[2-[(8E,10E,12E,14E)-15-cyano-4,5,6,7,9,10,14-heptamethylpentadeca-8,10,12,14-tetraen-2-yl]-9-[(E)-3-[2-[4-[[4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate (BioDeep_00000912276)

   

Marine Natural Products


代谢物信息卡片


[2-[(8E,10E,12E,14E)-15-cyano-4,5,6,7,9,10,14-heptamethylpentadeca-8,10,12,14-tetraen-2-yl]-9-[(E)-3-[2-[4-[[4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate

化学式: C52H85N4O12P (988.5901)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(CC2(C(C(C(O2)C(C)CC(C)C(C)C(C)C(C)C=C(C)C(=CC=CC(=CC#N)C)C)OP(=O)(O)O)(C)C)OC1CC=CC3=COC(=N3)C(C)CCNC(=O)C(C(C(COC)N(C)C)O)O)O
InChI: InChI=1S/C52H85N4O12P/c1-31(22-24-53)18-16-19-32(2)34(4)26-35(5)38(8)39(9)36(6)27-37(7)47-48(68-69(61,62)63)51(11,12)52(67-47)28-43(57)40(10)44(66-52)21-17-20-41-29-65-50(55-41)33(3)23-25-54-49(60)46(59)45(58)42(30-64-15)56(13)14/h16-20,22,26,29,33,35-40,42-48,57-59H,21,23,25,27-28,30H2,1-15H3,(H,54,60)(H2,61,62,63)/b18-16+,20-17+,31-22+,32-19+,34-26+

描述信息

D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
D009676 - Noxae > D002273 - Carcinogens
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

[2-[(8E,10E,12E,14E)-15-cyano-4,5,6,7,9,10,14-heptamethylpentadeca-8,10,12,14-tetraen-2-yl]-9-[(E)-3-[2-[4-[[4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate



