(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (BioDeep_00000911289)
代谢物信息卡片
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C22H23N6O5S2+ (515.1171288)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC5=C4CCC5)C(=O)O
InChI: InChI=1S/C22H22N6O5S2/c1-33-26-15(13-10-35-22(23)24-13)18(29)25-16-19(30)28-17(21(31)32)12(9-34-20(16)28)8-27-7-3-5-11-4-2-6-14(11)27/h3,5,7,10,16,20H,2,4,6,8-9H2,1H3,(H3-,23,24,25,29,31,32)/p+1/b26-15-/t16-,20-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DE - Fourth-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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PlantCyc(0)
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- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
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文献列表
- Soyoung Kang, June Young Jang, Jongsung Hahn, Dasohm Kim, Jun Yeong Lee, Kyoung Lok Min, Seungwon Yang, Jin Wi, Min Jung Chang. Dose Optimization of Cefpirome Based on Population Pharmacokinetics and Target Attainment during Extracorporeal Membrane Oxygenation.
Antimicrobial agents and chemotherapy.
2020 04; 64(5):. doi:
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Microbial drug resistance (Larchmont, N.Y.).
2020 Apr; 26(4):341-348. doi:
10.1089/mdr.2018.0473. [PMID: 31657651] - Robert Sauermann, Thomas Feurstein, Rudolf Karch, Maria C Kjellsson, Walter Jäger, Michaela Böhmdorfer, Andreas Püspök, Herbert Langenberger, Thomas Wild, Stefan Winkler, Markus Zeitlinger. Abscess penetration of cefpirome: concentrations and simulated pharmacokinetic profiles in pus.
European journal of clinical pharmacology.
2012 Oct; 68(10):1419-23. doi:
10.1007/s00228-012-1270-1. [PMID: 22441316] - J B Bulitta, M Kinzig, C B Landersdorfer, U Holzgrabe, U Stephan, F Sörgel. Comparable population pharmacokinetics and pharmacodynamic breakpoints of cefpirome in cystic fibrosis patients and healthy volunteers.
Antimicrobial agents and chemotherapy.
2011 Jun; 55(6):2927-36. doi:
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The Journal of antimicrobial chemotherapy.
2011 Jan; 66(1):160-4. doi:
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Antimicrobial agents and chemotherapy.
2010 Aug; 54(8):3481-3. doi:
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Arzneimittel-Forschung.
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2009 Mar; 47(3):178-86. doi:
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International journal of antimicrobial agents.
2008 Sep; 32(3):256-61. doi:
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Journal of veterinary science.
2007 Mar; 8(1):21-5. doi:
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2004 Mar; 53(3):506-11. doi:
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Khirurgiia.
2004; 60(4-5):39-41. doi:
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Anesthesia and analgesia.
2003 Oct; 97(4):1149-1154. doi:
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International journal of antimicrobial agents.
2003 Jun; 21(6):562-7. doi:
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Critical care medicine.
2002 Jul; 30(7):1478-82. doi:
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American journal of respiratory and critical care medicine.
2002 Jan; 165(2):273-6. doi:
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Intensive care medicine.
2001 Feb; 27(2):363-70. doi:
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Pathologie-biologie.
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Electrophoresis.
2000 May; 21(8):1558-64. doi:
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Clinical pharmacology and therapeutics.
2000 Apr; 67(4):368-72. doi:
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Clinical pharmacology and therapeutics.
2000 Mar; 67(3):229-36. doi:
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Intensive care medicine.
1999 Dec; 25(12):1427-31. doi:
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1999 Oct; 734(1):121-7. doi:
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The Keio journal of medicine.
1999 Jun; 48(2):93-6. doi:
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Intensive care medicine.
1999 May; 25(5):486-91. doi:
10.1007/s001340050885. [PMID: 10401943] - M Bergeret, J Raymond. In-vitro bactericidal activity of cefpirome and cefamandole in combination with glycopeptides against methicillin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy.
1999 Feb; 43(2):291-4. doi:
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Journal of clinical pharmacy and therapeutics.
1998 Oct; 23(5):375-9. doi:
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1998 Jan; 42(1):199-201. doi:
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Journal of clinical pharmacology.
