2-[3-[6-[5-[3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[4,5-dihydroxy-2-(hydroxymethyl)-6-[(Z)-3-hydroxy-1-(octadecanoylamino)octadec-4-en-2-yl]oxyoxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-amino-6-carboxy-4-hydroxyoxan-2-yl]-2,3-dihydroxypropoxy]-5-amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid (BioDeep_00000913270)

代谢物信息卡片

2-[3-[6-[5-[3-acetamido-5-hydroxy-6-(hydroxymethyl)-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-[4,5-dihydroxy-2-(hydroxymethyl)-6-[(Z)-3-hydroxy-1-(octadecanoylamino)octadec-4-en-2-yl]oxyoxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-amino-6-carboxy-4-hydroxyoxan-2-yl]-2,3-dihydroxypropoxy]-5-amino-4-hydroxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid

化学式: C80H144N4O37 (1752.9508934)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCC(=O)NCC(C(C=CCCCCCCCCCCCCC)O)OC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O)NC(=O)C)OC5(CC(C(C(O5)C(C(COC6(CC(C(C(O6)C(C(CO)O)O)N)O)C(=O)O)O)O)N)O)C(=O)O)O)O)O
InChI: InChI=1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30-

描述信息

同义名列表

1 个代谢物同义名

数据库引用编号

1 个数据库交叉引用编号

PubChem: 156963400

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Antoine Guilmot, Sofia Maldonado Slootjes, Amina Sellimi, Maroussia Bronchain, Bernard Hanseeuw, Leila Belkhir, Jean Cyr Yombi, Julien De Greef, Lucie Pothen, Halil Yildiz, Thierry Duprez, Catherine Fillée, Ahalieyah Anantharajah, Antoine Capes, Philippe Hantson, Philippe Jacquerye, Jean-Marc Raymackers, Frederic London, Souraya El Sankari, Adrian Ivanoiu, Pietro Maggi, Vincent van Pesch. Immune-mediated neurological syndromes in SARS-CoV-2-infected patients. Journal of neurology. 2021 Mar; 268(3):751-757. doi: 10.1007/s00415-020-10108-x. [PMID: 32734353]
Consuelo Gutiérrez-Ortiz, Antonio Méndez-Guerrero, Sara Rodrigo-Rey, Eduardo San Pedro-Murillo, Laura Bermejo-Guerrero, Ricardo Gordo-Mañas, Fernando de Aragón-Gómez, Julián Benito-León. Miller Fisher syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020 08; 95(5):e601-e605. doi: 10.1212/wnl.0000000000009619. [PMID: 32303650]
Matteo Tagliapietra, Gianluigi Zanusso, Sergio Ferrari, Riccardo Orlandi, Laura Bertolasi, Tiziana Cavallaro, Salvatore Monaco. Myelin uncompaction and axo-glial detachment in chronic ataxic neuropathy with monospecific IgM antibody to ganglioside GD1b. Journal of the peripheral nervous system : JPNS. 2020 03; 25(1):54-59. doi: 10.1111/jns.12359. [PMID: 31837178]
Zhaocai Jiang, Weina Ju, Shen Luo, Yu Yang. Diffuse large B-cell lymphoma involving peripheral nervous system with IgM antibodies against GM1 and GD1b: A case report. Medicine. 2019 Apr; 98(15):e15049. doi: 10.1097/md.0000000000015049. [PMID: 30985655]
Noor E Taams, Nicolette C Notermans, Willem-Jan R Fokkink, Anne P Tio-Gillen, Ruth Huizinga, Marco W J Schreurs, Bart C Jacobs. Clinical relevance of serum antibodies to GD1b in immune-mediated neuropathies. Journal of the peripheral nervous system : JPNS. 2018 12; 23(4):227-234. doi: 10.1111/jns.12285. [PMID: 30101437]
Rocio Garcia-Santibanez, Craig M Zaidman, R Brian Sommerville, Glenn Lopate, Conrad C Weihl, Alan Pestronk, Robert C Bucelli. CANOMAD and other chronic ataxic neuropathies with disialosyl antibodies (CANDA). Journal of neurology. 2018 Jun; 265(6):1402-1409. doi: 10.1007/s00415-018-8853-4. [PMID: 29633012]
Kenichi G N Suzuki, Hiromune Ando, Naoko Komura, Takahiro K Fujiwara, Makoto Kiso, Akihiro Kusumi. Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. Biochimica et biophysica acta. General subjects. 2017 Oct; 1861(10):2494-2506. doi: 10.1016/j.bbagen.2017.07.012. [PMID: 28734966]
