(5Z)-5-[(2E)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropyl)-4-methylidenecyclohexane-1,3-diol (BioDeep_00000912416)
代谢物信息卡片
(5Z)-5-[(2E)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropyl)-4-methylidenecyclohexane-1,3-diol
化学式: C30H50O4 (474.3709)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(C(C(C3=C)O)CCCO)O)C
InChI: InChI=1S/C30H50O4/c1-20(9-6-16-29(3,4)34)25-14-15-26-22(10-7-17-30(25,26)5)12-13-23-19-27(32)24(11-8-18-31)28(33)21(23)2/h12-13,20,24-28,31-34H,2,6-11,14-19H2,1,3-5H3/b22-12+,23-13-
描述信息
D050071 - Bone Density Conservation Agents
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yong-Fang Fu, Yi-Xun Guo, Shi-Hui Xia, Ting-Ting Zhou, Yun-Chao Zhao, Zhen-Hua Jia, Yan Zhang. Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice.
Experimental gerontology.
2024 May; 189(?):112408. doi:
10.1016/j.exger.2024.112408. [PMID: 38521178] - Tuo Shi, Ting Liu, Yuying Kou, Xing Rong, Lingxiao Meng, Yajun Cui, Ruihan Gao, Sumin Hu, Minqi Li. The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis.
Medicina (Kaunas, Lithuania).
2023 Aug; 59(8):. doi:
10.3390/medicina59081414. [PMID: 37629706] - Lijia Cui, Weibo Xia, Chuan Yu, Shuangshuang Dong, Yu Pei. Overview of the clinical efficacy and safety of eldecalcitol for the treatment of osteoporosis.
Archives of osteoporosis.
2022 05; 17(1):74. doi:
10.1007/s11657-022-01071-3. [PMID: 35513519] - Yasuhiro Takeuchi, Hitoshi Saito, Misako Makishima, Hiroko Yokoyama, Tomohiro Yamaguchi, Hiroyuki Fujii, Eri Inoue, Tomoya Isemura, Satoshi Kondo. Long-term safety of eldecalcitol in Japanese patients with osteoporosis: a retrospective, large-scale database study.
Journal of bone and mineral metabolism.
2022 Mar; 40(2):275-291. doi:
10.1007/s00774-021-01276-5. [PMID: 35041084] - Hongyan Liu, Guoqi Wang, Ting Wu, Yiming Mu, Weijun Gu. Efficacy and Safety of Eldecalcitol for Osteoporosis: A Meta-Analysis of Randomized Controlled Trials.
Frontiers in endocrinology.
2022; 13(?):854439. doi:
10.3389/fendo.2022.854439. [PMID: 35518938] - Eri Ito, Yuiko Sato, Tami Kobayashi, Satoshi Nakamura, Yosuke Kaneko, Tomoya Soma, Tatsuaki Matsumoto, Atushi Kimura, Kana Miyamoto, Hideo Matsumoto, Morio Matsumoto, Masaya Nakamura, Kazuki Sato, Takeshi Miyamoto. Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in mice.
Biochemical and biophysical research communications.
2021 01; 534(?):165-171. doi:
10.1016/j.bbrc.2020.11.122. [PMID: 33288195] - Zaoqian Zheng, Jinyu Luo. The therapeutic effect to eldecalcitol + bisphosphonate is superior to bisphosphonate alone in the treatment of osteoporosis: a meta-analysis.
Journal of orthopaedic surgery and research.
2020 Sep; 15(1):390. doi:
10.1186/s13018-020-01896-z. [PMID: 32907639] - Takahiko Obo, Nobuyuki Koriyama, Akinori Tokito, Kazuma Ogiso, Yoshihiko Nishio. Neurofibromatosis type 1 associated with hypophosphatemic osteomalacia due to hypersecretion of fibroblast growth factor 23: a case report.
Journal of medical case reports.
2020 May; 14(1):56. doi:
10.1186/s13256-020-02381-1. [PMID: 32384911] - Seishi Aihara, Shunsuke Yamada, Hideaki Oka, Taro Kamimura, Toshiaki Nakano, Kazuhiko Tsuruya, Atsumi Harada. Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility.
Renal failure.
2019 Nov; 41(1):88-97. doi:
10.1080/0886022x.2019.1578667. [PMID: 30909788] - Yan Jiang, Hai Tang, Xinlong Ma, Qun Cheng, Hua Lin, Xiaolan Jin, Zhenlin Zhang, Wei Yu, Shuli He, Tsuyoshi Kobayashi, Satomi Uehara, Toshio Matsumoto, Weibo Xia. Eldecalcitol increases bone mineral density in Chinese osteoporotic patients without vitamin D or calcium supplementation.
