2-[(Z)-3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid (BioDeep_00000913206)
代谢物信息卡片
2-[(Z)-3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyl]oxy-3-(3,4-dihydroxyphenyl)propanoic acid
化学式: C36H30O16 (718.153378)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C3C(C(OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)C(=O)OC(CC5=CC(=C(C=C5)O)O)C(=O)O)O)O
InChI: InChI=1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5-
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Guilian Zhang, Yuee Sun, Najeeb Ullah, Deepak Kasote, Longyi Zhu, Hui Liu, Ling Xu. Changes in secondary metabolites contents and stress responses in Salvia miltiorrhiza via ScWRKY35 overexpression: Insights from a wild relative Salvia castanea.
Plant physiology and biochemistry : PPB.
2024 Jun; 211(?):108671. doi:
10.1016/j.plaphy.2024.108671. [PMID: 38703500] - Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice.
Nutrients.
2024 Apr; 16(8):. doi:
10.3390/nu16081169. [PMID: 38674860] - Ying Zhang, Wenjuan Zhai, Minqi Fan, Jinjun Wu, Caiyan Wang. Salvianolic Acid B Significantly Suppresses the Migration of Melanoma Cells via Direct Interaction with β-Actin.
Molecules (Basel, Switzerland).
2024 Feb; 29(4):. doi:
10.3390/molecules29040906. [PMID: 38398656] - Yijie Li, Ranyun Chen, Jianzhi Wu, Xiaoyong Xue, Tiegang Liu, Guiying Peng, Ruiyu Wu, Lei Wang, Kexin Jia, Yajie Cai, Xiaojiaoyang Li. Salvianolic acid B protects against pulmonary fibrosis by attenuating stimulating protein 1-mediated macrophage and alveolar type 2 cell senescence.
Phytotherapy research : PTR.
2024 Feb; 38(2):620-635. doi:
10.1002/ptr.8070. [PMID: 37953063] - Qin Lihao, Liu Tingting, Zhang Jiawei, Bai Yifei, Tang Zheyu, Li Jingyan, Xue Tongqing, Jia Zhongzhi. 3D bioprinting of Salvianolic acid B-sodium alginate-gelatin skin scaffolds promotes diabetic wound repair via antioxidant, anti-inflammatory, and proangiogenic effects.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Feb; 171(?):116168. doi:
10.1016/j.biopha.2024.116168. [PMID: 38232662] - Yadong Fu, Xiaoxi Zhou, Lin Wang, Weiguo Fan, Siqi Gao, Danyan Zhang, Zhiyang Ling, Yaguang Zhang, Liyan Ma, Fang Bai, Jiamei Chen, Bing Sun, Ping Liu. Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis.
Redox biology.
2024 Feb; 69(?):103029. doi:
10.1016/j.redox.2024.103029. [PMID: 38184998] - Ewelina Piątczak, Joanna Kolniak-Ostek, Weronika Gonciarz, Paweł Lisiecki, Urszula Kalinowska-Lis, Magdalena Szemraj, Magdalena Chmiela, Sylwia Zielińska. The Effect of Salvia tomentosa Miller Extracts, Rich in Rosmarinic, Salvianolic and Lithospermic Acids, on Bacteria Causing Opportunistic Infections.
Molecules (Basel, Switzerland).
2024 Jan; 29(3):. doi:
10.3390/molecules29030590. [PMID: 38338335] - Ai-Cheng Wang, Xiao-Ming Qi, Qing-Fang Li, Yi-Jia Feng, Yuan-Lin Zhang, Hui-Zhi Wei, Jin-Shan Li, Yuan-Biao Qiao, Qing-Shan Li. Methionine redox regulation of actin-interacting proteins primarily governs antioxidative signaling and response to the salvianolic acid B treatment in EA.hy926 cells.
Toxicology and applied pharmacology.
2024 Jan; 483(?):116835. doi:
10.1016/j.taap.2024.116835. [PMID: 38272317] - Zhongwei Yao, Minshu Du, Yalu Wang, He Zhu, Luan Shu, Xia You, Jing Wang. Pharmacodynamic study of chitosan in combination with salvianolic acid B in the treatment of CC14 -induced liver fibrosis in mice.
Clinical and experimental pharmacology & physiology.
2024 01; 51(1):17-29. doi:
10.1111/1440-1681.13828. [PMID: 37749921] - Pinglan Lin, Furong Qiu, Ming Wu, Lin Xu, Di Huang, Chen Wang, Xuejun Yang, Chaoyang Ye. Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway.
Pharmaceutical biology.
2023 Dec; 61(1):23-29. doi:
10.1080/13880209.2022.2148169. [PMID: 36524761] - Mingzhi Zhong, Lei Zhang, Haomiao Yu, Jinqiu Liao, Yuanyuan Jiang, Songyue Chai, Ruiwu Yang, Long Wang, Xuexue Deng, Songlin Zhang, Qingmiao Li, Li Zhang. Identification and characterization of a novel tyrosine aminotransferase gene (SmTAT3-2) promotes the biosynthesis of phenolic acids in Salvia miltiorrhiza Bunge.
International journal of biological macromolecules.