1997 Dec; 37(12):1108-13. doi:
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Pathologie-biologie.
1997 May; 45(5):347-56. doi:
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1997 May; 45(5):498-500. doi:
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1997 Mar; 690(1-2):321-6. doi:
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The Japanese journal of antibiotics.
1997 Jan; 50(1):12-21. doi:
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Clinical pharmacology and therapeutics.
1996 Dec; 60(6):645-50. doi:
10.1016/s0009-9236(96)90212-x. [PMID: 8988066] - M Müller, O Haag, T Burgdorff, A Georgopoulos, W Weninger, B Jansen, G Stanek, H Pehamberger, E Agneter, H G Eichler. Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans.
Antimicrobial agents and chemotherapy.
1996 Dec; 40(12):2703-9. doi:
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The Japanese journal of antibiotics.
1996 Jun; 49(6):658-62. doi:
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Antimicrobial agents and chemotherapy.
1996 Mar; 40(3):819-21. doi:
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Antimicrobial agents and chemotherapy.
1995 Oct; 39(10):2348-9. doi:
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The Japanese journal of antibiotics.
1995 Mar; 48(3):380-8. doi:
. [PMID: 7752451] - M G Bergeron, M Bernier. Bactericidal activity of cefpirome (HR 810) against 513 gram-negative bacteria isolated from blood of septicemic patients.
Infection.
1994 Jul; 22(4):299-305. doi:
10.1007/bf01739925. [PMID: 8002094] - B Fantin, R Farinotti, A Thabaut, C Carbon. Conditions for the emergence of resistance to cefpirome and ceftazidime in experimental endocarditis due to Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy.
1994 Mar; 33(3):563-9. doi:
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Clinical pharmacokinetics.
1993 Oct; 25(4):263-73. doi:
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Clinical pharmacology and therapeutics.
1993 Oct; 54(4):395-401. doi:
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Scandinavian journal of infectious diseases. Supplementum.
1993; 91(?):33-40. doi:
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International journal of clinical pharmacology research.
1993; 13(4):225-9. doi:
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International journal of clinical pharmacology research.
1993; 13(6):317-24. doi:
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The Journal of antibiotics.
1993 Jan; 46(1):71-87. doi:
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1993; 91(?):14-24. doi:
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Medical laboratory sciences.
1992 Dec; 49(4):248-51. doi:
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1992 Nov; 36(11):2481-6. doi:
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1992 Oct; 36(10):2085-92. doi:
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Clinical pharmacology and therapeutics.
1992 Jul; 52(1):24-30. doi:
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The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):59-62. doi:
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1992 Apr; 29 Suppl A(?):87-94. doi:
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The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):63-70. doi:
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The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):47-50. doi:
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The Journal of antimicrobial chemotherapy.
1992 Apr; 29 Suppl A(?):51-7. doi:
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1992 Apr; 29 Suppl A(?):81-6. doi:
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1992 Apr; 29 Suppl A(?):95-104. doi:
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Journal of clinical pharmacology.
1992 Mar; 32(3):256-66. doi:
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Journal of chromatography.
1992 Feb; 574(2):356-60. doi:
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1991 Dec; 65(12):1514-8. doi:
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The Journal of antimicrobial chemotherapy.
1991 Oct; 28(4):617-9. doi:
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The Journal of antimicrobial chemotherapy.
1991 Aug; 28(2):291-9. doi:
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The Japanese journal of antibiotics.
1991 Jul; 44(7):748-69. doi:
. [PMID: 1886201] - F L Sapico, V J Ginunas, J Z Montgomerie, H N Canawati. Cefpirome, alone and in combination with gentamicin for enterococcal pyelonephritis in the rodent model.
Diagnostic microbiology and infectious disease.
1991 Jul; 14(4):297-300. doi:
10.1016/0732-8893(91)90020-g. [PMID: 1909613] - D R Baldwin, S R Maxwell, D Honeybourne, J M Andrews, J P Ashby, R Wise. The penetration of cefpirome into the potential sites of pulmonary infection.
The Journal of antimicrobial chemotherapy.
