Hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-2-imidazol-1-ylethyl]phosphinate (BioDeep_00000906901)
代谢物信息卡片
Hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]-2-imidazol-1-ylethyl]phosphinate
化学式: C5H8N2O7P2-2 (269.9806758)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN(C=N1)CC(O)(P(=O)(O)[O-])P(=O)(O)[O-]
InChI: InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)/p-2
描述信息
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen. Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded, Randomized Study.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.
2024 03; 40(3):714-722. doi:
10.1016/j.arthro.2023.09.033. [PMID: 37832742] - Kun Huang, Xiao Tang, Fang Tang. Combined chemotherapy of zoledronic acid and pamidronate in the treatment of bone metastases from nonsmall cell lung cancer and the effects on pain stress and bone metabolic indices.
Drug development research.
2024 Feb; 85(1):e22147. doi:
10.1002/ddr.22147. [PMID: 38349271] - ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu. Cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis: A meta-analysis and systematic review.
Seminars in arthritis and rheumatism.
2024 Feb; 64(?):152304. doi:
10.1016/j.semarthrit.2023.152304. [PMID: 37984227] - Xiaoxia Zheng, Jiangnan Ye, Qunzhang Zhan, Weifeng Zhao, Zhongqin Liao, Xiaolin Ye, Chongzheng Qu. Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: development and evaluation of a new nomogram.
BMC musculoskeletal disorders.
2023 Oct; 24(1):841. doi:
10.1186/s12891-023-06965-y. [PMID: 37880626] - Mei Liu, Shengqiang Qian, Jing Wu, Jing Xiao, Xiaohua Zeng. The effects of neoadjuvant zoledronic acid in breast cancer patients: A meta-analysis of randomized controlled trials.
Asian journal of surgery.
2023 Oct; 46(10):4124-4130. doi:
10.1016/j.asjsur.2023.01.049. [PMID: 36732184] - Houfu Leng, Anna Katharina Simon, Nicole J Horwood. Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease.
Autophagy.
2023 Sep; ?(?):1-3. doi:
10.1080/15548627.2023.2208931. [PMID: 37771244] - Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu. Dietary nitrate improves jaw bone remodelling in zoledronate-treated mice.
Cell proliferation.
2023 Jul; 56(7):e13395. doi:
10.1111/cpr.13395. [PMID: 36810909] - Kan Liu, Guanzhong Tan, Wei Sun, Qiang Lu, Jiaguang Tang, Dong Yu. Percutaneous kyphoplasty combined with zoledronic acid for the treatment of primary osteoporotic vertebral compression fracture: a prospective, multicenter study.
Archives of orthopaedic and trauma surgery.
2023 Jul; 143(7):3699-3706. doi:
10.1007/s00402-022-04557-4. [PMID: 35933563] - Sheng Wang, Maohua Huang, Minfeng Chen, Zhiting Sun, Yubo Jiao, Geni Ye, Jinghua Pan, Wencai Ye, Jianfu Zhao, Dongmei Zhang. Zoledronic acid and thymosin α1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells.
Journal for immunotherapy of cancer.
2023 06; 11(6):. doi:
10.1136/jitc-2022-006381. [PMID: 37295817] - Bao Liu, Qian Yang, Ying Cheng, Miao Liu, Qifeng Ji, Bangle Zhang, Zhifu Yang, Siyuan Zhou, Daozhou Liu. Calcium phosphate hybrid micelles inhibit orthotopic bone metastasis from triple negative breast cancer by simultaneously killing cancer cells and reprogramming the microenvironment of bone resorption and immunosuppression.
Acta biomaterialia.
2023 May; ?(?):. doi:
10.1016/j.actbio.2023.05.038. [PMID: 37236576] - Hong Jiacong, Yang Qirui, Li Haonan, Song Yichang, Chen Yan, Chen Keng. Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma.
Medical oncology (Northwood, London, England).
2023 Apr; 40(5):141. doi:
10.1007/s12032-023-01988-w. [PMID: 37036615] - Yi Cao, Bin Qiao, Qiaoqi Chen, Zhuoyan Xie, Xiaoyun Dou, Lihong Xu, Haitao Ran, Liang Zhang, Zhigang Wang. Tumor microenvironment remodeling via targeted depletion of M2-like tumor-associated macrophages for cancer immunotherapy.
Acta biomaterialia.
2023 04; 160(?):239-251. doi:
10.1016/j.actbio.2023.02.006. [PMID: 36774974] - Rezvan Adibi, Shiva Moein, Yousof Gheisari. Zoledronic acid targets chemo-resistant polyploid giant cancer cells.