Journal of bone and mineral metabolism.
2019 Nov; 37(6):1036-1047. doi:
10.1007/s00774-019-01009-9. [PMID: 31087185] - Tsuyoshi Asano, Tomohiro Shimizu, Daisuke Takahashi, Masahiro Ota, Dai Sato, Hiroki Hamano, Shigeto Hiratsuka, Masahiko Takahata, Norimasa Iwasaki. Potential association with early changes in serum calcium level after starting or switching to denosumab combined with eldecalcitol.
Journal of bone and mineral metabolism.
2019 Mar; 37(2):351-357. doi:
10.1007/s00774-018-0928-x. [PMID: 29721807] - Satoshi Kondo, Hiroyuki Kakihata, Yosuke Nishida, Yuko Furuno, Yumiko Kobayashi, Hidehiro Tabata, Makoto Nomura. The safety and effectiveness profile of eldecalcitol in a prospective, post-marketing observational study in Japanese male patients with osteoporosis.
Journal of bone and mineral metabolism.
2019 Mar; 37(2):292-300. doi:
10.1007/s00774-018-0915-2. [PMID: 29532248] - Ichiro Kaneko, Hiroko Segawa, Kayo Ikuta, Ai Hanazaki, Toru Fujii, Sawako Tatsumi, Shinsuke Kido, Tomoka Hasegawa, Norio Amizuka, Hitoshi Saito, Ken-Ichi Miyamoto. Eldecalcitol Causes FGF23 Resistance for Pi Reabsorption and Improves Rachitic Bone Phenotypes in the Male Hyp Mouse.
Endocrinology.
2018 07; 159(7):2741-2758. doi:
10.1210/en.2018-00109. [PMID: 29878089] - K Uenishi, M Tokiwa, S Kato, M Shiraki. Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2018 03; 29(3):723-732. doi:
10.1007/s00198-017-4351-2. [PMID: 29273827] - Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano. Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
PloS one.
2018; 13(10):e0199856. doi:
10.1371/journal.pone.0199856. [PMID: 30281599] - Satoshi Takeda, Mitsuru Saito, Sadaoki Sakai, Kenji Yogo, Keishi Marumo, Koichi Endo. Eldecalcitol, an Active Vitamin D3 Derivative, Prevents Trabecular Bone Loss and Bone Fragility in Type I Diabetic Model Rats.
Calcified tissue international.
2017 10; 101(4):433-444. doi:
10.1007/s00223-017-0298-8. [PMID: 28624935] - Hitoshi Saito, Hiroyuki Kakihata, Yosuke Nishida, Sawako Yatomi, Shigeru Nihojima, Yumiko Kobayashi, Hidehiro Tabata, Makoto Nomura. The safety and effectiveness profile of eldecalcitol in a prospective, post-marketing observational study in Japanese patients with osteoporosis: interim report.
Journal of bone and mineral metabolism.
2017 Jul; 35(4):456-463. doi:
10.1007/s00774-016-0779-2. [PMID: 27699492] - Kousuke Iba, Tomoko Sonoda, Junichi Takada, Takayuki Dohke, Toshihiko Yamashita. Further significant effects of eldecalcitol on bone resorption markers and bone mineral density in postmenopausal osteoporosis patients having undergone long-term bisphosphonate treatment.
Journal of bone and mineral metabolism.
2017 Mar; 35(2):171-176. doi:
10.1007/s00774-016-0738-y. [PMID: 26832388] - Hideo Saito, Koshi N Kishimoto, Yu Mori, Hiroshi Okuno, Masahiko Tanaka, Eiji Itoi. A vitamin D analogue, eldecalcitol, enhances expression of fast myosin heavy chain subtypes in differentiated C2C12 myoblasts.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.
2017 Mar; 22(2):345-350. doi:
10.1016/j.jos.2016.12.005. [PMID: 28017710] - Takao Suzuki. [Update on recent progress in vitamin D research. EldecalcitolR and Fall Prevention.].
Clinical calcium.
2017 ; 27(11):1595-1600. doi:
clica171115951600. [PMID: 29074832] - Kazuhiro Uenishi, Masataka Shiraki. [Update on recent progress in vitamin D research. Eldecalcitol and intestinal calcium absorption.].
Clinical calcium.
2017 ; 27(11):1587-1594. doi:
clica171115871594. [PMID: 29074831] - T Shintani, S N Z Rosli, F Takatsu, Y F Choon, Y Hayashido, S Toratani, E Usui, T Okamoto. Eldecalcitol (ED-71), an analog of 1α,25-dihydroxyvitamin D3 as a potential anti-cancer agent for oral squamous cell carcinomas.