2023 Nov; 254(Pt 2):127858. doi:
10.1016/j.ijbiomac.2023.127858. [PMID: 37924917] - Meng-Dan Wang, Shuo Zhang, Xing-Yang Liu, Pan-Pan Wang, Yi-Fan Zhu, Jun-Rong Zhu, Chong-Shan Lv, Shi-Ying Li, Sui-Feng Liu, Lei Wen. Salvianolic acid B ameliorates retinal deficits in an early-stage Alzheimer's disease mouse model through downregulating BACE1 and Aβ generation.
Acta pharmacologica Sinica.
2023 Nov; 44(11):2151-2168. doi:
10.1038/s41401-023-01125-3. [PMID: 37420104] - Zhuo Xu, Ke Cai, Shu-Lan Su, Yue Zhu, Feng Liu, Jin-Ao Duan. Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 3):117356. doi:
10.1016/j.jep.2023.117356. [PMID: 37890803] - Xiaojing Huang, Tingting Li, Xingyue Jiang, Zhuole Wang, Mingshui Wang, Xia Wu, Ji Li, Junfeng Shi. Co-assembled Supramolecular Hydrogel of Salvianolic Acid B and a Phosphopeptide for Enhanced Wound Healing.
ACS applied materials & interfaces.
2023 Oct; 15(39):45606-45615. doi:
10.1021/acsami.3c09219. [PMID: 37733024] - Fangbin Liu, Shengnan Li, Panpan Chen, Yanqiu Gu, Shaozhan Wang, Lei Wang, Chun Chen, Rong Wang, Yongfang Yuan. Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ.
International immunopharmacology.
2023 Sep; 122(?):110550. doi:
10.1016/j.intimp.2023.110550. [PMID: 37451016] - Yali Zhao, Chongyu Shao, Huifen Zhou, Li Yu, Yida Bao, Qianping Mao, Jiehong Yang, Haitong Wan. Salvianolic acid B inhibits atherosclerosis and TNF-α-induced inflammation by regulating NF-κB/NLRP3 signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Aug; 119(?):155002. doi:
10.1016/j.phymed.2023.155002. [PMID: 37572566] - Katarzyna Sykłowska-Baranek, Małgorzata Gaweł, Łukasz Kuźma, Beata Wileńska, Mateusz Kawka, Małgorzata Jeziorek, Konstantia Graikou, Ioanna Chinou, Ewa Szyszko, Piotr Stępień, Patryk Zakrzewski, Agnieszka Pietrosiuk. Rindera graeca (A. DC.) Boiss. & Heldr. (Boraginaceae) In Vitro Cultures Targeting Lithospermic Acid B and Rosmarinic Acid Production.
Molecules (Basel, Switzerland).
2023 Jun; 28(12):. doi:
10.3390/molecules28124880. [PMID: 37375435] - Jinyao Xu, Xiangjun Sun, Feng Qin, Xufeng Wang, Qian Chen, Ruicheng Yan. Protective effects of salvianolic acid B on intestinal ischemia/reperfusion injury in rats by regulating the AhR/IL-22/STAT6 axis.
Journal of receptor and signal transduction research.
2023 Jun; 43(3):73-82. doi:
10.1080/10799893.2023.2204949. [PMID: 37387514] - Zhao Zhiqiang, Zhang Chong, Zhu Yunxia. Salvianolic acid B promotes the invasion and migration of HO-induced HTR-8/Svneo trophoblast cells by upregulating matrix metalloproteinase-9 the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B pathway.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Jun; 43(3):457-465. doi:
10.19852/j.cnki.jtcm.20220707.005. [PMID: 37147746] - Xiaojin Xu, Chenhan Mao, Chengbo Zhang, Meng Zhang, Jianbin Gong, Xindong Wang. Salvianolic Acid B Inhibits Ferroptosis and Apoptosis during Myocardial Ischemia/Reperfusion Injury via Decreasing the Ubiquitin-Proteasome Degradation of GPX4 and the ROS-JNK/MAPK Pathways.
Molecules (Basel, Switzerland).
2023 May; 28(10):. doi:
10.3390/molecules28104117. [PMID: 37241859] - Qirou Wang, Nannan Li, Yajie Wang, Ruilin Li, Yanan Jia, Jingna Zhou, Junyu Liu, Min Zhang, Pengwei Zhuang, Chengwei He, Haixia Chen. Studies on the key constituents and the related mechanisms of Clerodendranthus spicatus in the treatment of diabetes based on network pharmacology.
Journal of ethnopharmacology.
2023 Mar; 303(?):115949. doi:
10.1016/j.jep.2022.115949. [PMID: 36435408] - Chun-Kun Yang, Qing-Quan Pan, Zhuang Tian, Yan-Jun DU, Feng-Qin Sun, Jin Lu, Jun Li. [Protective mechanism of salvianolic acid B on blood vessels].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Mar; 48(5):1176-1185. doi:
10.19540/j.cnki.cjcmm.20221102.707. [PMID: 37005801] - Ping Li, Yuanyuan Ou, Zilong Zhang, Wenwen Wang, Xu Ji, Minfeng Fang, Qian Li. Rapid separation and binding configuration prediction of the components in Danshen Decoction to endothelin A receptor using affinity chromatography and molecular dynamics simulation.
Journal of separation science.