Scientific reports.
2023 01; 13(1):419. doi:
10.1038/s41598-022-27090-1. [PMID: 36624105] - Pengfei Li, Xiaojian Wu, Ye Li, Jianhua Huang. Denosumab Versus Bisphosphonates for the Prevention of the Vertebral Fractures in Men with Osteoporosis: An Updated Network Meta-Analysis.
Clinical and investigative medicine. Medecine clinique et experimentale.
2022 09; 45(3):E14-22. doi:
10.25011/cim.v45i3.38875. [PMID: 36149052] - Lidija Chakuleska, Aleksandar Shkondrov, Georgi Popov, Nadya Zlateva-Panayotova, Reneta Petrova, Mariyana Atanasova, Ilina Krasteva, Irini Doytchinova, Rumyana Simeonova. Beneficial effects of the fructus Sophorae extract on experimentally induced osteoporosis in New Zealand white rabbits.
Acta pharmaceutica (Zagreb, Croatia).
2022 Jun; 72(2):289-302. doi:
10.2478/acph-2022-0012. [PMID: 36651509] - Wei Luo, Jin Zhang, Ling Xu, Yao Zhou, Dan Xu, Qiuju Lv, Yi Xiao, Qin Yang. Use of zoledronic acid in antiosteoporosis treatment is associated with a decreased blood lipid level in postmenopausal women with osteoporosis: a cohort study in China.
Postgraduate medicine.
2022 May; 134(4):406-412. doi:
10.1080/00325481.2022.2051983. [PMID: 35264059] - Shanshan Gao, Fraser Soares, Shiyan Wang, Chi Chun Wong, Huarong Chen, Zhenjie Yang, Weixin Liu, Minnie Y Y Go, Musaddeque Ahmed, Yong Zeng, Catherine Adell O'Brien, Joseph J Y Sung, Housheng Hansen He, Jun Yu. CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer.
Oncogene.
2021 12; 40(48):6601-6613. doi:
10.1038/s41388-021-01882-7. [PMID: 34621019] - J Zhao, H Qiu, Y Lin. Denosumab is not associated with risk of malignancy? More evidence is needed.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2021 10; 32(10):2133-2134. doi:
10.1007/s00198-021-05988-2. [PMID: 34383098] - Gabriella Iannuzzo, Gianpaolo De Filippo, Daniela Merlotti, Veronica Abate, Alessio Buonaiuto, Marco Evangelista, Marco Gentile, Alfonso Giaquinto, Tommaso Picchioni, Matteo Nicola Dario Di Minno, Pasquale Strazzullo, Luigi Gennari, Domenico Rendina. Effects of Bisphosphonate Treatment on Circulating Lipid and Glucose Levels in Patients with Metabolic Bone Disorders.
Calcified tissue international.
2021 06; 108(6):757-763. doi:
10.1007/s00223-021-00811-w. [PMID: 33559705] - Xin-Jun Cai, Zeng Wang, Ying-Ying Xu, Gao-Yi Yang, Ruo-Ying Zhang, Yu Wang. Candesartan treatment enhances liposome penetration and anti-tumor effect via depletion of tumor stroma and normalization of tumor vessel.
Drug delivery and translational research.
2021 06; 11(3):1186-1197. doi:
10.1007/s13346-020-00842-0. [PMID: 32822012] - Lingling Ou, Huaishan Wang, Qin Liu, Jie Zhang, Hezhe Lu, Liangping Luo, Changzheng Shi, Shaoqiang Lin, Liyun Dong, Yeye Guo, Lili Huang, Jinjin Zhu, Xiangfan Yin, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Cathy Zheng, Yi Fan, Wei Guo, Xiaowei Xu. Dichotomous and stable gamma delta T-cell number and function in healthy individuals.
Journal for immunotherapy of cancer.
2021 05; 9(5):. doi:
10.1136/jitc-2020-002274. [PMID: 34011536] - Xinlong Zang, Jingyi Zhou, Xiaoxu Zhang, Dawei Chen, Yantao Han, Xuehong Chen. Dual-targeting tumor cells and tumor associated macrophages with lipid coated calcium zoledronate for enhanced lung cancer chemoimmunotherapy.
International journal of pharmaceutics.
