2-Hydroxyoleanolate (BioDeep_00000901215)

   


代谢物信息卡片


2-Hydroxyoleanolate

化学式: C30H47O4- (471.3474162)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C)O)O)C)C)C2C1)C)C(=O)[O-])C
InChI: InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/p-1

描述信息

同义名列表

1 个代谢物同义名

2-Hydroxyoleanolate



数据库引用编号

1 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Kun Yang, Sheng-Bing Wang, Dong Pei, Lu-Mei Pu, Xin-Yi Huang. Effective separation of maslinic acid and oleanolic acid from olive pomace using high-speed shear off-line coupled with high-speed countercurrent chromatography and their antibacterial activity test. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024 Apr; 1236(?):124069. doi: 10.1016/j.jchromb.2024.124069. [PMID: 38442634]
  • Marta Ramos-Barbero, Eva E Rufino-Palomares, Sergio Serrano-Carmona, Manuel Hernández-Yera, Leticia García-Salguero, José Antonio Lupiáñez, Amalia Pérez-Jiménez. Effect of Nutraceutical Factors on Hepatic Intermediary Metabolism in Wistar Rats with Induced Tendinopathy. International journal of molecular sciences. 2024 Jan; 25(1):. doi: 10.3390/ijms25010629. [PMID: 38203800]
  • Aixa Aguilera-Garrido, Pablo Graván, Saúl A Navarro-Marchal, Marta Medina-O'Donnell, Andrés Parra, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González. Maslinic acid solid lipid nanoparticles as hydrophobic anticancer drug carriers: Formulation, in vitro activity and in vivo biodistribution. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114828. doi: 10.1016/j.biopha.2023.114828. [PMID: 37163783]
  • Elisabeta-Irina Geana, Corina Teodora Ciucure, Irina Mirela Apetrei, Maria Lisa Clodoveo, Constantin Apetrei. Discrimination of Olive Oil and Extra-Virgin Olive Oil from Other Vegetable Oils by Targeted and Untargeted HRMS Profiling of Phenolic and Triterpenic Compounds Combined with Chemometrics. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065292. [PMID: 36982366]
  • Fiammetta Alagna, James Reed, Ornella Calderini, Ramesha Thimmappa, Nicolò G M Cultrera, Alice Cattivelli, Davide Tagliazucchi, Soraya Mousavi, Roberto Mariotti, Anne Osbourn, Luciana Baldoni. OeBAS and CYP716C67 catalyze the biosynthesis of health-beneficial triterpenoids in olive (Olea europaea L.) fruits. The New phytologist. 2023 Mar; ?(?):. doi: 10.1111/nph.18863. [PMID: 36880371]
  • Yan He, Yi Wang, Kun Yang, Jia Jiao, Hong Zhan, Youjun Yang, De Lv, Weihong Li, Weijun Ding. Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248732. [PMID: 36557864]
  • Lin Wang, Yi-Fu Fan, Bing-Rui Li, Wen-Hui Sun, Li-Na Wang. Maslinic Acid Suppresses High Glucose-induced Inflammation by Epigenetically Inhibiting TXNIP Expression. Current medical science. 2022 Dec; 42(6):1213-1219. doi: 10.1007/s11596-022-2657-6. [PMID: 36350490]
  • Aixa Aguilera-Garrido, Elena Arranz, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González, Linda Giblin. Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid. Drug delivery. 2022 Dec; 29(1):1971-1982. doi: 10.1080/10717544.2022.2086937. [PMID: 35762633]
  • Tianqi Li, Huan Wang, Siyu Dong, Meng Liang, Jun Ma, XiaoWen Jiang, Wenhui Yu. Protective effects of maslinic acid on high fat diet-induced liver injury in mice. Life sciences. 2022 Jul; 301(?):120634. doi: 10.1016/j.lfs.2022.120634. [PMID: 35568228]
  • Karabo R Matee, Akinjide M Akinnuga, Angezwa Siboto, Phikelelani Ngubane, Andile Khathi. Bredemolic acid restores glucose utilization and attenuates oxidative stress in palmitic acid-induced insulin-resistant C2C12 cells. Endocrine regulations. 2022 Apr; 56(2):126-133. doi: 10.2478/enr-2022-0014. [PMID: 35489052]
