3-[[2-[[2-[[2-[[2-[[2-[[2-[[2-[[2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino]-1-hydroxy-3-methylbutylidene]amino]-1-hydroxy-4-methylsulfanylbutylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-(1H-imidazol-5-yl)propylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxy-3-(1H-indol-3-yl)propylidene]amino]-4-[5-carbamimidamido-1-(1-carboxy-2-phenylethyl)imino-1-hydroxypentan-2-yl]imino-4-hydroxybutanoic acid (BioDeep_00000912401)
代谢物信息卡片
化学式: C72H96N20O15S (1512.7084386000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=NC(CCSC)C(=NCC(=NC(CC1=CN=CN1)C(=NC(CC2=CC=CC=C2)C(=NC(CCCNC(=N)N)C(=NC(CC3=CNC4=CC=CC=C43)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(CC5=CC=CC=C5)C(=O)O)O)O)O)O)O)O)O)O)O)N=C(C(CC6=CC=C(C=C6)O)N)O
InChI: InChI=1S/C72H96N20O15S/c1-40(2)60(92-61(97)48(73)30-43-22-24-46(93)25-23-43)69(105)87-52(26-29-108-3)62(98)82-38-58(94)84-55(34-45-37-78-39-83-45)67(103)88-53(31-41-14-6-4-7-15-41)65(101)85-50(20-12-27-79-71(74)75)63(99)89-54(33-44-36-81-49-19-11-10-18-47(44)49)66(102)90-56(35-59(95)96)68(104)86-51(21-13-28-80-72(76)77)64(100)91-57(70(106)107)32-42-16-8-5-9-17-42/h4-11,14-19,22-25,36-37,39-40,48,50-57,60,81,93H,12-13,20-21,26-35,38,73H2,1-3H3,(H,78,83)(H,82,98)(H,84,94)(H,85,101)(H,86,104)(H,87,105)(H,88,103)(H,89,99)(H,90,102)(H,91,100)(H,92,97)(H,95,96)(H,106,107)(H4,74,75,79)(H4,76,77,80)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D009074 - Melanocyte-Stimulating Hormones
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Luana Palazzi, Antonella Pasquato, Mattia Vicario, Alexandre Roulin, Patrizia Polverino de Laureto, Laura Cendron. C-terminal tails mimicking bioactive intermediates cause different plasma degradation patterns and kinetics in neuropeptides γ-MSH, α-MSH, and neurotensin.
Journal of peptide science : an official publication of the European Peptide Society.
2020 Nov; 26(11):e3279. doi:
10.1002/psc.3279
. [PMID: 32812282] - Georgina Cope, Gaurav Kaushik, Siobhan M O'Sullivan, Vincent Healy. Gamma-melanocyte stimulating hormone regulates the expression and cellular localization of epithelial sodium channel in inner medullary collecting duct cells.
Peptides.
2013 Sep; 47(?):54-9. doi:
10.1016/j.peptides.2013.07.007
. [PMID: 23871693] - Georgina Cope, Evelyn T Flanagan, Belinda L Houghton, Sarah A Walsh, Edward J Johns, Vincent Healy. [Nle3,d-Phe6 ]-γ2 -melanocyte-stimulating hormone possesses the renal excretory but not the cardiovascular actions of the native γ2 -melanocyte-stimulating hormone in anaesthetized rats.
Clinical and experimental pharmacology & physiology.
2013 Jan; 40(1):5-12. doi:
10.1111/1440-1681.12025
. [PMID: 23106106] - Michael H Humphreys, Xi-Ping Ni, David Pearce. Cardiovascular effects of melanocortins.
European journal of pharmacology.
2011 Jun; 660(1):43-52. doi:
10.1016/j.ejphar.2010.10.102
. [PMID: 21199648] - Paru P Kathpalia, Carol Charlton, Madhumitha Rajagopal, Alan C Pao. The natriuretic mechanism of Gamma-Melanocyte-Stimulating Hormone.
Peptides.
2011 May; 32(5):1068-72. doi:
10.1016/j.peptides.2011.02.006
. [PMID: 21335042] - Vladimir Blagaić, Karlo Houra, Petra Turcić, Nikola Stambuk, Pasko Konjevoda, Alenka Boban-Blagaić, Tomislav Kelava, Marina Kos, Gorana Aralica, Filip Culo. The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice.
Molecules (Basel, Switzerland).
2010 Mar; 15(3):1232-41. doi:
10.3390/molecules15031232
. [PMID: 20335976] - Marissa L Smith, Nicole A Kohart, Brandon A Newmyer, Mark A Cline. Gamma(2)-melanocyte stimulating hormone decreases food intake in chicks.
Neuroscience letters.
2009 Nov; 465(3):210-3. doi:
10.1016/j.neulet.2009.08.021
. [PMID: 19682545] - Gangadarshni Chandramohan, Nicquanna Durham, Satyesh Sinha, Keith Norris, Nosratola D Vaziri. Role of gamma melanocyte-stimulating hormone-renal melanocortin 3 receptor system in blood pressure regulation in salt-resistant and salt-sensitive rats.
Metabolism: clinical and experimental.
