Methyltetrahydrofolic acid (BioDeep_00000913256)
代谢物信息卡片
Methyltetrahydrofolic acid
化学式: C20H25N7O6 (459.186623)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC(C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2CNC3=C(N2)C(=O)NC(=N3)N)C(=O)O
InChI: InChI=1S/C20H25N7O6/c1-9(18(30)31)6-13(19(32)33)25-16(28)10-2-4-11(5-3-10)22-7-12-8-23-15-14(24-12)17(29)27-20(21)26-15/h2-5,9,12-13,22,24H,6-8H2,1H3,(H,25,28)(H,30,31)(H,32,33)(H4,21,23,26,27,29)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Mingma Sherpa, Satendra Sharma, Rajnish Avasthi. Thrombophilic molecular markers in young patients (<40 years) with coronary artery disease.
Indian journal of pathology & microbiology.
2012 Jul; 55(3):343-6. doi:
10.4103/0377-4929.101741. [PMID: 23032828] - Niikee C Schoendorfer, Rima Obeid, Leith Moxon-Lester, Nita Sharp, Luis Vitetta, Roslyn N Boyd, Peter S W Davies. Methylation capacity in children with severe cerebral palsy.
European journal of clinical investigation.
2012 Jul; 42(7):768-76. doi:
10.1111/j.1365-2362.2011.02644.x. [PMID: 22299647] - J Enrique Salcedo-Sora, Edwin Ochong, Susan Beveridge, David Johnson, Alexis Nzila, Giancarlo A Biagini, Paul A Stocks, Paul M O'Neill, Sanjeev Krishna, Patrick G Bray, Stephen A Ward. The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters.
The Journal of biological chemistry.
2011 Dec; 286(52):44659-68. doi:
10.1074/jbc.m111.286054. [PMID: 21998306] - Yih-Hsin Chang, Wen-Mei Fu, Yu-Hui Wu, Chih-Jung Yeh, Chien-Ning Huang, Ming-Yuh Shiau. Prevalence of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Taiwanese patients with Type 2 diabetic mellitus.
Clinical biochemistry.
2011 Dec; 44(17-18):1370-4. doi:
10.1016/j.clinbiochem.2011.09.020. [PMID: 22008727] - Tian-Min Fu, Jonas Almqvist, Yu-He Liang, Lanfen Li, Yafei Huang, Xiao-Dong Su. Crystal structures of cobalamin-independent methionine synthase (MetE) from Streptococcus mutans: a dynamic zinc-inversion model.
Journal of molecular biology.
2011 Sep; 412(4):688-97. doi:
10.1016/j.jmb.2011.08.005. [PMID: 21840320] - Chan Woo Park, Ae Ra Han, Joanne Kwak-Kim, So Yeon Park, Jung Yeol Han, Mi Kyoung Koong, In Ok Song, Kwang Moon Yang. The role of methylenetetrahydrofolate reductase C677T polymorphism on the peripheral blood natural killer cell proportion in women with unexplained recurrent miscarriages.
Clinical and experimental reproductive medicine.
2011 Sep; 38(3):168-73. doi:
10.5653/cerm.2011.38.3.168. [PMID: 22384438] - Glenn Tisman, April Garcia. Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.
Journal of medical case reports.
2011 Aug; 5(?):413. doi:
10.1186/1752-1947-5-413. [PMID: 21867542] - Margaret F Carter, Theresa L Powell, Cun Li, Leslie Myatt, Donald Dudley, Peter Nathanielsz, Thomas Jansson. Fetal serum folate concentrations and placental folate transport in obese women.
American journal of obstetrics and gynecology.
2011 Jul; 205(1):83.e17-25. doi:
10.1016/j.ajog.2011.02.053. [PMID: 21514551] - Veronica E Ohrvik, Cornelia M Witthoft. Human folate bioavailability.
Nutrients.
2011 04; 3(4):475-90. doi:
10.3390/nu3040475. [PMID: 22254106] - Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris Bernstein. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
Clinical and experimental gastroenterology.
2011; 4(?):75-119. doi:
10.2147/ceg.s17114. [PMID: 21753893] - Florent Mouliere, Bruno Robert, Erika Arnau Peyrotte, Maguy Del Rio, Marc Ychou, Franck Molina, Celine Gongora, Alain R Thierry. High fragmentation characterizes tumour-derived circulating DNA.
PloS one.
2011; 6(9):e23418. doi:
10.1371/journal.pone.0023418. [PMID: 21909401] - Hala O El Mesallamy, Ebtehal El-Demerdash, Lamiaa N Hammad, Hekmat M El Magdoub. Effect of taurine supplementation on hyperhomocysteinemia and markers of oxidative stress in high fructose diet induced insulin resistance.
Diabetology & metabolic syndrome.
2010 Jun; 2(?):46. doi:
10.1186/1758-5996-2-46. [PMID: 20591133] - Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia.
Neuropsychiatric disease and treatment.
