Salvianolicacid A (BioDeep_00000911237)
代谢物信息卡片
Salvianolicacid A
化学式: C26H22O10 (494.1213)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C(C(=C(C=C2)O)O)C=CC3=CC(=C(C=C3)O)O)O)O
InChI: InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Haotian Yang, Bo Qiu, Chaojun Xue, Caihui Guo, Zhanjun Dong. Comparative pharmacokinetics of seven bioactive components in normal, sham-operated, and myocardial ischemia-reperfusion injury rats after oral administration of the Salvia Miltiorrhiza-Moutan Cortex herb pair.
Biomedical chromatography : BMC.
2021 Mar; 35(3):e5016. doi:
10.1002/bmc.5016. [PMID: 33125740] - Jianyang Pan, Luquan Zhang, Difeifei Xiong, Bailing Li, Haibin Qu. A HPLC-DAD-MS/MS Method for Simultaneous Determination of Six Active Ingredients of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection in Rat Plasma and its Application to Pharmacokinetic Studies.
Current drug metabolism.
2021; 22(1):60-69. doi:
10.2174/1389200221999200819143230. [PMID: 32819255] - Chengjing Sun, Shulan Su, Yue Zhu, Jianming Guo, Sheng Guo, Dawei Qian, Li Yu, Wei Gu, Jin-Ao Duan. Salvia miltiorrhiza stem-leaf active components of salvianolic acids and flavonoids improved the hemorheological disorder and vascular endothelial function on microcirculation dysfunction rats.
Phytotherapy research : PTR.
2020 Jul; 34(7):1704-1720. doi:
10.1002/ptr.6652. [PMID: 32185841] - Quanxin Ma, Qinqin Yang, Jiaojiao Chen, Chen Yu, Lizong Zhang, Weimin Zhou, Minli Chen. Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3 Inflammasome Activation in Zucker Diabetic Fatty Rats.
Molecules (Basel, Switzerland).
2020 Feb; 25(5):. doi:
10.3390/molecules25051089. [PMID: 32121151] - Jian Lyu, Yanming Xie, Zhifei Wang, Lianxin Wang. Salvianolic Acids for Injection Combined with Conventional Treatment for Patients with Acute Cerebral Infarction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Oct; 25(?):7914-7927. doi:
10.12659/msm.917421. [PMID: 31639122] - Jianping Li, Yingyi Wang, Xuejun Xu, Wenjuan Cao, Zhiqiang Shen, Nan Wang, Jing Leng, Ning Zou, Erxin Shang, Zhenhua Zhu, Jianming Guo, Jinao Duan. Improved dialysis removal of protein-bound uremic toxins by salvianolic acids.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Apr; 57(?):166-173. doi:
10.1016/j.phymed.2018.12.018. [PMID: 30772752] - Ying Song, Weihai Liu, Yi Ding, Yanyan Jia, Jinyi Zhao, Fan Wang, Juan Bai, Lianghua Cheng, Kai Gao, Meiyou Liu, Minna Yao, Liang Li, Yanmin Zhang, Aidong Wen, Langchong He. Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway.
American journal of physiology. Renal physiology.
2018 08; 315(2):F254-F262. doi:
10.1152/ajprenal.00508.2017. [PMID: 29384417] - Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.
Scientific reports.
2018 05; 8(1):8084. doi:
10.1038/s41598-018-26577-0. [PMID: 29795391] - Shuang Li, Xiuman Xie, Dongxiang Li, Zhiguo Yu, Ling Tong, Yunli Zhao. Simultaneous determination and tissue distribution studies of four phenolic acids in rat tissue by UFLC-MS/MS after intravenous administration of salvianolic acid for injection.
Biomedical chromatography : BMC.
2018 Mar; 32(3):. doi:
10.1002/bmc.4128. [PMID: 29105854] - Yaping Shao, Wen Zhang, Ling Tong, Jingyi Huang, Dongxiang Li, Wei Nie, Yan Zhu, Yunfei Li, Tao Lu. Simultaneous determination of eight bioactive components of Qishen Yiqi dripping pills in rat plasma using UFLC-MS/MS and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2017 Aug; 31(8):. doi:
10.1002/bmc.3941. [PMID: 28146302] - Xiuman Xie, Jingzhuo Miao, Wanyang Sun, Jingyi Huang, Dongxiang Li, Shuming Li, Ling Tong, Guoxiang Sun. Simultaneous determination and pharmacokinetic study of four phenolic acids in rat plasma using UFLC-MS/MS after intravenous administration of salvianolic acid for injection.