2009 Oct; 58(10):1424-9. doi:
10.1016/j.metabol.2009.04.022
. [PMID: 19570553] - Xi-Ping Ni, Claudia van Dijk, David Pearce, Michael H Humphreys. Evidence for a noradrenergic mechanism causing hypertension and abnormal glucose metabolism in rats with relative deficiency of gamma-melanocyte-stimulating hormone.
Experimental physiology.
2009 Aug; 94(8):867-76. doi:
10.1113/expphysiol.2009.046748
. [PMID: 19429645] - Petteri Rinne, Janne Harjunpää, Mika Scheinin, Eriika Savontaus. Blood pressure regulation and cardiac autonomic control in mice overexpressing alpha- and gamma-melanocyte stimulating hormone.
Peptides.
2008 Nov; 29(11):1943-52. doi:
10.1016/j.peptides.2008.06.012
. [PMID: 18638516] - Zhen-Chuan Fan, James L Sartin, Ya-Xiong Tao. Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor.
The Journal of endocrinology.
2008 Jan; 196(1):139-48. doi:
10.1677/joe-07-0403
. [PMID: 18180325] - Xi-Ping Ni, Aditi Bhargava, David Pearce, Michael H Humphreys. Modulation by dietary sodium intake of melanocortin 3 receptor mRNA and protein abundance in the rat kidney.
American journal of physiology. Regulatory, integrative and comparative physiology.
2006 Mar; 290(3):R560-7. doi:
10.1152/ajpregu.00279.2005
. [PMID: 16195498] - Andrea Beatríz Cragnolini, Mario Perelló, Helgi Birgir Schiöth, Teresa Nieves Scimonelli. alpha-MSH and gamma-MSH inhibit IL-1beta induced activation of the hypothalamic-pituitary-adrenal axis through central melanocortin receptors.
Regulatory peptides.
2004 Nov; 122(3):185-90. doi:
10.1016/j.regpep.2004.06.011
. [PMID: 15491790] - Janis Klovins, Tatjana Haitina, Aneta Ringholm, Maja Löwgren, Davids Fridmanis, Maija Slaidina, Susanne Stier, Helgi B Schiöth. Cloning of two melanocortin (MC) receptors in spiny dogfish: MC3 receptor in cartilaginous fish shows high affinity to ACTH-derived peptides while it has lower preference to gamma-MSH.
European journal of biochemistry.
2004 Nov; 271(21):4320-31. doi:
10.1111/j.1432-1033.2004.04374.x
. [PMID: 15511238] - Michael H Humphreys. Gamma-MSH, sodium metabolism, and salt-sensitive hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Mar; 286(3):R417-30. doi:
10.1152/ajpregu.00365.2003
. [PMID: 14761863] - Haim Mayan, Xi-Ping Ni, Shlomo Almog, Michael H Humphreys. Suppression of gamma-melanocyte-stimulating hormone secretion is accompanied by salt-sensitive hypertension in the rat.
Hypertension (Dallas, Tex. : 1979).
2003 Nov; 42(5):962-7. doi:
10.1161/01.hyp.0000097601.83235.f8
. [PMID: 14568996] - S James Wachira, Cleo A Hughes-Darden, Christopher V Taylor, Richard Ochillo, T Joan Robinson. Evidence for the interaction of protein kinase C and melanocortin 3-receptor signaling pathways.
Neuropeptides.
2003 Aug; 37(4):201-10. doi:
10.1016/s0143-4179(03)00026-x
. [PMID: 12906838] - S A Stanley, S Davies, C J Small, J V Gardiner, M A Ghatei, D M Smith, S R Bloom. gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo.
FEBS letters.
2003 May; 543(1-3):66-70. doi:
10.1016/s0014-5793(03)00402-2
. [PMID: 12753907] - Xi-Ping Ni, David Pearce, Andrew A Butler, Roger D Cone, Michael H Humphreys. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.
The Journal of clinical investigation.
2003 Apr; 111(8):1251-8. doi:
10.1172/jci16993
. [PMID: 12697744] - Hajime Watanobe, Helgi B Schiöth, Junkichi Izumi. Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats.
Journal of neurochemistry.
2003 Apr; 85(2):338-47. doi:
10.1046/j.1471-4159.2003.01683.x
. [PMID: 12675910] - M S Kim, C J Small, S H Russell, D G A Morgan, C R Abbott, S H alAhmed, D L Hay, M A Ghatei, D M Smith, S R Bloom. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors.
Journal of neuroendocrinology.
2002 Apr; 14(4):276-82. doi:
10.1046/j.1365-2826.2002.00769.x
. [PMID: 11963824] - Y Xia, J E Wikberg, T L Krukoff. Gamma(2)-melanocyte-stimulating hormone suppression of systemic inflammatory responses to endotoxin is associated with modulation of central autonomic and neuroendocrine activities.
Journal of neuroimmunology.
2001 Nov; 120(1-2):67-77. doi:
10.1016/s0165-5728(01)00408-8
. [PMID: 11694321] - G Chandramohan, X P Ni, J E Kalinyak, M H Humphreys. Dietary sodium modulates mRNA abundance of enzymes involved in pituitary processing of proopiomelanocortin.
Pituitary.
2001 Sep; 4(4):231-7. doi:
10.1023/a:1020746414046
. [PMID: 12501973]