8-((4-Chlorophenyl)thio)cyclic-3,5-GMP (BioDeep_00000912375)
代谢物信息卡片
化学式: C16H15ClN5O7PS (487.011832)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C4=C(C(=O)NC(=N4)N)N=C3SC5=CC=C(C=C5)Cl)O)OP(=O)(O1)O
InChI: InChI=1S/C16H15ClN5O7PS/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24)
描述信息
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jean-Yu Hwang, Wei-Chih Kan, Yao-Bin Liu, Lea-Yea Chuang, Jinn-Yuh Guh, Yu-Lin Yang, Jau-Shyang Huang. Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling.
Journal of cellular physiology.
2019 08; 234(10):17473-17481. doi:
10.1002/jcp.28369. [PMID: 30825199] - Nilberto R F Nascimento, Brandon A Kemp, Nancy L Howell, John J Gildea, Cláudia F Santos, Thurl E Harris, Robert M Carey. Role of SRC family kinase in extracellular renal cyclic guanosine 3',5'-monophosphate- and pressure-induced natriuresis.
Hypertension (Dallas, Tex. : 1979).
2011 Jul; 58(1):107-13. doi:
10.1161/hypertensionaha.110.168708. [PMID: 21482955] - Christian Bopp, Stefan Hofer, Cornelius Busch, Fabian Spöhr, Markus A Weigand, Eike Martin, Alexandra Klein. Time-limited hyporesponsiveness to inhaled nitric oxide and pulmonary phosphodiesterase activity in endotoxemic rats.
The Journal of surgical research.
2008 Nov; 150(1):66-73. doi:
10.1016/j.jss.2008.01.009. [PMID: 18468638] - Isabella Russo, Paola Del Mese, Gabriella Doronzo, Alessandro De Salve, Mariantonietta Secchi, Mariella Trovati, Giovanni Anfossi. Platelet resistance to the antiaggregatory cyclic nucleotides in central obesity involves reduced phosphorylation of vasodilator-stimulated phosphoprotein.
Clinical chemistry.
2007 Jun; 53(6):1053-60. doi:
10.1373/clinchem.2006.076208. [PMID: 17463178] - Jau-Shyang Huang, Lea-Yea Chuang, Jinn-Yuh Guh, Chorng-Jia Chen, Yu-Lin Yang, Tai-An Chiang, Min-Yuan Hung, Tung-Nan Liao. Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts.
Journal of the American Society of Nephrology : JASN.
2005 Aug; 16(8):2318-29. doi:
10.1681/asn.2005010030. [PMID: 15958724] - Xiao-Hong Jin, Helen E McGrath, John J Gildea, Helmy M Siragy, Robin A Felder, Robert M Carey. Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Hypertension (Dallas, Tex. : 1979).
2004 May; 43(5):1133-9. doi:
10.1161/01.hyp.0000123574.60586.7d. [PMID: 15007031] - Anna-Louise M Cook, John M Haynes. Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells.
Cellular signalling.
2004 Feb; 16(2):253-61. doi:
10.1016/s0898-6568(03)00134-7. [PMID: 14636895] - Kerry L Homer, Janet C Wanstall. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
British journal of pharmacology.
2002 Dec; 137(7):1071-81. doi:
10.1038/sj.bjp.0704971. [PMID: 12429580] - F C von Lintig, R B Pilz, G R Boss. Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells.
Oncogene.
2000 Aug; 19(35):4029-34. doi:
10.1038/sj.onc.1203741. [PMID: 10962559] - T C Rich, K A Fagan, H Nakata, J Schaack, D M Cooper, J W Karpen. Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion.
The Journal of general physiology.
2000 Aug; 116(2):147-61. doi:
10.1085/jgp.116.2.147. [PMID: 10919863] - X D Liu, C M Skold, T Umino, J R Spurzem, D J Romberger, S I Rennard. Sodium nitroprusside augments human lung fibroblast collagen gel contraction independently of NO-cGMP pathway.
American journal of physiology. Lung cellular and molecular physiology.
2000 May; 278(5):L1032-8. doi:
10.1152/ajplung.2000.278.5.l1032. [PMID: 10781435] - M Suhasini, H Li, S M Lohmann, G R Boss, R B Pilz. Cyclic-GMP-dependent protein kinase inhibits the Ras/Mitogen-activated protein kinase pathway.
Molecular and cellular biology.
1998 Dec; 18(12):6983-94. doi:
10.1128/mcb.18.12.6983. [PMID: 9819386] - A Kurtz, K H Götz, M Hamann, M Kieninger, C Wagner. Stimulation of renin secretion by NO donors is related to the cAMP pathway.
The American journal of physiology.
1998 04; 274(4):F709-17. doi:
10.1152/ajprenal.1998.274.4.f709. [PMID: 9575895] - A Sjöholm. Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.
Diabetes.
1997 Jul; 46(7):1141-7. doi:
10.2337/diab.46.7.1141. [PMID: 9200648] - N J Guzman, M Z Fang, S S Tang, J R Ingelfinger, L C Garg. Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells.
The Journal of clinical investigation.
1995 May; 95(5):2083-8. doi:
10.1172/jci117895. [PMID: 7537754]