(11E,13Z)-6-[4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-(3,5-dimethylpiperidin-1-yl)ethyl]-16-ethyl-4-hydroxy-15-[(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione (BioDeep_00000910845)
代谢物信息卡片
(11E,13Z)-6-[4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-7-[2-(3,5-dimethylpiperidin-1-yl)ethyl]-16-ethyl-4-hydroxy-15-[(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxymethyl]-5,9,13-trimethyl-1-oxacyclohexadeca-11,13-diene-2,10-dione
化学式: C46H80N2O13 (868.5660110000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC
InChI: InChI=1S/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19-
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Katsivelou Eleni, Perruchon Chiara, Karas A Panagiotis, Sarantidou Apostolia, Pappa Eleni, Katsoula Athanasia, Ligda Panagiota, Sotiraki Smaragda, Martin-Laurent Fabrice, Vasileiadis Sotirios, Karpouzas G Dimitrios. Accelerated dissipation, soil microbial toxicity and dispersal of antimicrobial resistance in soils repeatedly exposed to tiamulin, tilmicosin and sulfamethoxazole.
The Science of the total environment.
2023 Jun; ?(?):164817. doi:
10.1016/j.scitotenv.2023.164817. [PMID: 37329912] - C Perruchon, E Katsivelou, P A Karas, S Vassilakis, A A Lithourgidis, T A Kotsopoulos, S Sotiraki, S Vasileiadis, D G Karpouzas. Following the route of veterinary antibiotics tiamulin and tilmicosin from livestock farms to agricultural soils.
Journal of hazardous materials.
2022 05; 429(?):128293. doi:
10.1016/j.jhazmat.2022.128293. [PMID: 35066227] - Shimaa M Abou-Zeid, Amany I Ahmed, Ashraf Awad, Wafaa A Mohammed, Mohamed M M Metwally, Rafa Almeer, Mohamed M Abdel-Daim, Samah R Khalil. Moringa oleifera ethanolic extract attenuates tilmicosin-induced renal damage in male rats via suppression of oxidative stress, inflammatory injury, and intermediate filament proteins mRNA expression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jan; 133(?):110997. doi:
10.1016/j.biopha.2020.110997. [PMID: 33197759] - Wanhe Luo, Hua Qin, Dongmei Chen, Mengru Wu, Kuiyu Meng, Aoxue Zhang, Yunahu Pan, Wei Qu, Shuyu Xie. The dose regimen formulation of tilmicosin against Lawsonia intracellularis in pigs by pharmacokinetic-pharmacodynamic (PK-PD) model.
Microbial pathogenesis.
2020 Oct; 147(?):104389. doi:
10.1016/j.micpath.2020.104389. [PMID: 32707311] - Nan Zhang, Zhenxian Liu, Yanzhe Wei, Chuanzhen Zhang, Chunxiao Mao, Qinren Cai, Xiangguang Shen, Huanzhong Ding. Comparison of the pharmacokinetics of tilmicosin in plasma and lung tissue in healthy chickens and chickens experimentally infected with Mycoplasma gallisepticum.
Journal of veterinary pharmacology and therapeutics.
2020 Jul; 43(4):347-354. doi:
10.1111/jvp.12847. [PMID: 32133660] - Ashraf Awad, Samah R Khalil, Basma M Hendam, Reda M Abd El-Aziz, Mohamed M M Metwally, Tamer S Imam. Protective potency of Astragalus polysaccharides against tilmicosin- induced cardiac injury via targeting oxidative stress and cell apoptosis-encoding pathways in rat.
Environmental science and pollution research international.
2020 Jun; 27(17):20861-20875. doi:
10.1007/s11356-020-08565-y. [PMID: 32246429] - Samah R Khalil, Sabry M Abdel-Motal, Mohamed Abd-Elsalam, Noura E Abd El-Hameed, Ashraf Awad. Restoring strategy of ethanolic extract of Moringa oleifera leaves against Tilmicosin-induced cardiac injury in rats: Targeting cell apoptosis-mediated pathways.
Gene.
2020 Mar; 730(?):144272. doi:
10.1016/j.gene.2019.144272. [PMID: 31812513] - Qian Zhang, Haifeng Yang, Benazir Sahito, Xinyu Li, Lin Peng, Xiuge Gao, Hui Ji, Liping Wang, Shanxiang Jiang, Dawei Guo. Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin.
