[4-[2-(butanoylamino)-6-oxo-1H-purin-9-yl]-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate (BioDeep_00000913269)

   


代谢物信息卡片


[4-[2-(butanoylamino)-6-oxo-1H-purin-9-yl]-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate

化学式: C18H24N5O9P (485.13115840000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)COC(=O)CCC)OP(=O)(O4)O
InChI: InChI=1S/C18H24N5O9P/c1-3-5-10(24)20-18-21-15-12(16(26)22-18)19-8-23(15)17-14-13(31-33(27,28)32-14)9(30-17)7-29-11(25)6-4-2/h8-9,13-14,17H,3-7H2,1-2H3,(H,27,28)(H2,20,21,22,24,26)



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Casandra M Monzon, Jeffrey L Garvin. Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs. American journal of physiology. Renal physiology. 2019 08; 317(2):F411-F418. doi: 10.1152/ajprenal.00065.2019. [PMID: 31166708]
  • Mari L Salmi, Kacey E Morris, Stanley J Roux, D Marshall Porterfield. Nitric oxide and cGMP signaling in calcium-dependent development of cell polarity in Ceratopteris richardii. Plant physiology. 2007 May; 144(1):94-104. doi: 10.1104/pp.107.096131. [PMID: 17351052]
  • Lihua Chen, Günter Daum, Kanchan Chitaley, Scott A Coats, Daniel F Bowen-Pope, Martin Eigenthaler, Naresh R Thumati, Ulrich Walter, Alexander W Clowes. Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells. Arteriosclerosis, thrombosis, and vascular biology. 2004 Aug; 24(8):1403-8. doi: 10.1161/01.atv.0000134705.39654.53. [PMID: 15178555]
  • Tsutomu Sakurada, Shingo Kuboshima, Goichi Ogimoto, Tomoya Fujino, Takeo Sato, Teruhiko Maeba, Kenjiro Kimura. Aquaporin-1 is recruited to the plasma membrane by hyperosmotic stimuli via a protein kinase A-dependent pathway in rat peritoneal mesothelial cells. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 2004; 20(?):37-42. doi: NULL. [PMID: 15384792]
  • Yasuko Ishikawa, Hirokazu Iida, Hajime Ishida. The muscarinic acetylcholine receptor-stimulated increase in aquaporin-5 levels in the apical plasma membrane in rat parotid acinar cells is coupled with activation of nitric oxide/cGMP signal transduction. Molecular pharmacology. 2002 Jun; 61(6):1423-34. doi: 10.1124/mol.61.6.1423. [PMID: 12021404]
  • N Lambeng, P P Michel, Y Agid, M Ruberg. The relationship between differentiation and survival in PC12 cells treated with cyclic adenosine monophosphate in the presence of epidermal growth factor or nerve growth factor. Neuroscience letters. 2001 Jan; 297(2):133-6. doi: 10.1016/s0304-3940(00)01690-6. [PMID: 11121888]
  • O Zolle, A M Lawrie, A W Simpson. Activation of the particulate and not the soluble guanylate cyclase leads to the inhibition of Ca2+ extrusion through localized elevation of cGMP. The Journal of biological chemistry. 2000 Aug; 275(34):25892-9. doi: 10.1074/jbc.m000786200. [PMID: 10851228]
  • H F Cheng, J L Wang, M Z Zhang, J A McKanna, R C Harris. Nitric oxide regulates renal cortical cyclooxygenase-2 expression. American journal of physiology. Renal physiology. 2000 Jul; 279(1):F122-9. doi: 10.1152/ajprenal.2000.279.1.f122. [PMID: 10894794]
  • Z Krasznai, T Marian, H Izumi, S Damjanovich, L Balkay, L Tron, M Morisawa. Membrane hyperpolarization removes inactivation of Ca2+ channels, leading to Ca2+ influx and subsequent initiation of sperm motility in the common carp. Proceedings of the National Academy of Sciences of the United States of America. 2000 Feb; 97(5):2052-7. doi: 10.1073/pnas.040558097. [PMID: 10688893]
  • C D Collard, A Agah, W Reenstra, J Buras, G L Stahl. Endothelial nuclear factor-kappaB translocation and vascular cell adhesion molecule-1 induction by complement: inhibition with anti-human C5 therapy or cGMP analogues. Arteriosclerosis, thrombosis, and vascular biology. 1999 Nov; 19(11):2623-9. doi: 10.1161/01.atv.19.11.2623. [PMID: 10559004]