2021 Feb; 594(?):120174. doi:
10.1016/j.ijpharm.2020.120174. [PMID: 33338567] - Kang Wei, Yuxing Qu, Yi Gao, Yong Ma. Comparison of Efficacy of Teriparatide (Parathyroid Hormone 1-34) Alone and in Combination with Zoledronic Acid for Osteoporosis in Postmenopausal Women.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2021 Feb; 31(2):240-242. doi:
10.29271/jcpsp.2021.02.240. [PMID: 33645201] - Xin-Jun Cai, Wei-Dong Fei, Ying-Ying Xu, Hong Xu, Gao-Yi Yang, Jia-Wei Cao, Jian-Jun Ni, Kaiyi Tao, Zeng Wang. Liposome-Encapsulated Zoledronate Favors Tumor Vascular Normalization and Enhances Anticancer Efficacy of Cisplatin.
AAPS PharmSciTech.
2020 Jan; 21(2):57. doi:
10.1208/s12249-019-1614-6. [PMID: 31912318] - Jun Xie, Shaohua Li, Lianbo Xiao, Guilin Ouyang, Lin Zheng, Yubiao Gu, Chengxin Gao, Xiuwei Han. Zoledronic acid ameliorates the effects of secondary osteoporosis in rheumatoid arthritis patients.
Journal of orthopaedic surgery and research.
2019 Dec; 14(1):421. doi:
10.1186/s13018-019-1492-3. [PMID: 31823822] - Xue-Zhen Liang, Rui Li, Bo Xu, Di Luo, Guang-Bo Liu, Jiang Peng, Gang Li. Systematic evaluation of the mechanisms of zoledronic acid based on network pharmacology.
Computational biology and chemistry.
2019 Dec; 83(?):107097. doi:
10.1016/j.compbiolchem.2019.107097. [PMID: 31446368] - Reham Hussein Mohamed, Maha Tarek, Ghada Galal Hamam, Samar F Ezzat. Zoledronic acid prevents the hepatic changes associated with high fat diet in rats; the potential role of mevalonic acid pathway in nonalcoholic steatohepatitis.
European journal of pharmacology.
2019 Sep; 858(?):172469. doi:
10.1016/j.ejphar.2019.172469. [PMID: 31233751] - Tingting Zhang, Fubin Feng, Yan Yao, Lingyu Qi, Jinhui Tian, Chao Zhou, Shengjie Dong, Xue Wang, Changgang Sun. Efficacy and acceptability of neoadjuvant endocrine therapy in patients with hormone receptor-positive breast cancer: A network meta-analysis.
Journal of cellular physiology.
2019 08; 234(8):12393-12403. doi:
10.1002/jcp.28068. [PMID: 30652307] - Zhong Liu, Chun-Wen Li, Yi-Fan Mao, Kang Liu, Bo-Cheng Liang, Lian-Guo Wu, Xiao-Lin Shi. Study on Zoledronic Acid Reducing Acute Bone Loss and Fracture Rates in Elderly Postoperative Patients with Intertrochanteric Fractures.
Orthopaedic surgery.
2019 Jun; 11(3):380-385. doi:
10.1111/os.12460. [PMID: 31058448] - Xinlong Zang, Xiaoxu Zhang, Haiyang Hu, Mingxi Qiao, Xiuli Zhao, Yihui Deng, Dawei Chen. Targeted Delivery of Zoledronate to Tumor-Associated Macrophages for Cancer Immunotherapy.
Molecular pharmaceutics.
2019 05; 16(5):2249-2258. doi:
10.1021/acs.molpharmaceut.9b00261. [PMID: 30969779] - Xu Li, Solange A Valdes, Riyad F Alzhrani, Stephanie Hufnagel, Stephen D Hursting, Zhengrong Cui. Zoledronic Acid-containing Nanoparticles With Minimum Premature Release Show Enhanced Activity Against Extraskeletal Tumor.
ACS applied materials & interfaces.
2019 Feb; 11(7):7311-7319. doi:
10.1021/acsami.8b16588. [PMID: 30689348] - Elena Passeri, Daniela Mazzaccaro, Veronica Sansoni, Silvia Perego, Giovanni Nano, Chiara Verdelli, Giovanni Lombardi, Sabrina Corbetta. Effects of 12-months treatment with zoledronate or teriparatide on intima-media thickness of carotid artery in women with postmenopausal osteoporosis: A pilot study.
International journal of immunopathology and pharmacology.
2019 Jan; 33(?):2058738418822439. doi:
10.1177/2058738418822439. [PMID: 30791743] - Helena Migalovich Sheikhet, Jose Villacorta Hidalgo, Paul Fisch, Alexandra Balbir-Gurman, Yolanda Braun-Moscovici, Ilan Bank. Dysregulated CD25 and Cytokine Expression by γδ T Cells of Systemic Sclerosis Patients Stimulated With Cardiolipin and Zoledronate.
