Hispolon (BioDeep_00000910866)

Main id: BioDeep_00000026419

 

PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


Hispolon

化学式: C12H12O4 (220.0735552)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(/C=C(O)/C=C/C1=CC(O)=C(C=C1)O)=O
InChI: InChI=1S/C12H12O4/c1-8(13)6-10(14)4-2-9-3-5-11(15)12(16)7-9/h2-7,14-16H,1H3/b4-2+,10-6-

描述信息

Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1].

同义名列表

1 个代谢物同义名

Hispolon



数据库引用编号

6 个数据库交叉引用编号

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相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Ahmed Al Saqr, Mohammed F Aldawsari, Hamad Alrbyawi, Ishwor Poudel, Manjusha Annaji, Vanisree Mulabagal, Modukuri V Ramani, Subbaraju Gottumukkala, Amit K Tiwari, Muralikrishnan Dhanasekaran, Peter R Panizzi, Robert D Arnold, R Jayachandra Babu. Co-Delivery of Hispolon and Doxorubicin Liposomes Improves Efficacy Against Melanoma Cells. AAPS PharmSciTech. 2020 Nov; 21(8):304. doi: 10.1208/s12249-020-01846-2. [PMID: 33150503]
  • Ayesha Sarfraz, Azhar Rasul, Iqra Sarfraz, Muhammad Ajmal Shah, Ghulam Hussain, Nusrat Shafiq, Muqaddas Masood, Şevki Adem, Satyajit D Sarker, Xiaomeng Li. Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environmental research. 2020 11; 190(?):110017. doi: 10.1016/j.envres.2020.110017. [PMID: 32768475]
  • Ahmed Al Saqr, Mohammed Majrashi, Hamad Alrbyawi, Manoj Govindarajulu, Ayaka Fujihashi, Subbaraju Gottumukkala, Ishwor Poudel, Robert D Arnold, R Jayachandra Babu, Muralikrishnan Dhanasekaran. Elucidating the anti-melanoma effect and mechanisms of Hispolon. Life sciences. 2020 Sep; 256(?):117702. doi: 10.1016/j.lfs.2020.117702. [PMID: 32387411]
  • Xiaonan Wei, Yaxing Yang, Jiangfeng Ge, Xue Lin, Dandan Liu, Shuxiang Wang, Jinchao Zhang, Guoqiang Zhou, Shenghui Li. Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives. Journal of inorganic biochemistry. 2020 01; 202(?):110857. doi: 10.1016/j.jinorgbio.2019.110857. [PMID: 31669695]
  • Muhammad T Islam, Eunus S Ali, Ishaq N Khan, Subrata Shaw, Shaikh Jamal Uddin, Razina Rouf, Shrabanti Dev, Seyed S S Saravi, Niranjan Das, Swati Tripathi, Santosh U Yele, Asish K Das, Jamil A Shilpi, Siddhartha K Mishra, Mohammad S Mubarak. Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon. Anti-cancer agents in medicinal chemistry. 2020; 20(14):1636-1647. doi: 10.2174/1871520620666200619164947. [PMID: 32560616]
  • Ming-Shun Wu, Chih-Chiang Chien, Kur-Ta Cheng, Gottumukkala V Subbaraju, Yen-Chou Chen. Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells. The American journal of Chinese medicine. 2017; 45(8):1649-1666. doi: 10.1142/s0192415x17500896. [PMID: 29121802]
  • Shaukat Ali M Shaikh, Atanu Barik, Beena G Singh, Ramani V Modukuri, Neduri V Balaji, Gottumukkala V Subbaraju, Devidas B Naik, K Indira Priyadarsini. Free radical reactions of isoxazole and pyrazole derivatives of hispolon: kinetics correlated with molecular descriptors. Free radical research. 2016 Dec; 50(12):1361-1373. doi: 10.1080/10715762.2016.1247955. [PMID: 27733076]
  • Carsten Gründemann, Mandy Arnhold, Stefanie Meier, Christian Bäcker, Manuel Garcia-Käufer, Franziska Grunewald, Carmen Steinborn, Amy Marisa Klemd, Radim Wille, Roman Huber, Ulrike Lindequist. Effects of Inonotus hispidus Extracts and Compounds on Human Immunocompetent Cells. Planta medica. 2016 Oct; 82(15):1359-1367. doi: 10.1055/s-0042-111693. [PMID: 27428885]
  • Ji-Hun Kim, Yu Chul Kim, Byoungduck Park. Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors. Oncology reports. 2016 Feb; 35(2):1020-6. doi: 10.3892/or.2015.4440. [PMID: 26718925]
  • Neduri V Balaji, Modukuri V Ramani, Arabela G Viana, Leticia P Sanglard, Jason White, Vanisree Mulabagal, Crystal Lee, Theophilus J Gana, Nosa O Egiebor, Gottumukkala V Subbaraju, Amit K Tiwari. Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs. Bioorganic & medicinal chemistry. 2015 May; 23(9):2148-2158. doi: 10.1016/j.bmc.2015.03.002. [PMID: 25842364]
  • Yi-Chuan Chen, Heng-Yuan Chang, Jeng-Shyan Deng, Jian-Jung Chen, Shyh-Shyun Huang, I-Hsin Lin, Wan-Lin Kuo, Wei Chao, Guan-Jhong Huang. Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells. The American journal of Chinese medicine. 2013; 41(6):1439-57. doi: 10.1142/s0192415x13500961. [PMID: 24228611]
  • Yi-Chung Chien, Guang-Jhong Huang, Hsu-Chen Cheng, Chieh-Hsi Wu, Ming-Jyh Sheu. Hispolon attenuates balloon-injured neointimal formation and modulates vascular smooth muscle cell migration via AKT and ERK phosphorylation. Journal of natural products. 2012 Sep; 75(9):1524-33. doi: 10.1021/np3002145. [PMID: 22967007]
  • N A Awadh Ali, R A A Mothana, A Lesnau, H Pilgrim, U Lindequist. Antiviral activity of Inonotus hispidus. Fitoterapia. 2003 Jul; 74(5):483-5. doi: 10.1016/s0367-326x(03)00119-9. [PMID: 12837367]