Colloids and surfaces. B, Biointerfaces.
2020 Mar; 187(?):110649. doi:
10.1016/j.colsurfb.2019.110649. [PMID: 31767412] - Benazir Sahito, Qian Zhang, Haifeng Yang, Lin Peng, Xiuge Gao, Jam Kashif, Zain Ul Aabdin, Shanxiang Jiang, Liping Wang, Dawei Guo. Synthesis of Tilmicosin Nanostructured Lipid Carriers for Improved Oral Delivery in Broilers: Physiochemical Characterization and Cellular Permeation.
Molecules (Basel, Switzerland).
2020 Jan; 25(2):. doi:
10.3390/molecules25020315. [PMID: 31941074] - Xiaofeng Ji, Hua Yang, Jianmei Wang, Wei Zhou, Xiaoli Wang, Mingrong Qian. Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers.
Journal of food science.
2019 Oct; 84(10):3054-3062. doi:
10.1111/1750-3841.14794. [PMID: 31524951] - J Xiong, Q Zhu, S Yang, Y Zhao, L Cui, F Zhuang, Y Qiu, J Cao. Comparison of pharmacokinetics of tilmicosin in healthy pigs and pigs experimentally infected with Actinobacillus pleuropneumoniae.
New Zealand veterinary journal.
2019 Sep; 67(5):257-263. doi:
10.1080/00480169.2019.1633434. [PMID: 31208293] - Laura E Burns, David J Borts. Rapid untargeted screening for drug residues in animal tissues with liquid microjunction surface sampling probe mass spectrometry.
Analytica chimica acta.
2019 Jul; 1063(?):75-81. doi:
10.1016/j.aca.2019.01.029. [PMID: 30967188] - Mayada Ragab Farag, Wlaa M Elhady, Sarah Y A Ahmed, Heba S A Taha, Mahmoud Alagawany. Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway.
Research in veterinary science.
2019 Jun; 124(?):137-148. doi:
10.1016/j.rvsc.2019.03.010. [PMID: 30901666] - Jincheng Xiong, Qianqian Zhu, Yaxin Zhao, Shuaike Yang, Jiyue Cao, Yinsheng Qiu. Tilmicosin enteric granules and premix to pigs: Antimicrobial susceptibility testing and comparative pharmacokinetics.
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):336-345. doi:
10.1111/jvp.12753. [PMID: 30801755] - Ebru Çetin. Protective effect of ghrelin against tilmicosin-induced left ventricular dysfunction in rats.
Canadian journal of physiology and pharmacology.
2019 May; 97(5):407-412. doi:
10.1139/cjpp-2018-0511. [PMID: 30726105] - Y Yang, L Yuan, J Li, I Muhammad, P Cheng, T Xiao, X Zhang. Preparation and evaluation of tilmicosin microspheres and lung-targeting studies in rabbits.
Veterinary journal (London, England : 1997).
2019 Apr; 246(?):27-34. doi:
10.1016/j.tvjl.2019.01.007. [PMID: 30902186] - Beáta Lemli, Diána Derdák, Péter Laczay, Dorottya Kovács, Sándor Kunsági-Máté. Noncovalent Interaction of Tilmicosin with Bovine Serum Albumin.
Molecules (Basel, Switzerland).
2018 Jul; 23(8):. doi:
10.3390/molecules23081915. [PMID: 30065238] - Z Ling, L Yonghong, L Junfeng, Z Li, L Xianqiang. Tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles to pigs: Combined antibacterial activities and pharmacokinetics.
Journal of veterinary pharmacology and therapeutics.
2018 Apr; 41(2):307-313. doi:
10.1111/jvp.12465. [PMID: 29139136] - Samah S Oda, Amira E Derbalah. Impact of Diclofenac Sodium on Tilmicosin-Induced Acute Cardiotoxicity in Rats (Tilmicosin and Diclofenac Cardiotoxicity).
Cardiovascular toxicology.
2018 02; 18(1):63-75. doi:
10.1007/s12012-017-9414-2. [PMID: 28593443] - Luyan Zhu, Xiaoxia Cao, Qinxin Xu, Jing Su, Xihe Li, Wenzhong Zhou. Evaluation of the antibacterial activity of tilmicosin-SLN against Streptococcus agalactiae: in vitro and in vivo studies.