2023 Feb; ?(?):e2200944. doi:
10.1002/jssc.202200944. [PMID: 36820791] - Rao Yang, Shasha Li, Shuai Dong, Long Wang, Huiting Qin, Hongbin Zhan, Donghao Wang, Xiaoyan Cao, Hongxing Xu. SmJAZ4 interacts with SmMYB111 or SmMYC2 to inhibit the synthesis of phenolic acids in Salvia miltiorrhiza.
Plant science : an international journal of experimental plant biology.
2023 Feb; 327(?):111565. doi:
10.1016/j.plantsci.2022.111565. [PMID: 36526028] - Zi-Bo Li, Lin Jiang, Jia-Dong Ni, Yuan-Hang Xu, Fang Liu, Wen-Ming Liu, Shao-Gui Wang, Zhong-Qiu Liu, Cai-Yan Wang. Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells.
Acta pharmacologica Sinica.
2023 Jan; ?(?):. doi:
10.1038/s41401-022-01044-9. [PMID: 36627345] - Ling-Ling Zheng, Mei-Lan Chen, Li-Ping Kang, Ying-Li Wang, Xiu-Teng Zhou. [Effect of Rhizophagus intraradices on growth of Salvia miltiorrhiza].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(2):349-355. doi:
10.19540/j.cnki.cjcmm.20221017.101. [PMID: 36725224] - Manish Sharma, Rajesh Kumari Manhas. Biocontrol potential of Streptomyces sp. M4 and salvianolic acid B produced by it against Alternaria black leaf spot.
Microbial pathogenesis.
2022 Dec; 173(Pt A):105869. doi:
10.1016/j.micpath.2022.105869. [PMID: 36356795] - Bo Lu, Jianhua Li, MingTai Gui, Lei Yao, Mingsong Fan, Xunjie Zhou, Deyu Fu. Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.
Pharmaceutical biology.
2022 Dec; 60(1):1458-1468. doi:
10.1080/13880209.2022.2096644. [PMID: 35968584] - Xiangzeng Wang, Yao Cao, Jiaxin Yang, Tong Zhang, Qianqian Yang, Yanhua Zhang, Donghao Wang, Xiaoyan Cao. Transcription Factor SmSPL2 Inhibits the Accumulation of Salvianolic Acid B and Influences Root Architecture.
International journal of molecular sciences.
2022 Nov; 23(21):. doi:
10.3390/ijms232113549. [PMID: 36362335] - Yuehong Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye Ding, Jiayun Shen, Jianqiao Zhao, Huahan Qin, Yijiao Xu, Qian Zhou, Xindong Wang, Jianping Shen. Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway.
International immunopharmacology.
2022 Nov; 112(?):109257. doi:
10.1016/j.intimp.2022.109257. [PMID: 36174419] - Lan Yao, Renjie Zhao, Shiyang He, Qi Feng, Yingjin Qiao, Pei Wang, Jun Li. Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154414. doi:
10.1016/j.phymed.2022.154414. [PMID: 36057144] - Ling-Cui Meng, Jia-Yi Zheng, Yu-Hui Qiu, Li Zheng, Jue-Yan Zheng, Yu-Qing Liu, Xiao-Lu Miao, Xin-Yi Lu. Salvianolic acid B ameliorates non-alcoholic fatty liver disease by inhibiting hepatic lipid accumulation and NLRP3 inflammasome in ob/ob mice.
International immunopharmacology.
2022 Oct; 111(?):109099. doi:
10.1016/j.intimp.2022.109099. [PMID: 35932615] - Xiu-Rong Zhang, Tao Lin, Xiu-Li Wang, Xiao-Jie Wang, Heng Gu. [Preparation of salvianolic acid B, tanshinone Ⅱ_A, and glycyrrhetinic acid lipid emulsion and its protective effect against acute liver injury induced by acetaminophen].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4634-4642. doi:
10.19540/j.cnki.cjcmm.20220705.302. [PMID: 36164869] - Cheng Qian, Chunmei Yang, Yu Tang, Weiwei Zheng, Yueke Zhou, Shan Zhang, Mengyao Song, Peng Cheng, Zhonghong Wei, Chongjin Zhong, Li Wan, Aiyun Wang, Yang Zhao, Yin Lu. Pharmacological manipulation of Ezh2 with salvianolic acid B results in tumor vascular normalization and synergizes with cisplatin and T cell-mediated immunotherapy.
Pharmacological research.
2022 08; 182(?):106333. doi:
10.1016/j.phrs.2022.106333. [PMID: 35779815] - Xiang-Lin Kong, Qin Lyu, Ya-Qi Zhang, Dong-Fang Kang, Chao Li, Lei Zhang, Zi-Chen Gao, Xin-Xin Liu, Ji-Biao Wu, Yun-Lun Li. Effect of astragaloside IV and salvianolic acid B on antioxidant stress and vascular endothelial protection in the treatment of atherosclerosis based on metabonomics.
Chinese journal of natural medicines.
