Dammarane (BioDeep_00000901008)
Main id: BioDeep_00000177938
代谢物信息卡片
Dammarane
化学式: C30H54 (414.4225)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2(C1CCC3C2(CCC4C3(CCCC4(C)C)C)C)C
InChI: InChI=1S/C30H54/c1-21(2)11-9-12-22(3)23-15-19-29(7)24(23)13-14-26-28(6)18-10-17-27(4,5)25(28)16-20-30(26,29)8/h21-26H,9-20H2,1-8H3/t22-,23-,24-,25+,26-,28+,29-,30-/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Xue-Ting Zhao, De-Qiang Dou, Yang Qu, Guo-Gang Zhang. Structure elucidation and NMR spectral assignments of one new dammarane-type triterpenoid saponin from black ginseng.
Journal of Asian natural products research.
2024 May; 26(5):636-643. doi:
10.1080/10286020.2023.2253153. [PMID: 37681976] - Sunil Kumar, Neeti Singh, Vaibhavi Lahane, Vineeta Tripathi, Akhilesh Kumar Yadav, Rakesh Kumar Shukla. Methyl jasmonate inducible UGT79A18 is a novel glycosyltransferase involved in the bacoside biosynthetic pathway in Bacopa monnieri.
Physiologia plantarum.
2024 Mar; 176(2):e14260. doi:
10.1111/ppl.14260. [PMID: 38511471] - Daopeng Tan, Jianmei Wang, Xianting Wang, Lin Qin, Yimei Du, Changkuo Zhao, Peijun Liu, Qianru Zhang, Feifei Ma, Jian Xie, Di Wu, Yuqi He. New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity.
Journal of enzyme inhibition and medicinal chemistry.
2023 Dec; 38(1):2281263. doi:
10.1080/14756366.2023.2281263. [PMID: 37965892] - Abeer H Elmaidomy, Amr El Zawily, Aliasger K Salem, Faisal H Altemani, Naseh A Algehainy, Abdullah H Altemani, Mostafa E Rateb, Usama Ramadan Abdelmohsen, Nourhan Hisham Shady. New cytotoxic dammarane type saponins from Ziziphus spina-christi.
Scientific reports.
2023 11; 13(1):20612. doi:
10.1038/s41598-023-46841-2. [PMID: 37996449] - Daniele C P Rocha, Tháyna Sisnande, Daniel Gavino-Leopoldino, Iris Paula Guimarães-Andrade, Fernanda F Cruz, Iranaia Assunção-Miranda, Simony C Mendonça, Gilda Guimarães Leitão, Rosineide Costa Simas, Ronaldo Mohana-Borges, Suzana Guimarães Leitão, Diego Allonso. Antiviral, Cytoprotective, and Anti-Inflammatory Effect of Ampelozizyphus amazonicus Ducke Ethanolic Wood Extract on Chikungunya Virus Infection.
Viruses.
2023 11; 15(11):. doi:
10.3390/v15112232. [PMID: 38005909] - Hai-Zhen Liang, Peng-Xin Lu, Li-Li Chu, Gang Li, Chuan-Biao Li, Xiao-Juan Chen, Jie Zhang, Juan Song, Tao Zhang, Ying Luo, Ying Hu, Bai-Ping Ma. Dammarane-type saponins from Gynostemma pentaphyllum and their anti-aging activities via up-regulating mitochondria related proteins.
Phytochemistry.
2023 Sep; 213(?):113744. doi:
10.1016/j.phytochem.2023.113744. [PMID: 37301356] - Yue Liu, Yating Yang, Hanghang Wang, Han Li, Qi Lv, Xiachang Wang, Dalei Wu, Lihong Hu, Yinan Zhang. Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix.
Chinese journal of natural medicines.
2023 Aug; 21(8):599-609. doi:
10.1016/s1875-5364(23)60395-4. [PMID: 37611978] - Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhang. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction.
Neurochemical research.
2023 Jul; ?(?):. doi:
10.1007/s11064-023-03997-7. [PMID: 37490197] - Mei-Li Zhao, Xiang-Yu Li, Cheng-Xiang Lan, Zi-Ling Yuan, Jia-Lin Zhao, Ying Huang, Zhang-Li Hu, Bin Jia. Promoting Photosynthetic Production of Dammarenediol-II in Chlamydomonas reinhardtii via Gene Loading and Culture Optimization.
International journal of molecular sciences.
2023 Jul; 24(13):. doi:
10.3390/ijms241311002. [PMID: 37446180] - Purnama, Kindi Farabi, Dudi Runadi, Hadi Kuncoro, Desi Harneti, Nurlelasari, Tri Mayanti, Mohamad Nurul Azmi, Sofa Fajriah, Unang Supratman. The Cytotoxic Activity of Dammarane-Type Triterpenoids Isolated from the Stem Bark of Aglaia cucullata (Meliaceae).
Molecules (Basel, Switzerland).