International journal of nanomedicine.
2018; 13(?):4747-4755. doi:
10.2147/ijn.s168179. [PMID: 30147316] - Ling Zhang, Li Zhao, Yonghong Liu, Junfeng Liu, Xianqiang Li. Pharmacokinetics of tilmicosin in healthy pigs and in pigs experimentally infected with Haemophilus parasuis.
Journal of veterinary science.
2017 Dec; 18(4):431-437. doi:
10.4142/jvs.2017.18.4.431. [PMID: 28385011] - D M Foster, H J Sylvester, M G Papich. Comparison of direct sampling and brochoalveolar lavage for determining active drug concentrations in the pulmonary epithelial lining fluid of calves injected with enrofloxacin or tilmicosin.
Journal of veterinary pharmacology and therapeutics.
2017 Dec; 40(6):e45-e53. doi:
10.1111/jvp.12412. [PMID: 28457009] - Z Ling, L Yonghong, S Changqing, L Junfeng, Z Li, J Chunyu, L Xianqiang. Preparation, characterization, and pharmacokinetics of tilmicosin- and florfenicol-loaded hydrogenated castor oil-solid lipid nanoparticles.
Journal of veterinary pharmacology and therapeutics.
2017 Jun; 40(3):293-303. doi:
10.1111/jvp.12356. [PMID: 27687707] - Bing Li, Shi-Yue Gong, Xu-Zheng Zhou, Ya-Jun Yang, Jian-Yong Li, Xiao-Juan Wei, Fu-Sheng Cheng, Jian-Rong Niu, Xi-Wang Liu, Ji-Yu Zhang. Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics.
Biomedical chromatography : BMC.
2017 Mar; 31(3):. doi:
10.1002/bmc.3825. [PMID: 27564248] - Jun Cheng, Qing Ye, Zongbo Yang, Weijuan Yang, Junhu Zhou, Kefa Cen. Microstructure and antioxidative capacity of the microalgae mutant Chlorella PY-ZU1 during tilmicosin removal from wastewater under 15\% CO2.
Journal of hazardous materials.
2017 Feb; 324(Pt B):414-419. doi:
10.1016/j.jhazmat.2016.11.006. [PMID: 27829514] - Nan Zhang, Xiaomei Ye, Yuzhi Wu, Zilong Huang, Xiaoyan Gu, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding. Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin.
PloS one.
2017; 12(1):e0169134. doi:
10.1371/journal.pone.0169134. [PMID: 28052123] - Bing Li, Xu-Zheng Zhou, Jian-Rong Niu, Xiao-Juan Wei, Jian-Yong Li, Ya-Jun Yang, Xi-Wang Liu, Fu-Sheng Cheng, Ji-Yu Zhang. EFFICACY AND SAFETY OF BAN HUANG ORAL LIQUID FOR TREATING BOVINE RESPIRATORY DISEASES.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(2):47-59. doi:
10.21010/ajtcam.v14i2.6. [PMID: 28573221] - Floyd Besserer, Ryan Chuang, Matt Mink, Laurie Massey, Bruce Cload. Tilmicosin toxicity: a case of accidental human tilmicosin injection managed with calcium, high-dose insulin and intravenous lipid emulsion therapy.
Clinical toxicology (Philadelphia, Pa.).
2016 Sep; 54(8):812-3. doi:
10.1080/15563650.2016.1185109. [PMID: 27207720] - Joseph M Blondeau, Shantelle D Shebelski, Christine K Hesje. Bactericidal effects of various concentrations of enrofloxacin, florfenicol, tilmicosin phosphate, and tulathromycin on clinical isolates of Mannheimia haemolytica.
American journal of veterinary research.
2015 Oct; 76(10):860-8. doi:
10.2460/ajvr.76.10.860. [PMID: 26413823] - Haihong Hao, Junping Yao, Qinghua Wu, Yajing Wei, Menghong Dai, Zahid Iqbal, Xu Wang, Yulian Wang, Lingli Huang, Dongmei Chen, Yanfei Tao, Zhenli Liu, Zonghui Yuan. Microbiological toxicity of tilmicosin on human colonic microflora in chemostats.
Regulatory toxicology and pharmacology : RTP.
