DETA-NONOate (BioDeep_00000910891)
代谢物信息卡片
(1Z)-2,2-bis(2-aminoethyl)-1-(hydroxyimino)hydrazin-1-ium-1-olate
化学式: C4H13N5O2 (163.10691980000001)
中文名称: NOC-18
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CN(CCN)[N+](=NO)[O-])N
InChI: InChI=1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h10H,1-6H2/b9-7+
描述信息
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:50154
- PubChem: 135402056
- PubChem: 135445676
- ChEMBL: CHEMBL1163051
- ChEMBL: CHEMBL136200
- CAS: 146724-94-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jie Xiao, Ben Zhang, Zhengchen Su, Yakun Liu, Thomas R Shelite, Qing Chang, Yuan Qiu, Jiani Bei, Pingyuan Wang, Alexander Bukreyev, Lynn Soong, Yang Jin, Thomas Ksiazek, Angelo Gaitas, Shannan L Rossi, Jia Zhou, Michael Laposata, Tais B Saito, Bin Gong. Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation.
The Journal of biological chemistry.
2021 11; 297(5):101315. doi:
10.1016/j.jbc.2021.101315. [PMID: 34678311] - Tianyu Zhu, Min Zhou, Wentao Gao, Dan Fang, Zhiyong Liu, Guangyan Wu, Mimi Wan, Chun Mao, Jian Shen. Coronary Stents Decorated by Heparin/NONOate Nanoparticles for Anticoagulant and Endothelialized Effects.
Langmuir : the ACS journal of surfaces and colloids.
2020 03; 36(11):2901-2910. doi:
10.1021/acs.langmuir.0c00112. [PMID: 32114762] - Kseniia Porshneva, Diana Papiernik, Mateusz Psurski, Agnieszka Łupicka-Słowik, Rafał Matkowski, Marcin Ekiert, Marcin Nowak, Joanna Jarosz, Joanna Banach, Magdalena Milczarek, Tomasz M Goszczyński, Marcin Sieńczyk, Joanna Wietrzyk. Temporal inhibition of mouse mammary gland cancer metastasis by CORM-A1 and DETA/NO combination therapy.
Theranostics.
2019; 9(13):3918-3939. doi:
10.7150/thno.31461. [PMID: 31281522] - Oleg Palygin, Daria V Ilatovskaya, Vladislav Levchenko, Bradley T Endres, Aron M Geurts, Alexander Staruschenko. Nitric oxide production by glomerular podocytes.
Nitric oxide : biology and chemistry.
2018 01; 72(?):24-31. doi:
10.1016/j.niox.2017.11.005. [PMID: 29128399] - Thomas Lautz, Manuel Lasch, Julia Borgolte, Kerstin Troidl, Judith-Irina Pagel, Amelia Caballero-Martinez, Eike Christian Kleinert, Barbara Walzog, Elisabeth Deindl. Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3.
EBioMedicine.
2018 Jan; 27(?):237-246. doi:
10.1016/j.ebiom.2017.11.020. [PMID: 29233575] - Ratanesh Kumar Seth, Suvarthi Das, Sahar Pourhoseini, Diptadip Dattaroy, Stephen Igwe, Julie Basu Ray, Daping Fan, Gregory A Michelotti, Anna Mae Diehl, Saurabh Chatterjee. M1 polarization bias and subsequent nonalcoholic steatohepatitis progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1-induced oxidative stress in obese mice.
The Journal of pharmacology and experimental therapeutics.
2015 Jan; 352(1):77-89. doi:
10.1124/jpet.114.218131. [PMID: 25347994] - Juan Liu, Zhengju Chen, Liping Ye, Huixia Liu, Dou Dou, Limei Liu, Xiaoxing Yu, Yuansheng Gao. Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase.
Pflugers Archiv : European journal of physiology.
2014 Oct; 466(10):1999-2008. doi:
10.1007/s00424-014-1441-2. [PMID: 24413911] - Bojana B Beleslin Cokic, Vladan P Cokic, Sukanya Suresh, Stacey Wirt, Constance Tom Noguchi. Nitric oxide and hypoxia stimulate erythropoietin receptor via MAPK kinase in endothelial cells.