2022 Aug; 20(8):601-613. doi:
10.1016/s1875-5364(22)60186-9. [PMID: 36031232] - Hong Meng, Meng-Meng Zhao, Ru-Ya Yang, Xiao-Feng Deng, Hong-Yan Zhang, Yeong-Min Choi, In-Sook An, Sung-Kwan An, Yin-Mao Dong, Yi-Fan He, Li Li, Miao-Miao Guo, Fan Yi. Salvianolic acid B regulates collagen synthesis: Indirect influence on human dermal fibroblasts through the microvascular endothelial cell pathway.
Journal of cosmetic dermatology.
2022 Jul; 21(7):3007-3015. doi:
10.1111/jocd.14516. [PMID: 34648670] - Junqi Chen, Qinghong Hu, Yini Luo, Lina Luo, Hua Lin, Dandan Chen, Yuan Xu, Bihao Liu, Yu He, Chunling Liang, Yaoyu Liu, Jiuyao Zhou, Junbiao Wu. Salvianolic acid B attenuates membranous nephropathy by activating renal autophagy via microRNA-145-5p/phosphatidylinositol 3-kinase/AKT pathway.
Bioengineered.
2022 May; 13(5):13956-13969. doi:
10.1080/21655979.2022.2083822. [PMID: 35723058] - Qian-Qian Wang, Meng Wang, Yan Li, Yong-Hui Liu, Lian-Qing Sun. Attenuation of Oxidative Stress-Induced Cell Apoptosis and Pyroptosis in RSC96 Cells by Salvianolic Acid B.
Chinese journal of integrative medicine.
2022 Mar; 28(3):243-248. doi:
10.1007/s11655-021-3507-2. [PMID: 35084700] - Yingpeng Xu, Lijun Geng, Yiwen Zhang, J Andrew Jones, Meihong Zhang, Yuan Chen, Ronghui Tan, Mattheos A G Koffas, Zhengtao Wang, Shujuan Zhao. De novo Biosynthesis of Salvianolic Acid B in Saccharomyces cerevisiae Engineered with the Rosmarinic Acid Biosynthetic Pathway.
Journal of agricultural and food chemistry.
2022 Feb; 70(7):2290-2302. doi:
10.1021/acs.jafc.1c06329. [PMID: 35157428] - Jie Xiang, Chunling Zhang, Tietao Di, Lu Chen, Wei Zhao, Lianggang Wei, Shiyong Zhou, Xueli Wu, Gengxin Wang, Yun Zhang. Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells.
Bioengineered.
2022 02; 13(2):3486-3502. doi:
10.1080/21655979.2022.2026552. [PMID: 35068334] - Jing Chen, Yingchao Wang, Shufang Wang, Xiaoping Zhao, Lu Zhao, Yi Wang. Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling.
Journal of ethnopharmacology.
2022 Jan; 283(?):114667. doi:
10.1016/j.jep.2021.114667. [PMID: 34597652] - Feng-Xiang Zhang, Shuang-Shuang Cui, Yu-Lin-Lan Yuan, Chang Li, Rui-Man Li. Dissection of the potential anti-diabetes mechanism of salvianolic acid B by metabolite profiling and network pharmacology.
Rapid communications in mass spectrometry : RCM.
2022; 36(1):e9205. doi:
10.1002/rcm.9205. [PMID: 34636119] - Shanshan Zhang, Ruoqi Li, Yingyi Zheng, Yuan Zhou, Xiang Fan. Erythrocyte Membrane-Enveloped Salvianolic Acid B Nanoparticles Attenuate Cerebral Ischemia-Reperfusion Injury.
International journal of nanomedicine.
2022; 17(?):3561-3577. doi:
10.2147/ijn.s375908. [PMID: 35974873] - Yifan Zhang, Xiaoteng Feng, Min Du, Jie Ding, Ping Liu. Salvianolic acid B attenuates the inflammatory response in atherosclerosis by regulating MAPKs/ NF-κB signaling pathways in LDLR-/- mice and RAW264.7 cells.
International journal of immunopathology and pharmacology.
2022 Jan; 36(?):3946320221079468. doi:
10.1177/03946320221079468. [PMID: 35285334] - Mengqi Sun, Yun Ye, Yilan Huang, Wenxian Yin, Zhaolan Yu, Shurong Wang. Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal‑induced macrophages via inhibiting the Akt/mTOR signaling pathway.
Molecular medicine reports.
2021 11; 24(5):. doi:
10.3892/mmr.2021.12403. [PMID: 34490483] - Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam. Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease.
Journal of ethnopharmacology.
2021 Oct; 279(?):114389. doi:
10.1016/j.jep.2021.114389. [PMID: 34217797] - Bohan Lv, Yanxiang Wu, Juan Lian, Na Yu, Tian An, Tingye Wang, Xueli Bao, Fangfang Mo, Dandan Zhao, Xiuyan Yang, Jing Zhang, Zhiyong Zhang, Sihua Gao, Guangjian Jiang. Effects of Salvianolic acid B on RNA expression and co-expression network of lncRNAs in brown adipose tissue of obese mice.
Journal of ethnopharmacology.
2021 Oct; 278(?):114289. doi:
10.1016/j.jep.2021.114289. [PMID: 34090908] - Rao Yang, Shengsong Wang, Haolan Zou, Lin Li, Yonghui Li, Donghao Wang, Hongxing Xu, Xiaoyan Cao. R2R3-MYB Transcription Factor SmMYB52 Positively Regulates Biosynthesis of Salvianolic Acid B and Inhibits Root Growth in Salvia miltiorrhiza.