1991 Jul; 28(1):79-86. doi:
10.1093/jac/28.1.79. [PMID: 1769946] - K Nagano, N Nakayama, Y Tuji, H Miyazoe. [Laboratory and clinical studies on cefpirome in pediatrics].
The Japanese journal of antibiotics.
1991 May; 44(5):543-51. doi:
. [PMID: 1880934] - I Saito, Y Saiko, M Yokozawa, K Ono, T Tahara, Y Hosoi. [A basic study on cefpirome].
Hinyokika kiyo. Acta urologica Japonica.
1991 Apr; 37(4):441-6. doi:
. [PMID: 1909830] - T Nishimura, K Tabuki, S Aoki, M Takagi. [Laboratory and clinical studies of cefpirome in pediatric field].
The Japanese journal of antibiotics.
1991 Apr; 44(4):454-61. doi:
. [PMID: 1880924] - S Nakazawa, H Sato, Y Hirama, A Narita, K Matsumoto, S Nakazawa, H Suzuki, Y Nakanishi, K Nagao, K Niino. [Pharmacokinetic and clinical evaluation of cefpirome in the pediatric field].
The Japanese journal of antibiotics.
1991 Apr; 44(4):426-39. doi:
. [PMID: 1880921] - K Kuno, A Ogawa, H Takeuchi, K Tomita, O Kito, H Andou, Y Takimoto. [Bacteriological, pharmacokinetic and clinical studies of cefpirome in the field of pediatrics].
The Japanese journal of antibiotics.
1991 Apr; 44(4):440-6. doi:
. [PMID: 1880922] - S Matsuoka, Y Takahashi, Y Kuroda. [Clinical evaluation of cefpirome in pediatric field].
The Japanese journal of antibiotics.
1991 Apr; 44(4):462-5. doi:
. [PMID: 1880925] - U Kohdera, M Woo, M Kino, H Kawasaki, J Suzukawa, M Nakamura, S Cho, Y Hirabayashi, H Higashino, Y Kobayashi. [Pharmacokinetic and clinical study of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):213-22. doi:
. [PMID: 2041161] - T Haruta, S Kuroki, K Okura, M Yamakawa, H Nigami, M Naramura, N Yoshida, Y Kobayashi. [Pharmacokinetic and clinical studies of cefpirome in pediatric field].
The Japanese journal of antibiotics.
1991 Feb; 44(2):223-33. doi:
. [PMID: 1828275] - Y Toyonaga, K Yamori, N Sakaguchi, M Sugita, K Kawamura, K Seo. [Pharmacokinetic and clinical evaluation of cefpirome in the pediatric field].
The Japanese journal of antibiotics.
1991 Feb; 44(2):184-206. doi:
. [PMID: 2041159] - Y Sato, S Iwata, H Akita, K Sunakawa. [Pharmacokinetic and clinical studies on cefpirome in pediatrics].
The Japanese journal of antibiotics.
1991 Feb; 44(2):168-83. doi:
NULL. [PMID: 2041158] - H Meguro, R Fujii, T Tajima, T Abe. [Clinical evaluation of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):160-7. doi:
NULL. [PMID: 2041157] - H S Jafari, X Sáez-Llorens, O Ramilo, S L Shelton, G H McCracken. Pharmacokinetics and antibacterial efficacy of cefpirome (HR 810) in experimental Escherichia coli and Haemophilus influenzae type b meningitis.
Antimicrobial agents and chemotherapy.
1991 Feb; 35(2):220-3. doi:
10.1128/aac.35.2.220. [PMID: 2024953] - K Kida, T Morimoto, H Matsuda, M Murase. [Pharmacokinetical and clinical study of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):234-40. doi:
NULL. [PMID: 2041162] - T Ihara, H Kamiya, M Ito, M Sakurai. [Pharmacokinetics and clinical evaluation of cefpirome in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):207-12. doi:
NULL. [PMID: 2041160] - H Wakiguchi, M Fujieda, A Maeda, Y Shimazaki, N Ohishi, S Kido, T Takechi, K Takeda, H Maeda, H Morita. [Clinical efficacy of cefpirome against various infectious diseases in children].