Microvascular research.
2014 Mar; 92(?):34-40. doi:
10.1016/j.mvr.2014.01.009. [PMID: 24518819] - Thitiwat Suvachananonda, Amara Wankham, Sirada Srihirun, Pansakorn Tanratana, Supeenun Unchern, Suthat Fucharoen, Ampaiwan Chuansumrit, Nongnuch Sirachainan, Nathawut Sibmooh. Decreased nitrite levels in erythrocytes of children with β-thalassemia/hemoglobin E.
Nitric oxide : biology and chemistry.
2013 Sep; 33(?):1-5. doi:
10.1016/j.niox.2013.04.010. [PMID: 23680525] - María C Martí, Igor Florez-Sarasa, Daymi Camejo, Beatriz Pallol, Ana Ortiz, Miquel Ribas-Carbó, Ana Jiménez, Francisca Sevilla. Response of mitochondrial antioxidant system and respiratory pathways to reactive nitrogen species in pea leaves.
Physiologia plantarum.
2013 Feb; 147(2):194-206. doi:
10.1111/j.1399-3054.2012.01654.x. [PMID: 22607494] - Michal Aharoni-Simon, Sarit Anavi, Uwe Beifuss, Zecharia Madar, Oren Tirosh. Nitric oxide, can it be only good? Increasing the antioxidant properties of nitric oxide in hepatocytes by YC-1 compound.
Nitric oxide : biology and chemistry.
2012 Dec; 27(4):248-56. doi:
10.1016/j.niox.2012.08.076. [PMID: 22955014] - Monika Thumova, Vladimir Pech, Otto Froehlich, Diana Agazatian, Xiaonan Wang, Jill W Verlander, Young Hee Kim, Susan M Wall. Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.
American journal of physiology. Renal physiology.
2012 Sep; 303(6):F812-20. doi:
10.1152/ajprenal.00577.2011. [PMID: 22811483] - Marcela Simontacchi, Agustina Buet, Lorenzo Lamattina, Susana Puntarulo. Exposure to nitric oxide increases the nitrosyl-iron complexes content in sorghum embryonic axes.
Plant science : an international journal of experimental plant biology.
2012 Feb; 183(?):159-66. doi:
10.1016/j.plantsci.2011.08.006. [PMID: 22195589] - Elena Chiricozzi, Seila Fernandez-Fernandez, Vincenza Nardicchi, Angeles Almeida, Juan Pedro Bolaños, Gianfrancesco Goracci. Group IIA secretory phospholipase A2 (GIIA) mediates apoptotic death during NMDA receptor activation in rat primary cortical neurons.
Journal of neurochemistry.
2010 Mar; 112(6):1574-83. doi:
10.1111/j.1471-4159.2010.06567.x. [PMID: 20067579] - Juan Li, James White, Ling Guo, Xiaomin Zhao, Jiafu Wang, Eric J Smart, Xiang-An Li. Salt inactivates endothelial nitric oxide synthase in endothelial cells.
The Journal of nutrition.
2009 Mar; 139(3):447-51. doi:
10.3945/jn.108.097451. [PMID: 19176751] - Olena Glushakova, Tomoki Kosugi, Carlos Roncal, Wei Mu, Marcelo Heinig, Pietro Cirillo, Laura G Sánchez-Lozada, Richard J Johnson, Takahiko Nakagawa. Fructose induces the inflammatory molecule ICAM-1 in endothelial cells.
Journal of the American Society of Nephrology : JASN.
2008 Sep; 19(9):1712-20. doi:
10.1681/asn.2007121304. [PMID: 18508964] - Theresa A John, Basil O Ibe, J Usha Raj. Regulation of endothelial nitric oxide synthase: involvement of protein kinase G 1 beta, serine 116 phosphorylation and lipid structures.
Clinical and experimental pharmacology & physiology.