  • M Akahori, S Yamada, N Takeyama, T Tanaka. Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice. The Journal of surgical research. 1999 Aug; 85(2):286-93. doi: 10.1006/jsre.1999.5621. [PMID: 10423331]
  • M A Maselli, A L Piepoli, F Pezzolla, M L Caruso, D Lorusso. Effect of somatostatin on human gallbladder motility: an in vitro study. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 1999 Feb; 11(1):47-53. doi: 10.1046/j.1365-2982.1999.00134.x. [PMID: 10087534]
  • M Kubokawa, S Nakaya, Y Yoshioka, K Nakamura, F Sato, Y Mori, T Kubota. Activation of inwardly rectifying K+ channel in OK proximal tubule cells involves cGMP-dependent phosphorylation process. The Japanese journal of physiology. 1998 Dec; 48(6):467-76. doi: 10.2170/jjphysiol.48.467. [PMID: 10021500]
  • H Sakai, A Ikari, T Shimizu, T Sato, N Takeguchi. Cyclic GMP-dependent cytoprotection against ethanol-induced damage in rabbit isolated gastric parietal cells. European journal of pharmacology. 1998 Nov; 361(1):109-17. doi: 10.1016/s0014-2999(98)00689-x. [PMID: 9851548]
  • O Iimura, E Kusano, S Homma, S Takeda, U Ikeda, K Shimada, Y Asano. Atrial natriuretic peptide enhances IL-1 beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells. Kidney & blood pressure research. 1998; 21(1):36-41. doi: 10.1159/000025841. [PMID: 9661135]
  • C Amorena, A F Castro. Control of proximal tubule acidification by the endothelium of the peritubular capillaries. The American journal of physiology. 1997 Feb; 272(2 Pt 2):R691-4. doi: 10.1152/ajpregu.1997.272.2.r691. [PMID: 9124496]
  • H M Hwang, S C Weng, S K Lo, R K Yu, W H Tsai. Neuritogenesis, not receptor expression, of NG108-15 cells can be modulated by monosialoganglioside GM1. The Chinese journal of physiology. 1996; 39(4):211-7. doi: NULL. [PMID: 9058005]
  • A del Castillo-Olivares, A Esteban del Valle, J Márquez, I Núñez de Castro, M A Medina. Ehrlich cell plasma membrane redox system is modulated through signal transduction pathways involving cGMP and Ca2+ as second messengers. Journal of bioenergetics and biomembranes. 1995 Dec; 27(6):605-11. doi: 10.1007/bf02111658. [PMID: 8746847]
  • V Villiotou, G Deliconstantinos. Nitric oxide, peroxynitrite and nitroso-compounds formation by ultraviolet A (UVA) irradiated human squamous cell carcinoma: potential role of nitric oxide in cancer prognosis. Anticancer research. 1995 May; 15(3):931-42. doi: NULL. [PMID: 7544092]
  • D B Duridanova, H S Gagov, G V Petkov, G B Shkodrov, K K Boev. Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism. General physiology and biophysics. 1995 Apr; 14(2):139-51. doi: NULL. [PMID: 8846882]
  • J Hirsch, E Schlatter. K+ channels in the basolateral membrane of rat cortical collecting duct are regulated by a cGMP-dependent protein kinase. Pflugers Archiv : European journal of physiology. 1995 Jan; 429(3):338-44. doi: 10.1007/bf00374148. [PMID: 7761258]
  • A Butterweck, U Gergs, C Elfgang, K Willecke, O Traub. Immunochemical characterization of the gap junction protein connexin45 in mouse kidney and transfected human HeLa cells. The Journal of membrane biology. 1994 Sep; 141(3):247-56. doi: 10.1007/bf00235134. [PMID: 7807524]
  • D E Kohan, E Padilla. Endothelin-1 production by rat inner medullary collecting duct: effect of nitric oxide, cGMP, and immune cytokines. The American journal of physiology. 1994 Feb; 266(2 Pt 2):F291-7. doi: 10.1152/ajprenal.1994.266.2.f291. [PMID: 8141330]
