4-Hydroxynonanal (BioDeep_00000911039)
代谢物信息卡片
4-Hydroxynonanal
化学式: C9H18O2 (158.1306728)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(CCC=O)O
InChI: InChI=1S/C9H18O2/c1-2-3-4-6-9(11)7-5-8-10/h8-9,11H,2-7H2,1H3
描述信息
An hydroxy fatty aldehyde that is nonanal in which one of the hydrogens at position 4 has been replaced by a hydroxy group.
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael S Forbes, Barbara A Thornhill, Jordan J Minor, Katherine A Gordon, Carolina I Galarreta, Robert L Chevalier. Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis.
American journal of physiology. Renal physiology.
2012 Jul; 303(1):F120-9. doi:
10.1152/ajprenal.00110.2012. [PMID: 22535799] - Wen Li, Hui Liu, Jie-Sen Zhou, Jiao-Fei Cao, Xiao-Bo Zhou, Augustine M K Choi, Zhi-Hua Chen, Hua-Hao Shen. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2).
The Journal of biological chemistry.
2012 Jun; 287(25):20922-30. doi:
10.1074/jbc.m112.352336. [PMID: 22547061] - Qingling Li, Kristyen Tomcik, Shenghui Zhang, Michelle A Puchowicz, Guo-Fang Zhang. Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver.
Free radical biology & medicine.
2012 Mar; 52(6):1043-53. doi:
10.1016/j.freeradbiomed.2011.12.022. [PMID: 22245097] - Marek Banasik, Todd Stedeford, Robert P Strosznajder, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda. Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.
Journal of enzyme inhibition and medicinal chemistry.
2011 Dec; 26(6):883-9. doi:
10.3109/14756366.2011.557315. [PMID: 21395487] - Maryse Baradat, Isabelle Jouanin, Sabine Dalleau, Sylviane Taché, Mathilde Gieules, Laurent Debrauwer, Cécile Canlet, Laurence Huc, Jacques Dupuy, Fabrice H F Pierre, Françoise Guéraud. 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
Chemical research in toxicology.
2011 Nov; 24(11):1984-93. doi:
10.1021/tx2003036. [PMID: 21967605] - Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris Bernstein. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
Clinical and experimental gastroenterology.
2011; 4(?):75-119. doi:
10.2147/ceg.s17114. [PMID: 21753893] - Mark Lehnert, Henrik Lind, Zhi Zhong, Robert Schoonhoven, Ingo Marzi, John J Lemasters. Polyphenols of Camellia sinenesis decrease mortality, hepatic injury and generation of cytokines and reactive oxygen and nitrogen species after hemorrhage/resuscitation in rats.
BMC complementary and alternative medicine.
2010 Aug; 10(?):46. doi:
10.1186/1472-6882-10-46. [PMID: 20735845] - Shanmugam Lakshmi Devi, Carani V Anuradha. Oxidative and nitrosative stress in experimental rat liver fibrosis: Protective effect of taurine.
Environmental toxicology and pharmacology.
2010 Mar; 29(2):104-10. doi:
10.1016/j.etap.2009.11.005. [PMID: 21787590] - Linlin Zhong, Ziwen Liu, Ruilan Yan, Stephen Johnson, Yupei Zhao, Xiubin Fang, Deliang Cao. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels.
Biochemical and biophysical research communications.
2009 Sep; 387(2):245-50. doi:
10.1016/j.bbrc.2009.06.123. [PMID: 19563777] - Bradford G Hill, Sunday O Awe, Elena Vladykovskaya, Yonis Ahmed, Si-Qi Liu, Aruni Bhatnagar, Sanjay Srivastava. Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal.
The Biochemical journal.
2009 Jan; 417(2):513-24. doi:
10.1042/bj20081615. [PMID: 18800966] - David Wheeler, Veera Venkata Ratnam Bandaru, Peter A Calabresi, Avindra Nath, Norman J Haughey. A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis.
Brain : a journal of neurology.
2008 Nov; 131(Pt 11):3092-102. doi:
10.1093/brain/awn190. [PMID: 18772223] - Anil D'souza, Biji T Kurien, Rosalie Rodgers, Jaideep Shenoi, Sadamu Kurono, Hiroyuki Matsumoto, Kenneth Hensley, Swapan K Nath, R Hal Scofield. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE.