International journal of molecular sciences.
2021 Sep; 22(17):. doi:
10.3390/ijms22179538. [PMID: 34502445] - Haolan Zou, Xiaorong Guo, Rao Yang, Shengsong Wang, Lin Li, Junfeng Niu, Donghao Wang, Xiaoyan Cao. MiR408-SmLAC3 Module Participates in Salvianolic Acid B Synthesis in Salvia miltiorrhiza.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147541. [PMID: 34299156] - Jia Li, Ya-Hui Chen, Lan-Zhu Li, Feizuo Wang, Wei Song, Raphael N Alolga, Wei Zhou, Heming Yu, Feng-Qing Huang, Xiaojian Yin. Omics and Transgenic Analyses Reveal that Salvianolic Acid B Exhibits its Anti-Inflammatory Effects through Inhibiting the Mincle-Syk-Related Pathway in Macrophages.
Journal of proteome research.
2021 07; 20(7):3734-3748. doi:
10.1021/acs.jproteome.1c00325. [PMID: 34080425] - Rui Chen, Chenqi Zhu, Liu Xu, Yi Gu, Shujing Ren, Hua Bai, Qin Zhou, Xin Liu, Shengfeng Lu, Xiaolin Bi, Weidong Li, Xiaobin Jia, Zhipeng Chen. An injectable peptide hydrogel with excellent self-healing ability to continuously release salvianolic acid B for myocardial infarction.
Biomaterials.
2021 07; 274(?):120855. doi:
10.1016/j.biomaterials.2021.120855. [PMID: 33975276] - Xuehai Zheng, Duo Chen, Binghua Chen, Limin Liang, Zhen Huang, Wenfang Fan, Jiannan Chen, Wenjin He, Huibin Chen, Luqiang Huang, Youqiang Chen, Jinmao Zhu, Ting Xue. Insights into salvianolic acid B biosynthesis from chromosome-scale assembly of the Salvia bowleyana genome.
Journal of integrative plant biology.
2021 Jul; 63(7):1309-1323. doi:
10.1111/jipb.13085. [PMID: 33634943] - Zhenfeng Sun, Dan Luo, Sang Wang, Ruofei Huang, Pin Dong. Salvianolic acid B inhibits myofibroblast differentiation and extracellular matrix accumulation in nasal polyp fibroblasts via the TGF-β1 signaling pathway.
Molecular medicine reports.
2021 Jun; 23(6):. doi:
10.3892/mmr.2021.12117. [PMID: 33899116] - Zuzana Bednarikova, Miroslav Gancar, Rui Wang, Lulu Zheng, Yun Tang, Yating Luo, Yan Huang, Barbora Spodniakova, Lei Ma, Zuzana Gazova. Extracts from Chinese herbs with anti-amyloid and neuroprotective activities.
International journal of biological macromolecules.
2021 May; 179(?):475-484. doi:
10.1016/j.ijbiomac.2021.03.013. [PMID: 33675837] - Shiling Hu, Jue Wang, Yongjing Zhang, Haoyun Bai, Cheng Wang, Nan Wang, Langchong He. Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.
Journal of medical virology.
2021 05; 93(5):3143-3151. doi:
10.1002/jmv.26874. [PMID: 33580518] - Bei-Bei Ma, Tian-Yu Lou, Yao-Yue Liang, Ting-Ting Wang, Rui-Ji Li, Jin-Hui Liu, Chen-Xiao Wang, Shang-Yue Yu, Yu-Dong Guo, Jing Wang, Zhi-Bin Wang. [Analysis and comparison of metabolic processes of salvianolic acid A and salvianolic acid B in rats based on UHPLC-LTQ-Orbitrap MS technology].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 May; 46(9):2276-2286. doi:
10.19540/j.cnki.cjcmm.20200820.201. [PMID: 34047131] - Ayman Abo Elmaaty, Khaled M Darwish, Muhammad Khattab, Sameh S Elhady, Mohammed Salah, Mohammed I A Hamed, Ahmed A Al-Karmalawy, Moustafa M Saleh. In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins.
Journal of biomolecular structure & dynamics.
2021 Apr; ?(?):1-28. doi:
10.1080/07391102.2021.1918256. [PMID: 33928870] - C Yang, C Cheng, J Wang, K Chen, J Zhan, X Pan, X Xu, W Xu, S Liu. [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2021 Apr; 41(4):475-482. doi:
10.12122/j.issn.1673-4254.2021.04.01. [PMID: 33963705] - Yan Guo, Jie-Hong Yang, Shi-Dong Cao, Cheng-Xian Gao, Yu He, Yu Wang, Hai-Tong Wan, Bo Jin. Effect of main ingredients of Danhong Injection against oxidative stress induced autophagy injury via miR-19a/SIRT1 pathway in endothelial cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Mar; 83(?):153480. doi:
10.1016/j.phymed.2021.153480. [PMID: 33548866] - Jie Zhang, Sheng-Lan Liu, Hui Wang, Li-Ying Shi, Jin-Ping Li, Lu-Juan Jia, Bao-Ping Xie. The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats.
Chinese journal of natural medicines.