  • P Ruiz-Torres, F J Lucio, M González-Rubio, M Rodríguez-Puyol, D Rodríguez-Puyol. A dual effect of somatostatin on the proliferation of cultured rat mesangial cells. Biochemical and biophysical research communications. 1993 Sep; 195(2):1057-62. doi: 10.1006/bbrc.1993.2151. [PMID: 8103984]
  • E Busse, G Zimmer, O Bartsch, B Kornhuber. Cellular changes in HeLa cells and cervix cells after treatment with cyclic nucleotides. Oncology. 1993 Jul; 50(4):241-4. doi: 10.1159/000227188. [PMID: 8388554]
  • R A Bialecki, T N Tulenko. Acute exposure to cholesterol increases arterial nitroprusside- and endothelium-mediated relaxation. The American journal of physiology. 1993 Jan; 264(1 Pt 1):C32-9. doi: 10.1152/ajpcell.1993.264.1.c32. [PMID: 8430773]
  • J Barsony, W McKoy. Molybdate increases intracellular 3',5'-guanosine cyclic monophosphate and stabilizes vitamin D receptor association with tubulin-containing filaments. The Journal of biological chemistry. 1992 Dec; 267(34):24457-65. doi: . [PMID: 1280259]
  • S Shaw, P Weidmann, A Zimmermann. Urodilatin, not nitroprusside, combined with dopamine reverses ischemic acute renal failure. Kidney international. 1992 Nov; 42(5):1153-9. doi: 10.1038/ki.1992.399. [PMID: 1453600]
  • J L Garvin. ANF inhibits norepinephrine-stimulated fluid absorption in rat proximal straight tubules. The American journal of physiology. 1992 Oct; 263(4 Pt 2):F581-5. doi: 10.1152/ajprenal.1992.263.4.f581. [PMID: 1415729]
  • V I Gudoshnikov, I N Baranova, V P Fedotov. [Effects of dibutyryl derivatives of cyclic nucleotides on synthesis of total RNA and proteins in cultured fetal rat hepatocytes]. Biulleten' eksperimental'noi biologii i meditsiny. 1991 May; 111(5):478-80. doi: NULL. [PMID: 1715212]
  • K E Mate, J C Rodger. Stability of the acrosome of the brush-tailed possum (Trichosurus vulpecula) and tammar wallaby (Macropus eugenii) in vitro and after exposure to conditions and agents known to cause capacitation or acrosome reaction of eutherian spermatozoa. Journal of reproduction and fertility. 1991 Jan; 91(1):41-8. doi: 10.1530/jrf.0.0910041. [PMID: 1847424]
  • S J Pandol, M S Schoeffield-Payne. Cyclic GMP regulates free cytosolic calcium in the pancreatic acinar cell. Cell calcium. 1990 Aug; 11(7):477-86. doi: 10.1016/0143-4160(90)90080-e. [PMID: 1980234]
  • P C Singhal, A Santiago, J Satriano, R M Hays, D Schlondorff. Effects of vasoactive agents on uptake of immunoglobulin G complexes by mesangial cells. The American journal of physiology. 1990 Mar; 258(3 Pt 2):F589-96. doi: 10.1152/ajprenal.1990.258.3.f589. [PMID: 2156448]
  • N M Hoosein, P A Kiener, R C Curry, M G Brattain. Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin-like peptide. Experimental cell research. 1990 Jan; 186(1):15-21. doi: 10.1016/0014-4827(90)90204-n. [PMID: 2298233]
  • V P Fedotov, I N Baranova, V I Gudoshnikov. [The effect of dibutyryl derivatives of cyclic nucleotides on albumin production in a primary culture of rat liver cells]. Voprosy meditsinskoi khimii. 1990 Jan; 36(1):69-72. doi: NULL. [PMID: 2160754]
  • J L Garvin. Inhibition of Jv by ANF in rat proximal straight tubules requires angiotensin. The American journal of physiology. 1989 Nov; 257(5 Pt 2):F907-11. doi: 10.1152/ajprenal.1989.257.5.f907. [PMID: 2556043]
  • D Menozzi, S Sato, R T Jensen, J D Gardner. Cyclic GMP does not inhibit protein kinase C-mediated enzyme secretion in rat pancreatic acini. The Journal of biological chemistry. 1989 Jan; 264(2):995-9. doi: 10.1016/s0021-9258(19)85042-1. [PMID: 2463255]
  • S A Wank, R T Jensen, J D Gardner. Kinetics of binding of cholecystokinin to pancreatic acini. The American journal of physiology. 1988 Jul; 255(1 Pt 1):G106-12. doi: 10.1152/ajpgi.1988.255.1.g106. [PMID: 3389410]