The Japanese journal of antibiotics.
1991 Feb; 44(2):241-5. doi:
NULL. [PMID: 2041163] - T Haruta, K Okura, S Kuroki, Y Kobayashi. [Transferability of cefpirome to cerebrospinal fluid of rabbits with meningitis caused by Staphylococcus aureus].
The Japanese journal of antibiotics.
1991 Jan; 44(1):58-61. doi:
NULL. [PMID: 2041148] - R Okamoto, A Tamura, T Yoshida, I Komiya, H Ogino, S Inouye, S Kondo, M Inoue, S Mitsuhashi. In vitro and in vivo antibacterial activities of ME1220 and ME1221, novel cephalosporins.
Drugs under experimental and clinical research.
1991; 17(4):205-12. doi:
NULL. [PMID: 1794294] - S Iwata, M Ikeda, E Isohata, Y Kin, T Yokota, Y Kusumoto, Y Sato, H Akita, T Oikawa, K Sunakawa. [The influence of cefpirome on intestinal bacterial flora].
The Japanese journal of antibiotics.
1991 Jan; 44(1):62-83. doi:
NULL. [PMID: 2041149] - S Inoue, H Morioka, R Satoh, Y Yoshida, M Omosu, T Kobayashi. [Antigenicity study of cefpirome sulfate].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):129-45. doi:
10.2131/jts.15.supplementiii_129. [PMID: 2074601] - T Deki, A Matsuoka, K Marutani, T Nakagawa, K Masuda, T Matsuzawa, K Horiuchi, T Ohishi, T Ohtani, R Niki. [Nephrotoxicity of cefpirome sulfate in rabbits--single and multiple intravenous administration].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):173-200. doi:
10.2131/jts.15.supplementiii_173. [PMID: 2074603] - T Deki, S Higo, Y Sakamaki, T Uchiyama, T Ohtani, S Kokuba, Y Kumagai. [Six-month intraperitoneal toxicity study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):11-52. doi:
10.2131/jts.15.supplementiii_11. [PMID: 2074600] - O Sugiyama, K Tanaka, M Toya, S Igarashi, K Watanabe, S Watanabe, K Tsuji, Y Kumagai. [Fertility study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):53-64. doi:
10.2131/jts.15.supplementiii_53. [PMID: 2074604] - O Sugiyama, K Tanaka, M Toya, S Igarashi, K Watanabe, S Watanabe, K Tsuji, Y Kumagai. [Teratological study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):65-89. doi:
10.2131/jts.15.supplementiii_65. [PMID: 2074605] - O Sugiyama, S Watanabe, K Tanaka, M Toya, S Igarashi, K Watanabe, K Tsuji, Y Kumagai. [Perinatal and postnatal study of cefpirome sulfate in rats].
The Journal of toxicological sciences.
1990 Nov; 15 Suppl 3(?):91-107. doi:
10.2131/jts.15.supplementiii_91. [PMID: 2132572] - J M Valdes, A L Baltch, R P Smith, M Franke, W J Ritz, S Williams, P Michelsen, J Singh. Comparative therapy with cefpirome alone and in combination with rifampin and/or gentamicin against a disseminated Pseudomonas aeruginosa infection in leukopenic mice.
The Journal of infectious diseases.
1990 Nov; 162(5):1112-7. doi:
10.1093/infdis/162.5.1112. [PMID: 2121835] - G Horstmann, K Engelbart. Chronic intravenous toxicity of the new antibiotic cefpirome in monkeys.
Arzneimittel-Forschung.
1990 Nov; 40(11):1250-9. doi:
NULL. [PMID: 1982210] - C Cojocel. Biochemical aspects of the renal tolerance for cefpirome and other cephalosporins.
Arzneimittel-Forschung.
1990 Oct; 40(10):1140-4. doi:
. [PMID: 2291753] - H H Donaubauer, K Engelbart, D Mayer. Subchronic and chronic toxicity of the new antibiotic cefpirome in rats.
Arzneimittel-Forschung.
1990 Sep; 40(9):1034-8. doi:
NULL. [PMID: 2080939]