Journal of pharmaceutical and biomedical analysis.
2017 Feb; 134(?):53-59. doi:
10.1016/j.jpba.2016.10.017. [PMID: 27875788] - Li Shen, Bing Han, Yuan Geng, Jinhua Wang, Zhengmin Wang, Mingwei Wang. Amelioration of cognitive impairments in APPswe/PS1dE9 mice is associated with metabolites alteration induced by total salvianolic acid.
PloS one.
2017; 12(3):e0174763. doi:
10.1371/journal.pone.0174763. [PMID: 28358909] - Qiyan Wang, Chun Li, Qian Zhang, Yuanyuan Wang, Tianjiao Shi, Linghui Lu, Yi Zhang, Yong Wang, Wei Wang. The effect of Chinese herbs and its effective components on coronary heart disease through PPARs-PGC1α pathway.
BMC complementary and alternative medicine.
2016 Dec; 16(1):514. doi:
10.1186/s12906-016-1496-z. [PMID: 27955667] - Ping Wu, Yu Yan, Lin-Lin Ma, Bi-Yu Hou, Yang-Yang He, Li Zhang, Zi-Ran Niu, Jun-Ke Song, Xiao-Cong Pang, Xiu-Ying Yang, Guan-Hua Du. Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury.
The Journal of biological chemistry.
2016 Oct; 291(42):22288-22301. doi:
10.1074/jbc.m115.712703. [PMID: 27417135] - Zhanli Liu, Xunyang Zheng, Yanlei Guo, Weihan Qin, Lei Hua, Yong Yang. Quantitatively metabolic profiles of salvianolic acids in rats after gastric-administration of Salvia miltiorrhiza extract.
Fitoterapia.
2016 Sep; 113(?):27-34. doi:
10.1016/j.fitote.2016.06.017. [PMID: 27370098] - Jingzhuo Miao, Wanyang Sun, Jingyi Huang, Xiaolin Liu, Shuming Li, Xiaoping Han, Ling Tong, Guoxiang Sun. Characterization of metabolites in rats after intravenous administration of salvianolic acid for injection by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.
Biomedical chromatography : BMC.
2016 Sep; 30(9):1487-97. doi:
10.1002/bmc.3710. [PMID: 26910272] - Xiuman Xie, Wanyang Sun, Jingzhuo Miao, Jingyi Huang, Jingyao Xu, Xiaolin Liu, Henry Sun, Ling Tong, Guoxiang Sun. Development and validation of a UFLC-MS/MS method for determination of 7'(Z)-(8″S, 8‴S)-epi-salvianolic acid E, (7'R, 8'R, 8″S, 8‴S)-epi-salvianolic acid B and salvianolic acid B in rat plasma and its application to pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jun; 1022(?):6-12. doi:
10.1016/j.jchromb.2016.03.042. [PMID: 27064533] - Li Guan, Yan-Lin Zhang, Zong-Yang Li, Ming-Xia Zhu, Wei-Juan Yao, Jin-Yuan Zhao. Salvianolic acids attenuate rat hippocampal injury after acute CO poisoning by improving blood flow properties.
BioMed research international.
2015; 2015(?):526483. doi:
10.1155/2015/526483. [PMID: 25705671] - Qing-Xi Yue, Fu-Bo Xie, Xiao-Yi Song, Wan-Ying Wu, Bao-Hong Jiang, Shu-Hong Guan, Min Yang, Xuan Liu, De-An Guo. Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury.
Journal of ethnopharmacology.
2012 Jun; 141(2):659-67. doi:
10.1016/j.jep.2011.08.044. [PMID: 21903157] - Qian Yang, Siwang Wang, Yanhua Xie, Jianbo Wang, Hua Li, Xuanxuan Zhou, Wenbo Liu. Effect of salvianolic acid B and paeonol on blood lipid metabolism and hemorrheology in myocardial ischemia rabbits induced by pituitruin.
International journal of molecular sciences.
2010 Sep; 11(10):3696-704. doi:
10.3390/ijms11103696. [PMID: 21152295] - H Kaji, K Inoue, M Yun, K Uchida, T Sugioyama, T Tobe. [Immunohistochemical and ultrastructural study on the islet of autotransplanted pancreas in dogs].
Nihon Geka Gakkai zasshi.
1992 Jan; 93(1):62-70. doi:
NULL. [PMID: 1549097]