  • Ghassab M Al-Mazaideh, Mohammed Hf Shalayel, Saada Nour, Farhan Khashim Al-Swailmi, Saleem Aladaileh. In silico anti-fungal efficacy and the mechanism of binding of some Syzygium aromaticum ingredient compounds to aspartate semialdehyde dehydrogenase, 6C8W and 6C85, enzymes from Blastomyces dermatitidis. Pakistan journal of pharmaceutical sciences. 2021 Nov; 34(6):2219-2226. doi: . [PMID: 35034884]
  • Khong Trong Quan, Byung Gu Min, In Hyun Hwang, Yeon Jung Choi, Sang Kyum Kim, MinKyun Na. Oleanane triterpenoids from Rubia philippinensis and their inhibitory effect on 20-HETE synthesis. Natural product research. 2021 Apr; 35(8):1267-1273. doi: 10.1080/14786419.2019.1645656. [PMID: 31343260]
  • Lei Yu, Xiaofang Xie, Xiaoyu Cao, Junren Chen, Guanru Chen, Yan Chen, Gangmin Li, Junyuan Qin, Fu Peng, Cheng Peng. The Anticancer Potential of Maslinic Acid and Its Derivatives: A Review. Drug design, development and therapy. 2021; 15(?):3863-3879. doi: 10.2147/dddt.s326328. [PMID: 34526766]
  • Kung-Wen Lu, Mei-Due Yang, Shu-Fen Peng, Jaw-Chyun Chen, Po-Yuan Chen, Hung-Yi Chen, Tai-Jung Lu, Fu-Shin Chueh, Jin-Cherng Lien, Kuang-Chi Lai, Kuo-Ching Liu, Yin-Ying Tai. Maslinic Acid Induces DNA Damage and Impairs DNA Repair in Human Cervical Cancer HeLa Cells. Anticancer research. 2020 Dec; 40(12):6869-6877. doi: 10.21873/anticanres.14709. [PMID: 33288579]
  • Feng Zhang, Jian Huang, Rong-Jing He, Lu Wang, Peng-Chao Huo, Xiao-Qing Guan, Sheng-Quan Fang, Yan-Wei Xiang, Shou-Ning Jia, Guang-Bo Ge. Herb-drug interaction between Styrax and warfarin: Molecular basis and mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Oct; 77(?):153287. doi: 10.1016/j.phymed.2020.153287. [PMID: 32739573]
  • Su Wen Phang, Bee Kee Ooi, Nafees Ahemad, Wei Hsum Yap. Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis. Vascular pharmacology. 2020 May; 128-129(?):106675. doi: 10.1016/j.vph.2020.106675. [PMID: 32200116]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Ameliorative Effects of Bredemolic Acid on Markers Associated with Renal Dysfunction in a Diet-Induced Prediabetic Rat Model. Oxidative medicine and cellular longevity. 2020; 2020(?):2978340. doi: 10.1155/2020/2978340. [PMID: 32655765]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Bredemolic Acid Improves Cardiovascular Function and Attenuates Endothelial Dysfunction in Diet-Induced Prediabetes: Effects on Selected Markers. Cardiovascular therapeutics. 2020; 2020(?):1936406. doi: 10.1155/2020/1936406. [PMID: 32117470]
  • Akinjide Moses Akinnuga, Angezwa Siboto, Bongiwe Khumalo, Ntethelelo Hopewell Sibiya, Phikelelani Ngubane, Andile Khathi. Bredemolic Acid Ameliorates Selected Liver Function Biomarkers in a Diet-Induced Prediabetic Rat Model. Canadian journal of gastroenterology & hepatology. 2020; 2020(?):2475301. doi: 10.1155/2020/2475301. [PMID: 32149046]
  • Blessing Nkazimulo Mkhwanazi, Fanie Retief van Heerden, Greanious Alfred Mavondo, Musa Vuyisile Mabandla, Cephas Tagumirwa Musabayane. Triterpene derivative improves the renal function of streptozotocin-induced diabetic rats: a follow-up study on maslinic acid. Renal failure. 2019 Nov; 41(1):547-554. doi: 10.1080/0886022x.2019.1623818. [PMID: 31234683]
  • Chian-Jiun Liou, Yi-Wen Dai, Chia-Ling Wang, Li-Wen Fang, Wen-Chung Huang. Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 11; 33(11):11791-11803. doi: 10.1096/fj.201900413rrr. [PMID: 31361524]
