CID 5884629 (BioDeep_00000913348)

   


代谢物信息卡片


CID 5884629

化学式: C47H68O17 (904.4456278)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC=CC=CC(=O)OC1C(=CC(=O)OC)CC2CC(OC(=O)CC(CC3CC(C(C(O3)(CC4CC(=CC(=O)OC)CC(O4)C=CC(C1(O2)O)(C)C)O)(C)C)OC(=O)C)O)C(C)O
InChI: InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16-,30-20+,31-22+

描述信息

同义名列表

1 个代谢物同义名

CID 5884629



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Youngki You, Joydip Das. Molecular dynamics simulation studies on binding of activator and inhibitor to Munc13-1 C1 in the presence of membrane. Journal of biomolecular structure & dynamics. 2022; 40(24):14160-14175. doi: 10.1080/07391102.2021.2001375. [PMID: 34779746]
  • Xiang Rong Tian, Hai Feng Tang, Xiao Lin Tian, Jia Jun Hu, Li Li Huang, Kirk R Gustafson. Review of bioactive secondary metabolites from marine bryozoans in the progress of new drugs discovery. Future medicinal chemistry. 2018 06; 10(12):1497-1514. doi: 10.4155/fmc-2018-0012. [PMID: 29788787]
  • Elsayed I Salim, Samar F Harras, Aisha G Abdalla, Mohmmed H Mona. Syphacia muris infection in rats attenuates colorectal carcinogenesis through oxidative stress and gene expression alterations. Implications for modulatory effects by Bryostatin-1. Acta parasitologica. 2018 Mar; 63(1):198-209. doi: 10.1515/ap-2018-0023. [PMID: 29351079]
  • Steven M Ryckbosch, Paul A Wender, Vijay S Pande. Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes. Nature communications. 2017 02; 8(1):6. doi: 10.1038/s41467-016-0015-8. [PMID: 28232750]
  • Daniel C Buehler, Matthew D Marsden, Sean Shen, Daniel B Toso, Xiaomeng Wu, Joseph A Loo, Z Hong Zhou, Valerie A Kickhoefer, Paul A Wender, Jerome A Zack, Leonard H Rome. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS nano. 2014 Aug; 8(8):7723-32. doi: 10.1021/nn5002694. [PMID: 25061969]
  • A Gonelli, C Mischiati, R Guerrini, R Voltan, S Salvadori, G Zauli. Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents. Mini reviews in medicinal chemistry. 2009 Apr; 9(4):498-509. doi: 10.2174/138955709787847967. [PMID: 19356127]
  • Miao-Kun Sun, Daniel L Alkon. Synergistic effects of chronic bryostatin-1 and alpha-tocopherol on spatial learning and memory in rats. European journal of pharmacology. 2008 Apr; 584(2-3):328-37. doi: 10.1016/j.ejphar.2008.02.014. [PMID: 18313045]
  • Matthew C Tuthill, Carolyn E Oki, Patricia S Lorenzo. Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes. Molecular cancer therapeutics. 2006 Mar; 5(3):602-10. doi: 10.1158/1535-7163.mct-05-0317. [PMID: 16546974]
  • Qiming J Wang, Tzan-Wei Fang, Dazhi Yang, Nancy E Lewin, Johan Van Lint, Victor E Marquez, Peter M Blumberg. Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D. Molecular pharmacology. 2003 Dec; 64(6):1342-8. doi: 10.1124/mol.64.6.1342. [PMID: 14645664]
  • Tushar Varma, Si Qi Liu, Matthew West, Visith Thongboonkerd, Peter P Ruvolo, W Stratford May, Aruni Bhatnagar. Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase. FEBS letters. 2003 Jan; 534(1-3):175-9. doi: 10.1016/s0014-5793(02)03834-6. [PMID: 12527382]
  • K Z Liu, C P Schultz, J B Johnston, F W Beck, A M Al-Katib, R M Mohammad, H H Mantsch. Infrared spectroscopic study of bryostatin 1-induced membrane alterations in a B-CLL cell line. Leukemia. 1999 Aug; 13(8):1273-80. doi: 10.1038/sj.leu.2401463. [PMID: 10450757]
  • S J Slater, F J Taddeo, A Mazurek, B A Stagliano, S K Milano, M B Kelly, C Ho, C D Stubbs. Inhibition of membrane lipid-independent protein kinase Calpha activity by phorbol esters, diacylglycerols, and bryostatin-1. The Journal of biological chemistry. 1998 Sep; 273(36):23160-8. doi: 10.1074/jbc.273.36.23160. [PMID: 9722545]
  • K Z Liu, C P Schultz, R M Mohammad, A M Al-Katib, J B Johnston, H H Mantsch. Similarities between the sensitivity to 2-chlorodeoxyadenosine of lymphocytes from CLL patients and bryostatin 1-treated WSU-CLL cells: an infrared spectroscopic study. Cancer letters. 1998 May; 127(1-2):185-93. doi: 10.1016/s0304-3835(98)00036-6. [PMID: 9619876]
  • H W Cook, N D Ridgway, D M Byers. Involvement of phospholipase D and protein kinase C in phorbol ester and fatty acid stimulated turnover of phosphatidylcholine and phosphatidylethanolamine in neural cells. Biochimica et biophysica acta. 1998 Feb; 1390(1):103-17. doi: 10.1016/s0005-2760(97)00162-8. [PMID: 9487144]
  • R M Mohammad, K Katato, V P Almatchy, N Wall, K Z Liu, C P Schultz, H H Mantsch, M Varterasian, A M al-Katib. Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: preclinical studies. Clinical cancer research : an official journal of the American Association for Cancer Research. 1998 Feb; 4(2):445-53. doi: . [PMID: 9516935]
  • G S Bignami, F Wagner, P G Grothaus, P Rustagi, D E Davis, A S Kraft. Biological activity of 26-succinylbryostatin 1. Biochimica et biophysica acta. 1996 Jul; 1312(3):197-206. doi: 10.1016/0167-4889(96)00018-3. [PMID: 8703988]
  • V L Sylvia, Z Schwartz, E B Ellis, S H Helm, R Gomez, D D Dean, B D Boyan. Nongenomic regulation of protein kinase C isoforms by the vitamin D metabolites 1 alpha,25-(OH)2D3 and 24R,25-(OH)2D3. Journal of cellular physiology. 1996 Jun; 167(3):380-93. doi: 10.1002/(sici)1097-4652(199606)167:3<380::aid-jcp2>3.0.co;2-l. [PMID: 8655592]
  • M G Kazanietz, N E Lewin, J D Bruns, P M Blumberg. Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. The Journal of biological chemistry. 1995 May; 270(18):10777-83. doi: 10.1074/jbc.270.18.10777. [PMID: 7537738]
  • M G Kazanietz, N E Lewin, F Gao, G R Pettit, P M Blumberg. Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes. Molecular pharmacology. 1994 Aug; 46(2):374-9. doi: . [PMID: 8078499]
  • J Grabarek, J A Ware. Protein kinase C activation without membrane contact in platelets stimulated by bryostatin. The Journal of biological chemistry. 1993 Mar; 268(8):5543-9. doi: NULL. [PMID: 8449916]