João Sequeira, Ana Calado, Margarida Dias, Manuel Manita. Parvovirus B19 infection associated with hemolytic anemia and cranial polyneuropathy. Journal of neurovirology. 2017 10; 23(5):786-788. doi: 10.1007/s13365-017-0562-8. [PMID: 28831691]
Tae Hwan Han, Do Yeon Kim, Dong Woo Park, Jin-Hwa Moon. Transient Isolated Lower Bulbar Palsy With Elevated Serum Anti-GM1 and Anti-GD1b Antibodies During Aripiprazole Treatment. Pediatric neurology. 2017 01; 66(?):96-99. doi: 10.1016/j.pediatrneurol.2016.07.011. [PMID: 28341090]
Naoko Komura, Kenichi G N Suzuki, Hiromune Ando, Miku Konishi, Akihiro Imamura, Hideharu Ishida, Akihiro Kusumi, Makoto Kiso. Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. Methods in enzymology. 2017; 597(?):239-263. doi: 10.1016/bs.mie.2017.06.004. [PMID: 28935104]
Linbo Zhao, Anthony T Marciano, Courtney R Rivet, Michael J Imperiale. Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. Virology. 2016 May; 492(?):66-72. doi: 10.1016/j.virol.2016.02.007. [PMID: 26901486]
Naoto Oikawa, Teruhiko Matsubara, Ryoto Fukuda, Hanaki Yasumori, Hiroyuki Hatsuta, Shigeo Murayama, Toshinori Sato, Akemi Suzuki, Katsuhiko Yanagisawa. Imbalance in fatty-acid-chain length of gangliosides triggers Alzheimer amyloid deposition in the precuneus. PloS one. 2015; 10(3):e0121356. doi: 10.1371/journal.pone.0121356. [PMID: 25798597]
Barbara Viljetić, Irena Labak, Senka Majić, Anamaria Stambuk, Marija Heffer. Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes. Biochimica et biophysica acta. 2012 Sep; 1820(9):1437-43. doi: 10.1016/j.bbagen.2011.12.010. [PMID: 22206893]
Antonino Uncini. A common mechanism and a new categorization for anti-ganglioside antibody-mediated neuropathies. Experimental neurology. 2012 Jun; 235(2):513-6. doi: 10.1016/j.expneurol.2012.03.023. [PMID: 22507308]
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Seong-Hae Jeong, Jungmoo Nam, Min Jeong Kwon, Jong Kuk Kim, Ji Soo Kim. Nystagmus and ataxia associated with antiganglioside antibodies. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2011 Dec; 31(4):326-30. doi: 10.1097/wno.0b013e31822f6707. [PMID: 21918476]
Vivian Marino Mazucato, Adriana Maria Mariano Silveira E Souza, Liliana Martos Nicoletti, Maria Célia Jamur, Constance Oliver. GD1b-derived gangliosides modulate FcεRI endocytosis in mast cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2011 Apr; 59(4):428-40. doi: 10.1369/0022155411400868. [PMID: 21411813]
Ricardo D Lardone, Nobuhiro Yuki, Masaaki Odaka, Jose L Daniotti, Fernando J Irazoqui, Gustavo A Nores. Anti-GM1 IgG antibodies in Guillain-Barré syndrome: fine specificity is associated with disease severity. Journal of neurology, neurosurgery, and psychiatry. 2010 Jun; 81(6):629-33. doi: 10.1136/jnnp.2009.183665. [PMID: 19965859]
S Attarian, J Boucraut, A M Hubert, D Uzenot, E Delmont, A Verschueren, J Franques, J P Azulay, J Pouget. Chronic ataxic neuropathies associated with anti-GD1b IgM antibodies: response to IVIg therapy. Journal of neurology, neurosurgery, and psychiatry. 2010 Jan; 81(1):61-4. doi: 10.1136/jnnp.2009.185736. [PMID: 19726417]
Alina Serb, Catalin Schiopu, Corina Flangea, Zeljka Vukelić, Eugen Sisu, Leon Zagrean, Alina D Zamfir. High-throughput analysis of gangliosides in defined regions of fetal brain by fully automated chip-based nanoelectrospray ionization multi-stage mass spectrometry. European journal of mass spectrometry (Chichester, England). 2009; 15(4):541-53. doi: 10.1255/ejms.1009. [PMID: 19661562]
Adriana Maria Mariano Silveira e Souza, Vivian Marino Mazucato, Rodrigo Orlandini de Castro, Fabiana Matioli, Pietro Ciancaglini, Tony de Paiva Paulino, Maria Célia Jamur, Constance Oliver. The alpha-galactosyl derivatives of ganglioside GD(1b) are essential for the organization of lipid rafts in RBL-2H3 mast cells. Experimental cell research. 2008 Aug; 314(13):2515-28. doi: 10.1016/j.yexcr.2008.05.014. [PMID: 18585706]