  • Dimitris Tsoukalas, Persefoni Fragkiadaki, Anca Oana Docea, Athanasios K Alegakis, Evangelia Sarandi, Maria Thanasoula, Demetrios A Spandidos, Aristidis Tsatsakis, Mayya Petrovna Razgonova, Daniela Calina. Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives. Molecular medicine reports. 2019 Oct; 20(4):3701-3708. doi: 10.3892/mmr.2019.10614. [PMID: 31485647]
  • Xin-Yi Huang, Xia Zhang, Dong Pei, Jian-Fei Liu, Yuan Gong, Haji Akber Aisa, Duo-Long Di. Continuous separation of maslinic and oleanolic acids from olive pulp by high-speed countercurrent chromatography with elution-extrusion mode. Journal of separation science. 2019 Jun; 42(11):2080-2088. doi: 10.1002/jssc.201900112. [PMID: 31087537]
  • M Emília Juan, Glòria Lozano-Mena, Marta Sánchez-González, Joana M Planas. Reduction of Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon by Maslinic Acid, a Pentacyclic Triterpene from Olea europaea L. Molecules (Basel, Switzerland). 2019 Apr; 24(7):. doi: 10.3390/molecules24071266. [PMID: 30939812]
  • Zhubo Dai, Yun Liu, Zhoutong Sun, Dong Wang, Ge Qu, Xiaolin Ma, Feiyu Fan, Lili Zhang, Shoulian Li, Xueli Zhang. Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories. Metabolic engineering. 2019 01; 51(?):70-78. doi: 10.1016/j.ymben.2018.10.001. [PMID: 30339834]
  • Aymen Ben Nejma, Mansour Znati, Adam Daich, Mohamed Othman, Ata Martin Lawson, Hichem Ben Jannet. Design and semisynthesis of new herbicide as 1,2,3-triazole derivatives of the natural maslinic acid. Steroids. 2018 Oct; 138(?):102-107. doi: 10.1016/j.steroids.2018.07.004. [PMID: 30016641]
  • Joaquín Velasco, Francisca Holgado, Gloria Márquez-Ruiz, María Victoria Ruiz-Méndez. Concentrates of triterpenic acids obtained from crude olive pomace oils: characterization and evaluation of their potential antioxidant activity. Journal of the science of food and agriculture. 2018 Oct; 98(13):4837-4844. doi: 10.1002/jsfa.9012. [PMID: 29574746]
  • Xiukun Lin, Ulku Ozbey, Uteuliyev Yerzhan Sabitaliyevich, Rukset Attar, Beraat Ozcelik, Yuanyan Zhang, Mingyue Guo, Minghua Liu, Saleh S Alhewairini, Ammad Ahmad Farooqi. Maslinic acid as an effective anticancer agent. Cellular and molecular biology (Noisy-le-Grand, France). 2018 Jul; 64(10):87-91. doi: . [PMID: 30084808]
  • Yao Li, Sheng Guo, Quanjin Ren, Dandan Wei, Ming Zhao, Shulan Su, Zhishu Tang, Jin-Ao Duan. Pharmacokinetic Comparisons of Multiple Triterpenic Acids from Jujubae Fructus Extract Following Oral Delivery in Normal and Acute Liver Injury Rats. International journal of molecular sciences. 2018 07; 19(7):. doi: 10.3390/ijms19072047. [PMID: 30011885]
  • Wei Hsum Yap, Bee Kee Ooi, Nafees Ahmed, Yang Mooi Lim. Maslinic acid modulates secreted phospholipase A2-IIA (sPLA2-IIA)-mediated inflammatory effects in macrophage foam cells formation. Journal of biosciences. 2018 Jun; 43(2):277-285. doi: . [PMID: 29872016]
  • Roseane Leandra da Rosa, Luciane Ângela Nottar Nesello, Luisa Nathalia Bolda Mariano, Lincon Bordignon Somensi, Adriana Campos, Ana Myrelle Pinheiro, Sabrina Costa, Marjana Rial, Mariana Tozzo, Valdir Cechinel-Filho, Sérgio Faloni de Andrade, Luísa Mota Da Silva. Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids. Naunyn-Schmiedeberg's archives of pharmacology. 2018 01; 391(1):95-101. doi: 10.1007/s00210-017-1442-8. [PMID: 29209743]
  • Ninh Khac Ban, Nguyen Thi Kim Thoa, Tran My Linh, Do Thi Trang, Phan Van Kiem, Nguyen Xuan Nhiem, Bui Huu Tai, Chau Van Minh, Jae-Hyoung Song, Hyun-Jeong Ko, Seung Hyun Kim. Labdane-type diterpenoids from Vitex limonifolia and their antivirus activities. Journal of natural medicines. 2018 Jan; 72(1):290-297. doi: 10.1007/s11418-017-1125-2. [PMID: 28914420]
