(4Z,10E,14E,16E)-21,24-dihydroxy-4-methoxyimino-5,11,13,22-tetramethyl-6-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2-oxane]-2-one (BioDeep_00000910903)
代谢物信息卡片
化学式: C37H53NO8 (639.3770978)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC(=CCC2CC(CC3(O2)CC(=NOC)C(C(O3)C(=CC(C)C)C)C)OC(=O)C4C=C(C(C5C4(C(=CC=C1)CO5)O)O)C)C
InChI: InChI=1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31-
描述信息
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- L Laber, C Eichberg, A Zimmerbeutel, R-A Düring, T W Donath. Effects of macrocyclic lactone anthelmintics on seed germination of temperate grassland species.
Plant biology (Stuttgart, Germany).
2023 Dec; 25(7):1046-1057. doi:
10.1111/plb.13577
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The Science of the total environment.
2023 Sep; 905(?):167152. doi:
10.1016/j.scitotenv.2023.167152
. [PMID: 37730042] - Haiyan Wang, Yuqing Liu, Xu Cheng, Yanyan Zhang, Shanshan Li, Xiangjing Wang, Wensheng Xiang. Titer improvement of milbemycins via coordinating metabolic competition and transcriptional co-activation controlled by Streptomyces antibiotic regulatory protein family regulator in Streptomyces bingchenggensis.
Biotechnology and bioengineering.
2022 05; 119(5):1252-1263. doi:
10.1002/bit.28044
. [PMID: 35084043] - Beesan Tan, Nicholas Opoku, Simon K Attah, Kwablah Awadzi, Annette C Kuesel, Janis Lazdins-Helds, Craig Rayner, Victoria Ryg-Cornejo, Mark Sullivan, Lawrence Fleckenstein. Pharmacokinetics of oral moxidectin in individuals with Onchocerca volvulus infection.
PLoS neglected tropical diseases.
2022 03; 16(3):e0010005. doi:
10.1371/journal.pntd.0010005
. [PMID: 35333880] - Nilima Dinesh Kumar, Bram M Ter Ellen, Ellen M Bouma, Berit Troost, Denise P I van de Pol, Heidi H van der Ende-Metselaar, Djoke van Gosliga, Leonie Apperloo, Orestes A Carpaij, Maarten van den Berge, Martijn C Nawijn, Ymkje Stienstra, Izabela A Rodenhuis-Zybert, Jolanda M Smit. Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0154321. doi:
10.1128/aac.01543-21
. [PMID: 34633839] - Carsten Eichberg, Alwin M Hartman, Alexandra-Marie Kronenberger, Rolf-Alexander Düring, Tobias W Donath. Temperature moderates impact of formulated moxidectin on seed germination of three temperate grassland species.
PloS one.
2022; 17(11):e0277865. doi:
10.1371/journal.pone.0277865
. [PMID: 36409735] - Dave M Leathwick, Paul C Mason, Karl Fraser, Chris M Miller, Peter Green. Route of administration affects the efficacy of moxidectin against Ostertagiinae nematodes in farmed red deer (Cervus elaphus).
Veterinary parasitology.
2021 Oct; 298(?):109525. doi:
10.1016/j.vetpar.2021.109525
. [PMID: 34274762] - Thomas Geurden, Filip De Keersmaecker, Sofie De Keersmaecker, Edwin Claerebout, Dave M Leathwick, Martin K Nielsen, Christian W Sauermann. Three-year study to evaluate an anthelmintic treatment regimen with reduced treatment frequency in horses on two study sites in Belgium.
Veterinary parasitology.
2021 Oct; 298(?):109538. doi:
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. [PMID: 34364153] - Daniela Hofmann, Somphou Sayasone, Khanpaseuth Sengngam, Bounthunh Chongvilay, Jan Hattendorf, Jennifer Keiser. Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial.
The Lancet. Infectious diseases.
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2021 Apr; 38(4):602-608. doi:
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. [PMID: 33684319] - Benedetto Morandi, Maria Chiara Sabetti, Fabrizia Veronesi, Giulia Morganti, Marco Pietra, Giovanni Poglayen, Nikolina Linta, Gary Conboy, Roberta Galuppi. A case of a dog refractory to different treatments for pulmonary capillariasis.
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Applied microbiology and biotechnology.
2021 Mar; 105(5):1875-1887. doi:
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Animal reproduction science.
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Veterinary parasitology.
2021 Feb; 290(?):109362. doi:
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PLoS neglected tropical diseases.
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BMC microbiology.
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Journal of veterinary internal medicine.
2020 Sep; 34(5):1734-1745. doi:
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Pest management science.
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. [PMID: 32549573] - Haiyan Wang, Xu Cheng, Yuqing Liu, Shanshan Li, Yanyan Zhang, Xiangjing Wang, Wensheng Xiang. Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis.
Applied microbiology and biotechnology.
2020 Apr; 104(7):2935-2946. doi:
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Veterinary parasitology, regional studies and reports.
