(E)-CefpodoximeProxetil (BioDeep_00000911282)
代谢物信息卡片
1-[(Isopropoxycarbonyl)oxy]ethyl (6R,7R)-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
化学式: C21H27N5O9S2 (557.1250132000001)
中文名称: 头孢泊肟酯杂质D
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)OC(=O)OC(C)OC(=O)C1=C(CSC2N1C(=O)C2NC(=O)C(=NOC)C3=CSC(=N3)N)COC
InChI: InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13+
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Laura De Petris, Ermanno Ruffini. Roultella ornithinolytica infection in infancy: a case of febrile urinary tract infection.
CEN case reports.
2018 11; 7(2):234-236. doi:
10.1007/s13730-018-0333-2. [PMID: 29721836] - Lubna Bashir, Muhammad Harris Shoaib, Shazia Naz, Rabia Ismail Yousuf, Sabahat Jabeen, Fozia Israr, Fahad Siddiqui. Development and validation of HPLC method for the determination of Cefpodoxime Proxetil in human plasma.
Pakistan journal of pharmaceutical sciences.
2017 Sep; 30(5):1603-1607. doi:
NULL. [PMID: 29084679] - Ali Mujtaba, Kanchan Kohli. Validated HPLC method for the pharmacokinetic study of oral extended-release cefpodoxime proxetil chitosan-alginate beads in rabbits.
International journal of biological macromolecules.
2017 May; 98(?):111-116. doi:
10.1016/j.ijbiomac.2017.01.099. [PMID: 28137463] - Sameh Ahmed, Hanaa M Abdel-Wadood, Niveen A Mohamed. Highly sensitive and selective high-performance liquid chromatography method for bioequivalence study of cefpodoxime proxetil in rabbit plasma via fluorescence labeling of its active metabolite.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Sep; 934(?):34-40. doi:
10.1016/j.jchromb.2013.06.036. [PMID: 23896427] - Amrita Bajaj, Monica R P Rao, Ishwar Khole, Ghansham Munjapara. Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate.
Drug development and industrial pharmacy.
2013 May; 39(5):635-45. doi:
10.3109/03639045.2012.683440. [PMID: 22564007] - Saurabh K Yadav, Bharati Agrawal, Rajendra N Goyal. AuNPs-poly-DAN modified pyrolytic graphite sensor for the determination of Cefpodoxime Proxetil in biological fluids.
Talanta.
2013 Apr; 108(?):30-7. doi:
10.1016/j.talanta.2013.02.044. [PMID: 23601866] - Anil Dubala, Janaki Sankarachari Krishnan Nagarajan, Chandran Sathish Vimal, Renjith George. Simultaneous quantification of cefpodoxime proxetil and clavulanic acid in human plasma by LC-MS using solid phase extraction with application to pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Mar; 921-922(?):49-55. doi:
10.1016/j.jchromb.2013.01.018. [PMID: 23434877] - Niveen A Mohamed, Hanaa M Abdel-Wadood, Sameh Ahmed. An efficient one-pot reaction for selective fluorimetric determination of cefpodoxime and its prodrug.
Talanta.
2011 Sep; 85(4):2121-7. doi:
10.1016/j.talanta.2011.07.053. [PMID: 21872067] - V Kumar, R Madabushi, M B B Lucchesi, H Derendorf. Pharmacokinetics of cefpodoxime in plasma and subcutaneous fluid following oral administration of cefpodoxime proxetil in male beagle dogs.
Journal of veterinary pharmacology and therapeutics.
2011 Apr; 34(2):130-5. doi:
10.1111/j.1365-2885.2010.01198.x. [PMID: 21395603] - Momin A Mujeeb, Milind L Pardeshi. Pharmacokinetics of cefpodoxime proxetil with special reference to biochemical parameters, tissue residue, and spermatozoa motility in rats.
Indian journal of medical sciences.
2011 Feb; 65(2):43-9. doi:
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American journal of veterinary research.