2023 Jun; 28(13):. doi:
10.3390/molecules28134946. [PMID: 37446608] - Miao Ye, Lingjie Ruan, Lina Huang, Haiyin Zheng, Wen Xu, Wei Xu, Lixia Chen, Hua Li. Triterpenoids with diverse skeletons from the roots of Rhus chinensis and their protective effects on isoproterenol-induced heart failure in zebrafish.
Phytochemistry.
2023 Jun; 213(?):113749. doi:
10.1016/j.phytochem.2023.113749. [PMID: 37307886] - Shan-Bin Li, Xiao-Ya Xian, Cai-Feng Peng, Li-Qun Chen, Qin Luo, Li-Sheng Wang, Xian-Li Zhou, Cheng-Qin Liang. Two new dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus.
Journal of Asian natural products research.
2023 May; 25(5):438-445. doi:
10.1080/10286020.2022.2099384. [PMID: 35923147] - Xiaoqin Liang, Shengping Deng, Yan Huang, Liwei Pan, Yanling Chang, Ping Hou, Chenyang Ren, Weifeng Xu, Ruiyun Yang, Kanyuan Li, Jun Li, Ruijie He. Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083294. [PMID: 37110527] - Ling-Jie Ruan, Li-Na Huang, Xin-Yi Gao, Chang-Jie Lai, Lin-Jing Zhang, Yu-Fan Wu, Mei Sha, Miao Ye. [Isolation and quantification of a 17-epi-dammarane triterpenoid rhuslactone from roots of Rhus chinensis and its preventive effects on coronary heart disease and thrombosis in zebrafish].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Mar; 48(6):1558-1567. doi:
10.19540/j.cnki.cjcmm.20221227.201. [PMID: 37005844] - Kindi Farabi, Desi Harneti, Darwati, Tri Mayanti, Nurlelasari, Rani Maharani, Aprilia Permata Sari, Tati Herlina, Ace Tatang Hidayat, Unang Supratman, Sofa Fajriah, Mohamad Nurul Azmi, Yoshihito Shiono. Dammarane-Type Triterpenoid from the Stem Bark of Aglaia elliptica (Meliaceae) and Its Cytotoxic Activities.
Molecules (Basel, Switzerland).
2022 Oct; 27(19):. doi:
10.3390/molecules27196757. [PMID: 36235298] - Jun Wang, Xian-Hua Meng, Wei-Feng Wang, Chun-Yan Sang, Thi-Kim-Quy Ha, Jun-Li Yang. Dammarane triterpenoids with rare skeletons from Gynostemma pentaphyllum and their cytotoxic activities.
Fitoterapia.
2022 Oct; 162(?):105280. doi:
10.1016/j.fitote.2022.105280. [PMID: 35964850] - Hong-Xia Zhang, Zhong-Ze Wang, Zhi-Zhi Du. Sensory-guided isolation and identification of new sweet-tasting dammarane-type saponins from Jiaogulan (Gynostemma pentaphyllum) herbal tea.
Food chemistry.
2022 Sep; 388(?):132981. doi:
10.1016/j.foodchem.2022.132981. [PMID: 35468461] - Yuan-Yuan Zhou, Hui-Rui Gao, Hong-Juan Song, Dan-Da Ma, Xiao-Juan Zhang, Yan-Ping Sun, Yan Liu, Xiao-Li Wang, Bing-You Yang, Hai-Xue Kuang. Two new dammarane-type triterpenoids from the green walnut husks of Juglans mandshurica Maxim.
Natural product research.
2022 Apr; 36(7):1812-1819. doi:
10.1080/14786419.2020.1818233. [PMID: 32954873] - Yuan-Ru Zheng, Chun-Lin Fan, Ye Chen, Jing-Yu Quan, Ling-Zhu Shi, Chun-Yang Tian, Xiao Shang, Ni-Shan Xu, Wen-Cai Ye, Lin-Zhong Yu, Jun-Shan Liu. Anti-inflammatory, anti-angiogenetic and antiviral activities of dammarane-type triterpenoid saponins from the roots of Panax notoginseng.
Food & function.
2022 Mar; 13(6):3590-3602. doi:
10.1039/d1fo04089h. [PMID: 35262135] - Ya-Ping Huang, Yun-Shan Wang, Bi-Wen Liu, Zhe Song, Xiao-Shuang Liang, Yuan Teng, Jian Zhang, Zhi-Qi Yin, Ke Pan. Dammarane-type saponins with proprotein convertase subtilisin/kexin type 9 inhibitory activity from Gynostemma pentaphyllum.
Phytochemistry.
2022 Feb; 194(?):113005. doi:
10.1016/j.phytochem.2021.113005. [PMID: 34798409] - Xueni Niu, Xiaoyu Fan, Chongning Lv, Jincai Lu. Two new dammarane-type ginsenosides from Panax ginseng.
Natural product research.
2021 Dec; ?(?):1-6. doi:
10.1080/14786419.2021.1991338. [PMID: 34927483] - Yun-Yun Lou, Xian Zheng, Ya-Ping Huang, Long Mu, Xiao-Gai Zhang, Zhi-Wei Zhao, Zhe Song, Jian Zhang, Zhi-Qi Yin, Ke Pan. New dammarane-type triterpenoid saponins from Gynostemma pentaphyllum and their Sirt1 agonist activity.