The Journal of steroid biochemistry and molecular biology.
2016 11; 164(?):79-84. doi:
10.1016/j.jsbmb.2015.09.043. [PMID: 26444325] - Kosuke Ebina, Takaaki Noguchi, Makoto Hirao, Shoichi Kaneshiro, Yasunori Tsukamoto, Hideki Yoshikawa. Comparison of the effects of 12 months of monthly minodronate monotherapy and monthly minodronate combination therapy with vitamin K2 or eldecalcitol in patients with primary osteoporosis.
Journal of bone and mineral metabolism.
2016 May; 34(3):243-50. doi:
10.1007/s00774-015-0710-2. [PMID: 26303222] - Zhixing Xu, Changchun Fan, Xuechun Zhao, Hairong Tao. Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials.
Drug design, development and therapy.
2016; 10(?):509-17. doi:
10.2147/dddt.s84264. [PMID: 26869769] - Keijiro Mukaiyama, Shigeharu Uchiyama, Yukio Nakamura, Shota Ikegami, Akira Taguchi, Mikio Kamimura, Hiroyuki Kato. Eldecalcitol, in Combination with Bisphosphonate, Is Effective for Treatment of Japanese Osteoporotic Patients.
The Tohoku journal of experimental medicine.
2015 12; 237(4):339-43. doi:
10.1620/tjem.237.339. [PMID: 26639092] - Satoshi Kondo, Toshiyuki Takano, Yoshiyuki Ono, Hitoshi Saito, Toshio Matsumoto. Eldecalcitol reduces osteoporotic fractures by unique mechanisms.
The Journal of steroid biochemistry and molecular biology.
2015 Apr; 148(?):232-8. doi:
10.1016/j.jsbmb.2015.01.016. [PMID: 25625663] - Naomi Sasaki, Masataka Tsunoda, Ryota Ikee, Nobuo Hashimoto. Efficacy and safety of eldecalcitol, a new active vitamin D3 analog, in the bone metabolism of postmenopausal women receiving maintenance hemodialysis.
Journal of bone and mineral metabolism.
2015 Mar; 33(2):213-20. doi:
10.1007/s00774-014-0582-x. [PMID: 24763728] - A Sakai, M Ito, T Tomomitsu, H Tsurukami, S Ikeda, F Fukuda, H Mizunuma, T Inoue, H Saito, T Nakamura. Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2015 Mar; 26(3):1193-202. doi:
10.1007/s00198-014-2991-z. [PMID: 25592133] - Hitoshi Saito, Suguru Harada. Eldecalcitol replaces endogenous calcitriol but does not fully compensate for its action in vivo.
The Journal of steroid biochemistry and molecular biology.
2014 Oct; 144 Pt A(?):189-96. doi:
10.1016/j.jsbmb.2013.11.013. [PMID: 24291401] - Toshiyuki Takano, Satoshi Kondo, Hitoshi Saito, Toshio Matsumoto. Relationship between the effect of eldecalcitol and serum 25(OH)D level.
The Journal of steroid biochemistry and molecular biology.
2014 Oct; 144 Pt A(?):124-7. doi:
10.1016/j.jsbmb.2013.11.005. [PMID: 24240066] - Ayako Shiraishi, Sadaoki Sakai, Hitoshi Saito, Fumiaki Takahashi. Eldecalcitol improves mechanical strength of cortical bones by stimulating the periosteal bone formation in the senescence-accelerated SAM/P6 mice - a comparison with alfacalcidol.
The Journal of steroid biochemistry and molecular biology.
2014 Oct; 144 Pt A(?):119-23. doi:
10.1016/j.jsbmb.2013.10.024. [PMID: 24189542] - Alex J Brown, Fanjie Zhang, Nancy E Cooke, Cynthia S Ritter. The role of the serum vitamin D binding protein in the actions of the vitamin D analog eldecalcitol (ED-71) on bone and mineral metabolism.
Calcified tissue international.
2013 Aug; 93(2):163-71. doi:
10.1007/s00223-013-9737-3. [PMID: 23689467] - Junichi Kikuta, Shunsuke Kawamura, Fumie Okiji, Mai Shirazaki, Sadaoki Sakai, Hitoshi Saito, Masaru Ishii. Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D.
Proceedings of the National Academy of Sciences of the United States of America.
2013 Apr; 110(17):7009-13. doi:
10.1073/pnas.1218799110. [PMID: 23569273] - Yuko Noguchi, Hisaya Kawate, Masatoshi Nomura, Ryoichi Takayanagi. Eldecalcitol for the treatment of osteoporosis.
