[3-Methoxy-2-phosphonooxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate (BioDeep_00000913211)
代谢物信息卡片
化学式: C18H22O12P2 (492.0586472)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C(=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)(O)O)OP(=O)(O)O
InChI: InChI=1S/C18H22O12P2/c1-25-13-8-7-12(16(29-31(19,20)21)18(13)30-32(22,23)24)6-5-11-9-14(26-2)17(28-4)15(10-11)27-3/h5-10H,1-4H3,(H2,19,20,21)(H2,22,23,24)/b6-5+
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael R L Stratford, Lisa K Folkes. Quantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Jun; 898(?):1-6. doi:
10.1016/j.jchromb.2012.03.040. [PMID: 22578514] - J Cummings, M Zweifel, N Smith, P Ross, J Peters, G Rustin, P Price, M R Middleton, T Ward, C Dive. Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial.
British journal of cancer.
2012 May; 106(11):1766-71. doi:
10.1038/bjc.2012.165. [PMID: 22538971] - Dan M Patterson, Martin Zweifel, Mark R Middleton, Patricia M Price, Lisa K Folkes, Michael R L Stratford, Phil Ross, Sarah Halford, Jane Peters, Jai Balkissoon, Dai J Chaplin, Anwar R Padhani, Gordon J S Rustin. Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012 Mar; 18(5):1415-25. doi:
10.1158/1078-0432.ccr-11-2414. [PMID: 22235096] - Michael R L Stratford, Lisa K Folkes. Validation of a method for the determination of the anticancer agent Combretastatin A1 phosphate (CA1P, OXi4503) in human plasma by HPLC with post-column photolysis and fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2673-6. doi:
10.1016/j.jchromb.2011.07.014. [PMID: 21820978] - Mamta Wankhede, Casey Dedeugd, Dietmar W Siemann, Brian S Sorg. In vivo functional differences in microvascular response of 4T1 and Caki-1 tumors after treatment with OXi4503.
Oncology reports.
2010 Mar; 23(3):685-92. doi:
10.3892/or_00000685. [PMID: 20127007] - Yuval Shaked, Terence Tang, Jill Woloszynek, Laura G Daenen, Shan Man, Ping Xu, Shi-Rong Cai, Jeffrey M Arbeit, Emile E Voest, David J Chaplin, Jon Smythe, Adrian Harris, Paul Nathan, Ian Judson, Gordon Rustin, Francesco Bertolini, Daniel C Link, Robert S Kerbel. Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.
Cancer research.
2009 Oct; 69(19):7524-8. doi:
10.1158/0008-5472.can-09-0381. [PMID: 19738066] - Dietmar W Siemann, Wenyin Shi. Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503).
Anticancer research.
2008 Jul; 28(4B):2027-31. doi:
NULL. [PMID: 18751370] - Howard W Salmon, Christopher Mladinich, Dietmar W Siemann. Evaluations of vascular disrupting agents CA4P and OXi4503 in renal cell carcinoma (Caki-1) using a silicon based microvascular casting technique.
European journal of cancer (Oxford, England : 1990).
2006 Nov; 42(17):3073-8. doi:
10.1016/j.ejca.2006.06.016. [PMID: 16956760]