C53H85ClN14O17 (BioDeep_00000904465)
代谢物信息卡片
C53H85ClN14O17
化学式: C53H85ClN14O17 (1224.590535)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCC(CC(=O)NC1COC(=O)C(NC(=O)C(NC(=O)C(=CCC)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CO)CCN)CCN)CCCN=C(N)N)CC2=CC=CC=C2)C(C(=O)O)O)C(CCl)O)O
InChI: InChI=1S/C53H85ClN14O17/c1-3-5-6-7-8-12-17-30(70)25-39(72)60-37-28-85-52(84)40(38(71)26-54)67-50(81)41(42(73)51(82)83)68-46(77)31(14-4-2)61-47(78)35(24-29-15-10-9-11-16-29)65-43(74)32(18-13-23-59-53(57)58)62-44(75)33(19-21-55)63-45(76)34(20-22-56)64-48(79)36(27-69)66-49(37)80/h9-11,14-16,30,32-38,40-42,69-71,73H,3-8,12-13,17-28,55-56H2,1-2H3,(H,60,72)(H,61,78)(H,62,75)(H,63,76)(H,64,79)(H,65,74)(H,66,80)(H,67,81)(H,68,77)(H,82,83)(H4,57,58,59)/b31-14-/t30?,32-,33-,34-,35-,36-,37-,38+,40-,41+,42?/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anastasiia A Zakharova, Svetlana S Efimova, Ludmila V Schagina, Valery V Malev, Olga S Ostroumova. Blocking ion channels induced by antifungal lipopeptide syringomycin E with amide-linked local anesthetics.
Scientific reports.
2018 08; 8(1):11543. doi:
10.1038/s41598-018-30077-6. [PMID: 30069037] - Svetlana S Efimova, Anastasiia A Zakharova, Artem A Ismagilov, Ludmila V Schagina, Valery V Malev, Pavel V Bashkirov, Olga S Ostroumova. Lipid-mediated regulation of pore-forming activity of syringomycin E by thyroid hormones and xanthene dyes.
Biochimica et biophysica acta. Biomembranes.
2018 Mar; 1860(3):691-699. doi:
10.1016/j.bbamem.2017.12.010. [PMID: 29253504] - Svetlana S Efimova, Anastasiia A Zakharova, Ludmila V Schagina, Olga S Ostroumova. Two types of syringomycin E channels in sphingomyelin-containing bilayers.
European biophysics journal : EBJ.
2016 Jan; 45(1):91-8. doi:
10.1007/s00249-015-1101-2. [PMID: 26658744] - Lucia Becucci, Vania Tramonti, Alberto Fiore, Vincenzo Fogliano, Andrea Scaloni, Rolando Guidelli. Channel-forming activity of syringomycin E in two mercury-supported biomimetic membranes.
Biochimica et biophysica acta.
2015 Apr; 1848(4):932-41. doi:
10.1016/j.bbamem.2014.12.007. [PMID: 25554594] - Moeko Toume, Motohiro Tani. Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae.
FEMS microbiology letters.
2014 Sep; 358(1):64-71. doi:
10.1111/1574-6968.12535. [PMID: 25040056] - Massimiliano Anselmi, Tommaso Eliseo, Laura Zanetti-Polzi, Maria Rosaria Fullone, Vincenzo Fogliano, Alfredo Di Nola, Maurizio Paci, Ingeborg Grgurina. Structure of the lipodepsipeptide syringomycin E in phospholipids and sodium dodecylsulphate micelle studied by circular dichroism, NMR spectroscopy and molecular dynamics.
Biochimica et biophysica acta.
2011 Sep; 1808(9):2102-10. doi:
10.1016/j.bbamem.2011.04.018. [PMID: 21658366] - S S Efimova, O S Ostroumova, V V Malev, L V Shchagina. [Transport of large organic ions through syringomycin channels in the membranes containing dipole modifiers].
Tsitologiia.
2011; 53(5):450-6. doi:
". [PMID: 21786689] - O S Ostroumova, S S Efimova, L V Shchagina. [Conductance of phytotoxin channels in the presence of large organic ions].
Tsitologiia.
2009; 51(8):670-5. doi:
". [PMID: 19799351] - Olga S Ostroumova, Valery V Malev, Andrey N Bessonov, Jon Y Takemoto, Ludmila V Schagina. Altering the activity of syringomycin E via the membrane dipole potential.