2021 Feb; 19(2):153-160. doi:
10.1016/s1875-5364(21)60016-x. [PMID: 33641786] - Mei-Ting Liu, Jing Zhao, Shao-Ping Li. Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza.
Journal of chromatography. A.
2021 Jan; 1637(?):461826. doi:
10.1016/j.chroma.2020.461826. [PMID: 33387914] - Qing Yuan, Jin-Xin Wang, Rui-Lin Li, Zhuang-Zhuang Jia, Shao-Xia Wang, Hong Guo, Li-Juan Chai, Li-Min Hu. Effects of salvianolate lyophilized injection combined with Xueshuantong injection in regulation of BBB function in a co-culture model of endothelial cells and pericytes.
Brain research.
2021 01; 1751(?):147185. doi:
10.1016/j.brainres.2020.147185. [PMID: 33129805] - Yongfang Gong, Dong Li, Lili Li, Juan Yang, Hanyan Ding, Chong Zhang, Guanhua Wen, Chao Wu, Zhirui Fang, Shu Hou, Yan Yang. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jan; 147(?):111912. doi:
10.1016/j.fct.2020.111912. [PMID: 33290806] - Jie Li, Bo Li, Lu Luo, Fulin Cao, Bingyue Yang, Jing Gao, Yonggang Yan, Gang Zhang, Liang Peng, Benxiang Hu. Increased phenolic acid and tanshinone production and transcriptional responses of biosynthetic genes in hairy root cultures of Salvia przewalskii Maxim. treated with methyl jasmonate and salicylic acid.
Molecular biology reports.
2020 Nov; 47(11):8565-8578. doi:
10.1007/s11033-020-05899-1. [PMID: 33048323] - Lin Li, Rui Li, Ruyuan Zhu, Beibei Chen, Yimiao Tian, Hao Zhang, Bingke Xia, Qiangqiang Jia, Lili Wang, Dandan Zhao, Fangfang Mo, Yu Li, Shujing Zhang, Sihua Gao, Dongwei Zhang, Shuzhen Guo. Salvianolic acid B prevents body weight gain and regulates gut microbiota and LPS/TLR4 signaling pathway in high-fat diet-induced obese mice.
Food & function.
2020 Oct; 11(10):8743-8756. doi:
10.1039/d0fo01116a. [PMID: 32955050] - Ying Yang, Ke Pei, Qian Zhang, Danyang Wang, Huichao Feng, Ziwei Du, Chunxiao Zhang, Zichen Gao, Wenqing Yang, Jibiao Wu, Yunlun Li. Salvianolic acid B ameliorates atherosclerosis via inhibiting YAP/TAZ/JNK signaling pathway in endothelial cells and pericytes.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 10; 1865(10):158779. doi:
10.1016/j.bbalip.2020.158779. [PMID: 32739616] - Jing-Jing Peng, Yu-Cui Wu, Shi-Qiang Wang, Jun-Feng Niu, Xiao-Yan Cao. SmbHLH53 is relevant to jasmonate signaling and plays dual roles in regulating the genes for enzymes in the pathway for salvianolic acid B biosynthesis in Salvia miltiorrhiza.
Gene.
2020 Sep; 756(?):144920. doi:
10.1016/j.gene.2020.144920. [PMID: 32593720] - Manish Sharma, Rajesh Kumari Manhas. Purification and characterization of salvianolic acid B from Streptomyces sp. M4 possessing antifungal activity against fungal phytopathogens.
Microbiological research.
2020 Aug; 237(?):126478. doi:
10.1016/j.micres.2020.126478. [PMID: 32361340] - Yang Hu, Man Wang, Yunzheng Pan, Qingju Li, Li Xu. Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis.
Molecular medicine reports.
2020 08; 22(2):1325-1334. doi:
10.3892/mmr.2020.11229. [PMID: 32626974] - Hanqing Liu, Wei Liu, Huiliang Qiu, Dezhi Zou, Huayang Cai, Qiuxiong Chen, Chaoyang Zheng, Danping Xu. Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 08; 393(8):1527-1539. doi:
10.1007/s00210-019-01755-7. [PMID: 31853618] - Yu He, Ruirui Lu, Junbiao Wu, Yu Pang, Jicheng Li, Junqi Chen, Bihao Liu, Yuan Zhou, Jiuyao Zhou. Salvianolic acid B attenuates epithelial-mesenchymal transition in renal fibrosis rats through activating Sirt1-mediated autophagy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Aug; 128(?):110241. doi:
10.1016/j.biopha.2020.110241. [PMID: 32450523] - Xiaocong Ma, Meiwen Tang, Liying Lu, Jinghui Zheng, Jingjing Huang, Junhong Li, Weisheng Luo. Effects of salvianolic acid B on liver fibrosis: A protocol for systematic review and meta analysis.
Medicine.
2020 Jul; 99(28):e21036. doi:
10.1097/md.0000000000021036. [PMID: 32664111] - Pan-Pan Feng, Xue-Sheng Fang, Si-Hui Zhao, Jun-Yan Fu, Hui-Ting Zhang, Yan-Lin Yi, Chang-Yi Li, Chun-Ling Jiang, Da-Peng Chen. Salvianolic acid B decreases interleukin-1β-induced colitis recurrence in mice.