2008 Feb; 35(2):148-58. doi:
10.1111/j.1440-1681.2007.04801.x. [PMID: 17892503] - Mark S Wainwright, Dava Grundhoefer, Shruti Sharma, Stephen M Black. A nitric oxide donor reduces brain injury and enhances recovery of cerebral blood flow after hypoxia-ischemia in the newborn rat.
Neuroscience letters.
2007 Mar; 415(2):124-9. doi:
10.1016/j.neulet.2007.01.019. [PMID: 17270345] - Defeng Wu, Arthur Cederbaum. Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity.
Toxicology and applied pharmacology.
2006 Oct; 216(2):282-92. doi:
10.1016/j.taap.2006.05.019. [PMID: 16938321] - Anna Lewinska, Grzegorz Bartosz. Yeast flavohemoglobin protects against nitrosative stress and controls ferric reductase activity.
Redox report : communications in free radical research.
2006; 11(5):231-9. doi:
10.1179/135100006x154987. [PMID: 17132272] - Mukut Sharma, Ellen T McCarthy, Virginia J Savin, Elias A Lianos. Nitric oxide preserves the glomerular protein permeability barrier by antagonizing superoxide.
Kidney international.
2005 Dec; 68(6):2735-44. doi:
10.1111/j.1523-1755.2005.00744.x. [PMID: 16316348] - Y S Weems, E Lennon, T Uchima, A Raney, K Goto, A Ong, H Zaleski, C W Weems. Is nitric oxide luteolytic or antiluteolytic?.
Prostaglandins & other lipid mediators.
2005 Dec; 78(1-4):129-38. doi:
10.1016/j.prostaglandins.2005.06.002. [PMID: 16303611] - Masato Shinkai, Toko Shinkai, Martina A Pirker, Sandra Montedonico, Prem Puri. Effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants.
Journal of pediatric surgery.
2005 Jun; 40(6):1030-3. doi:
10.1016/j.jpedsurg.2005.03.022. [PMID: 15991191] - Tadeusz J Scislo, Nobusuke Tan, Donal S O'Leary. Differential role of nitric oxide in regional sympathetic responses to stimulation of NTS A2a adenosine receptors.
American journal of physiology. Heart and circulatory physiology.
2005 Feb; 288(2):H638-49. doi:
10.1152/ajpheart.00857.2004. [PMID: 15539419] - Masato Shinkai, Toko Shinkai, Martina E Pirker, Sandra Montedonico, Prem Puri. Effect of nitric oxide on the development of nitrofen-induced fetal hypoplastic lung explants.
Journal of pediatric surgery.
2005 Jan; 40(1):17-21. doi:
10.1016/j.jpedsurg.2004.09.007. [PMID: 15861370] - Y Shimada, K Yokoyama, H Goto, N Sekiya, N Mantani, E Tahara, H Hikiami, K Terasawa. Protective effect of keishi-bukuryo-gan and its constituent medicinal plants against nitric oxide donor-induced neuronal death in cultured cerebellar granule cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2004 Jul; 11(5):404-10. doi:
10.1016/j.phymed.2003.04.002. [PMID: 15330495] - An S De Vriese, Henk J Blom, Sandra G Heil, Siska Mortier, Leo A J Kluijtmans, Johan Van de Voorde, Norbert H Lameire. Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.
Circulation.
2004 May; 109(19):2331-6. doi:
10.1161/01.cir.0000129138.08493.4d. [PMID: 15117854] - Hollis Rogers, Gazi B Zibari, Jenifer Roberts, Richard Turnage, David J Lefer. Nitric oxide attenuates ischaemia-reperfusion (I/R) injury in the diabetic liver.
Clinical transplantation.
2004; 18 Suppl 12(?):7-11. doi:
10.1111/j.1399-0012.2004.00210. [PMID: 15217400] - El-Sayed Akool, Hartmut Kleinert, Farid M A Hamada, Mohamed H Abdelwahab, Ulrich Förstermann, Josef Pfeilschifter, Wolfgang Eberhardt. Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Molecular and cellular biology.