Bioorganic chemistry.
2021 11; 116(?):105357. doi:
10.1016/j.bioorg.2021.105357. [PMID: 34562675] - Li-Ping Zhu, Hui-Min Yang, Xian Zheng, Guan-Tao Zheng, Cui-Hua Jiang, Jian Zhang, Zhi-Qi Yin. Four new dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus and their SIRT1 activation activities.
Fitoterapia.
2021 Oct; 154(?):105003. doi:
10.1016/j.fitote.2021.105003. [PMID: 34333032] - Soh Désiré, Nkwengoua Ernestine, Tchebemou Bakang Bruno, Sidjui Sidjui Lazare, Dzo Defokou Ulrich, Mehreen Lateef, Bernd Schneider, Muhammad Shaiq Ali, Nyassé Barthélemy. A new dammarane type triterpene glucoside from the aerial parts of Gouania longipetala (Rhamnaceae).
Natural product research.
2021 Oct; 35(19):3192-3203. doi:
10.1080/14786419.2019.1690483. [PMID: 31782674] - Xin Weng, Yun-Yun Lou, Yun-Shan Wang, Ya-Ping Huang, Jian Zhang, Zhi-Qi Yin, Ke Pan. New dammarane-type glycosides from Gynostemma pentaphyllum and their lipid-lowering activity.
Bioorganic chemistry.
2021 06; 111(?):104843. doi:
10.1016/j.bioorg.2021.104843. [PMID: 33845383] - Chenguo Li, Shengping Deng, Wei Liu, Dexiong Zhou, Yan Huang, Cheng-Qin Liang, Lili Hao, Gaorong Zhang, Shanshan Su, Xia Xu, Ruiyun Yang, Jun Li, Xishan Huang. α-Glucosidase inhibitory and anti-inflammatory activities of dammarane triterpenoids from the leaves of Cyclocarya paliurus.
Bioorganic chemistry.
2021 06; 111(?):104847. doi:
10.1016/j.bioorg.2021.104847. [PMID: 33798849] - Chong-Kang Yang, Jiao Xiong, Yong Shen. Two new dammarane-type triterpenoids from the stems and leaves of Panax notoginseng.
Journal of Asian natural products research.
2021 Apr; 23(4):341-347. doi:
10.1080/10286020.2020.1731801. [PMID: 32124646] - Xian-Li Zhou, Shan-Bin Li, Meng-Qi Yan, Qin Luo, Li-Sheng Wang, Ling-Li Shen, Mei-Lian Liao, Cai-Hua Lu, Xia-Yan Liu, Cheng-Qin Liang. Bioactive dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus.
Phytochemistry.
2021 Mar; 183(?):112618. doi:
10.1016/j.phytochem.2020.112618. [PMID: 33352359] - Tong-Yao Xuan, Jie Tan, Hui-Hui Sun, Can Yang, Wen-Yan Lv, Ji-Hua Zhang, Ke-Qing Zhang, Ze-Qun Nie, Zi-Jun Ye, Xiao-Ai He, Gang-Zhi Zhu, Kang-Ping Xu. Cyclocarioside O-Q, three novel seco-dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus.
Natural product research.
2021 Jan; 35(1):167-173. doi:
10.1080/14786419.2019.1616722. [PMID: 31198051] - Baobao Zhang, Xiaolong Hu, Huizhe Wang, Rong Wang, Zhongxuan Sun, Xiaomei Tan, Shumeng Liu, Hao Wang. Effects of a dammarane-type saponin, ginsenoside Rd, in nicotine-induced vascular endothelial injury.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Dec; 79(?):153325. doi:
10.1016/j.phymed.2020.153325. [PMID: 32920289] - Ran Xu, Jiao Zhang, Jingmao You, Limei Gao, Yongchang Li, Shaopeng Zhang, Wenjun Zhu, Shaohua Shu, Chao Xiong, Hui Xiong, Ping Chen, Jie Guo, Zhiguo Liu. Full-length transcriptome sequencing and modular organization analysis of oleanolic acid- and dammarane-type saponins related gene expression patterns in Panax japonicus.
Genomics.
2020 11; 112(6):4137-4147. doi:
10.1016/j.ygeno.2020.06.045. [PMID: 32653517] - Ning Jiang, Haixia Wang, Jingwei Lv, Qiong Wang, Cong Lu, Yujiao Li, Xinmin Liu. Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways.
Phytotherapy research : PTR.
2020 Oct; 34(10):2721-2729. doi:
10.1002/ptr.6713. [PMID: 32431006] - Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators.
Bioorganic & medicinal chemistry letters.
2020 09; 30(17):127364. doi:
10.1016/j.bmcl.2020.127364. [PMID: 32738969] - Maojing Yin, Jingjing Zhang, Lizhi Wang, Fangyi Li, Zhenfa Li, Wei Xiang, Songtao Bie, Chunhua Wang, Zheng Li. Ten New Dammarane-Type Saponins with Hypolipidemia Activity from a Functional Herbal Tea-Gynostemma pentaphyllum.
Molecules (Basel, Switzerland).
