(9Z,19Z,21Z)-2,13,15,17,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaene-6,23-dione (BioDeep_00000913240)

   


代谢物信息卡片


(9Z,19Z,21Z)-2,13,15,17,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaene-6,23-dione

化学式: C41H56N4O11 (780.3945386)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)O)C)OC)C)C)O)O)C=NN5CCN(CC5)C)C
InChI: InChI=1S/C41H56N4O11/c1-20-11-10-12-21(2)40(53)43-31-26(19-42-45-16-14-44(8)15-17-45)36(50)28-29(37(31)51)35(49)25(6)38-30(28)39(52)41(7,56-38)55-18-13-27(54-9)22(3)33(47)24(5)34(48)23(4)32(20)46/h10-13,18-20,22-24,27,32-34,46-51H,14-17H2,1-9H3,(H,43,53)/b11-10-,18-13-,21-12-,42-19+

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins

同义名列表

1 个代谢物同义名

(9Z,19Z,21Z)-2,13,15,17,27,29-hexahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-(4-methylpiperazin-1-yl)iminomethyl]-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaene-6,23-dione



数据库引用编号

1 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • T J F Vanbrabant, A C Dijkmans, J den Hartigh, D J Touw, S M Arend. Rifampin levels in daily practice: the accuracy of a single measurement. The Netherlands journal of medicine. 2018 07; 76(5):235-242. doi: NULL. [PMID: 30019679]
  • Kim H Hee, Jerold J Seo, Lawrence S Lee. Development and validation of liquid chromatography tandem mass spectrometry method for simultaneous quantification of first line tuberculosis drugs and metabolites in human plasma and its application in clinical study. Journal of pharmaceutical and biomedical analysis. 2015 Jan; 102(?):253-60. doi: 10.1016/j.jpba.2014.09.019. [PMID: 25459921]
  • Sang Hoon Song, Ho Eun Chang, Sun Hee Jun, Kyoung Un Park, Jae Ho Lee, Eun-Mi Lee, Young-Han Song, Junghan Song. Relationship between CES2 genetic variations and rifampicin metabolism. The Journal of antimicrobial chemotherapy. 2013 Jun; 68(6):1281-4. doi: 10.1093/jac/dkt036. [PMID: 23471941]
  • D H Vu, R A Koster, A M A Wessels, B Greijdanus, J W C Alffenaar, D R A Uges. Troubleshooting carry-over of LC-MS/MS method for rifampicin, clarithromycin and metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Feb; 917-918(?):1-4. doi: 10.1016/j.jchromb.2012.12.023. [PMID: 23353809]
  • Stefan Oswald, Jette Peters, Monica Venner, Werner Siegmund. LC-MS/MS method for the simultaneous determination of clarithromycin, rifampicin and their main metabolites in horse plasma, epithelial lining fluid and broncho-alveolar cells. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 55(1):194-201. doi: 10.1016/j.jpba.2011.01.019. [PMID: 21310577]
  • Femke de Velde, Jan-Willem C Alffenaar, A Mireille A Wessels, Ben Greijdanus, Donald R A Uges. Simultaneous determination of clarithromycin, rifampicin and their main metabolites in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jun; 877(18-19):1771-7. doi: 10.1016/j.jchromb.2009.04.038. [PMID: 19457725]
  • S-W Um, S W Lee, S Y Kwon, H I Yoon, K U Park, J Song, C-T Lee, J-H Lee. Low serum concentrations of anti-tuberculosis drugs and determinants of their serum levels. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2007 Sep; 11(9):972-8. doi: NULL. [PMID: 17705974]
  • Joyce Pullen, Leo M L Stolk, Pieter L J Degraeuwe, Frank H van Tiel, Cees Neef, Luc J I Zimmermann. Pharmacokinetics of intravenous rifampicin (rifampin) in neonates. Therapeutic drug monitoring. 2006 Oct; 28(5):654-61. doi: 10.1097/01.ftd.0000245382.79939.a4. [PMID: 17038881]
  • R Panchagnula, K J Kaur, I Singh, C L Kaul. The WHO simplified study protocol in practice: investigation of combined formulations supplied by the WHO. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 1999 Nov; 3(11 Suppl 3):S336-42; discussion S351. doi: NULL. [PMID: 10593714]
  • A A Firsov, V S Dombrovskiĭ, I B Kadenatsi, E V Gagaeva, L S Strachunskiĭ. [Correlation between pharmacokinetic parameters of rifampicin and its biologically active metabolite as related to estimation of the relative bioavailability of the antibiotic]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1996 Apr; 41(4):36-43. doi: NULL. [PMID: 8967809]
  • L Ye, J T Stewart, H Zhang. A comparison of disc and cartridge solid-phase extraction for the LC determination of rifampin and 25-desacetylrifampin in human serum. Journal of pharmaceutical and biomedical analysis. 1995 Aug; 13(9):1185-8. doi: 10.1016/0731-7085(95)01538-v. [PMID: 8573647]