数据库引用编号

1 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yan Tang, JungWoo Yang, Wang Zheng, Jingfeng Tang, Xing-Zhen Chen, Jianzheng Yang, Zuocheng Wang. Polycystin-1 Inhibits Cell Proliferation through Phosphatase PP2A/B56α. BioMed research international. 2019; 2019(?):2582401. doi: 10.1155/2019/2582401. [PMID: 31641668]
  • Mariko Tsukamoto, Erina Hiyama, Karen Hirotani, Takafumi Gotoh, Tetsuichiro Inai, Hiroshi Iida. Translocation of Tektin 3 to the equatorial segment of heads in bull spermatozoa exposed to dibutyryl cAMP and calyculin A. Molecular reproduction and development. 2017 01; 84(1):30-43. doi: 10.1002/mrd.22763. [PMID: 27883267]
  • Renáta Hudák, János Vincze, László Csernoch, Ildikó Beke Debreceni, Tamás Oláh, Ferenc Erdődi, Kenneth J Clemetson, János Kappelmayer. The Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation. BioMed research international. 2017; 2017(?):9795271. doi: 10.1155/2017/9795271. [PMID: 28680886]
  • Huiwen Ren, Baoxue Yang, Joseph A Ruiz, Orhan Efe, Titilayo O Ilori, Jeff M Sands, Janet D Klein. Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane. American journal of physiology. Renal physiology. 2016 12; 311(6):F1189-F1197. doi: 10.1152/ajprenal.00150.2016. [PMID: 27488997]
  • Kouichi Tachibana, Seyed Mohammad Ali Haghparast, Jun Miyake. Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin. Cell adhesion & migration. 2015; 9(6):502-12. doi: 10.1080/19336918.2015.1113366. [PMID: 26555866]
  • Hidetaka Kaya, Ryo Nakajima, Megumi Iwano, Masahiro M Kanaoka, Sachie Kimura, Seiji Takeda, Tomoko Kawarazaki, Eriko Senzaki, Yuki Hamamura, Tetsuya Higashiyama, Seiji Takayama, Mitsutomo Abe, Kazuyuki Kuchitsu. Ca2+-activated reactive oxygen species production by Arabidopsis RbohH and RbohJ is essential for proper pollen tube tip growth. The Plant cell. 2014 Mar; 26(3):1069-80. doi: 10.1105/tpc.113.120642. [PMID: 24610725]
  • Kyung Jin Jung, Dae Hyun Kim, Eun Kyeong Lee, Chang Woo Song, Byung Pal Yu, Hae Young Chung. Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-κB in aged rat kidney. Free radical biology & medicine. 2013 Aug; 61(?):206-17. doi: 10.1016/j.freeradbiomed.2013.04.005. [PMID: 23583701]
  • Huamei Forsman, Karin Önnheim, Emil Andréasson, Karin Christenson, Anna Karlsson, Johan Bylund, Claes Dahlgren. Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. PloS one. 2013; 8(3):e60169. doi: 10.1371/journal.pone.0060169. [PMID: 23555913]
  • Koji Takahashi, Ken-ichiro Hayashi, Toshinori Kinoshita. Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis. Plant physiology. 2012 Jun; 159(2):632-41. doi: 10.1104/pp.112.196428. [PMID: 22492846]
  • Masaki Okumura, Shin-ichiro Inoue, Koji Takahashi, Kimitsune Ishizaki, Takayuki Kohchi, Toshinori Kinoshita. Characterization of the plasma membrane H+-ATPase in the liverwort Marchantia polymorpha. Plant physiology. 2012 Jun; 159(2):826-34. doi: 10.1104/pp.112.195537. [PMID: 22496511]
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  • Cheng-Han Lee, Kuo-Hsing Kuo, Jiazhen Dai, Joyce M Leo, Chun Yong Seow, Cornelis van Breemen. Calyculin-A disrupts subplasmalemmal junction and recurring Ca2+ waves in vascular smooth muscle. Cell calcium. 2005 Jan; 37(1):9-16. doi: 10.1016/j.ceca.2004.06.002. [PMID: 15541459]
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  • Mercedes Pozuelo Rubio, Kathryn M Geraghty, Barry H C Wong, Nicola T Wood, David G Campbell, Nick Morrice, Carol Mackintosh. 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. The Biochemical journal. 2004 Apr; 379(Pt 2):395-408. doi: 10.1042/bj20031797. [PMID: 14744259]
  • Olga V Leontieva, Jennifer D Black. Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells. The Journal of biological chemistry. 2004 Feb; 279(7):5788-801. doi: 10.1074/jbc.m308375200. [PMID: 14638691]
  • P Koldkjaer, T G Pottinger, S F Perry, A R Cossins. Seasonality of the red blood cell stress response in rainbow trout (Oncorhynchus mykiss). The Journal of experimental biology. 2004 Jan; 207(Pt 2):357-67. doi: 10.1242/jeb.00747. [PMID: 14668319]
  • Nathalie Lalevée, Véronique Resin, Serge Arnaudeau, Nicolas Demaurex, Michel F Rossier. Intracellular transport of calcium from plasma membrane to mitochondria in adrenal H295R cells: implication for steroidogenesis. Endocrinology. 2003 Oct; 144(10):4575-85. doi: 10.1210/en.2003-0268. [PMID: 12960050]
  • Luo Gu, Hui Zhang, Qi Chen, Jing Chen. Calyculin A-induced actin phosphorylation and depolymerization in renal epithelial cells. Cell motility and the cytoskeleton. 2003 Apr; 54(4):286-95. doi: 10.1002/cm.10099. [PMID: 12601691]
  • V A Alekseenko, K O Gusev, E V Kaznacheeva. [Effects of actin cytoskeleton rearrangements on channel activation by calcium entry into A431 cells]. Tsitologiia. 2003; 45(2):143-8. doi: NULL. [PMID: 12722478]
  • Stephanie Chauvin, Margaret Bencsik, Tom Bambino, Robert A Nissenson. Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Molecular endocrinology (Baltimore, Md.). 2002 Dec; 16(12):2720-32. doi: 10.1210/me.2002-0049. [PMID: 12456793]
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  • Barbara Köhler, Michael R Blatt. Protein phosphorylation activates the guard cell Ca2+ channel and is a prerequisite for gating by abscisic acid. The Plant journal : for cell and molecular biology. 2002 Oct; 32(2):185-94. doi: 10.1046/j.1365-313x.2002.01414.x. [PMID: 12383084]
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