Langmuir : the ACS journal of surfaces and colloids.
2008 Apr; 24(7):2987-91. doi:
10.1021/la800206v. [PMID: 18324870] - Olga S Ostroumova, Yuri A Kaulin, Philip A Gurnev, Ludmila V Schagina. Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.
Langmuir : the ACS journal of surfaces and colloids.
2007 Jun; 23(13):6889-92. doi:
10.1021/la7005452. [PMID: 17508767] - Olga S Ostroumova, Philip A Gurnev, Ludmila V Schagina, Sergey M Bezrukov. Asymmetry of syringomycin E channel studied by polymer partitioning.
FEBS letters.
2007 Mar; 581(5):804-8. doi:
10.1016/j.febslet.2007.01.063. [PMID: 17289034] - E Mátyus, L Monticelli, K E Kövér, Z Xu, K Blaskó, J Fidy, D P Tieleman. Structural investigation of syringomycin-E using molecular dynamics simulation and NMR.
European biophysics journal : EBJ.
2006 Aug; 35(6):459-67. doi:
10.1007/s00249-006-0053-y. [PMID: 16544138] - Andrey N Bessonov, Ludmila V Schagina, Jon Y Takemoto, Philip A Gurnev, Irina M Kuznetsova, Konstantin K Turoverov, Valery V Malev. Actin and amphiphilic polymers influence on channel formation by Syringomycin E in lipid bilayers.
European biophysics journal : EBJ.
2006 May; 35(5):382-92. doi:
10.1007/s00249-006-0045-y. [PMID: 16470378] - O S Ostroumova, V V Malev, Yu A Kaulin, Ph A Gurnev, J Y Takemoto, L V Schagina. Voltage-dependent synchronization of gating of syringomycin E ion channels.
FEBS letters.
2005 Oct; 579(25):5675-9. doi:
10.1016/j.febslet.2005.08.087. [PMID: 16219309] - Yuri A Kaulin, Jon Y Takemoto, Ludmila V Schagina, Olga S Ostroumova, R Wangspa, John H Teeter, Joseph G Brand. Sphingolipids influence the sensitivity of lipid bilayers to fungicide, syringomycin E.
Journal of bioenergetics and biomembranes.
2005 Oct; 37(5):339-48. doi:
10.1007/s10863-005-8645-2. [PMID: 16341778] - O S Ostroumova, F A Gur'nev, J Y Takemoto, L V Shchagina, V V Malev. [Kinetic parameters of single ion channels and stationary conductivities of phytotoxin modified lipid bilayers].
Tsitologiia.
2005; 47(4):338-43. doi:
". [PMID: 16706157] - Zsófia Szabó, Marianna Budai, Katalin Blaskó, Pál Gróf. Molecular dynamics of the cyclic lipodepsipeptides' action on model membranes: effects of syringopeptin22A, syringomycin E, and syringotoxin studied by EPR technique.
Biochimica et biophysica acta.
2004 Jan; 1660(1-2):118-30. doi:
10.1016/j.bbamem.2003.11.007. [PMID: 14757227] - A N Bessonov, F A Gur'nev, I M Kuznetsova, J Y Takemoto, K K Turoverov, V V Malev, L V Shchagina. [Interaction between filamentous actin and lipid bilayer causes the increase of syringomycin E channel-forming activity].
Tsitologiia.
2004; 46(7):628-33. doi:
". [PMID: 15473373] - Ludmila V Schagina, Philip A Gurnev, Jon Y Takemoto, Valery V Malev. Effective gating charge of ion channels induced by toxin syringomycin E in lipid bilayers.
Bioelectrochemistry (Amsterdam, Netherlands).
2003 Aug; 60(1-2):21-7. doi:
10.1016/s1567-5394(03)00041-0. [PMID: 12893306] - Yang Ju Im, Jolanta Idkowiak-Baldys, Karin Thevissen, Bruno P A Cammue, Jon Y Takemoto. IPT1-independent sphingolipid biosynthesis and yeast inhibition by syringomycin E and plant defensin DmAMP1.
FEMS microbiology letters.
2003 Jun; 223(2):199-203. doi:
10.1016/s0378-1097(03)00375-6. [PMID: 12829286] - Sheri Woo, Vincenzo Fogliano, Felice Scala, Matteo Lorito. Synergism between fungal enzymes and bacterial antibiotics may enhance biocontrol.
