1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one (BioDeep_00000910937)

   


代谢物信息卡片


1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one

化学式: C21H20O5 (352.13106700000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C=CC=CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
InChI: InChI=1S/C21H20O5/c1-25-20-13-15(8-11-18(20)23)5-3-4-6-17(22)10-7-16-9-12-19(24)21(14-16)26-2/h3-14,23-24H,1-2H3/b5-3+,6-4+,10-7+

描述信息

同义名列表

1 个代谢物同义名

1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chutima Jansakun, Wanatsanan Chulrik, Waraluck Chaichompoo, Pathumwadee Yotmanee, Kanokporn Lehboon, Wilanee Chunglok, Apsorn Sattayakhom, Poonsit Hiransai, Kornyok Kamdee, Tanyarath Utaipan, Apichart Suksamrarn, Warangkana Chunglok. 1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 in silico. Molecular medicine reports. 2021 03; 23(3):. doi: 10.3892/mmr.2021.11848. [PMID: 33495830]
  • Wei Zhu, Zhijian Zhao, Fuju Chou, Li Zuo, Tongzu Liu, Shuyuan Yeh, David Bushinsky, Guohua Zeng, Chawnshang Chang. Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals. Cell death & disease. 2019 03; 10(4):275. doi: 10.1038/s41419-019-1358-y. [PMID: 30894518]
  • Dalin He, Lei Li, Guodong Zhu, Liang Liang, Zhenfeng Guan, Luke Chang, Yuan Chen, Shuyuan Yeh, Chawnshang Chang. ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen receptor-dependent HIF2α/VEGF signaling pathway. Cancer research. 2014 Aug; 74(16):4420-30. doi: 10.1158/0008-5472.can-13-2681. [PMID: 24924778]
  • Liang Liang, Lei Li, Jing Tian, Soo Ok Lee, Qiang Dang, Chiung-Kuei Huang, Shuyuan Yeh, Erdal Erturk, David Bushinsky, Luke S Chang, Dalin He, Chawnshang Chang. Androgen receptor enhances kidney stone-CaOx crystal formation via modulation of oxalate biosynthesis & oxidative stress. Molecular endocrinology (Baltimore, Md.). 2014 Aug; 28(8):1291-303. doi: 10.1210/me.2014-1047. [PMID: 24956378]
  • Chiung-Kuei Huang, Haiyan Pang, Lin Wang, Yuanjie Niu, Jie Luo, Eugene Chang, Janet D Sparks, Soo Ok Lee, Chawnshang Chang. New therapy via targeting androgen receptor in monocytes/macrophages to battle atherosclerosis. Hypertension (Dallas, Tex. : 1979). 2014 Jun; 63(6):1345-53. doi: 10.1161/hypertensionaha.113.02804. [PMID: 24688120]
  • Shu Fang Soh, Chiung-Kuei Huang, Soo Ok Lee, Defeng Xu, Shuyuan Yeh, Jun Li, Eu Leong Yong, Yinhan Gong, Chawnshang Chang. Determination of androgen receptor degradation enhancer ASC-J9(®) in mouse sera and organs with liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2014 Jan; 88(?):117-22. doi: 10.1016/j.jpba.2013.08.020. [PMID: 24042123]
  • Shinichi Yamashita, Kuo-Pao Lai, Kun-Lung Chuang, Defeng Xu, Hiroshi Miyamoto, Tatsuo Tochigi, See-Tong Pang, Lei Li, Yoichi Arai, Hsing-Jien Kung, Shuyuan Yeh, Chawnshang Chang. ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia (New York, N.Y.). 2012 Jan; 14(1):74-83. doi: 10.1593/neo.111436. [PMID: 22355276]
  • Chatchawan Changtam, Poonpilas Hongmanee, Apichart Suksamrarn. Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. European journal of medicinal chemistry. 2010 Oct; 45(10):4446-57. doi: 10.1016/j.ejmech.2010.07.003. [PMID: 20691508]
  • Chatchawan Changtam, Harry P de Koning, Hasan Ibrahim, M Sohail Sajid, Matthew K Gould, Apichart Suksamrarn. Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. European journal of medicinal chemistry. 2010 Mar; 45(3):941-56. doi: 10.1016/j.ejmech.2009.11.035. [PMID: 20004045]
  • Jiann-Jyh Lai, Kuo-Pao Lai, Kuang-Hsiang Chuang, Philip Chang, I-Chen Yu, Wen-Jye Lin, Chawnshang Chang. Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression. The Journal of clinical investigation. 2009 Dec; 119(12):3739-51. doi: 10.1172/jci39335. [PMID: 19907077]
  • Wen-Lung Ma, Cheng-Lung Ma, Cheng-Lung Hsu, Ming-Heng Wu, Chun-Te Wu, Cheng-Chia Wu, Jiann-Jyh Lai, Yuh-Shan Jou, Chun-Wei Chen, Shuyuan Yeh, Chawnshang Chang. Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology. 2008 Sep; 135(3):947-55, 955.e1. doi: 10.1053/j.gastro.2008.05.046. [PMID: 18639551]
  • Zhiming Yang, Yu-Jia Chang, I-Chen Yu, Shuyuan Yeh, Cheng-Chia Wu, Hiroshi Miyamoto, Diane E Merry, Gen Sobue, Lu-Min Chen, Shu-Shi Chang, Chawnshang Chang. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nature medicine. 2007 Mar; 13(3):348-53. doi: 10.1038/nm1547. [PMID: 17334372]