 10097751] - B J Monk, D S Alberts, R A Burger, P T Fanta, A V Hallum, K D Hatch, S E Salmon. In vitro phase II comparison of the cytotoxicity of a novel platinum analog, nedaplatin (254-S), with that of cisplatin and carboplatin against fresh, human cervical cancers.
Gynecologic oncology.
1998 Nov; 71(2):308-12. doi:
10.1006/gyno.1998.5140. [PMID: 9826477] - H Yamanaka, T Motohiro, T Michiura, A Asai, T Mori, K Hioki. Nedaplatin and 5-FU combined with radiation in the treatment for esophageal cancer.
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi.
1998 Oct; 46(10):943-8. doi:
10.1007/bf03217851. [PMID: 9847566] - M Yakushiji, T Sugiyama, K Ushijima. [Promising new drugs for gynecological cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
1997 Oct; 24(13):1932-7. doi:
". [PMID: 9350238] - D S Alberts, P T Fanta, K L Running, L P Adair, D J Garcia, R Liu-Stevens, S E Salmon. In vitro phase II comparison of the cytotoxicity of a novel platinum analog, nedaplatin (254-S), with that of cisplatin and carboplatin against fresh, human ovarian cancers.
Cancer chemotherapy and pharmacology.
1997; 39(6):493-7. doi:
10.1007/s002800050604. [PMID: 9118460] - H Koga, T Inamura, K Ikezaki, T Nomura, K Samoto, M Fukui. Increased delivery of a new cisplatin analogue (254-S) in a rat brain tumor by an intracarotid infusion of bradykinin.
Neurological research.
1996 Jun; 18(3):244-7. doi:
10.1080/01616412.1996.11740413. [PMID: 8837061] - T Hara, M Matsumoto, S Tsuji, S Nagasawa, A Hiraoka, T Masaoka, K Kodama, T Horai, T Sakuma, T Seya. Homologous complement activation on drug-induced apoptotic cells from a human lung adenocarcinoma cell line.
Immunobiology.
1996 199; 196(5):491-503. doi:
10.1016/s0171-2985(97)80066-6. [PMID: 9145327] - I Takahashi, Y Maehara, H Kusumoto, T Kusumoto, H Baba, S Kohnoe, K Sugimachi. Interaction of cis-diamminedichloro-platinum(II) and its analogues cis-1,1- cyclobutanedicarboxylato(2R)-2-methyl-1,4-butanediammineplatinum(II) and cis-diammine(glycolato)platinum with hyperthermia in vivo.
Oncology.
1996 Jan; 53(1):68-72. doi:
10.1159/000227538. [PMID: 8570136] - J Kigawa, Y Minagawa, H Itamochi, Y Kanamori, H Ishihara, N Terakawa. Platinum concentrations in uterus and serum after internal iliac arterial infusion of platinum compounds in rabbits.
Obstetrics and gynecology.
1995 Aug; 86(2):265-8. doi:
10.1016/0029-7844(95)00117-a. [PMID: 7617358] - M Fukuda, Y Ohe, F Kanzawa, M Oka, K Hara, N Saijo. Evaluation of novel platinum complexes, inhibitors of topoisomerase I and II in non-small cell lung cancer (NSCLC) sublines resistant to cisplatin.
Anticancer research.
1995 Mar; 15(2):393-8. doi:
. [PMID: 7763011] - M Koenuma, H Kasai, N Uchida, T Wada, M Hattori, T Oguma, T Totani, M Inaba. Pharmacokinetic correlation between experimental and clinical effects on human non-small cell lung cancers of cis-diammineglycolatoplatinum (254-S) and cis-diamminedichloroplatinum.
Anticancer research.
1995 Mar; 15(2):417-21. doi:
NULL. [PMID: 7763015] - S Akima, K Yoshida, N Tsuboi, K Horiuchi. [Evaluation of the chemotherapy of a transplantable bladder tumour strain (NM-B-1) by two anti-cancer drugs in combination with a pressor agent in nude mice].
Nihon Ika Daigaku zasshi.
1995 Feb; 62(1):19-27. doi:
10.1272/jnms1923.62.19. [PMID: 7721973] - K Ota, T Oguma, K Shimamura. Pharmacokinetics of platinum in cancer patients following intravenous infusion of cis-diammine(glycolato)platinum, 254-S.
Anticancer research.
1994 May; 14(3B):1383-7. doi:
NULL. [PMID: 8067710] - T Koizumi, K Kubo, S Shinozaki, S Koyama, T Amari, T Hayano, K Fujimoto, T Kobayashi, M Sekiguchi, R Sakai. Pharmacokinetic evaluation of (glycolato-O,O')diammine platinum(II) in lung lymph in sheep.
Japanese journal of cancer research : Gann.
1993 Apr; 84(4):468-73. doi:
10.1111/j.1349-7006.1993.tb00160.x. [PMID: 8514614] - T Miya, Y Sasaki, A Karato, N Saijo. Pharmacokinetic study of mitomycin C with emphasis on the influence of aging.
Japanese journal of cancer research : Gann.