  • C W Kohn, R Sams, J J Kowalski, J Powers, S Wallace. Pharmacokinetics of single intravenous and single and multiple dose oral administration of rifampin in mares. Journal of veterinary pharmacology and therapeutics. 1993 Jun; 16(2):119-31. doi: 10.1111/j.1365-2885.1993.tb00156.x. [PMID: 8345562]
  • J R Morgan, K W Clarke, S G Brear. Phenomenon of rifampicin-induced discolouration of body fluids. Respiratory medicine. 1993 May; 87(4):320-1. doi: 10.1016/0954-6111(93)90040-7. [PMID: 9728237]
  • A el-Yazigi, D A Raines. Simultaneous microdetermination of rifampin, deacetylrifampin, isoniazid, and acetylisoniazid in plasma by liquid chromatography with dual electrochemical and spectrophotometric detection. Pharmaceutical research. 1992 Jun; 9(6):812-6. doi: 10.1023/a:1015867925185. [PMID: 1409366]
  • K K Manuĭlov, E V Gagaeva. [Quantitative analysis of rifampicin and 25-desacetylrifampicin in the plasma using high performance liquid chromatography]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1989 Sep; 34(9):682-4. doi: NULL. [PMID: 2610536]
  • M Ishii, H Ogata. Determination of rifampicin and its main metabolites in human plasma by high-performance liquid chromatography. Journal of chromatography. 1988 Apr; 426(2):412-6. doi: 10.1016/s0378-4347(00)81972-6. [PMID: 3392154]
  • K Chan. [A simultaneous determination of rifampin and 25-deacetylrifampicin in cerebrospinal fluid and plasma of rabbit by liquid chromatography]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1987 Nov; 8(6):555-9. doi: NULL. [PMID: 3451670]
  • A V Ziia, G B Sokolov, A A Firsov. [Pharmacokinetics of rifampicin administered intravenously to pulmonary tuberculosis patients]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology. 1987 Mar; 32(3):223-7. doi: NULL. [PMID: 3579252]
  • S Oldfield, J D Berg, H J Stiles, B M Buckley. Measurement of rifampicin and 25-desacetylrifampicin in biological fluids using high-performance liquid chromatography with direct sample injection. Journal of chromatography. 1986 Apr; 377(?):423-9. doi: 10.1016/s0378-4347(00)80804-x. [PMID: 3711237]
  • U Loos, E Musch, J C Jensen, G Mikus, H K Schwabe, M Eichelbaum. Pharmacokinetics of oral and intravenous rifampicin during chronic administration. Klinische Wochenschrift. 1985 Dec; 63(23):1205-11. doi: 10.1007/bf01733779. [PMID: 4087830]
  • C Immanuel, K Jayasankar, A S Narayana, G R Sarma. Self-induction of rifampicin metabolism in man. The Indian journal of medical research. 1985 Nov; 82(?):381-7. doi: NULL. [PMID: 4093155]
  • Y Adachi, T Nanno, M Yamashita, S Ueshima, T Yamamoto. Induction of rat liver bilirubin-conjugating enzymes and glutathione S-transferase by rifampicin. Gastroenterologia Japonica. 1985 Apr; 20(2):104-10. doi: 10.1007/bf02776672. [PMID: 3161772]
  • A Weber, K E Opheim, A L Smith, K Wong. High-pressure liquid chromatographic quantitation of rifampin and its two major metabolites in urine and serum. Reviews of infectious diseases. 1983 Jul; 5 Suppl 3(?):S433-9. doi: 10.1093/clinids/5.supplement_3.s433. [PMID: 6635434]
  • G Houin, A Beucler, S Richelet, R Brioude, C Lafaix, J P Tillement. Pharmacokinetics of rifampicin and desacetylrifampicin in tuberculous patients after different rates of infusion. Therapeutic drug monitoring. 1983; 5(1):67-72. doi: 10.1097/00007691-198303000-00005. [PMID: 6845401]
  • C Advenier, C Gobert, G Houin, D Bidet, S Richelet, J P Tillement. Pharmacokinetic studies of rifampicin in the elderly. Therapeutic drug monitoring. 1983; 5(1):61-5. doi: 10.1097/00007691-198303000-00004. [PMID: 6845400]
  • M Guillaumont, M Leclercq, Y Frobert, B Guise, R Harf. Determination of rifampicin, desacetylrifampicin, isoniazid and acetylisoniazid by high-performance liquid chromatography: application to human serum extracts, polymorphonucleocytes and alveolar macrophages. Journal of chromatography. 1982 Nov; 232(2):369-76. doi: 10.1016/s0378-4347(00)84176-6. [PMID: 7153283]
  • B Ratti, R R Parenti, A Toselli, L F Zerilli. Quantitative assay of rifampicin and its main metabolite 25-desacetylrifampicin in human plasma by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1981 Oct; 225(2):526-31. doi: 10.1016/s0378-4347(00)80308-4. [PMID: 7298788]