2010 May; 6(?):159-95. doi:
10.2147/ndt.s6564. [PMID: 20505848] - Shazia Micheal, Raheel Qamar, Farah Akhtar, Muhammad Imran Khan, Wajid Ali Khan, Asifa Ahmed. MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma.
Molecular vision.
2009 Nov; 15(?):2268-78. doi:
NULL. [PMID: 19936026] - Jadranka Sertic, Ljiljana Juricic, Hana Ljubic, Tamara Bozina, Jasna Lovric, Jasenka Markeljevic, Bojan Jelakovic, Marijan Merkler, Zeljko Reiner. Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity.
BMC research notes.
2009 Oct; 2(?):203. doi:
10.1186/1756-0500-2-203. [PMID: 19804633] - Kubilay Ukinc, Halil Onder Ersoz, Caner Karahan, Cihangir Erem, Selcuk Eminagaoglu, Arif Bayram Hacihasanoglu, Mustafa Yilmaz, Mustafa Kocak. Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy.
Endocrine.
2009 Oct; 36(2):255-61. doi:
10.1007/s12020-009-9218-7. [PMID: 19598005] - Valérie Van Wilder, Veerle De Brouwer, Karen Loizeau, Bernadette Gambonnet, Catherine Albrieux, Dominique Van Der Straeten, Willy E Lambert, Roland Douce, Maryse A Block, Fabrice Rebeille, Stéphane Ravanel. C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status.
The New phytologist.
2009; 182(1):137-145. doi:
10.1111/j.1469-8137.2008.02707.x. [PMID: 19076298] - Zigmund Luka. Methyltetrahydrofolate in folate-binding protein glycine N-methyltransferase.
Vitamins and hormones.
2008; 79(?):325-45. doi:
10.1016/s0083-6729(08)00411-1. [PMID: 18804700] - K M Li, L P Rivory, S J Clarke. Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
British journal of cancer.
2007 Oct; 97(8):1071-6. doi:
10.1038/sj.bjc.6603995. [PMID: 17912246] - Valérie de Crécy-Lagard, Basma El Yacoubi, Rocío Díaz de la Garza, Alexandre Noiriel, Andrew D Hanson. Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations.
BMC genomics.
2007 Jul; 8(?):245. doi:
10.1186/1471-2164-8-245. [PMID: 17645794] - Anna-Lena Lindberg, Rajiv Kumar, Walter Goessler, Ranjit Thirumaran, Eugen Gurzau, Kvetoslava Koppova, Peter Rudnai, Giovanni Leonardi, Tony Fletcher, Marie Vahter. Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms.
Environmental health perspectives.
2007 Jul; 115(7):1081-6. doi:
10.1289/ehp.10026. [PMID: 17637926] - Azza M Kamel, Heba S Moussa, Gamal T Ebid, Rong R Bu, Kishor G Bhatia. Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia.
Journal of the Egyptian National Cancer Institute.
2007 Jun; 19(2):96-105. doi:
NULL. [PMID: 19034339] - C Lee Elmore, Xuchu Wu, Daniel Leclerc, Erica D Watson, Teodoro Bottiglieri, Natalia I Krupenko, Sergey A Krupenko, James C Cross, Rima Rozen, Roy A Gravel, Rowena G Matthews. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase.
Molecular genetics and metabolism.
2007 May; 91(1):85-97. doi:
10.1016/j.ymgme.2007.02.001. [PMID: 17369066] - Dorothy J Vanderjagt, Hugh S Brock, George S Melah, Aliyu U El-Nafaty, Michael J Crossey, Robert H Glew. Nutritional factors associated with anaemia in pregnant women in northern Nigeria.
Journal of health, population, and nutrition.
2007 Mar; 25(1):75-81. doi:
NULL. [PMID: 17615906] - James D Finkelstein. Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine.
Clinical chemistry and laboratory medicine.
2007; 45(12):1694-9. doi:
10.1515/cclm.2007.341. [PMID: 17963455] - Rowena G Matthews, C Lee Elmore. Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias.
Clinical chemistry and laboratory medicine.
2007; 45(12):1700-3. doi:
10.1515/cclm.2007.324. [PMID: 17937607] - Sayaka Mori, Kazuyuki Sugahara, Akiko Uemura, Yasuaki Yamada, Kyouko Uzihara, Hideko Hayashida, Tsuyoshi Ideguchi, Kiyomi Ishibashi, Mio Nakazato, Takahiro Maeda, Noboru Takamura, Shimeru Kamihira. The possibility of a valuable resource of circulating DNA for single nucleotide polymorphisms genotyping: the application of a rapid and simple polymerase chain reaction with melting curve analysis for methyltetrahydrofolate reductase polymorphisms.
Laboratory hematology : official publication of the International Society for Laboratory Hematology.
2007; 13(1):1-5. doi:
10.1532/lh96.06031. [PMID: 17353175] - Marilena Greco, Fernanda Chiriacò, Piero Del Boccio, Luigi Tagliaferro, Raffaele Acierno, Paola Menegazzi, Eleonora Pinca, Francesco Pignatelli, Carlo Storelli, Giorgio Federici, Andrea Urbani, Michele Maffia. A proteomic approach for the characterization of C677T mutation of the human gene methylenetetrahydrofolate reductase.