2015 Oct; 73(1):201-8. doi:
10.1016/j.yrtph.2015.07.008. [PMID: 26190303] - Mohamed M Abdel-Daim, Emad W Ghazy, Mostafa Fayez. Synergistic protective role of mirazid (Commiphora molmol) and ascorbic acid against tilmicosin-induced cardiotoxicity in mice.
Canadian journal of physiology and pharmacology.
2015 Jan; 93(1):45-51. doi:
10.1139/cjpp-2014-0336. [PMID: 25429612] - Tulay Avci, Muammer Elmas. Milk and blood pharmacokinetics of tylosin and tilmicosin following parenteral administrations to cows.
TheScientificWorldJournal.
2014; 2014(?):869096. doi:
10.1155/2014/869096. [PMID: 25177733] - John D Mitchell, Shan Goh, Quintin A McKellar, Declan J McKeever. In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony.
Veterinary journal (London, England : 1997).
2013 Sep; 197(3):806-11. doi:
10.1016/j.tvjl.2013.05.025. [PMID: 23810743] - X F Wang, S L Zhang, L Y Zhu, S Y Xie, Z Dong, Y Wang, W Z Zhou. Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo.
Veterinary journal (London, England : 1997).
2012 Jan; 191(1):115-20. doi:
10.1016/j.tvjl.2010.11.019. [PMID: 21900026] - P Bosi, G Merialdi, S Scandurra, S Messori, L Bardasi, I Nisi, D Russo, L Casini, P Trevisi. Feed supplemented with 3 different antibiotics improved food intake and decreased the activation of the humoral immune response in healthy weaned pigs but had differing effects on intestinal microbiota.
Journal of animal science.
2011 Dec; 89(12):4043-53. doi:
10.2527/jas.2010-3311. [PMID: 21724943] - Shuyu Xie, Fenghua Wang, Yan Wang, Luyan Zhu, Zhao Dong, Xiaofang Wang, Xihe Li, Wenzhong Zhou. Acute toxicity study of tilmicosin-loaded hydrogenated castor oil-solid lipid nanoparticles.
Particle and fibre toxicology.
2011 Nov; 8(?):33. doi:
10.1186/1743-8977-8-33. [PMID: 22098626] - G Gallina, L Lucatello, I Drigo, M Cocchi, S Scandurra, F Agnoletti, C Montesissa. Kinetics and intrapulmonary disposition of tilmicosin after single and repeated oral bolus administrations to rabbits.
Veterinary research communications.
2010 Jun; 34 Suppl 1(?):S69-72. doi:
10.1007/s11259-010-9385-2. [PMID: 20480234] - C Paraud, I Pors, C Chartier. Evaluation of oral tilmicosin efficacy against severe cryptosporidiosis in neonatal kids under field conditions.
Veterinary parasitology.
2010 May; 170(1-2):149-52. doi:
10.1016/j.vetpar.2010.01.024. [PMID: 20149542] - Yan-Ming Liu, Yan-Mei Shi, Zhuan-Li Liu, Long-Fei Peng. Sensitive determination of tilmicosin, erythromycin ethylsuccinate and clindamycin by CE with electrochemiluminescence detection using azithromycin as internal standard and its applications.
Journal of separation science.
2010 May; 33(9):1305-11. doi:
10.1002/jssc.200900843. [PMID: 20235137] - C Han, C M Qi, B K Zhao, J Cao, S Y Xie, S L Wang, W Z Zhou. Hydrogenated castor oil nanoparticles as carriers for the subcutaneous administration of tilmicosin: in vitro and in vivo studies.
Journal of veterinary pharmacology and therapeutics.
2009 Apr; 32(2):116-23. doi:
10.1111/j.1365-2885.2008.01009.x. [PMID: 19290940] - C Clark, P M Dowling, S Ross, M Woodbury, J O Boison. Pharmacokinetics of tilmicosin in equine tissues and plasma.
Journal of veterinary pharmacology and therapeutics.
2008 Feb; 31(1):66-70. doi:
10.1111/j.1365-2885.2007.00909.x. [PMID: 18177321] - Mohammad Nouri, Peter D Constable. Effect of parenteral administration of erythromycin, tilmicosin, and tylosin on abomasal emptying rate in suckling calves.
American journal of veterinary research.