2010 Dec; 71(12):1484-91. doi:
10.2460/ajvr.71.12.1484. [PMID: 21118001] - Yuan Gao, Shuai Qian, Jianjun Zhang. Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension.
Chemical & pharmaceutical bulletin.
2010 Jul; 58(7):912-7. doi:
10.1248/cpb.58.912. [PMID: 20606336] - Natalie A Carrillo, Steeve Giguère, Ronald R Gronwall, Murray P Brown, Kelly A Merritt, Jeffrey J O'Kelley. Disposition of orally administered cefpodoxime proxetil in foals and adult horses and minimum inhibitory concentration of the drug against common bacterial pathogens of horses.
American journal of veterinary research.
2005 Jan; 66(1):30-5. doi:
10.2460/ajvr.2005.66.30. [PMID: 15691032] - Mara Aleksić, Milos Ilić, Vera Kapetanović. Adsorptive properties of cefpodoxime proxetil as a tool for a new method of its determination in urine.
Journal of pharmaceutical and biomedical analysis.
2004 Nov; 36(4):899-903. doi:
10.1016/j.jpba.2004.08.035. [PMID: 15533687] - Yong-hong Xiao, Lei Gao, Yun Li, Yuan Lü, Jian Liu, Yan Liu. [Comparison of pharmacokinetics/pharmacodynamics of cefdinir, cefpodoxime proxetil and cefaclor against common bacteria of community acquired infections].
Zhonghua yi xue za zhi.
2004 Nov; 84(22):1867-71. doi:
. [PMID: 15631795] - Georges Nicolaos, Sylvie Crauste-Manciet, Robert Farinotti, Denis Brossard. Improvement of cefpodoxime proxetil oral absorption in rats by an oil-in-water submicron emulsion.
International journal of pharmaceutics.
2003 Sep; 263(1-2):165-71. doi:
10.1016/s0378-5173(03)00365-x. [PMID: 12954191] - T Madhusudana Reddy, M Sreedhar, S Jayarama Reddy. Voltammetric behavior of cefixime and cefpodoxime proxetil and determination in pharmaceutical formulations and urine.
Journal of pharmaceutical and biomedical analysis.
2003 Mar; 31(4):811-8. doi:
10.1016/s0731-7085(02)00721-5. [PMID: 12644208] - K Totsuka, K Shimizu, N Mori, T Sugihara, A Sakai, S Yamaji, Y Michisuji, Y Shinohara, A Kubo, H Tokuoka. Effects of food intake and age on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic. Comparison with cefpodoxime proxetil.
International journal of antimicrobial agents.
2001 Nov; 18(5):463-9. doi:
10.1016/s0924-8579(01)00443-5. [PMID: 11711262] - K Orrhage, S Sjöstedt, C E Nord. Effect of supplements with lactic acid bacteria and oligofructose on the intestinal microflora during administration of cefpodoxime proxetil.
The Journal of antimicrobial chemotherapy.
2000 Oct; 46(4):603-12. doi:
10.1093/jac/46.4.603. [PMID: 11020259] - S M Abdel-Rahman, S Maxson, C Teo, A E Hubbard, G L Kearns. Cerebrospinal fluid pharmacokinetics of cefpodoxime proxetil in piglets.
Journal of clinical pharmacology.
2000 Mar; 40(3):290-5. doi:
10.1177/00912700022008964. [PMID: 10709158] - G L Kearns, S M Abdel-Rahman, R F Jacobs, T G Wells, M T Borin. Cefpodoxime pharmacokinetics in children: effect of food.
The Pediatric infectious disease journal.
1998 Sep; 17(9):799-804. doi:
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The Journal of antimicrobial chemotherapy.
1998 Jun; 41(6):629-34. doi:
10.1093/jac/41.6.629. [PMID: 9687101] - F Vyhnánek, O Lochmann. [Treatment of infectious complications affecting the skin and soft tissues with cefpodoxime proxetil].
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne.