  • L Menapace, U Armato, J F Whitfield. The effects of corticotrophin (ACTH1-24), cyclic AMP and TPA (12-O-tetradecanoyl phorbol-13-acetate) on DNA replication and proliferation of primary rabbit adrenocortical cells in a synthetic medium. Biochemical and biophysical research communications. 1987 Nov; 148(3):1295-303. doi: 10.1016/s0006-291x(87)80274-7. [PMID: 2825683]
  • F Suzuki, K Kato, T Kato, N Ogasawara. S-100 protein in clonal astroglioma cells is released by adrenocorticotropic hormone and corticotropin-like intermediate-lobe peptide. Journal of neurochemistry. 1987 Nov; 49(5):1557-63. doi: 10.1111/j.1471-4159.1987.tb01027.x. [PMID: 2822856]
  • M Younes, R T Jensen, J D Gardner. Cholecystokinin-induced residual stimulation of enzyme secretion from mouse pancreatic acini. Biochimica et biophysica acta. 1987 Oct; 930(3):410-8. doi: 10.1016/0167-4889(87)90014-0. [PMID: 2443185]
  • R G Appel, J Wang, M S Simonson, M J Dunn. A mechanism by which atrial natriuretic factor mediates its glomerular actions. The American journal of physiology. 1986 Dec; 251(6 Pt 2):F1036-42. doi: 10.1152/ajprenal.1986.251.6.f1036. [PMID: 2947473]
  • C J Hubbard. Cyclic AMP changes in the component cells of Graafian follicles: possible influences on maturation in the follicle-enclosed oocytes of hamsters. Developmental biology. 1986 Dec; 118(2):343-51. doi: 10.1016/0012-1606(86)90003-5. [PMID: 3025032]
  • C L Huang, H E Ives, M G Cogan. In vivo evidence that cGMP is the second messenger for atrial natriuretic factor. Proceedings of the National Academy of Sciences of the United States of America. 1986 Oct; 83(20):8015-8. doi: 10.1073/pnas.83.20.8015. [PMID: 3020563]
  • A Iguchi, M Gotoh, H Matsunaga, M Ohuchi, T Nomura, N Sakamoto. Increase in plasma glucose concentration after intracerebroventricular injection of N,O'-dibutyryl cyclic adenosine 3',5'-monophosphate. Endocrinology. 1986 Jul; 119(1):125-9. doi: 10.1210/endo-119-1-125. [PMID: 2873022]
  • M P Murtaugh, W T Moore, P J Davies. Cyclic AMP potentiates the retinoic acid-induced expression of tissue transglutaminase in peritoneal macrophages. The Journal of biological chemistry. 1986 Jan; 261(2):614-21. doi: NULL. [PMID: 2867089]
  • T Uno, H Kanayama, Y Miyazaki, K Ogawa, T Satake. Increased cyclic GMP in atrial fibrillation. Journal of electrocardiology. 1986 Jan; 19(1):51-7. doi: 10.1016/s0022-0736(86)80007-3. [PMID: 3027221]
  • P Hamet, J Tremblay, S C Pang, R Garcia, G Thibault, J Gutkowska, M Cantin, J Genest. Effect of native and synthetic atrial natriuretic factor on cyclic GMP. Biochemical and biophysical research communications. 1984 Sep; 123(2):515-27. doi: 10.1016/0006-291x(84)90260-2. [PMID: 6091631]
  • R A Liddle, I D Goldfine, J A Williams. Bioassay of plasma cholecystokinin in rats: effects of food, trypsin inhibitor, and alcohol. Gastroenterology. 1984 Sep; 87(3):542-9. doi: NULL. [PMID: 6204904]
  • N Skreb, L Hofman, Y Skreb, E Suchanek, D Serman. Cyclic nucleotides affect growth and differentiation of cultured rat embryonic shields. Developmental biology. 1984 Feb; 101(2):367-72. doi: 10.1016/0012-1606(84)90150-7. [PMID: 6319211]
  • R E Worthington, G C Fuller. Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. Thrombosis research. 1984 Jan; 33(2):163-75. doi: 10.1016/0049-3848(84)90177-4. [PMID: 6322377]
  • F Joó, P Temesvári, E Dux. Regulation of the macromolecular transport in the brain microvessels: the role of cyclic GMP. Brain research. 1983 Nov; 278(1-2):165-74. doi: 10.1016/0006-8993(83)90235-4. [PMID: 6315153]