2007 Dec; 68(12):1392-8. doi:
10.2460/ajvr.68.12.1392. [PMID: 18052746] - Michael Herrera, Haiqing Ding, Robert McClanahan, Jane G Owens, Robert P Hunter. Quantitative determination of tilmicosin in canine serum by high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 857(1):9-14. doi:
10.1016/j.jchromb.2007.06.017. [PMID: 17627909] - E A Abu-Basha, N M Idkaidek, A F Al-Shunnaq. Pharmacokinetics of tilmicosin (Provitil powder and Pulmotil liquid AC) oral formulations in chickens.
Veterinary research communications.
2007 May; 31(4):477-85. doi:
10.1007/s11259-006-3543-6. [PMID: 17225089] - A Kart, K Yapar, M Karapehlivan, M Citil. The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine.
2007 Apr; 54(3):144-6. doi:
10.1111/j.1439-0442.2007.00897.x. [PMID: 17381679] - A Womble, S Giguère, Y V S N Murthy, C Cox, E Obare. Pulmonary disposition of tilmicosin in foals and in vitro activity against Rhodococcus equi and other common equine bacterial pathogens.
Journal of veterinary pharmacology and therapeutics.
2006 Dec; 29(6):561-8. doi:
10.1111/j.1365-2885.2006.00804.x. [PMID: 17083461] - Haiyang Jiang, Shuangyang Ding, Jiancheng Li, Dianjin An, Cun Li, Jianzhong Shen. Residue depletion of tilmicosin in cattle after subcutaneous administration.
Journal of agricultural and food chemistry.
2006 Jul; 54(14):5208-13. doi:
10.1021/jf060863x. [PMID: 16819937] - Ross C Beier, Lawrence C Creemer, Richard L Ziprin, David J Nisbet. Production and characterization of monoclonal antibodies against the antibiotic tilmicosin.
Journal of agricultural and food chemistry.
2005 Dec; 53(25):9679-88. doi:
10.1021/jf051987x. [PMID: 16332115] - Jianzhong Shen, Cun Li, Haiyang Jiang, Suxia Zhang, Ping Guo, Shuangyang Ding, Xiaowei Li. Pharmacokinetics of tilmicosin after oral administration in swine.
American journal of veterinary research.
2005 Jun; 66(6):1071-4. doi:
10.2460/ajvr.2005.66.1071. [PMID: 16008233] - C Clark, M Woodbury, P Dowling, S Ross, J O Boison. A preliminary investigation of the disposition of tilmicosin residues in elk tissues and serum.
Journal of veterinary pharmacology and therapeutics.
2004 Oct; 27(5):385-7. doi:
10.1111/j.1365-2885.2004.00609.x. [PMID: 15500580] - Yue Zhang, Haiyang Jiang, Xingjun Jin, Zhangqi Shen, Jianzhong Shen, Caixia Fu, Junlin Guo. Residue depletion of tilmicosin in chicken tissues.
Journal of agricultural and food chemistry.
2004 May; 52(9):2602-5. doi:
10.1021/jf035515z. [PMID: 15113165] - L A Dykman, M V Sumaroka, S A Staroverov, I S Zaĭtseva, V A Bogatyrev. [Immunogenic properties of the colloidal gold].
Izvestiia Akademii nauk. Seriia biologicheskaia.
2004 Jan; ?(1):86-91. doi:
NULL. [PMID: 15049073] - Jeffrey N Carter, Glacia L Meredith, Marie Montelongo, Donald R Gill, Clinton R Krehbiel, Mark E Payton, Anthony W Confer. Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease.
American journal of veterinary research.
2002 Aug; 63(8):1111-7. doi:
10.2460/ajvr.2002.63.1111. [PMID: 12171163] - D P Alt, R L Zuerner, C A Bolin. Evaluation of antibiotics for treatment of cattle infected with Leptospira borgpetersenii serovar hardjo.
Journal of the American Veterinary Medical Association.
2001 Sep; 219(5):636-9. doi:
10.2460/javma.2001.219.636. [PMID: 11549093] - R Draisci, L Palleschi, E Ferretti, L Achene, A Cecilia. Confirmatory method for macrolide residues in bovine tissues by micro-liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2001 Aug; 926(1):97-104. doi:
10.1016/s0021-9673(01)00838-x. [PMID: 11554423] - C M Stobba-Wiley, J P Chang, D T Elsbury, J W Moran, J M Turner, R S Readnour, C M Stobba-Wiley, J P Chang, D T Elsbury, J W Moran, J M Turner, R S Readnour. Determination of tilmicosin residues in chicken, cattle, swine, and sheep tissues by liquid chromatography.