2003 Jul; 23(14):4901-16. doi:
10.1128/mcb.23.14.4901-4916.2003. [PMID: 12832476] - Melek Bor-Kucukatay, Rosalinda B Wenby, Herbert J Meiselman, Oguz K Baskurt. Effects of nitric oxide on red blood cell deformability.
American journal of physiology. Heart and circulatory physiology.
2003 May; 284(5):H1577-84. doi:
10.1152/ajpheart.00665.2002. [PMID: 12521942] - Chen F Lam, Peter V van Heerden, Kenneth F Ilett, Paul Caterina, Pierre Filion. Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.
Chest.
2003 Mar; 123(3):869-74. doi:
10.1378/chest.123.3.869. [PMID: 12628890] - Adam M Dukelow, Sean Weicker, Tim A Karachi, Habib M Razavi, David G McCormack, Mariamma G Joseph, Sanjay Mehta. Effects of nebulized diethylenetetraamine-NONOate in a mouse model of acute Pseudomonas aeruginosa pneumonia.
Chest.
2002 Dec; 122(6):2127-36. doi:
10.1378/chest.122.6.2127. [PMID: 12475857] - Jeffrey G Dickhout, Takefumi Mori, Allen W Cowley. Tubulovascular nitric oxide crosstalk: buffering of angiotensin II-induced medullary vasoconstriction.
Circulation research.
2002 Sep; 91(6):487-93. doi:
10.1161/01.res.0000035243.66189.92. [PMID: 12242266] - Wolfgang Eberhardt, Karl-Friedrich Beck, Josef Pfeilschifter. Cytokine-induced expression of tPA is differentially modulated by NO and ROS in rat mesangial cells.
Kidney international.
2002 Jan; 61(1):20-30. doi:
10.1046/j.1523-1755.2002.00087.x. [PMID: 11786081] - An S De Vriese, Johan Van de Voorde, Norbert H Lameire. Effects of connexin-mimetic peptides on nitric oxide synthase- and cyclooxygenase-independent renal vasodilation.
Kidney international.
2002 Jan; 61(1):177-85. doi:
10.1046/j.1523-1755.2002.00122.x. [PMID: 11786099] - S Pervin, R Singh, G Chaudhuri. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1.
Proceedings of the National Academy of Sciences of the United States of America.
2001 Mar; 98(6):3583-8. doi:
10.1073/pnas.041603998. [PMID: 11248121] - A S De Vriese, J Van de Voorde, H J Blom, P M Vanhoutte, M Verbeke, N H Lameire. The impaired renal vasodilator response attributed to endothelium-derived hyperpolarizing factor in streptozotocin--induced diabetic rats is restored by 5-methyltetrahydrofolate.
Diabetologia.
2000 Sep; 43(9):1116-25. doi:
10.1007/s001250051502. [PMID: 11043857] - X D Liu, C M Skold, T Umino, J R Spurzem, D J Romberger, S I Rennard. Sodium nitroprusside augments human lung fibroblast collagen gel contraction independently of NO-cGMP pathway.
American journal of physiology. Lung cellular and molecular physiology.
2000 May; 278(5):L1032-8. doi:
10.1152/ajplung.2000.278.5.l1032. [PMID: 10781435] - M Akahori, S Yamada, N Takeyama, T Tanaka. Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice.
The Journal of surgical research.
1999 Aug; 85(2):286-93. doi:
10.1006/jsre.1999.5621. [PMID: 10423331] - T Jilling, I Y Haddad, S H Cheng, S Matalon. Nitric oxide inhibits heterologous CFTR expression in polarized epithelial cells.
The American journal of physiology.
1999 07; 277(1):L89-96. doi:
10.1152/ajplung.1999.277.1.l89. [PMID: 10409234] - S D Idriss, T Gudi, D E Casteel, V G Kharitonov, R B Pilz, G R Boss. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase.
The Journal of biological chemistry.
1999 Apr; 274(14):9489-93. doi:
10.1074/jbc.274.14.9489. [PMID: 10092632] - R P Magnusson, R E McCarty. Acid-induced phosphorylation of adenosine 5'-diphosphate bound to coupling factor 1 in spinach chloroplast thylakoids.
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