Antonie van Leeuwenhoek.
2002 Aug; 81(1-4):353-6. doi:
10.1023/a:1020540818163. [PMID: 12448733] - Vincenzo Fogliano, Alessandro Ballio, Monica Gallo, Sheridan Woo, Felice Scala, Matteo Lorito. Pseudomonas lipodepsipeptides and fungal cell wall-degrading enzymes act synergistically in biological control.
Molecular plant-microbe interactions : MPMI.
2002 Apr; 15(4):323-33. doi:
10.1094/mpmi.2002.15.4.323. [PMID: 12026170] - Valery V Malev, Ludmila V Schagina, Philip A Gurnev, Jon Y Takemoto, Ekaterina M Nestorovich, Sergey M Bezrukov. Syringomycin E channel: a lipidic pore stabilized by lipopeptide?.
Biophysical journal.
2002 Apr; 82(4):1985-94. doi:
10.1016/s0006-3495(02)75547-1. [PMID: 11916856] - F A Gur'nev, Iu A Kaulin, A V Tikhomirova, R Wangspa, D Takemoto, V V Malev, L V Shchagina. [Activity of toxins produced by Pseudomonas syringae pv. syringae in model and cell membranes].
Tsitologiia.
2002; 44(3):296-304. doi:
". [PMID: 12094768] - V V Malev, Y A Kaulin, S M Bezrukov, P A Gurnev, J Y Takemoto, L V Shchagina. Kinetics of opening and closure of syringomycin E channels formed in lipid bilayers.
Membrane & cell biology.
2001; 14(6):813-29. doi:
". [PMID: 11817576] - G Agner, Y A Kaulin, P A Gurnev, Z Szabo, L V Schagina, J Y Takemoto, K Blasko. Membrane-permeabilizing activities of cyclic lipodepsipeptides, syringopeptin 22A and syringomycin E from Pseudomonas syringae pv. syringae in human red blood cells and in bilayer lipid membranes.
Bioelectrochemistry (Amsterdam, Netherlands).
2000 Dec; 52(2):161-7. doi:
10.1016/s0302-4598(00)00098-2. [PMID: 11129239] - H Hama, D A Young, J A Radding, D Ma, J Tang, S D Stock, J Y Takemoto. Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E.
FEBS letters.
2000 Jul; 478(1-2):26-8. doi:
10.1016/s0014-5793(00)01821-4. [PMID: 10922463] - G Agner, Y A Kaulin, L V Schagina, J Y Takemoto, K Blasko. Effect of temperature on the formation and inactivation of syringomycin E pores in human red blood cells and bimolecular lipid membranes.
Biochimica et biophysica acta.
2000 Jun; 1466(1-2):79-86. doi:
10.1016/s0005-2736(00)00173-5. [PMID: 10825433] - S D Stock, H Hama, J A Radding, D A Young, J Y Takemoto. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups.
Antimicrobial agents and chemotherapy.
2000 May; 44(5):1174-80. doi:
10.1128/aac.44.5.1174-1180.2000. [PMID: 10770748] - Iu A Kaulin, L V Shchagina. [Effect of electrolyte composition of various solutions on potential-sensitive ion channels, formed by syringomycin E in lipid bilayers].
Tsitologiia.
1999; 41(7):610-4. doi:
". [PMID: 10496022] - K N Sorensen, A A Wanstrom, S D Allen, J Y Takemoto. Efficacy of syringomycin E in a murine model of vaginal candidiasis.
The Journal of antibiotics.
1998 Aug; 51(8):743-9. doi:
10.7164/antibiotics.51.743. [PMID: 9766466] - Y A Kaulin, L V Schagina, S M Bezrukov, V V Malev, A M Feigin, J Y Takemoto, J H Teeter, J G Brand. Cluster organization of ion channels formed by the antibiotic syringomycin E in bilayer lipid membranes.
Biophysical journal.
1998 Jun; 74(6):2918-25. doi:
10.1016/s0006-3495(98)77999-8. [PMID: 9635746] - L V Schagina, Y A Kaulin, A M Feigin, J Y Takemoto, J G Brand, V V Malev. Properties of ionic channels formed by the antibiotic syringomycin E in lipid bilayers: dependence on the electrolyte concentration in the bathing solution.
Membrane & cell biology.
1998; 12(4):537-55. doi:
". [PMID: 10367570]