Clinical interventions in aging.
2013; 8(?):1313-21. doi:
10.2147/cia.s49825. [PMID: 24101867] - Masataka Shiraki, Hitoshi Saito, Toshio Matsumoto. Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels.
Current medical research and opinion.
2012 Sep; 28(9):1547-52. doi:
10.1185/03007995.2012.712506. [PMID: 22794117] - Tatsuo Suda, Fumiaki Takahashi, Naoyuki Takahashi. Bone effects of vitamin D - Discrepancies between in vivo and in vitro studies.
Archives of biochemistry and biophysics.
2012 Jul; 523(1):22-9. doi:
10.1016/j.abb.2011.11.011. [PMID: 22107950] - Sadaoki Sakai, Koichi Endo, Satoshi Takeda, Masahiko Mihara, Ayako Shiraishi. Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength.
Bone.
2012 May; 50(5):1054-63. doi:
10.1016/j.bone.2012.02.005. [PMID: 22366400] - Suguru Harada, Toshihide Mizoguchi, Yasuhiro Kobayashi, Yuko Nakamichi, Satoshi Takeda, Sadaoki Sakai, Fumiaki Takahashi, Hitoshi Saito, Hisataka Yasuda, Nobuyuki Udagawa, Tatsuo Suda, Naoyuki Takahashi. Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2012 Feb; 27(2):461-73. doi:
10.1002/jbmr.555. [PMID: 22052469] - Alex J Brown, Cynthia S Ritter. The vitamin D analog 1α,25-Dihydroxy-2β-(3-Hydroxypropyloxy) vitamin D(3) (Eldecalcitol) is a potent regulator of calcium and phosphate metabolism.
Calcified tissue international.
2011 Nov; 89(5):372-8. doi:
10.1007/s00223-011-9528-7. [PMID: 21912832] - Toshio Matsumoto, Masako Ito, Yasufumi Hayashi, Takako Hirota, Yusuke Tanigawara, Teruki Sone, Masao Fukunaga, Masataka Shiraki, Toshitaka Nakamura. A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.
Bone.
2011 Oct; 49(4):605-12. doi:
10.1016/j.bone.2011.07.011. [PMID: 21784190] - Mark Sanford, Paul L McCormack. Eldecalcitol: a review of its use in the treatment of osteoporosis.
Drugs.
2011 Sep; 71(13):1755-70. doi:
10.2165/11206790-000000000-00000. [PMID: 21902297] - Cynthia S Ritter, Alex J Brown. Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.
Journal of cellular biochemistry.
2011 May; 112(5):1348-52. doi:
10.1002/jcb.23051. [PMID: 21337382] - Suguru Harada, Satoshi Takeda, Akiko Uno, Fumiaki Takahashi, Hitoshi Saito. Eldecalcitol is less effective in suppressing parathyroid hormone compared to calcitriol in vivo.
The Journal of steroid biochemistry and molecular biology.
2010 Jul; 121(1-2):281-3. doi:
10.1016/j.jsbmb.2010.04.001. [PMID: 20398764] - Toshio Matsumoto, Toshiyuki Takano, Shinji Yamakido, Fumiaki Takahashi, Naoki Tsuji. Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism.
The Journal of steroid biochemistry and molecular biology.
2010 Jul; 121(1-2):261-4. doi:
10.1016/j.jsbmb.2010.03.035. [PMID: 20298784] - Susumi Hatakeyama, Satoshi Nagashima, Naoko Imai, Keisuke Takahashi, Jun Ishihara, Atsuko Sugita, Takeshi Nihei, Hitoshi Saito, Fumiaki Takahashi, Noboru Kubodera. Synthesis and biological evaluation of a 3-positon epimer of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71).
The Journal of steroid biochemistry and molecular biology.
2007 Mar; 103(3-5):222-6. doi:
10.1016/j.jsbmb.2006.12.025. [PMID: 17207991] - Toshio Matsumoto, Noboru Kubodera. ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.
The Journal of steroid biochemistry and molecular biology.
2007 Mar; 103(3-5):584-6. doi:
10.1016/j.jsbmb.2006.12.088. [PMID: 17298881] - Atsushi Shionoiri. [New horizons of ED-71 (vitamin D analog)].
Clinical calcium.
2006 Jan; 16(1):131-5. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Sep; 823(2):61-8. doi:
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The Journal of clinical endocrinology and metabolism.
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Nihon rinsho. Japanese journal of clinical medicine.
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Journal of cellular biochemistry.
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Bone.
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
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Biochemical and biophysical research communications.
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