ABT-773 (BioDeep_00000009041)

   


代谢物信息卡片


(1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-13-ethyl-2,4,6,8,10,14-hexamethyl-6-[(E)-3-(3-quinolyl)allyloxy]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone

化学式: C42H59N3O10 (765.4200234000001)
中文名称: 喹红霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OCC=CC4=CC5=CC=CC=C5N=C4)C)C)NC(=O)O2)C
InChI: InChI=1S/C42H59N3O10/c1-11-32-42(8)36(44-40(50)55-42)25(4)33(46)23(2)21-41(7,51-18-14-15-28-20-29-16-12-13-17-30(29)43-22-28)37(26(5)34(47)27(6)38(49)53-32)54-39-35(48)31(45(9)10)19-24(3)52-39/h12-17,20,22-27,31-32,35-37,39,48H,11,18-19,21H2,1-10H3,(H,44,50)/b15-14+/t23-,24-,25+,26+,27-,31+,32-,35-,36-,37-,39+,41+,42-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

6 个代谢物同义名

(1R,2R,4R,6S,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-13-ethyl-2,4,6,8,10,14-hexamethyl-6-[(E)-3-(3-quinolyl)allyloxy]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone; Abbott-195773; Cethromycin; A-195773; ABT-773; Cethromycin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • E Azoulay-Dupuis, J Mohler, J P Bédos, C Barau, B Fantin. Efficacy of cethromycin, a new ketolide, against Streptococcus pneumoniae susceptible or resistant to erythromycin in a murine pneumonia model. Antimicrobial agents and chemotherapy. 2006 Sep; 50(9):3033-8. doi: 10.1128/aac.00920-05. [PMID: 16940099]
  • John E Conte, Jeffrey A Golden, Juliana Kipps, Elisabeth Zurlinden. Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin. Antimicrobial agents and chemotherapy. 2004 Sep; 48(9):3508-15. doi: 10.1128/aac.48.9.3508-3515.2004. [PMID: 15328118]
  • David A Katz, David R Grimm, Steven C Cassar, Maria C Gentile, Xin Ye, Matthew J Rieser, Eric F Gordon, Jill E Polzin, Linda E Gustavson, Rita M Driscoll, Robert F O'dea, Laura A Williams, Stanley Bukofzer. CYP3A5 genotype has a dose-dependent effect on ABT-773 plasma levels. Clinical pharmacology and therapeutics. 2004 Jun; 75(6):516-28. doi: 10.1016/j.clpt.2004.01.013. [PMID: 15179406]
  • Qiulei Ren, John E Conte, Elisabeth Zurlinden, Emil T Lin. A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of cethromycin (ABT-773) in human plasma, bronchoalveolar lavage fluid, and alveolar cells. Journal of chromatographic science. 2003 Oct; 41(9):494-9. doi: 10.1093/chromsci/41.9.464. [PMID: 14596787]
  • M W Pletz, V Preechachatchaval, J Bulitta, M Allewelt, O Burkhardt, H Lode. ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate. Antimicrobial agents and chemotherapy. 2003 Mar; 47(3):1129-31. doi: 10.1128/aac.47.3.1129-1131.2003. [PMID: 12604553]
  • Myo-Kyoung Kim, Wen Zhou, Pamela R Tessier, Dawei Xuan, Min Ye, Charles H Nightingale, David P Nicolau. Bactericidal effect and pharmacodynamics of cethromycin (ABT-773) in a murine pneumococcal pneumonia model. Antimicrobial agents and chemotherapy. 2002 Oct; 46(10):3185-92. doi: 10.1128/aac.46.10.3185-3192.2002. [PMID: 12234843]
  • Dawei Xuan, Min Ye, Myo Kim, Charles H Nightingale, David P Nicolau. Pharmacokinetics of ABT-773, a new semi-synthetic ketolide in neutropenic lung-infected mice: a population approach. The Journal of pharmacy and pharmacology. 2002 Jan; 54(1):71-5. doi: 10.1211/0022357021771940. [PMID: 11829132]
  • P H Edelstein, F Higa, M A Edelstein. In vitro activity of ABT-773 against Legionella pneumophila, its pharmacokinetics in guinea pigs, and its use to treat guinea pigs with L. pneumophila pneumonia. Antimicrobial agents and chemotherapy. 2001 Oct; 45(10):2685-90. doi: 10.1128/aac.45.10.2685-2690.2001. [PMID: 11557455]
  • M J Mitten, J Meulbroek, M Nukkala, L Paige, K Jarvis, A Oleksijew, A Tovcimak, L Hernandez, J D Alder, P Ewing, Y S Or, Z Ma, A M Nilius, K Mollison, R K Flamm. Efficacies of ABT-773, a new ketolide, against experimental bacterial infections. Antimicrobial agents and chemotherapy. 2001 Sep; 45(9):2585-93. doi: 10.1128/aac.45.9.2585-2593.2001. [PMID: 11502533]
  • J M Andrews, T M Weller, J P Ashby, R M Walker, R Wise. The in vitro activity of ABT773, a new ketolide antimicrobial agent. The Journal of antimicrobial chemotherapy. 2000 Dec; 46(6):1017-22. doi: 10.1093/jac/46.6.1017. [PMID: 11102425]