1996 May; 45(2):68-70. doi:
NULL. [PMID: 8756403] - T N Bairamis, T P Nikolopoulos, D A Kafetzis, P Begue, B Lenfant, D C Kandiloros, N J Apostolopoulos. Concentrations of cefpodoxime in plasma, adenoid, and tonsillar tissue after repeated administrations of cefpodoxime proxetil in children.
The Journal of antimicrobial chemotherapy.
1996 Apr; 37(4):821-4. doi:
10.1093/jac/37.4.821. [PMID: 8722549] - F Kees, M Wellenhofer, K Bröhl, H Grobecker. Bioavailability of cefpodoxime proxetil with co-administered acetylcysteine.
Arzneimittel-Forschung.
1996 Apr; 46(4):435-8. doi:
. [PMID: 8740095] - T Ishioka. Pharmacokinetic study and clinical evaluation of cefpodoxime proxetil in the elderly with impaired renal function.
Journal of chemotherapy (Florence, Italy).
1995 Nov; 7 Suppl 4(?):122-3. doi:
NULL. [PMID: 8904130] - M T Borin, M R Driver, K K Forbes. Effect of timing of food on absorption of cefpodoxime proxetil.
Journal of clinical pharmacology.
1995 May; 35(5):505-9. doi:
10.1002/j.1552-4604.1995.tb04095.x. [PMID: 7657851] - M T Borin, K K Forbes. Effect of food on absorption of cefpodoxime proxetil oral suspension in adults.
Antimicrobial agents and chemotherapy.
1995 Jan; 39(1):273-5. doi:
10.1128/aac.39.1.273. [PMID: 7695323] - M T Borin, J J Ferry, K K Forbes, G S Hughes. Pharmacokinetics of cefpodoxime proxetil in healthy young and elderly volunteers.
Journal of clinical pharmacology.
1994 Jul; 34(7):774-81. doi:
10.1002/j.1552-4604.1994.tb02039.x. [PMID: 7929873] - C Edlund, C Stark, C E Nord. The relationship between an increase in beta-lactamase activity after oral administration of three new cephalosporins and protection against intestinal ecological disturbances.
The Journal of antimicrobial chemotherapy.
1994 Jul; 34(1):127-38. doi:
10.1093/jac/34.1.127. [PMID: 7961199] - C A Johnson, A Ateshkadi, S W Zimmerman, G S Hughes, W A Craig, P M Carey, M T Borin. Pharmacokinetics and ex vivo susceptibility of cefpodoxime proxetil in patients receiving continuous ambulatory peritoneal dialysis.
Antimicrobial agents and chemotherapy.
1993 Dec; 37(12):2650-5. doi:
10.1128/aac.37.12.2650. [PMID: 8109931] - B Brismar, C Edlund, C E Nord. Impact of cefpodoxime proxetil and amoxicillin on the normal oral and intestinal microflora.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
1993 Sep; 12(9):714-9. doi:
10.1007/bf02009388. [PMID: 8243490] - M T Borin, G S Hughes, J S Kelloway, B E Shapiro, C E Halstenson. Disposition of cefpodoxime proxetil in hemodialysis patients.
Journal of clinical pharmacology.
1992 Nov; 32(11):1038-44. doi:
10.1002/j.1552-4604.1992.tb03808.x. [PMID: 1474165] - J E Frampton, R N Brogden, H D Langtry, M M Buckley. Cefpodoxime proxetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential.
Drugs.
1992 Nov; 44(5):889-917. doi:
10.2165/00003495-199244050-00011. [PMID: 1280571] - C Muller-Serieys, C Bancal, M C Dombret, P Soler, G Murciano, M Aubier, E Bergogne-Berezin. Penetration of cefpodoxime proxetil in lung parenchyma and epithelial lining fluid of noninfected patients.
Antimicrobial agents and chemotherapy.
1992 Oct; 36(10):2099-103. doi:
10.1128/aac.36.10.2099. [PMID: 1444291] - E Chachaty, C Depitre, N Mario, C Bourneix, P Saulnier, G Corthier, A Andremont. Presence of Clostridium difficile and antibiotic and beta-lactamase activities in feces of volunteers treated with oral cefixime, oral cefpodoxime proxetil, or placebo.