Proteomics.
2006 Oct; 6(19):5350-61. doi:
10.1002/pmic.200600130. [PMID: 16955529] - Tian Min Fu, Xiao Yan Zhang, Lan Fen Li, Yu He Liang, Xiao Dong Su. Preparation, crystallization and preliminary X-ray analysis of the methionine synthase (MetE) from Streptococcus mutans.
Acta crystallographica. Section F, Structural biology and crystallization communications.
2006 Oct; 62(Pt 10):984-5. doi:
10.1107/s1744309106035640. [PMID: 17012790] - Flaubert Tchantchou. Homocysteine metabolism and various consequences of folate deficiency.
Journal of Alzheimer's disease : JAD.
2006 Aug; 9(4):421-7. doi:
10.3233/jad-2006-9408. [PMID: 16917151] - Jee-Young Lee, Manho Kim. Cerebral Venous Thrombosis and Livedo Reticularis in a Case with MTHFR 677TT Homozygote.
Journal of clinical neurology (Seoul, Korea).
2006 Jun; 2(2):137-40. doi:
10.3988/jcn.2006.2.2.137. [PMID: 20396498] - Hee Jin Huh, Hyun Sook Chi, Eun Hee Shim, Seongsoo Jang, Chan Jeoung Park. Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.
Thrombosis research.
2006; 117(5):501-6. doi:
10.1016/j.thromres.2005.04.009. [PMID: 15935452] - M Pufulete, R Al-Ghnaniem, J A Rennie, P Appleby, N Harris, S Gout, P W Emery, T A Sanders. Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer.
British journal of cancer.
2005 Mar; 92(5):838-42. doi:
10.1038/sj.bjc.6602439. [PMID: 15726099] - Alison Blackburn, Michael C Bibby, Mark D Lucock, Anna Nicolaou. Temporal evaluation of methionine synthase and related metabolites in the MAC15A mouse adenocarcinoma animal model.
International journal of cancer.
2004 Nov; 112(4):577-84. doi:
10.1002/ijc.20451. [PMID: 15382038] - J J Strain, L Dowey, M Ward, K Pentieva, H McNulty. B-vitamins, homocysteine metabolism and CVD.
The Proceedings of the Nutrition Society.
2004 Nov; 63(4):597-603. doi:
10.1079/pns2004390. [PMID: 15831132] - A Pathare, S Alkindi, T Albalushi, R Bayoumi, D Dennison, S Muralitharan. Heterozygous methylene tetrahydrofolate reductase mutation with mild hyperhomocysteinemia associated with deep vein thrombosis.
Clinical and laboratory haematology.
2004 Apr; 26(2):143-6. doi:
10.1111/j.1365-2257.2004.00585.x. [PMID: 15053809] - David A Edmondson, Jonathan B Towne, Dennis W Foley, Majed Abu-Hajir, Mahendr S Kochar. Cocaine-induced renal artery dissection and thrombosis leading to renal infarction.
WMJ : official publication of the State Medical Society of Wisconsin.
2004; 103(7):66-9. doi:
NULL. [PMID: 15696837] - Carole Tonetti, Jean-Marie Saudubray, Bernard Echenne, Pierre Landrieu, Stéphane Giraudier, Jacqueline Zittoun. Relations between molecular and biological abnormalities in 11 families from siblings affected with methylenetetrahydrofolate reductase deficiency.
European journal of pediatrics.
2003 Jul; 162(7-8):466-475. doi:
10.1007/s00431-003-1196-9. [PMID: 12733064] - M Malouf, Evans J Grimley, Sastre A Areosa. Folic acid with or without vitamin B12 for cognition and dementia.
The Cochrane database of systematic reviews.
2003; ?(4):CD004514. doi:
10.1002/14651858.cd004514. [PMID: 14584018] - Gherardo Buccianti, Sara Raselli, Ivano Baragetti, Fabrizia Bamonti, Enzo Corghi, Cristina Novembrino, Cristina Patrosso, Franco M Maggi, Alberico L Catapano. 5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2002 May; 17(5):857-64. doi:
10.1093/ndt/17.5.857. [PMID: 11981074] - Anil Pathare, Salam al Kindi, Talal al Belushi, Riad Bayoumi, David Dennison, S Murlitharan. Heterozygous methylene tetrahydrofolate reductase mutation with mild hyperhomocysteinemia associated with deep vein thrombosis.
Haematologia.
2002; 32(4):551-6. doi:
NULL. [PMID: 12803132] - E S Sills, M G Genton, M Perloe, G L Schattman, J A Bralley, M J Tucker. Plasma homocysteine, fasting insulin, and androgen patterns among women with polycystic ovaries and infertility.
The journal of obstetrics and gynaecology research.
2001 Jun; 27(3):163-8. doi:
10.1111/j.1447-0756.2001.tb01241.x. [PMID: 11561833]