2020 Aug; 25(16):. doi:
10.3390/molecules25163737. [PMID: 32824271] - Xiaoshu Zhang, Guohui Shi, Xiaojun Wu, Yuqing Zhao. Gypensapogenin H from hydrolyzate of total Gynostemma pentaphyllum saponins induces apoptosis in human breast carcinoma cells.
Natural product research.
2020 Jun; 34(11):1642-1646. doi:
10.1080/14786419.2018.1525370. [PMID: 30470142] - Pamita Bhandari, Nitisha Sendri, Shinde Bhagatsing Devidas. Dammarane triterpenoid glycosides in Bacopa monnieri: A review on chemical diversity and bioactivity.
Phytochemistry.
2020 Apr; 172(?):112276. doi:
10.1016/j.phytochem.2020.112276. [PMID: 32058865] - Afef Ladhari, Immacolata Tufano, Marina DellaGreca. Influence of new effective allelochemicals on the distribution of Cleome arabica L. community in nature.
Natural product research.
2020 Mar; 34(6):773-781. doi:
10.1080/14786419.2018.1501688. [PMID: 30445848] - Shao-Fang Xing, Man Lin, Yu-Rong Wang, Tuo Chang, Wei-Ye Cui, Xiang-Lan Piao. Novel dammarane-type saponins from Gynostemma pentaphyllum and their neuroprotective effect.
Natural product research.
2020 Mar; 34(5):651-658. doi:
10.1080/14786419.2018.1495638. [PMID: 30320511] - Miao Ye, Wen Xu, Da-Qing He, Xian Wu, Wen-Fang Lai, Xiao-Qin Zhang, Yu Lin, Wei Xu, Xu-Wen Li. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis.
Journal of natural products.
2020 02; 83(2):362-373. doi:
10.1021/acs.jnatprod.9b00857. [PMID: 32031812] - Wei Liu, Shengping Deng, Dexiong Zhou, Yan Huang, Chenguo Li, Lili Hao, Gaorong Zhang, Shanshan Su, Xia Xu, Ruiyun Yang, Jun Li, Xishan Huang. 3,4-seco-Dammarane Triterpenoid Saponins with Anti-Inflammatory Activity Isolated from the Leaves of Cyclocarya paliurus.
Journal of agricultural and food chemistry.
2020 Feb; 68(7):2041-2053. doi:
10.1021/acs.jafc.9b06898. [PMID: 31967813] - Lu Ma, Xude Wang, Wei Li, Dongyu Miao, Yan Li, Jincai Lu, Yuqing Zhao. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
European journal of medicinal chemistry.
2020 Feb; 187(?):111964. doi:
10.1016/j.ejmech.2019.111964. [PMID: 31862444] - Thi Kieu My Than, Thanh Ky Pham, Thanh Binh Pham, Thao Nguyen Phuong, Dat Nguyen Tien. New dammarane-type triterpenoid glycosides from Gynostemma burmanicum.
Natural product research.
2020 Jan; 34(2):217-224. doi:
10.1080/14786419.2018.1527831. [PMID: 30580625] - Fan Sun, Jingya Ruan, Wei Zhao, Ying Zhang, Guilin Xiang, Jiejing Yan, Mimi Hao, Lijie Wu, Yi Zhang, Tao Wang. New Dammarane-Type Triterpenoid Saponins from Panax notoginseng Leaves and Their Nitric Oxide Inhibitory Activities.
Molecules (Basel, Switzerland).
2019 Dec; 25(1):. doi:
10.3390/molecules25010139. [PMID: 31905770] - Amina Khatun, Mahmudur Rahman, Mohammad Sharifur Rahman, Md Khalid Hossain, Mohammad Abdur Rashid. Terpenoids and phytosteroids isolated from Commelina benghalensis Linn. with antioxidant activity.
Journal of basic and clinical physiology and pharmacology.
2019 Nov; 31(1):. doi:
10.1515/jbcpp-2018-0218. [PMID: 31770097] - Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Cong Lu, Qiong Wang, Tian-Ji Xia, Yu Bao, Shan-Shan Li, Xin-Min Liu. Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus.
Brain research bulletin.
2019 11; 153(?):239-249. doi:
10.1016/j.brainresbull.2019.09.007. [PMID: 31542427] - Jung Yeon Han, So-Hyeon Baek, Hye Jeong Jo, Do Won Yun, Yong Eui Choi. Genetically modified rice produces ginsenoside aglycone (protopanaxadiol).
Planta.
2019 Oct; 250(4):1103-1110. doi:
10.1007/s00425-019-03204-4. [PMID: 31168665] - Carlos Henrique Corrêa Dos Santos, Mario Geraldo de Carvalho, Katrin Franke, Ludger Wessjohann. Dammarane-type triterpenoids from the stem of Ziziphus glaziovii Warm. (Rhamnaceae).
Phytochemistry.