1992 Dec; 83(12):1382-5. doi:
10.1111/j.1349-7006.1992.tb02773.x. [PMID: 1336497] - M Horiuchi, H Miyake, K Ota. [Ototoxicity of cis-diammine glycolato platinum, 254-S].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Aug; 19(9):1327-32. doi:
. [PMID: 1503488] - K Furuse, M Fukuoka, H Asamoto, H Niitani, I Kimura, A Sakuma, Y Yamaguchi. [A randomized comparative study of 254-S plus vindesine (VDS) vs. cisplatin (CDDP) plus VDS in patients with advanced non-small cell lung cancer (NSCLC)].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Jul; 19(7):1019-26. doi:
. [PMID: 1320846] - K Ota, A Wakui, H Majima, H Niitani, Y Inuyama, M Ogawa, Y Ariyoshi, O Yoshida, T Taguchi, I Kimura. [Phase I study of a new platinum complex 254-S, cis-diammine (glycolato)-platinum (II)].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Jun; 19(6):855-61. doi:
. [PMID: 1605663] - K Noda, M Ikeda, M Yakushiji, H Nishimura, Y Terashima, H Sasaki, T Hata, H Kuramoto, K Tanaka, T Takahashi. [A phase II clinical study of cis-diammine glycolato platinum, 254-S, for cervical cancer of the uterus].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Jun; 19(6):885-92. doi:
NULL. [PMID: 1605666] - T Taguchi, A Wakui, K Nabeya, M Kurihara, K Isono, T Kakegawa, K Ota. [A phase II clinical study of cis-diammine glycolato platinum, 254-S, for gastrointestinal cancers. 254-S Gastrointestinal Cancer Study Group].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Apr; 19(4):483-8. doi:
NULL. [PMID: 1558398] - Y Sasaki. [Pharmacological approach to the platinum compounds].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Apr; 19(4):456-62. doi:
NULL. [PMID: 1313667] - Y Sasaki, T Amano, M Morita, T Shinkai, K Eguchi, T Tamura, Y Ohe, A Kojima, N Saijo. Phase I study and pharmacological analysis of cis-diammine(glycolato)platinum (254-S; NSC 375101D) administered by 5-day continuous intravenous infusion.
Cancer research.
1991 Mar; 51(5):1472-7. doi:
NULL. [PMID: 1997185] - Y Sasaki, T Shinkai, K Eguchi, T Tamura, Y Ohe, T Ohmori, N Saijo. Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer chemotherapy and pharmacology.
1991; 27(4):263-70. doi:
10.1007/bf00685110. [PMID: 1847845] - K Hirabayashi, E Okada, T Oguma, K Shimamura. [Pharmacokinetics of cis-diammine (glycolato) platinum (254-S), a new platinum antitumor agent, following an intravenous and intraperitoneal infusion bioactive platinum concentration profile].
Gan to kagaku ryoho. Cancer & chemotherapy.
1990 Nov; 17(11):2221-7. doi:
NULL. [PMID: 2241186] - Y Kameyama, N Okazaki, M Nakagawa, H Koshida, M Nakamura, M Gemba. Nephrotoxicity of a new platinum compound, 254-S, evaluated with rat kidney cortical slices.
Toxicology letters.
1990 Jun; 52(1):15-24. doi:
10.1016/0378-4274(90)90161-e. [PMID: 2356567] - Y Ariyoshi, K Ota. [Preclinical and clinical evaluation of toxicity and antitumor activity of cisplatin analogues].
Gan to kagaku ryoho. Cancer & chemotherapy.
1989 Apr; 16(4 Pt 2-2):1379-85. doi:
. [PMID: 2658826] - H Fujita, M Okamoto, A Takao. [Pharmacokinetics of new cisplatin analogues in experimental animals].
Gan to kagaku ryoho. Cancer & chemotherapy.
1989 Apr; 16(4 Pt 2-2):1366-72. doi:
NULL. [PMID: 2658824] - T Machida, Y Akasaka. [Experimental evaluation of cisplatin analogous in urogenital cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
1989 Apr; 16(4 Pt 2-2):1386-92. doi:
NULL. [PMID: 2658827] - H Majima. [Present status of cisplatin (CDDP) analogues in Japan].
Gan to kagaku ryoho. Cancer & chemotherapy.
1989 Apr; 16(4 Pt 2-2):1373-8. doi:
NULL. [PMID: 2658825] - Y Sasaki, T Tamura, K Eguchi, T Shinkai, Y Fujiwara, M Fukuda, Y Ohe, M Bungo, N Horichi, S Niimi. Pharmacokinetics of (glycolate-0,0')-diammine platinum (II), a new platinum derivative, in comparison with cisplatin and carboplatin.
Cancer chemotherapy and pharmacology.
1989; 23(4):243-6. doi:
10.1007/bf00451649. [PMID: 2647312] - Y Sasaki, T Ohta, T Tamura, K Eguchi, T Shinkai, M Noguchi, N Saijo. A case report of pulmonary adenocarcinoma responding to (glycolato-0,0') diammineplatinum (II), a new platinum complex.
Japanese journal of clinical oncology.
1987 Sep; 17(3):285-90. doi:
NULL. [PMID: 3312721] - A L Sheffer, D T Fearon, K F Austen. Methyltestosterone therapy in hereditary angioedema.
Annals of internal medicine.
1977 Mar; 86(3):306-8. doi:
10.7326/0003-4819-86-3-306. [PMID: 320930]