S D Arbogast, S Khanna, D W Koontz, R L Tomsak, B Katirji, R J Leigh. Chronic ataxic neuropathy mimicking dorsal midbrain syndrome. Journal of neurology, neurosurgery, and psychiatry. 2007 Nov; 78(11):1276-7. doi: 10.1136/jnnp.2007.120444. [PMID: 17504882]
Katrin Deinhardt, Otto Berninghausen, Hugh J Willison, Colin R Hopkins, Giampietro Schiavo. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. The Journal of cell biology. 2006 Jul; 174(3):459-71. doi: 10.1083/jcb.200508170. [PMID: 16880274]
Yasuhiro Yamazaki, Yasuko Nagatsuka, Eriko Oshima, Yasuo Suzuki, Yoshio Hirabayashi, Tsutomu Hashikawa. Comprehensive analysis of monoclonal antibodies against detergent-insoluble membrane/lipid rafts of HL60 cells. Journal of immunological methods. 2006 Apr; 311(1-2):106-16. doi: 10.1016/j.jim.2006.01.019. [PMID: 16564536]
Jonathan A Low, Brian Magnuson, Billy Tsai, Michael J Imperiale. Identification of gangliosides GD1b and GT1b as receptors for BK virus. Journal of virology. 2006 Feb; 80(3):1361-6. doi: 10.1128/jvi.80.3.1361-1366.2006. [PMID: 16415013]
Xuesong Chen, Shaopeng Chi, Mingna Liu, Wei Yang, Taotao Wei, Zhi Qi, Fuyu Yang. Inhibitory effect of ganglioside GD1b on K+ current in hippocampal neurons and its involvement in apoptosis suppression. Journal of lipid research. 2005 Dec; 46(12):2580-5. doi: 10.1194/jlr.m500252-jlr200. [PMID: 16199892]
Mirjana Gavella, Marina Kveder, Vaskresenija Lipovac, Romina Rakos, Greta Pifat. Trisialoganglioside GT1b prevents increase in sperm membrane molecular ordering induced by in vitro lipid peroxidation. Journal of andrology. 2005 Nov; 26(6):724-31. doi: 10.2164/jandrol.05038. [PMID: 16291967]
Jong Seok Bae, Byoung Joon Kim. Cerebellar ataxia and acute motor axonal neuropathy associated with Anti GD1b and Anti GM1 antibodies. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2005 Sep; 12(7):808-10. doi: 10.1016/j.jocn.2004.09.019. [PMID: 16054817]
Johannes Müthing, Iris Meisen, Bernhard Kniep, Jörg Haier, Norbert Senninger, Ulrich Neumann, Martin Langer, Klaus Witthohn, Jadranka Milosević, Jasna Peter-Katalinić. Tumor-associated CD75s gangliosides and CD75s-bearing glycoproteins with Neu5Acalpha2-6Galbeta1-4GlcNAc-residues are receptors for the anticancer drug rViscumin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Jan; 19(1):103-5. doi: 10.1096/fj.04-2494fje. [PMID: 15520251]
Ken-ichi Kaida, Daiji Morita, Mami Kanzaki, Keiko Kamakura, Kazuo Motoyoshi, Minako Hirakawa, Susumu Kusunoki. Ganglioside complexes as new target antigens in Guillain-Barré syndrome. Annals of neurology. 2004 Oct; 56(4):567-71. doi: 10.1002/ana.20222. [PMID: 15389898]
Masashi Nishio, Satoshi Fukumoto, Keiko Furukawa, Akiko Ichimura, Hiroshi Miyazaki, Susumu Kusunoki, Takeshi Urano, Koichi Furukawa. Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells. The Journal of biological chemistry. 2004 Aug; 279(32):33368-78. doi: 10.1074/jbc.m403816200. [PMID: 15145933]
Masaaki Noguchi, Kiyoshi Mori, Shigetaka Yamazaki, Kouichi Suda, Naotake Sato, Kazuo Oshimi. Multifocal motor neuropathy caused by a B-cell lymphoma producing a monoclonal IgM autoantibody against peripheral nerve myelin glycolipids GM1 and GD1b. British journal of haematology. 2003 Nov; 123(4):600-5. doi: 10.1046/j.1365-2141.2003.04651.x. [PMID: 14616962]
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Megumi Saito, Hisayo Kitamura, Kiyoshi Sugiyama. Occurrence and tissue distribution of c-series gangliosides in the common squid Todarodes pacificus. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2002 Mar; 131(3):433-41. doi: 10.1016/s1096-4959(01)00517-6. [PMID: 11959025]
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