BMC medical genetics.
2008 Jul; 9(?):62. doi:
10.1186/1471-2350-9-62. [PMID: 18606005] - Gilles Cambonie, Blandine Comte, Catherine Yzydorczyk, Thierry Ntimbane, Nathalie Germain, Ngoc Loan Oanh Lê, Patrick Pladys, Cindy Gauthier, Isabelle Lahaie, Daniel Abran, Jean-Claude Lavoie, Anne Monique Nuyt. Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Mar; 292(3):R1236-45. doi:
10.1152/ajpregu.00227.2006. [PMID: 17138729] - Giancarlo Aldini, Paola Granata, Cristina Marinello, Giangiacomo Beretta, Marina Carini, Roberto Maffei Facino. Effects of UVB radiation on 4-hydroxy-2-trans-nonenal metabolism and toxicity in human keratinocytes.
Chemical research in toxicology.
2007 Mar; 20(3):416-23. doi:
10.1021/tx0601657. [PMID: 17305372] - Caroline Asselin, Bertrand Bouchard, Jean-Claude Tardif, Christine Des Rosiers. Circulating 4-hydroxynonenal-protein thioether adducts assessed by gas chromatography-mass spectrometry are increased with disease progression and aging in spontaneously hypertensive rats.
Free radical biology & medicine.
2006 Jul; 41(1):97-105. doi:
10.1016/j.freeradbiomed.2006.03.011. [PMID: 16781458] - J Dwivedi, L D Trombetta. Acute toxicity and bioaccumulation of tributyltin in tissues of Urolophus jamaicensis (yellow stingray).
Journal of toxicology and environmental health. Part A.
2006 Jul; 69(14):1311-23. doi:
10.1080/15287390500356800. [PMID: 16760138] - Françoise Guéraud, Géraldine Peiro, Hervé Bernard, Jacques Alary, Christophe Créminon, Laurent Debrauwer, Estelle Rathahao, Marie-Françoise Drumare, Cécile Canlet, Jean-Michel Wal, Georges Bories. Enzyme immunoassay for a urinary metabolite of 4-hydroxynonenal as a marker of lipid peroxidation.
Free radical biology & medicine.
2006 Jan; 40(1):54-62. doi:
10.1016/j.freeradbiomed.2005.08.011. [PMID: 16337879] - E Rathahao, G Peiro, N Martins, J Alary, F Guéraud, L Debrauwer. Liquid chromatography-multistage tandem mass spectrometry for the quantification of dihydroxynonene mercapturic acid (DHN-MA), a urinary end-metabolite of 4-hydroxynonenal.
Analytical and bioanalytical chemistry.
2005 Apr; 381(8):1532-9. doi:
10.1007/s00216-005-3095-6. [PMID: 15770473] - Kirsty B Gordon, I Mhairi Macrae, Hilary V O Carswell. Effects of 17beta-oestradiol on cerebral ischaemic damage and lipid peroxidation.
Brain research.
2005 Mar; 1036(1-2):155-62. doi:
10.1016/j.brainres.2004.12.052. [PMID: 15725413] - Werner Siems, Tilman Grune. Intracellular metabolism of 4-hydroxynonenal.
Molecular aspects of medicine.
2003 Aug; 24(4-5):167-75. doi:
10.1016/s0098-2997(03)00011-6. [PMID: 12892994] - Alison Hinshelwood, Gail McGarvie, Elizabeth M Ellis. Substrate specificity of mouse aldo-keto reductase AKR7A5.
Chemico-biological interactions.
2003 Feb; 143-144(?):263-9. doi:
10.1016/s0009-2797(02)00173-4. [PMID: 12604212] - Eileen McCracken, Jill H Fowler, Deborah Dewar, Steve Morrison, James McCulloch. Grey matter and white matter ischemic damage is reduced by the competitive AMPA receptor antagonist, SPD 502.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2002 Sep; 22(9):1090-7. doi:
10.1097/00004647-200209000-00006. [PMID: 12218414]