Chinese medical journal.
2020 Jun; 133(12):1436-1444. doi:
10.1097/cm9.0000000000000773. [PMID: 32472783] - Wei Wang, Yang Liu, Chao Yang, Weitao Jia, Xin Qi, Changsheng Liu, Xiaolin Li. Delivery of Salvianolic Acid B for Efficient Osteogenesis and Angiogenesis from Silk Fibroin Combined with Graphene Oxide.
ACS biomaterials science & engineering.
2020 06; 6(6):3539-3549. doi:
10.1021/acsbiomaterials.0c00558. [PMID: 33463186] - Yanan Shi, Da Pan, Lihui Yan, Hengyu Chen, Ximei Zhang, Jihong Yuan, Biao Mu. Salvianolic acid B improved insulin resistance through suppression of hepatic ER stress in ob/ob mice.
Biochemical and biophysical research communications.
2020 06; 526(3):733-737. doi:
10.1016/j.bbrc.2020.03.124. [PMID: 32265029] - Young Shin Ko, Hana Jin, Sang Won Park, Hye Jung Kim. Salvianolic acid B protects against oxLDL-induced endothelial dysfunction under high-glucose conditions by downregulating ROCK1-mediated mitophagy and apoptosis.
Biochemical pharmacology.
2020 04; 174(?):113815. doi:
10.1016/j.bcp.2020.113815. [PMID: 31972167] - Mustafa T Ardah, Simona S Ghanem, Sara A Abdulla, Guohua Lv, Mohamed M Emara, Katerina E Paleologou, Nishant N Vaikath, Jia-Hong Lu, Min Li, Konstantinos Vekrellis, David Eliezer, Omar M A El-Agnaf. Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
BMC complementary medicine and therapies.
2020 Mar; 20(1):73. doi:
10.1186/s12906-020-2849-1. [PMID: 32143619] - Yong-Mei Jin, Xiang-Ming Tao, Yi-Ning Shi, Youjin Lu, Jin-Yu Mei. Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2/HO-1 signaling pathway.
Canadian journal of physiology and pharmacology.
2020 Mar; 98(3):162-168. doi:
10.1139/cjpp-2019-0349. [PMID: 31604020] - Jun Shi, Siyi Guo, Yanting Wu, Guitian Chen, Jianhui Lai, Xiaoqi Xu. Behaviour of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B on the migration, proliferation, and survival of human skin fibroblasts.
Journal of liposome research.
2020 Mar; 30(1):93-106. doi:
10.1080/08982104.2019.1593451. [PMID: 31012367] - Chang-Ling Li, Bin Liu, Zhao-Yang Wang, Fei Xie, Wen Qiao, Jie Cheng, Jiang-Ying Kuang, Ying Wang, Ming-Xiang Zhang, De-Shan Liu. Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3.
Journal of molecular and cellular cardiology.
2020 02; 139(?):98-112. doi:
10.1016/j.yjmcc.2020.01.009. [PMID: 31982427] - Jing Wang, Chi Liu, Weitao Que, Masayuki Fujino, Guoqing Tong, Hua Yan, Xiao-Kang Li. Immunomodulatory effects of Salvianolic acid B in a spontaneous abortion mouse model.
Journal of reproductive immunology.
2020 02; 137(?):103075. doi:
10.1016/j.jri.2019.103075. [PMID: 31918160] - So-Hee Kim, Jihye Lee, Ye Lin Jung, Aerum Hong, Sang-Jip Nam, Byung-Kwan Lim. Salvianolic Acid B Inhibits Hand-Foot-Mouth Disease Enterovirus 71 Replication through Enhancement of AKT Signaling Pathway.
Journal of microbiology and biotechnology.
2020 Jan; 30(1):38-43. doi:
10.4014/jmb.1907.07079. [PMID: 31752055] - Yalan Wu, Suowen Xu, Xiao Yu Tian. The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms.
Oxidative medicine and cellular longevity.
2020; 2020(?):5472096. doi:
10.1155/2020/5472096. [PMID: 33062143] - Ziru Zhang, Jianbo Ji, Dawei Zhang, Maoqiang Ma, Longru Sun. Protective effects and potential mechanism of salvianolic acid B on sodium laurate-induced thromboangiitis obliterans in rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Jan; 66(?):153110. doi:
10.1016/j.phymed.2019.153110. [PMID: 31790900] - Yaolan Lin, Chao Han, Qiqi Xu, Wenli Wang, Lingnan Li, Dongrong Zhu, Jianguang Luo, Lingyi Kong. Integrative countercurrent chromatography for the target isolation of lysine-specific demethylase 1 inhibitors from the roots of Salvia miltiorrhiza.
Talanta.
2020 Jan; 206(?):120195. doi:
10.1016/j.talanta.2019.120195. [PMID: 31514831] - Anna Lewinska, Lakshman Sodagam, Dominika Bloniarz, Karsten Siems, Maciej Wnuk, Suresh I S Rattan. Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro.
Molecules (Basel, Switzerland).