2019 Jun; 162(?):250-259. doi:
10.1016/j.phytochem.2019.03.010. [PMID: 30965192] - Wei Li, Yi Wu, Mali Wan, Yang Chu, Xiangyang Wang, Shuming Li, Zuhui Liu, Xue Chen, Navaneethakrishnan Polachi, Shuiping Zhou, He Sun. Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):254-259. doi:
10.1016/j.jpba.2019.03.008. [PMID: 30878903] - Po-Yen Chen, Chih-Chao Chang, Hui-Chi Huang, Li-Jie Zhang, Chia-Ching Liaw, Yu-Chi Lin, Nham-Linh Nguyen, Thanh-Hoa Vo, Yung-Yi Cheng, Susan L Morris-Natschke, Kuo-Hsiung Lee, Yao-Haur Kuo. New Dammarane-type Saponins from Gynostemma pentaphyllum.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071375. [PMID: 30965662] - Thi Kim Quy Ha, Ha Thanh Tung Pham, Hyo Moon Cho, Van On Tran, Jun-Li Yang, Da-Woon Jung, Darren R Williams, Won Keun Oh. 12,23-Dione dammarane triterpenes from Gynostemma longipes and their muscle cell proliferation activities via activation of the AMPK pathway.
Scientific reports.
2019 02; 9(1):1186. doi:
10.1038/s41598-018-37808-9. [PMID: 30718856] - Lena C E Lundqvist, Darren Rattigan, Emad Ehtesham, Camila Demmou, Claes-Göran Östenson, Corine Sandström. Profiling and activity screening of Dammarane-type triterpen saponins from Gynostemma pentaphyllum with glucose-dependent insulin secretory activity.
Scientific reports.
2019 01; 9(1):627. doi:
10.1038/s41598-018-37517-3. [PMID: 30679754] - Ning Jiang, Bei-Yue Zhang, Li-Ming Dong, Jing-Wei Lv, Cong Lu, Qiong Wang, Lin-Xi Fan, Hong-Xia Zhang, Rui-Le Pan, Xin-Min Liu. Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress-induced depressive mice.
Phytotherapy research : PTR.
2018 Jun; 32(6):1023-1029. doi:
10.1002/ptr.6040. [PMID: 29468732] - Liming Dong, Yanyan Yang, Yan Lu, Cong Lu, Jingwei Lv, Ning Jiang, Qiuxia Xu, Yue Gao, Qi Chang, Xinmin Liu. Radioprotective effects of dammarane sapogenins against 60 Co-induced myelosuppression in mice.
Phytotherapy research : PTR.
2018 Apr; 32(4):741-749. doi:
10.1002/ptr.6027. [PMID: 29356175] - Cheng-Zhen Gu, Yi-Jun Qiao, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Min Xu, Ying-Jun Zhang. New triterpenoid saponins from the steaming treated roots of Panax notoginseng.
Natural product research.
2018 Feb; 32(3):294-301. doi:
10.1080/14786419.2017.1356833. [PMID: 28758425] - Yan-Jiao Chen, Liang Na, Jialong Fan, Jianping Zhao, Nusrat Hussain, Yu-Qing Jian, Hanwen Yuan, Bin Li, Bin Liu, M Iqbal Choudhary, Ikhlas Khan, Wei Wang. Seco-dammarane triterpenoids from the leaves of Cyclocarya paliurus.
Phytochemistry.
2018 Jan; 145(?):85-92. doi:
10.1016/j.phytochem.2017.10.013. [PMID: 29107810] - Xin-Yi Liu, Shan Wang, Chuang-Jun Li, Jie Ma, Fang-You Chen, Ying Peng, Xiao-Liang Wang, Dong-Ming Zhang. Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.
Phytochemistry.
2018 Jan; 145(?):10-17. doi:
10.1016/j.phytochem.2017.09.020. [PMID: 29035776] - Meng Ding, Lei Xu, Yumeng Zhang, Yuqing Zhao. Polymorphic characterization and bioavailability of 20(R)-25-methoxyl-dammarane-3β,12β,20-triol, a novel dammarane triterpenoid saponin, as anticancer agents.
Journal of pharmaceutical and biomedical analysis.
2017 Oct; 145(?):773-782. doi:
10.1016/j.jpba.2017.08.007. [PMID: 28818803] - Li-Dong Shao, Ying Bao, Yu Shen, Jia Su, Ying Leng, Qin-Shi Zhao. Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold.
European journal of medicinal chemistry.
2017 Jul; 135(?):324-338. doi:
10.1016/j.ejmech.2017.04.059. [PMID: 28458137] - Alen Bozicevic, Maria De Mieri, Angela Di Benedetto, Frank Gafner, Matthias Hamburger. Dammarane-type saponins from leaves of Ziziphus spina-christi.
Phytochemistry.
2017 Jun; 138(?):134-144. doi:
10.1016/j.phytochem.2017.02.028. [PMID: 28274571] - Wu-Xi Zhou, Yuan-Yuan Sun, Wei-Hui Yuan, Yu-Qing Zhao. Water-soluble derivatives of 25-OCH3-PPD and their anti-proliferative activities.
Steroids.
2017 05; 121(?):32-39. doi:
10.1016/j.steroids.2017.03.005. [PMID: 28322864] - Thanh Tra Nguyen, Bich Ngan Truong, Huong Doan Thi Mai, Marc Litaudon, Van Hung Nguyen, Thao Do Thi, Van Minh Chau, Van Cuong Pham. Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum.