Journal of AOAC International.
2000 Jul; 83(4):837-46. doi:
NULL. [PMID: 10995110] - G C Duff, D A Walker, K J Malcolm-Callis, M W Wiseman, D M Hallford. Effects of preshipping vs. arrival medication with tilmicosin phosphate and feeding chlortetracycline on health and performance of newly received beef cattle.
Journal of animal science.
2000 Feb; 78(2):267-74. doi:
10.2527/2000.782267x. [PMID: 10709916] - M Atef, K Abo el-Sooud, E Nahed, M Tawfik. Elimination of tilmicosin in lactating ewes.
DTW. Deutsche tierarztliche Wochenschrift.
1999 Jul; 106(7):291-4. doi:
NULL. [PMID: 10481373] - S Modric, A I Webb, M Davidson. Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats.
Laboratory animal science.
1999 Jun; 49(3):248-53. doi:
NULL. [PMID: 10403438] - B Scorneaux, T R Shryock. Intracellular accumulation, subcellular distribution, and efflux of tilmicosin in bovine mammary, blood, and lung cells.
Journal of dairy science.
1999 Jun; 82(6):1202-12. doi:
10.3168/jds.s0022-0302(99)75343-9. [PMID: 10386306] - P Wallgren, T Segall, A Pedersen Mörner, A Gunnarsson. Experimental infections with Actinobacillus pleuropneumoniae in pigs--II. Comparison of antibiotics for oral strategic treatment.
Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B.
1999 May; 46(4):261-9. doi:
NULL. [PMID: 10379236] - S Modric, A I Webb, H Derendorf. Pharmacokinetics and pharmacodynamics of tilmicosin in sheep and cattle.
Journal of veterinary pharmacology and therapeutics.
1998 Dec; 21(6):444-52. doi:
10.1046/j.1365-2885.1998.00177.x. [PMID: 9885967] - J W Moran, J M Turner, M R Coleman. Determination of tilmicosin in bovine and porcine sera by liquid chromatography.
Journal of AOAC International.
1997 Nov; 80(6):1183-9. doi:
10.1093/jaoac/80.6.1183. [PMID: 9419857] - D W Morck, J K Merrill, M S Gard, M E Olson, P N Nation. Treatment of experimentally induced pneumonic pasteurellosis of young calves with tilmicosin.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
1997 Jul; 61(3):187-92. doi:
NULL. [PMID: 9242998] - A Ramadan. Pharmacokinetics of tilmicosin in serum and milk of goats.
Research in veterinary science.
1997 Jan; 62(1):48-50. doi:
10.1016/s0034-5288(97)90179-x. [PMID: 9160424] - S G McKay, D W Morck, J K Merrill, M E Olson, S C Chan, K M Pap. Use of tilmicosin for treatment of pasteurellosis in rabbits.
American journal of veterinary research.
1996 Aug; 57(8):1180-4. doi:
NULL. [PMID: 8836371] - S A Brown, N R Deleeuw, G L Stahl, R D Roof. Characterization of plasma and lung concentrations after ceftiofur sodium and tilmicosin phosphate administered subcutaneously to mice.
Journal of veterinary pharmacology and therapeutics.
1995 Oct; 18(5):385-7. doi:
10.1111/j.1365-2885.1995.tb00610.x. [PMID: 8587160] - G Ziv, M Shem-Tov, A Glickman, M Winkler, A Saran. Tilmicosin antibacterial activity and pharmacokinetics in cows.
Journal of veterinary pharmacology and therapeutics.
1995 Oct; 18(5):340-5. doi:
10.1111/j.1365-2885.1995.tb00601.x. [PMID: 8587151] - M R Coleman, J S Peloso, J W Moran. Microbiological plate assay for determination of tilmicosin in bovine serum.
Journal of AOAC International.
1995 May; 78(3):659-62. doi:
10.1093/jaoac/78.3.659. [PMID: 7756878] - W Chan, G C Gerhardt, C D Salisbury. Determination of tylosin and tilmicosin residues in animal tissues by reversed-phase liquid chromatography.
Journal of AOAC International.
1994 Mar; 77(2):331-3. doi:
10.1093/jaoac/77.2.331. [PMID: 8199468]