Frontiers in immunology.
2018; 9(?):753. doi:
10.3389/fimmu.2018.00753. [PMID: 29706966] - Lili Cheng, Mengmeng Ge, Zhou Lan, Zhilong Ma, Wenna Chi, Wenhua Kuang, Kun Sun, Xinbin Zhao, Ye Liu, Yaqian Feng, Yuedong Huang, Maoguo Luo, Liping Li, Bin Zhang, Xiaoyu Hu, Lina Xu, Xiaohui Liu, Yi Huo, Haiteng Deng, Jinliang Yang, Qiaoran Xi, Yonghui Zhang, Julie A Siegenthaler, Ligong Chen. Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Archives of toxicology.
2018 Jan; 92(1):469-485. doi:
10.1007/s00204-017-2048-0. [PMID: 28871336] - Bin Zhao, Wenqian Zhao, Yiqiang Wang, Zhao Zhao, Changfeng Zhao, Shue Wang, Chunzheng Gao. Prior administration of vitamin K2 improves the therapeutic effects of zoledronic acid in ovariectomized rats by antagonizing zoledronic acid-induced inhibition of osteoblasts proliferation and mineralization.
PloS one.
2018; 13(8):e0202269. doi:
10.1371/journal.pone.0202269. [PMID: 30125322] - Qiaoli Tang, Shan Jiang, Wenjun Jia, Di Shen, Yudong Qiu, Yue Zhao, Bin Xue, Chaojun Li. Zoledronic acid, an FPPS inhibitor, ameliorates liver steatosis through inhibiting hepatic de novo lipogenesis.
European journal of pharmacology.
2017 Nov; 814(?):169-177. doi:
10.1016/j.ejphar.2017.08.010. [PMID: 28843826] - Jia-Jia Li, Wei-Ling Chen, Jian-Yi Wang, Qian-Wen Hu, Zhen-Ping Sun, Shuai Zhang, Sheng Liu, Xiang-Hui Han. Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse Xenograft model.
Acta pharmacologica Sinica.
2017 Oct; 38(10):1369-1380. doi:
10.1038/aps.2017.13. [PMID: 28414206] - Diti Desai, Jixi Zhang, Jouko Sandholm, Jaakko Lehtimäki, Tove Grönroos, Johanna Tuomela, Jessica M Rosenholm. Lipid Bilayer-Gated Mesoporous Silica Nanocarriers for Tumor-Targeted Delivery of Zoledronic Acid in Vivo.
Molecular pharmaceutics.
2017 09; 14(9):3218-3227. doi:
10.1021/acs.molpharmaceut.7b00519. [PMID: 28737925] - Xu Li, Youssef W Naguib, Zhengrong Cui. In vivo distribution of zoledronic acid in a bisphosphonate-metal complex-based nanoparticle formulation synthesized by a reverse microemulsion method.
International journal of pharmaceutics.
2017 Jun; 526(1-2):69-76. doi:
10.1016/j.ijpharm.2017.04.053. [PMID: 28455136] - Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti, Massimo Massaia. The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells.
Nature communications.
2017 06; 8(?):15663. doi:
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Journal of ethnopharmacology.
2017 May; 204(?):77-85. doi:
10.1016/j.jep.2017.04.007. [PMID: 28412218] - Edson Yoshihiro Mada, Alana Claro Cunha Santos, Angelica Cristina Fonseca, Claudia Cristina Biguetti, Fernando Tozze Alves Neves, Patrícia Pinto Saraiva, Mariza Akemi Matsumoto. Effects of green tea and bisphosphonate association on dental socket repair of rats.
Archives of oral biology.
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Orthopaedic surgery.
2017 Feb; 9(1):103-109. doi:
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Scientific reports.
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Nanomedicine : nanotechnology, biology, and medicine.
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Journal of biological regulators and homeostatic agents.
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Journal of cancer research and clinical oncology.
2015 Jun; 141(6):1025-36. doi:
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PloS one.
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PloS one.
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Endocrinology.
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Carcinogenesis.
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Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2014 Oct; 43(9):711-21. doi:
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Pathology oncology research : POR.
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Bone.
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2013 Dec; 35(12):941-5. doi:
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Bone.
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International journal of nanomedicine.
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Chemical communications (Cambridge, England).
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Journal of lipid research.
2011 Nov; 52(11):1957-64. doi:
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