  • C M Cameron, J A Rillema. Effects of cyclic nucleotides on lipid biosynthesis in mouse mammary gland explants. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1983 Jul; 173(3):306-11. doi: 10.3181/00379727-173-41647. [PMID: 6191334]
  • I S Pomeranz, J S Davison, E A Shaffer. In vitro effects of pancreatic polypeptide and motilin on contractility of human gallbladder. Digestive diseases and sciences. 1983 Jun; 28(6):539-44. doi: 10.1007/bf01308156. [PMID: 6861584]
  • D A Harbour, T J Hill, W A Blyth. Prostaglandins enhance intercellular adhesion of Vero cells infected with herpes simplex virus. The Journal of general virology. 1983 Mar; 64 Pt 3(?):507-12. doi: 10.1099/0022-1317-64-3-507. [PMID: 6298342]
  • K L Cox, G L Rosenquist, C K Iwahashi-Hosoda. Noncholecystokinin peptides in human serum which cause gallbladder contraction. Life sciences. 1982 Dec; 31(26):3023-9. doi: 10.1016/0024-3205(82)90070-4. [PMID: 7162364]
  • F Fremuth, R W Holley, J H Baldwin. Interactions between the growth effects of a kidney epithelial cell growth inhibitor and extracellular concentrations of cyclic nucleotides. Neoplasma. 1982; 29(3):295-300. doi: NULL. [PMID: 6290910]
  • S E Dicker, C A Morris, F L Pearce. Role of a renal arginylesteropeptidase in the production of a renotrophic factor in unilaterally nephrectomized rats. The Journal of physiology. 1981 Jun; 315(?):413-9. doi: 10.1113/jphysiol.1981.sp013755. [PMID: 7310717]
  • H Wakasugi, H Stolze, W Haase, I Schulz. Effect of La3+ on secretagogue-induced Ca2+ fluxes in rat isolated pancreatic acinar cells. The American journal of physiology. 1981 Apr; 240(4):G281-9. doi: 10.1152/ajpgi.1981.240.4.g281. [PMID: 7223893]
  • U Trechsel, C M Taylor, J P Bonjour, H Fleisch. Influence of prostaglandins and of cyclic nucleotides on the metabolism of 25-hydroxyvitamin D3 in primary chick kidney cell culture. Biochemical and biophysical research communications. 1980 Apr; 93(4):1210-6. doi: 10.1016/0006-291x(80)90618-x. [PMID: 6249282]
  • R T Jensen, G F Lemp, J D Gardner. Interaction of cholecystokinin with specific membrane receptors on pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America. 1980 Apr; 77(4):2079-83. doi: 10.1073/pnas.77.4.2079. [PMID: 6246521]
  • R A Haak, L M Ingraham, R L Baehner, L A Boxer. Membrane fluidity in human and mouse Chediak-Higashi leukocytes. The Journal of clinical investigation. 1979 Jul; 64(1):138-44. doi: 10.1172/jci109432. [PMID: 221541]
  • W K Ramp, C W Cooper, A J Ross, S A Wells. Effects of calcium and cyclic nucleotides on rat calcitonin and parathyroid hormone secretion. Molecular and cellular endocrinology. 1979 Jun; 14(3):205-15. doi: 10.1016/0303-7207(79)90046-7. [PMID: 223903]
  • R W Wrenn, D M Biddulph. Correlation between cyclic AMP levels and calcium efflux in isolated renal cortical tubules. Journal of cyclic nucleotide research. 1979; 5(3):239-50. doi: . [PMID: 225358]
  • R Chanderbhan, V A Hodges, C R Treadwell, G V Vahouny. Prostaglandin synthesis in rat adrenocortical cells. Journal of lipid research. 1979 Jan; 20(1):116-24. doi: 10.1016/s0022-2275(20)40657-1. [PMID: 220350]
  • I Yoshida, M Azuma, T Suenaga, F Mizuno. Regulation of interferon production by dibutyryl cyclic GMP in serum-free human diploid cell cultures. The Journal of general virology. 1978 May; 39(2):303-10. doi: 10.1099/0022-1317-39-2-303. [PMID: 206656]
  • H Saito, K Suda, M Schwab, H Thoenen. Potentiation of the NGF-mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia. Japanese journal of pharmacology. 1977 Jun; 27(3):445-51. doi: 10.1254/jjp.27.445. [PMID: 199774]