Bioorganic & medicinal chemistry letters.
2017 04; 27(8):1665-1669. doi:
10.1016/j.bmcl.2017.03.014. [PMID: 28318944] - Kumiko Kitamura, Yusuke Takamura, Taku Iwamoto, Mitsuru Nomura, Hideaki Iwasaki, Motoyasu Ohdera, Michiaki Murakoshi, Keikichi Sugiyama, Kazuki Matsuyama, Yasuko Manabe, Nobuharu L Fujii, Tohru Fushiki. Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle.
Bioscience, biotechnology, and biochemistry.
2017 Feb; 81(2):335-342. doi:
10.1080/09168451.2016.1246173. [PMID: 27771987] - Fabiana de Souza Figueiredo, Rita Celano, Danila de Sousa Silva, Fernanda das Neves Costa, Peter Hewitson, Svetlana Ignatova, Anna Lisa Piccinelli, Luca Rastrelli, Suzana Guimarães Leitão, Gilda Guimarães Leitão. Countercurrent chromatography separation of saponins by skeleton type from Ampelozizyphus amazonicus for off-line ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry analysis and characterisation.
Journal of chromatography. A.
2017 Jan; 1481(?):92-100. doi:
10.1016/j.chroma.2016.12.053. [PMID: 28027839] - Wei Xu, Xin Liu, Xiao-Li Liu, Ai-Ling Jia, Xin-Wen Wang, Zhi-Dong Qiu. Two new dammarane-type triterpenoid saponins from notoginseng medicinal fungal substance.
Journal of Asian natural products research.
2016 Dec; 18(12):1138-1142. doi:
10.1080/10286020.2016.1189907. [PMID: 27268250] - Carlos Henrique Corrêa Dos Santos, Izabeau Pontes Borges, Virgínia Claudia da Silva, Paulo Teixeira de Sousa, Nair Honda Kawashita, Amanda Martins Baviera, Mario Geraldo de Carvalho. A new dammarane saponin and other triterpenoids from Siolmatra brasiliensis and evaluation of the antidiabetic activity of its extract.
Pharmaceutical biology.
2016 Sep; 54(9):1539-47. doi:
10.3109/13880209.2015.1107108. [PMID: 26810155] - Wei Xu, Jin-Hui Zhang, Xin-Wen Wang, Xiao-Li Liu, Xin Liu, Zhi-Dong Qiu. Two new triterpenoid saponins from ginseng medicinal fungal substance.
Journal of Asian natural products research.
2016 Sep; 18(9):865-70. doi:
10.1080/10286020.2016.1169274. [PMID: 27053377] - Tomoe Ohta, Seikou Nakamura, Souichi Nakashima, Yoshimi Oda, Takahiro Matsumoto, Masashi Fukaya, Mamiko Yano, Masayuki Yoshikawa, Hisashi Matsuda. Chemical structures of constituents from the whole plant of Bacopa monniera.
Journal of natural medicines.
2016 Jul; 70(3):404-11. doi:
10.1007/s11418-016-0986-0. [PMID: 27010932] - Nuraqilah Othman, Li Pan, Michele Mejin, Julian C L Voong, Hee-byung Chai, Caroline M Pannell, A Douglas Kinghorn, Tiong C Yeo. Cyclopenta[b]benzofuran and Secodammarane Derivatives from the Stems of Aglaia stellatopilosa.
Journal of natural products.
2016 Apr; 79(4):784-91. doi:
10.1021/acs.jnatprod.5b00810. [PMID: 26974604] - Yong-Jin Yang, Juan Yao, Xiao-Jie Jin, Zhuan-Ning Shi, Tian-Fei Shen, Jian-Guo Fang, Xiao-Jun Yao, Ying Zhu. Sesquiterpenoids and tirucallane triterpenoids from the roots of Scorzonera divaricata.
Phytochemistry.
2016 Apr; 124(?):86-98. doi:
10.1016/j.phytochem.2016.01.015. [PMID: 26832425] - Hoang Linh Mai, Philippe Grellier, Elise Prost, Pascale Lemoine, Cyril Poullain, Vincent Dumontet, Brigitte Deguin, Thi Bach Hue Vo, Sylvie Michel, Raphaël Grougnet. Triterpenes from the exudate of Gardenia urvillei.
Phytochemistry.
2016 Feb; 122(?):193-202. doi:
10.1016/j.phytochem.2015.11.001. [PMID: 26608669] - Xiangrong Zhang, Yi Zhang, Shuang Guo, Feifei Bai, Tong Wu, Yuqing Zhao. Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats.
Drug design, development and therapy.
2016; 10(?):3707-3716. doi:
10.2147/dddt.s114374. [PMID: 27877020] - Liu Han, Zhuo Li, Qian Zheng, Jin-Ping Liu, Ping-Ya Li. A new triterpenoid compound from stems and leaves of American ginseng.
Natural product research.
