(7,8-Dihydro-5-((E)-((a-(3-pyridyl)benzylidene)aminooxy)ethyl)-1-naphthyloxy)acetic acid (BioDeep_00000912361)
代谢物信息卡片
(7,8-Dihydro-5-((E)-((a-(3-pyridyl)benzylidene)aminooxy)ethyl)-1-naphthyloxy)acetic acid
化学式: C27H26N2O4 (442.18924760000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=C(CC1)C(=CC=C2)OCC(=O)O)CCON=C(C3=CC=CC=C3)C4=CN=CC=C4
InChI: InChI=1S/C27H26N2O4/c1-19-12-13-24-23(10-5-11-25(24)32-18-26(30)31)22(19)14-16-33-29-27(20-7-3-2-4-8-20)21-9-6-15-28-17-21/h2-11,15,17H,12-14,16,18H2,1H3,(H,30,31)/b29-27-
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0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Hitoshi Kashiwagi, Koh-Ichi Yuhki, Fumiaki Kojima, Shima Kumei, Osamu Takahata, Yoshiki Sakai, Shuh Narumiya, Fumitaka Ushikubi. The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an antiplatelet effect due to its inhibitory action on thromboxane A2 synthesis in mice.
The Journal of pharmacology and experimental therapeutics.
2015 May; 353(2):269-78. doi:
10.1124/jpet.115.222612. [PMID: 25740898] - Mai Hazekawa, Kana Morihata, Miyako Yoshida, Yoshiki Sakai, Takahiro Uchida. The angiogenic effect of ONO-1301, a novel long-acting prostacyclin agonist loaded in PLGA microspheres prepared using different molecular weights of PLGA, in a murine sponge model.
Drug development and industrial pharmacy.
2014 Nov; 40(11):1435-42. doi:
10.3109/03639045.2013.828220. [PMID: 23937583] - Yasuhiko Kubota, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Hiroshi Watabe, Takashi Daimon, Yoshiki Sakai, Toshiaki Akita, Yoshiki Sawa. Impact of cardiac support device combined with slow-release prostacyclin agonist in a canine ischemic cardiomyopathy model.
The Journal of thoracic and cardiovascular surgery.
2014 Mar; 147(3):1081-7. doi:
10.1016/j.jtcvs.2013.05.035. [PMID: 24131787] - Yoichiro Hirata, Hirotsugu Kurobe, Etsuko Uematsu, Shusuke Yagi, Takeshi Soeki, Hirotsugu Yamada, Daiju Fukuda, Michio Shimabukuro, Mizuho Nakayama, Kunio Matsumoto, Yoshiki Sakai, Tetsuya Kitagawa, Masataka Sata. Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.
European journal of pharmacology.
2013 Jan; 699(1-3):81-7. doi:
10.1016/j.ejphar.2012.11.045. [PMID: 23219794] - Atsuhiro Nakamura, Noritoshi Nagaya, Hiroaki Obata, Katsuya Sakai, Yoshiki Sakai, Masanori Yoshikawa, Kaoru Hamada, Kunio Matsumoto, Hiroshi Kimura. Oral administration of a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity for pulmonary arterial hypertension.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(8):2127-33. doi:
10.1253/circj.cj-13-0107. [PMID: 23676973] - Takahiro Uchida, Mai Hazekawa, Miyako Yoshida, Kunio Matsumoto, Yoshiki Sakai. Novel long-acting prostacyclin agonist (ONO-1301) with an angiogenic effect: promoting synthesis of hepatocyte growth factor and increasing cyclic AMP concentration via IP-receptor signaling.
Journal of pharmacological sciences.
2013; 123(4):392-401. doi:
10.1254/jphs.13073fp. [PMID: 24292413] - Tatsuyo Nasu, Masaru Kinomura, Katsuyuki Tanabe, Hiroko Yamasaki, Su Le Htay, Daisuke Saito, Norikazu Hinamoto, Hiroyuki Watatani, Haruyo Ujike, Yoshinori Suzuki, Takeshi Sugaya, Hitoshi Sugiyama, Yoshiki Sakai, Kunio Matsumoto, Yohei Maeshima, Hirofumi Makino. Sustained-release prostacyclin analog ONO-1301 ameliorates tubulointerstitial alterations in a mouse obstructive nephropathy model.