Antimicrobial agents and chemotherapy.
1992 Sep; 36(9):2009-13. doi:
10.1128/aac.36.9.2009. [PMID: 1416894] - N Saathoff, H Lode, K Neider, K M Depperman, K Borner, P Koeppe. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist.
Antimicrobial agents and chemotherapy.
1992 Apr; 36(4):796-800. doi:
10.1128/aac.36.4.796. [PMID: 1354432] - J V St Peter, M T Borin, G S Hughes, J S Kelloway, B E Shapiro, C E Halstenson. Disposition of cefpodoxime proxetil in healthy volunteers and patients with impaired renal function.
Antimicrobial agents and chemotherapy.
1992 Jan; 36(1):126-31. doi:
10.1128/aac.36.1.126. [PMID: 1590677] - M T Borin, G S Hughes, R K Patel, M E Royer, K S Cathcart. Pharmacokinetic and tolerance studies of cefpodoxime after single- and multiple-dose oral administration of cefpodoxime proxetil.
Journal of clinical pharmacology.
1991 Dec; 31(12):1137-45. doi:
10.1002/j.1552-4604.1991.tb03686.x. [PMID: 1761737] - A Caisson, J F Chantot. [Study of the bactericidal effect of cefpodoxime using an in vitro pharmacokinetic model].
Pathologie-biologie.
1991 Oct; 39(8):774-9. doi:
NULL. [PMID: 1762835] - M T Borin. A review of the pharmacokinetics of cefpodoxime proxetil.
Drugs.
1991; 42 Suppl 3(?):13-21. doi:
10.2165/00003495-199100423-00005. [PMID: 1726203] - K G Naber, M Kinzig, D Adam, F Sörgel, A H Bajorski, R Kiehn. Concentrations of cefpodoxime in plasma, ejaculate and in prostatic fluid and adenoma tissue.
Infection.
1991 Jan; 19(1):30-5. doi:
10.1007/bf01643755. [PMID: 1707399] - R Fujii. Clinical trials of cefpodoxime proxetil suspension in paediatrics.
Drugs.
1991; 42 Suppl 3(?):57-60. doi:
10.2165/00003495-199100423-00011. [PMID: 1726209] - H M Theopold, C Matthias, D Adam. Cefpodoxime proxetil concentrations in head and neck tissues.
Infection.
1991 Jan; 19(1):41-3. doi:
10.1007/bf01643757. [PMID: 2013507] - B Wiedemann, E Luhmer, M T Zühlsdorf. Microbiological evaluation of cefpodoxime proxetil.
Drugs.
1991; 42 Suppl 3(?):6-12. doi:
10.2165/00003495-199100423-00004. [PMID: 1726210] - P Gehanno, J M Andrews, F Ichou, E Sultan, B Lenfant. Concentrations of cefpodoxime in plasma and tonsillar tissue after a single oral dose of cefpodoxime proxetil.
The Journal of antimicrobial chemotherapy.
1990 Dec; 26 Suppl E(?):47-51. doi:
10.1093/jac/26.suppl_e.47. [PMID: 2292530] - R Dumont, F Guetat, J M Andrews, E Sultan, B Lenfant. Concentrations of cefpodoxime in plasma and pleural fluid after a single oral dose of cefpodoxime proxetil.
The Journal of antimicrobial chemotherapy.
1990 Dec; 26 Suppl E(?):41-6. doi:
10.1093/jac/26.suppl_e.41. [PMID: 2292529] - L Couraud, J M Andrews, H Lecoeur, E Sultan, B Lenfant. Concentrations of cefpodoxime in plasma and lung tissue after a single oral dose of cefpodoxime proxetil.
The Journal of antimicrobial chemotherapy.
1990 Dec; 26 Suppl E(?):35-40. doi:
10.1093/jac/26.suppl_e.35. [PMID: 2292528] - D Tremblay, A Dupront, C Ho, D Coussediere, B Lenfant. Pharmacokinetics of cefpodoxime in young and elderly volunteers after single doses.
