1-Palmitoyl-2-arachidonyl-phosphatidylcholine (BioDeep_00000911288)
代谢物信息卡片
1-Palmitoyl-2-arachidonyl-phosphatidylcholine
化学式: C44H81NO8P+ (782.5699)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
InChI: InChI=1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-21-22-23-25-27-29-31-33-35-37-44(47)53-42(41-52-54(48,49)51-39-38-45(3,4)5)40-50-43(46)36-34-32-30-28-26-24-19-17-15-13-11-9-7-2/h14,16,20-21,23,25,29,31,42H,6-13,15,17-19,22,24,26-28,30,32-41H2,1-5H3/p+1/b16-14-,21-20-,25-23-,31-29-/t42-/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- John E Burke, Yuan-Hao Hsu, Raymond A Deems, Sheng Li, Virgil L Woods, Edward A Dennis. A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2.
The Journal of biological chemistry.
2008 Nov; 283(45):31227-36. doi:
10.1074/jbc.m804492200. [PMID: 18753135] - Salam Ibrahim, Anaël Djimet-Baboun, Valérie Pruneta-Deloche, Catherine Calzada, Michel Lagarde, Gabriel Ponsin. Transfer of very low density lipoprotein-associated phospholipids to activated human platelets.
Journal of lipid research.
2006 Feb; 47(2):341-8. doi:
10.1194/jlr.m500209-jlr200. [PMID: 16293890] - Ruihua Wu, Guoqiu Shen, Robert Morris, Madhumita Patnaik, James B Peter. Elevated autoantibodies against oxidized palmitoyl arachidonoyl phosphocholine in patients with hypertension and myocardial infarction.
Journal of autoimmunity.
2005 Jun; 24(4):353-60. doi:
10.1016/j.jaut.2005.03.001. [PMID: 15913955] - Richard M Epand, Angela Kam, Nadia Bridgelal, Akihiko Saiga, Matthew K Topham. The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol.
Biochemistry.
2004 Nov; 43(46):14778-83. doi:
10.1021/bi0484724. [PMID: 15544348] - Kerry-Anne Rye, MyNgan Duong, Maria K Psaltis, Linda K Curtiss, David J Bonnet, Roland Stocker, Philip J Barter. Evidence that phospholipids play a key role in pre-beta apoA-I formation and high-density lipoprotein remodeling.
Biochemistry.
2002 Oct; 41(41):12538-45. doi:
10.1021/bi025998k. [PMID: 12369845] - Douglas R Moellering, Anna-Liisa Levonen, Young-Mi Go, Rakesh P Patel, Dale A Dickinson, Henry Jay Forman, Victor M Darley-Usmar. Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress.
The Biochemical journal.
2002 Feb; 362(Pt 1):51-9. doi:
10.1042/0264-6021:3620051. [PMID: 11829739] - Valery N Bochkov, Diana Mechtcheriakova, Marcus Lucerna, Joakim Huber, Roland Malli, Wolfgang F Graier, Erhard Hofer, Bernd R Binder, Norbert Leitinger. Oxidized phospholipids stimulate tissue factor expression in human endothelial cells via activation of ERK/EGR-1 and Ca(++)/NFAT.
Blood.
2002 Jan; 99(1):199-206. doi:
10.1182/blood.v99.1.199. [PMID: 11756172] - H Lee, W Shi, P Tontonoz, S Wang, G Subbanagounder, C C Hedrick, S Hama, C Borromeo, R M Evans, J A Berliner, L Nagy. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells.
Circulation research.
2000 Sep; 87(6):516-21. doi:
10.1161/01.res.87.6.516. [PMID: 10988245] - N Khaselev, R C Murphy. Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine.
Journal of lipid research.
2000 Apr; 41(4):564-72. doi:
10.1016/s0022-2275(20)32404-4. [PMID: 10744777] - A E Drobnies, B van Der Ende, J L Thewalt, R B Cornell. CTP:phosphocholine cytidylyltransferase activation by oxidized phosphatidylcholines correlates with a decrease in lipid order: a 2H NMR analysis.
Biochemistry.
1999 Nov; 38(47):15606-14. doi:
10.1021/bi991573v. [PMID: 10569945] - R Yamauchi, H Mizuno, K Kato. Preparation and characterization of 8a-(phosphatidylcholine-dioxy)-alpha-tocopherones and their formation during the peroxidation of phosphatidylcholine in liposomes.
Bioscience, biotechnology, and biochemistry.
1998 Jul; 62(7):1293-300. doi:
10.1271/bbb.62.1293. [PMID: 9720211] - T Yoshida, H Otake, Y Aramaki, T Hara, S Tsuchiya, A Hamada, H Utsumi. Free radicals from 1-palmitoyl-2-arachidonoylphosphatidylcholine liposomes in Fe2+/ascorbic acid solution.
Biological & pharmaceutical bulletin.
1996 Jun; 19(6):779-82. doi:
10.1248/bpb.19.779. [PMID: 8799472] - M J Pete, D W Wu, J H Exton. Subcellular fractions of bovine brain degrade phosphatidylcholine by sequential deacylation of the sn-1 and sn-2 positions.
Biochimica et biophysica acta.
1996 Feb; 1299(3):325-32. doi:
10.1016/0005-2760(95)00225-1. [PMID: 8597587] - K Kikugawa, K Hiramoto, Y Okamoto, Y K Hasegawa. Enhancement of nitrogen dioxide-induced lipid peroxidation and DNA strand breaking by cysteine and glutathione.
Free radical research.
1994 Nov; 21(6):399-408. doi:
10.3109/10715769409056592. [PMID: 7834054] - S Baghieri, M H Garner. Na,K-ATPase and phospholipid degradation in bovine and human lenses.
Current eye research.
1992 May; 11(5):459-67. doi:
10.3109/02713689209001800. [PMID: 1318822] - F Ghomashchi, S Schüttel, M K Jain, M H Gelb. Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles.
Biochemistry.
1992 Apr; 31(15):3814-24. doi:
10.1021/bi00130a012. [PMID: 1567837] - D C Mitchell, M Straume, B J Litman. Role of sn-1-saturated,sn-2-polyunsaturated phospholipids in control of membrane receptor conformational equilibrium: effects of cholesterol and acyl chain unsaturation on the metarhodopsin I in equilibrium with metarhodopsin II equilibrium.
Biochemistry.
1992 Jan; 31(3):662-70. doi:
10.1021/bi00118a005. [PMID: 1731921] - J B Feix, B Kalyanaraman. Spin trapping of lipid-derived radicals in liposomes.
Biochimica et biophysica acta.
1989 Aug; 992(2):230-5. doi:
10.1016/0304-4165(89)90015-9. [PMID: 2547451] - K E Stremler, D M Stafforini, S M Prescott, G A Zimmerman, T M McIntyre. An oxidized derivative of phosphatidylcholine is a substrate for the platelet-activating factor acetylhydrolase from human plasma.
The Journal of biological chemistry.
1989 Apr; 264(10):5331-4. doi:
NULL. [PMID: 2494162] - R M Kramer, J A Jakubowski, D Deykin. Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2.
Biochimica et biophysica acta.
1988 Apr; 959(3):269-79. doi:
10.1016/0005-2760(88)90200-7. [PMID: 3355850] - F H Chilton, J M Ellis, S C Olson, R L Wykle. 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.
The Journal of biological chemistry.
1984 Oct; 259(19):12014-9. doi:
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