2016; 30(1):13-9. doi:
10.1080/14786419.2015.1030403. [PMID: 25894541] - Xiao-Shu Zhang, Chen Zhao, Wei-zhuo Tang, Xiao-jun Wu, Yu-Qing Zhao. Gypensapogenin H, a novel dammarane-type triterpene induces cell cycle arrest and apoptosis on prostate cancer cells.
Steroids.
2015 Dec; 104(?):276-83. doi:
10.1016/j.steroids.2015.10.014. [PMID: 26514740] - Byong-Kyu Shin, Jihyung Lee, Tae Hoon Choi. Conformational studies of dammarane-type triterpenoids using computational and NMR spectroscopic methods.
Magnetic resonance in chemistry : MRC.
2015 Dec; 53(12):1035-42. doi:
10.1002/mrc.4302. [PMID: 26249364] - Zhiwei Huang, Juncheng Lin, Zuxin Cheng, Ming Xu, Xinying Huang, Zhijian Yang, Jingui Zheng. Production of dammarane-type sapogenins in rice by expressing the dammarenediol-II synthase gene from Panax ginseng C.A. Mey.
Plant science : an international journal of experimental plant biology.
2015 Oct; 239(?):106-14. doi:
10.1016/j.plantsci.2015.07.021. [PMID: 26398795] - Cheng-Zhen Gu, Jun-Jiang Lv, Xiao-Xia Zhang, Yi-Jun Qiao, Hui Yan, Yan Li, Dong Wang, Hong-Tao Zhu, Huai-Rong Luo, Chong-Ren Yang, Min Xu, Ying-Jun Zhang. Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng.
Journal of natural products.
2015 Aug; 78(8):1829-40. doi:
10.1021/acs.jnatprod.5b00027. [PMID: 26200131] - Xiao-Shu Zhang, Jia-Qing Cao, Chen Zhao, Xu-de Wang, Xiao-jun Wu, Yu-Qing Zhao. Novel dammarane-type triterpenes isolated from hydrolyzate of total Gynostemma pentaphyllum saponins.
Bioorganic & medicinal chemistry letters.
2015 Aug; 25(16):3095-9. doi:
10.1016/j.bmcl.2015.06.022. [PMID: 26099540] - Che Zhao, Tianhui Xu, Yanlong Liang, Shoujing Zhao, Luquan Ren, Qian Wang, Bo Dou. Functional analysis of β-amyrin synthase gene in ginsenoside biosynthesis by RNA interference.
Plant cell reports.
2015 Aug; 34(8):1307-15. doi:
10.1007/s00299-015-1788-7. [PMID: 25899218] - Jiaqing Cao, Xiaoshu Zhang, Fanzhi Qu, Zhenghong Guo, Yuqing Zhao. Dammarane triterpenoids for pharmaceutical use: a patent review (2005 - 2014).
Expert opinion on therapeutic patents.
2015 Jul; 25(7):805-17. doi:
10.1517/13543776.2015.1038239. [PMID: 25892194] - Cheng-Zhen Gu, Jun-Jiang Lv, Xiao-Xia Zhang, Hui Yan, Hong-Tao Zhu, Huai-Rong Luo, Dong Wang, Chong-Ren Yang, Min Xu, Ying-Jun Zhang. Minor dehydrogenated and cleavaged dammarane-type saponins from the steamed roots of Panax notoginseng.
Fitoterapia.
2015 Jun; 103(?):97-105. doi:
10.1016/j.fitote.2015.03.014. [PMID: 25797537] - Chul Lee, Jin Woo Lee, Qinghao Jin, Hari Jang, Hyun-Jae Jang, Mun-Chual Rho, Myung Koo Lee, Chong Kil Lee, Mi Kyeong Lee, Bang Yeon Hwang. Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation.
Journal of natural products.
2015 May; 78(5):971-6. doi:
10.1021/np500803e. [PMID: 25895106] - Cen Yuan, Fa-Xiang Xu, Xiao-Jun Huang, Shao-Ping Li, Qing-Wen Zhang. A novel 12, 23-epoxy dammarane saponin from Panax notoginseng.
Chinese journal of natural medicines.
2015 Apr; 13(4):303-6. doi:
10.1016/s1875-5364(15)30019-4. [PMID: 25908629] - Thanika Pathomwichaiwat, Pannee Ochareon, Noppamas Soonthornchareonnon, Zulfiqar Ali, Ikhlas A Khan, Sompop Prathanturarug. Alkaline phosphatase activity-guided isolation of active compounds and new dammarane-type triterpenes from Cissus quadrangularis hexane extract.
Journal of ethnopharmacology.
2015 Feb; 160(?):52-60. doi:
10.1016/j.jep.2014.11.026. [PMID: 25449449] - Dong Gu Lee, Ah Young Lee, Kyung-Tack Kim, Eun Ju Cho, Sanghyun Lee. Novel Dammarane-Type Triterpene Saponins from Panax ginseng Root.
Chemical & pharmaceutical bulletin.