The Journal of antimicrobial chemotherapy.
1990 Dec; 26 Suppl E(?):21-8. doi:
10.1093/jac/26.suppl_e.21. [PMID: 2292526] - M T Borin, G S Hughes, C R Spillers, R K Patel. Pharmacokinetics of cefpodoxime in plasma and skin blister fluid following oral dosing of cefpodoxime proxetil.
Antimicrobial agents and chemotherapy.
1990 Jun; 34(6):1094-9. doi:
10.1128/aac.34.6.1094. [PMID: 2393268] - D Höffler, P Koeppe, M Corcilius, A Przyklinik. Cefpodoxime proxetil in patients with endstage renal failure on hemodialysis.
Infection.
1990 May; 18(3):157-62. doi:
10.1007/bf01642104. [PMID: 2365467] - G S Hughes, D L Heald, R Patel, C R Spillers, D H Batts, A R Euler. Gastric emptying and the pharmacokinetics of the cephalosporin antibiotic, cefpodoxime proxetil.
Methods and findings in experimental and clinical pharmacology.
1990 Apr; 12(3):197-204. doi:
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Antimicrobial agents and chemotherapy.
1990 Feb; 34(2):232-4. doi:
10.1128/aac.34.2.232. [PMID: 2327771] - R Fujii, H Meguro, O Arimasu, H Shiraishi, T Abe, H Yoshioka, H Sakata, K Iseki, Y Takahashi, K Murono. [Overall clinical evaluation of cefpodoxime proxetil against infections in pediatric fields].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1439-55. doi:
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The Japanese journal of antibiotics.
1989 Jul; 42(7):1456-63. doi:
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The Japanese journal of antibiotics.
1989 Jul; 42(7):1571-92. doi:
NULL. [PMID: 2810731] - H Akita, Y Sato, S Iwata, K Sunakawa. [Pharmacokinetic, bacteriological and clinical studies on cefpodoxime proxetil in the field of pediatrics].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1547-60. doi:
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The Japanese journal of antibiotics.
1989 Jul; 42(7):1505-18. doi:
NULL. [PMID: 2810727] - H Kimura, H Takeuchi, H Ishikawa, F Hayakawa, N Yamamoto, Y Nakao, K Kuno. [Bacteriological, pharmacokinetic and clinical studies on cefpodoxime proxetil in the pediatric field].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1593-606. doi:
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The Japanese journal of antibiotics.
1989 Jul; 42(7):1561-70. doi:
NULL. [PMID: 2810730] - T Nishimura, K Tabuki, S Aoki, M Takagi. [Laboratory and clinical studies of cefpodoxime proxetil in pediatric field].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1607-20. doi:
. [PMID: 2810732] - Y Toyonaga, M Koizumi, H Imai, M Sugita, T Takahashi, Y Fukushima, M Yamasaki, M Hori. [Bacteriological, pharmacokinetic and clinical studies on cefpodoxime proxetil in the pediatric field].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1519-46. doi:
. [PMID: 2810728] - T Motohiro, K Oda, M Aramaki, A Kawakami, K Tanaka, T Koga, Y Sakata, T Fujimoto, K Yokochi, F Yamashita. [Pharmacokinetic and clinical studies on cefpodoxime proxetil dry syrup in the field of pediatrics].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1629-66. doi:
. [PMID: 2681864] - S Iwata, K Yamada, Y Kin, T Yokota, Y Kusumoto, Y Sato, H Akita, S Nanri, T Oikawa, K Sunakawa. [The influence of cefpodoxime proxetil on the intestinal bacterial flora].
The Japanese journal of antibiotics.
1989 Jul; 42(7):1667-84. doi:
NULL. [PMID: 2681865] - T Yokota, E Suzuki, K Arai. Cefpodoxime proxetil, its in vitro antibacterial activity, affinity to bacterial penicillin-binding proteins, and synergy of bactericidal activity with serum complement and mouse-cultured macrophages.
Drugs under experimental and clinical research.
1988; 14(8):495-500. doi:
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