American journal of physiology. Renal physiology.
2012 Jun; 302(12):F1616-29. doi:
10.1152/ajprenal.00538.2011. [PMID: 22419696] - Mai Hazekawa, Yoshiki Sakai, Miyako Yoshida, Tamami Haraguchi, Takahiro Uchida. Single injection of ONO-1301-loaded PLGA microspheres directly after ischaemia reduces ischaemic damage in rats subjected to middle cerebral artery occlusion.
The Journal of pharmacy and pharmacology.
2012 Mar; 64(3):353-9. doi:
10.1111/j.2042-7158.2011.01416.x. [PMID: 22309267] - Qing Xu, Mizuho Nakayama, Yoshinori Suzuki, Katsuya Sakai, Takahiro Nakamura, Yoshiki Sakai, Kunio Matsumoto. Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression.
American journal of physiology. Gastrointestinal and liver physiology.
2012 Feb; 302(4):G420-9. doi:
10.1152/ajpgi.00216.2011. [PMID: 22159278] - Mai Hazekawa, Yoshiki Sakai, Miyako Yoshida, Tamami Haraguchi, Takahiro Uchida. The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia.
Journal of microencapsulation.
2012; 29(3):211-8. doi:
10.3109/02652048.2011.622054. [PMID: 22360765] - H Yamasaki, Y Maeshima, T Nasu, D Saito, K Tanabe, K Hirokoshi-Kawahara, H Sugiyama, Y Sakai, H Makino. Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model.
Prostaglandins, leukotrienes, and essential fatty acids.
2011 Mar; 84(3-4):99-107. doi:
10.1016/j.plefa.2010.11.005. [PMID: 21177088] - Yoichiro Hirata, Takeshi Soeki, Masashi Akaike, Yoshiki Sakai, Takashi Igarashi, Masataka Sata. Synthetic prostacycline agonist, ONO-1301, ameliorates left ventricular dysfunction and cardiac fibrosis in cardiomyopathic hamsters.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2009 Dec; 63(10):781-6. doi:
10.1016/j.biopha.2009.09.003. [PMID: 19906506] - Hiroaki Obata, Yoshiki Sakai, Shunsuke Ohnishi, Satoshi Takeshita, Hidezo Mori, Makoto Kodama, Kenji Kangawa, Yoshifusa Aizawa, Noritoshi Nagaya. Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats.
American journal of respiratory and critical care medicine.
2008 Jan; 177(2):195-201. doi:
10.1164/rccm.200703-349oc. [PMID: 17975203] - Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Masaharu Kataoka, Takashi Iwase, Takeshi Horio, Yoshinori Miyahara, Yoshiki Sakai, Kenji Kangawa, Hiroshi Kimura. Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.
American journal of physiology. Lung cellular and molecular physiology.
2006 Jan; 290(1):L59-65. doi:
10.1152/ajplung.00042.2005. [PMID: 16155090] - Masaharu Kataoka, Noritoshi Nagaya, Toru Satoh, Takefumi Itoh, Shinsuke Murakami, Takashi Iwase, Yoshinori Miyahara, Shingo Kyotani, Yoshiki Sakai, Kenji Kangawa, Satoshi Ogawa. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension.
American journal of respiratory and critical care medicine.
2005 Dec; 172(12):1575-80. doi:
10.1164/rccm.200501-102oc. [PMID: 16192456] - H Imawaka, Y Sugiyama. Kinetic study of the hepatobiliary transport of a new prostaglandin receptor agonist.
The Journal of pharmacology and experimental therapeutics.
1998 Mar; 284(3):949-57. doi:
NULL. [PMID: 9495854] - K Minamoto. [Beneficial effect of a stable PGI2 analogue (ONO-1301) on prostanoid release after reperfusion in canine left single lung allotransplantation model].
[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai.
1997 Dec; 45(12):1931-42. doi:
NULL. [PMID: 9455104] - K Hayashi, T Nagamatsu, T Oka, Y Suzuki. Modulation of anti-glomerular basement membrane nephritis in rats by ONO-1301, a non-prostanoid prostaglandin I2 mimetic compound with inhibitory activity against thromboxane A2 synthase.
Japanese journal of pharmacology.
1997 Jan; 73(1):73-82. doi:
10.1254/jjp.73.73. [PMID: 9032136]