  • Se Jin Jeon, Eunji Kim, Jin Su Lee, Hee Kyong Oh, Jiabao Zhang, Yubeen Kwon, Dae Sik Jang, Jong Hoon Ryu. Maslinic acid ameliorates NMDA receptor blockade-induced schizophrenia-like behaviors in mice. Neuropharmacology. 2017 Nov; 126(?):168-178. doi: 10.1016/j.neuropharm.2017.09.014. [PMID: 28899728]
  • Nguyen Huu Tung, Kensuke Nakajima, Takuhiro Uto, Nguyen Thanh Hai, Dinh Doan Long, Tomoe Ohta, Shigeru Oiso, Hiroko Kariyazono, Yukihiro Shoyama. Bioactive Triterpenes from the Root of Salvia miltiorrhiza Bunge. Phytotherapy research : PTR. 2017 Sep; 31(9):1457-1460. doi: 10.1002/ptr.5877. [PMID: 28766764]
  • Miroslav Novakovic, Jasmina Nikodinovic-Runic, Jovana Veselinovic, Tatjana Ilic-Tomic, Vera Vidakovic, Vele Tesevic, Slobodan Milosavljevic. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp. viridis Bark. Journal of natural products. 2017 05; 80(5):1255-1263. doi: 10.1021/acs.jnatprod.6b00805. [PMID: 28368586]
  • Maria Ferhat, Zahia Kabouchea, Yoshinori Fujimoto, Hiroshi Araya. Two New Triterpenes and Other Compounds from Mentha aquatica (Lamiaceae). Natural product communications. 2017 Apr; 12(4):483-486. doi: ". [PMID: 30520576]
  • Prasad G Jamkhande, Shahbaz K Pathan, Shailesh J Wadher. In silico PASS analysis and determination of antimycobacterial, antifungal, and antioxidant efficacies of maslinic acid in an extract rich in pentacyclic triterpenoids. International journal of mycobacteriology. 2016 12; 5(4):417-425. doi: 10.1016/j.ijmyco.2016.06.020. [PMID: 27931683]
  • Amalia Pérez-Jiménez, Eva E Rufino-Palomares, Nieves Fernández-Gallego, M Carmen Ortuño-Costela, Fernando J Reyes-Zurita, Juan Peragón, Leticia García-Salguero, Khalida Mokhtari, Pedro P Medina, José A Lupiáñez. Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Nov; 23(12):1301-1311. doi: 10.1016/j.phymed.2016.07.001. [PMID: 27765349]
  • Jun Cao, Li-Qing Peng, Jing-Jing Xu. Microcrystalline cellulose based matrix solid phase dispersion microextration for isomeric triterpenoid acids in loquat leaves by ultrahigh-performance liquid chromatography and quadrupole time-of-flight mass spectrometry. Journal of chromatography. A. 2016 Nov; 1472(?):16-26. doi: 10.1016/j.chroma.2016.10.034. [PMID: 27776775]
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  • Satoshi Fukumitsu, Myra O Villareal, Takashi Fujitsuka, Kazuhiko Aida, Hiroko Isoda. Anti-inflammatory and anti-arthritic effects of pentacyclic triterpenoids maslinic acid through NF-κB inactivation. Molecular nutrition & food research. 2016 Feb; 60(2):399-409. doi: 10.1002/mnfr.201500465. [PMID: 26499467]
  • Mluleki Luvuno, Hlengiwe Prosperity Mbongwa, Andile Khathi. THE EFFECTS OF Syzygium aromaticum-DERIVED TRITERPENES ON GASTROINTESTINAL GHRELIN EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2016; 13(4):8-14. doi: 10.21010/ajtcam.v13i4.2. [PMID: 28852714]
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  • Blessing N Mkhwanazi, Metse R Serumula, Rene B Myburg, Fanie R Van Heerden, Cephas T Musabayane. Antioxidant effects of maslinic acid in livers, hearts and kidneys of streptozotocin-induced diabetic rats: effects on kidney function. Renal failure. 2014 Apr; 36(3):419-31. doi: 10.3109/0886022x.2013.867799. [PMID: 24344651]
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  • Althaf Hussain Shaik, S N Rasool, M Abdul Kareem, G Saayi Krushna, P Mohammad Akhtar, Kodidhela Lakshmi Devi. Maslinic acid protects against isoproterenol-induced cardiotoxicity in albino Wistar rats. Journal of medicinal food. 2012 Aug; 15(8):741-6. doi: 10.1089/jmf.2012.2191. [PMID: 22846081]
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