2019 Dec; 25(1):. doi:
10.3390/molecules25010141. [PMID: 31905790] - Yufeng Wang, Xiaoqing Xu, Peipei Hu, Ning Jia, Shiliang Ji, Hongjie Yuan. Effect of Toll-Like Receptor 4/Myeloid Differentiation Factor 88 Inhibition by Salvianolic Acid B on Neuropathic Pain After Spinal Cord Injury in Mice.
World neurosurgery.
2019 Dec; 132(?):e529-e534. doi:
10.1016/j.wneu.2019.08.086. [PMID: 31449993] - Zhang Yifan, Xu Luwei, Liang Kai, Zhou Liuhua, Ge Yuzheng, Jia Ruipeng. Protective effect of salvianolic acid B against oxidative injury associated with cystine stone formation.
Urolithiasis.
2019 Dec; 47(6):503-510. doi:
10.1007/s00240-019-01114-4. [PMID: 30778619] - Yumei Wu, Xunan Song, Dereje Kebebe, Xinyue Li, Zhifeng Xue, Jiawei Li, Shouying Du, Jiaxin Pi, Zhidong Liu. Brain targeting of Baicalin and Salvianolic acid B combination by OX26 functionalized nanostructured lipid carriers.
International journal of pharmaceutics.
2019 Nov; 571(?):118754. doi:
10.1016/j.ijpharm.2019.118754. [PMID: 31604118] - Shengnan Li, Rong Wang, Bin Wu, Yuanyuan Wang, Fuxing Song, Yanqiu Gu, Yongfang Yuan. Salvianolic acid B protects against ANIT-induced cholestatic liver injury through regulating bile acid transporters and enzymes, and NF-κB/IκB and MAPK pathways.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 09; 392(9):1169-1180. doi:
10.1007/s00210-019-01657-8. [PMID: 31098695] - L W Huang, N Jiang, J Ping, J Zhang, L M Xu. [Study on anti- fibrotic mechanism of Fuzheng -Huayu formula to suppress autophagy in mice].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2019 Aug; 27(8):621-627. doi:
10.3760/cma.j.issn.1007-3418.2019.08.007. [PMID: 31594080] - Xia Liu, Mengxia Jin, Min Zhang, Tianqi Li, Shanshan Sun, Jinyue Zhang, Jungui Dai, Yinghong Wang. The application of combined 1H NMR-based metabolomics and transcriptomics techniques to explore phenolic acid biosynthesis in Salvia miltiorrhiza Bunge.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):126-138. doi:
10.1016/j.jpba.2019.04.030. [PMID: 31035094] - Jing Zhao, Xing-Chen Yang, Masayuki Fujino, Naotsugu Ichimaru, Weitao Que, Xiao-Kang Li, Shiro Takahara. Salvianolic acid B ameliorates liver injury in a murine aGvHD model by decreasing inflammatory responses via upregulation of HO-1.
Transplant immunology.
2019 08; 55(?):101203. doi:
10.1016/j.trim.2019.03.002. [PMID: 30904623] - Peng Lu, Yue Xing, Zhifeng Xue, Zhe Ma, Bing Zhang, Hui Peng, Qi Tony Zhou, Hongfei Liu, Zhidong Liu, Jiawei Li. Pharmacokinetics of salvianolic acid B, rosmarinic acid and Danshensu in rat after pulmonary administration of Salvia miltiorrhiza polyphenolic acid solution.
Biomedical chromatography : BMC.
2019 Aug; 33(8):e4561. doi:
10.1002/bmc.4561. [PMID: 31017297] - Yu-En Shih, Chao-Hsiang Chen, Nan-Hei Lin, Jason T C Tzen. Development of Indirect Competitive ELISA for Lithospermic Acid B of Salvia miltiorrhiza with Its Specific Antibodies Generated via Artificial Oil Bodies.
Molecules (Basel, Switzerland).
2019 May; 24(10):. doi:
10.3390/molecules24101952. [PMID: 31117255] - Danqing Wang, Shuangshuang Zhang, Han Tang, Cuiping Jiang, Bingwei Wang, Jianping Liu. Development of sustained-release pellets to modulate the in vivo processes of the main active components of Danshen: A pharmacokinetic and pharmacodynamic evaluation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 May; 58(?):152793. doi:
10.1016/j.phymed.2018.12.016. [PMID: 31005724] - Tiantian Ye, Haibin Qu, Xingchu Gong. Preparation of Salvianolic Acid B Disodium Salt Considering the Water Extract Quality Standard.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071269. [PMID: 30939842] - Qian-Qian Wang, Cui Zhai, Alafate Wahafu, Yan-Ting Zhu, Yong-Hui Liu, Lian-Qing Sun. Salvianolic acid B inhibits the development of diabetic peripheral neuropathy by suppressing autophagy and apoptosis.
The Journal of pharmacy and pharmacology.
2019 Mar; 71(3):417-428. doi:
10.1111/jphp.13044. [PMID: 30537209] - Ya-Li Wang, Qian Zhang, Shi-Jun Yin, Liang Cai, Yu-Xiu Yang, Wen-Jing Liu, Yuan-Jia Hu, Hua Chen, Feng-Qing Yang. Screening of blood-activating active components from Danshen-Honghua herbal pair by spectrum-effect relationship analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 54(?):149-158. doi:
10.1016/j.phymed.2018.09.176. [PMID: 30668364]