2015; 63(11):927-34. doi:
10.1248/cpb.c15-00302. [PMID: 26521857] - Xiang-Lan Piao, Shao-Fang Xing, Cai-Xia Lou, Dao-Jin Chen. Novel dammarane saponins from Gynostemma pentaphyllum and their cytotoxic activities against HepG2 cells.
Bioorganic & medicinal chemistry letters.
2014 Oct; 24(20):4831-3. doi:
10.1016/j.bmcl.2014.08.059. [PMID: 25227718] - Jun-Li Yang, Thi-Kim-Quy Ha, Basanta Dhodary, Kuk-Hwa Kim, Junsoo Park, Chul-Ho Lee, Young-Choong Kim, Won-Keun Oh. Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng.
Journal of natural products.
2014 Jul; 77(7):1615-23. doi:
10.1021/np5002303. [PMID: 24968750] - Hui-Jiao Yan, Jun-Song Wang, Ling-Yi Kong. Cytotoxic dammarane-type triterpenoids from the stem bark of Dysoxylum binecteriferum.
Journal of natural products.
2014 Feb; 77(2):234-42. doi:
10.1021/np400700g. [PMID: 24547740] - Qian Wu, Moonhee Jang, Xiang-Lan Piao. Determination by UPLC-MS of four dammarane-type saponins from heat-processed Gynostemma pentaphyllum.
Bioscience, biotechnology, and biochemistry.
2014; 78(2):311-6. doi:
10.1080/09168451.2014.882751. [PMID: 25036687] - Tien-Lam Tran, Young-Ran Kim, Jun-Li Yang, Dool-Ri Oh, Trong-Tuan Dao, Won-Keun Oh. Dammarane triterpenes from the leaves of Panax ginseng enhance cellular immunity.
Bioorganic & medicinal chemistry.
2014 Jan; 22(1):499-504. doi:
10.1016/j.bmc.2013.11.002. [PMID: 24290061] - Ming-Ming Ding, Fu-Lin Yan, Jing Tan, Yi-Xiao Bai, Xiang Wang, Yan-Xia Yang. Two new dammarane-type glycosides from Phlomis umbrosa.
Natural product research.
2014; 28(1):18-23. doi:
10.1080/14786419.2013.828291. [PMID: 23972014] - Yue Liu, Man-Qi Zhang, Xia-Lei Li, Tun-Hai Xu, Sheng-Xu Xie, Ya-Juan Xu, Dong-Ming Xu. Study on chemical constituents of Cyclocarya paliurus.
Journal of Asian natural products research.
2014; 16(2):206-9. doi:
10.1080/10286020.2013.825254. [PMID: 24286491] - Russell B Williams, Vanessa L Norman, Matt G Goering, Mark O'Neil-Johnson, Gary R Eldridge, Courtney M Starks. Acetylated dammarane-type bisdesmosides from Combretum inflatum.
Journal of natural products.
2013 Sep; 76(9):1592-7. doi:
10.1021/np4002652. [PMID: 23978065] - Jin-Ping Liu, Xu Tian, Hai-Yu Liu, Qing-He Zhang, Dan Lu, Ping-Ya Li, Chun-Fang Zhao. Two novel dammarane-type compounds from the leaves and stems of Panax quinquefolium L.
Journal of Asian natural products research.
2013 Sep; 15(9):974-8. doi:
10.1080/10286020.2013.794416. [PMID: 24266579] - Xiang-Lan Piao, Qian Wu, Jing Yang, Seo Young Park, Dao-Jin Chen, Hui-Min Liu. Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells.
Archives of pharmacal research.
2013 Jul; 36(7):874-9. doi:
10.1007/s12272-013-0086-6. [PMID: 23508742] - Peng Cao, Guobiao Liang, Xu Gao, Xiaogang Wang, Zhiqing Li. Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line.
Archives of pharmacal research.
2013 Mar; 36(3):322-6. doi:
10.1007/s12272-013-0030-9. [PMID: 23435909] - Usama W Hawas, Amira M Gamal-Eldeen, Samy K El-Desouky, Young-Kyoon Kim, Antje Huefner, Robert Saf. Induction of caspase-8 and death receptors by a new dammarane skeleton from the dried fruits of Forsythia koreana.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2013 Jan; 68(1-2):29-38. doi:
. [PMID: 23659170] - Kouichi Yoshizaki, Hari Prasad Devkota, Shoji Yahara. Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4).
Chemical & pharmaceutical bulletin.
2013; 61(3):273-8. doi:
10.1248/cpb.c12-00794. [PMID: 23238233] - Zheng Xiang, Jia Lv, Zhixun Zhou, Yingying Li, Deqiang Dou, Jinming Zhao. Two new dammarane-type saponins from leaves of Panax quinquefolium.
Natural product research.
2013; 27(14):1271-6. doi:
10.1080/14786419.2012.730045. [PMID: 23030625] - Xiao-Shu Zhang, Xiu-Li Bi, Wan-Xiao, Jia-Qing Cao, Xi-Chun Xia, Yun-Peng Diao, Yu-Qing Zhao. Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.
Bioorganic & medicinal chemistry letters.
2013 Jan; 23(1):297-300. doi:
10.1016/j.bmcl.2012.10.097. [PMID: 23177789]