2020 04; 20(?):100374. doi:
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. [PMID: 32448518] - Laura G Cooper, Gabriel Caffe, Julieta Cerutti, Martin K Nielsen, Oscar S Anziani. Reduced efficacy of ivermectin and moxidectin against Parascaris spp. in foals from Argentina.
Veterinary parasitology, regional studies and reports.
2020 04; 20(?):100388. doi:
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 03; 70(6):1193-1201. doi:
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Veterinary microbiology.
2020 Mar; 242(?):108607. doi:
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Parasites & vectors.
2020 Mar; 13(1):98. doi:
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Parasites & vectors.
2020 Mar; 13(1):70. doi:
10.1186/s13071-020-3947-0
. [PMID: 32113470] - Anastasia Diakou, Dimitris Dimzas, Christos Astaras, Ioannis Savvas, Angela Di Cesare, Simone Morelli, Κostantinos Neofitos, Despina Migli, Donato Traversa. Clinical investigations and treatment outcome in a European wildcat (Felis silvestris silvestris) infected by cardio-pulmonary nematodes.
Veterinary parasitology, regional studies and reports.
2020 01; 19(?):100357. doi:
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PloS one.
2020; 15(8):e0236143. doi:
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Parasites & vectors.
2019 Nov; 12(1):519. doi:
10.1186/s13071-019-3760-9
. [PMID: 31685011] - R A Torres-Fajardo, P G González-Pech, C A Sandoval-Castro, J Ventura-Cordero, J F J Torres-Acosta. Criollo goats limit their grass intake in the early morning suggesting a prophylactic self-medication behaviour in a heterogeneous vegetation.
Tropical animal health and production.
2019 Nov; 51(8):2473-2479. doi:
10.1007/s11250-019-01966-3
. [PMID: 31197723] - Roger K Prichard, Timothy G Geary. Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance.
International journal for parasitology. Drugs and drug resistance.
2019 08; 10(?):69-83. doi:
10.1016/j.ijpddr.2019.06.002
. [PMID: 31229910] - Luise Kultscher, Barbara Hinney, Ronald Schmäschke, Anja Joachim, Thomas Wittek. Current anthelmintic treatment is not always effective at controlling strongylid infections in German alpaca herds.
Parasites & vectors.
2019 Jul; 12(1):330. doi:
10.1186/s13071-019-3588-3
. [PMID: 31266521] - L K Novelo-Chi, P G González-Pech, J Ventura-Cordero, J F J Torres-Acosta, C A Sandoval-Castro, R Cámara-Sarmiento. Gastrointestinal nematode infection and feeding behaviour of goats in a heterogeneous vegetation: No evidence of therapeutic self-medication.
Behavioural processes.
2019 May; 162(?):7-13. doi:
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Veterinary parasitology.
2019 Apr; 268(?):46-52. doi:
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Tropical animal health and production.
2019 Mar; 51(3):613-618. doi:
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Biomedical chromatography : BMC.
2019 Feb; 33(2):e4389. doi:
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Veterinary parasitology.
2019 Feb; 266(?):73-79. doi:
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Journal of veterinary pharmacology and therapeutics.
2019 Jan; 42(1):111-115. doi:
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Parasites & vectors.
2018 Nov; 11(1):589. doi:
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. [PMID: 30449275] - Sally A Kinrade, Jay W Mason, Carlos R Sanabria, Craig R Rayner, Julie M Bullock, Stephanie H Stanworth, Mark T Sullivan. Evaluation of the Cardiac Safety of Long-Acting Endectocide Moxidectin in a Randomized Concentration-QT Study.
Clinical and translational science.
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International journal of dermatology.
2018 Nov; 57(11):1293-1298. doi:
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The Veterinary clinics of North America. Small animal practice.
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Veterinary parasitology.
2018 Oct; 262(?):11-15. doi:
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. [PMID: 30389005] - Keke Wei, Yuanjie Wu, Lei Li, Weihong Jiang, Jinfeng Hu, Yinhua Lu, Shaoxin Chen. MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus.
Applied microbiology and biotechnology.
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Journal of the American Association for Laboratory Animal Science : JAALAS.
2018 09; 57(5):483-497. doi:
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. [PMID: 30185284] - Leticia M Mesa, J Hörler, I Lindt, M F Gutiérrez, L Negro, G Mayora, L Montalto, M Ballent, A Lifschitz. Effects of the Antiparasitic Drug Moxidectin in Cattle Dung on Zooplankton and Benthic Invertebrates and its Accumulation in a Water-Sediment System.
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Parasites & vectors.
2018 Jul; 11(1):425. doi:
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Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2018 Jul; 35(7):1278-1285. doi:
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Journal of the American Association for Laboratory Animal Science : JAALAS.
2018 05; 57(3):229-235. doi:
NULL
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International journal for parasitology.
2018 05; 48(6):403-412. doi:
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Tropical animal health and production.
2018 Apr; 50(4):801-806. doi:
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International journal for parasitology. Drugs and drug resistance.
2018 04; 8(1):22-30. doi:
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Parasites & vectors.
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